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Protein

40S ribosomal protein S1-A

Gene

RPS1A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32497-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S1-AUniRule annotation
Alternative name(s):
RP10A
Gene namesi
Name:RPS1AUniRule annotation
Synonyms:PLC1, RPS10A
Ordered Locus Names:YLR441C
ORF Names:L9753.9
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR441C.
SGDiS000004433. RPS1A.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central
  • cytosolic small ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation1 Publication
ChainiPRO_00001535412 – 25540S ribosomal protein S1-AAdd BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine; partialUniRule annotation1 Publication1
Modified residuei245PhosphothreonineCombined sources1
Cross-linki248Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei254PhosphothreonineCombined sources1

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP33442.
PRIDEiP33442.
TopDownProteomicsiP33442.

PTM databases

iPTMnetiP33442.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi31700. 72 interactors.
DIPiDIP-4147N.
IntActiP33442. 59 interactors.
MINTiMINT-8285687.

Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni23 – 26Combined sources4
Beta strandi29 – 33Combined sources5
Beta strandi36 – 39Combined sources4
Beta strandi41 – 47Combined sources7
Beta strandi53 – 55Combined sources3
Helixi57 – 60Combined sources4
Beta strandi65 – 70Combined sources6
Helixi71 – 74Combined sources4
Beta strandi75 – 77Combined sources3
Beta strandi83 – 87Combined sources5
Beta strandi93 – 98Combined sources6
Beta strandi99 – 103Combined sources5
Helixi107 – 113Combined sources7
Beta strandi116 – 118Combined sources3
Beta strandi120 – 122Combined sources3
Beta strandi125 – 128Combined sources4
Beta strandi130 – 132Combined sources3
Beta strandi134 – 137Combined sources4
Beta strandi140 – 142Combined sources3
Beta strandi151 – 153Combined sources3
Helixi159 – 175Combined sources17
Beta strandi176 – 179Combined sources4
Helixi180 – 188Combined sources9
Turni189 – 191Combined sources3
Helixi192 – 202Combined sources11
Beta strandi208 – 211Combined sources4
Beta strandi215 – 219Combined sources5
Helixi225 – 228Combined sources4
Helixi229 – 231Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10S11-255[»]
3J6Yelectron microscopy6.10S11-255[»]
3J77electron microscopy6.20S11-255[»]
3J78electron microscopy6.30S11-255[»]
3V88X-ray3.00B1-255[»]
4U3MX-ray3.00S1/s12-255[»]
4U3NX-ray3.20S1/s12-255[»]
4U3UX-ray2.90S1/s12-255[»]
4U4NX-ray3.10S1/s12-255[»]
4U4OX-ray3.60S1/s12-255[»]
4U4QX-ray3.00S1/s12-255[»]
4U4RX-ray2.80S1/s12-255[»]
4U4UX-ray3.00S1/s12-255[»]
4U4YX-ray3.20S1/s12-255[»]
4U4ZX-ray3.10S1/s12-255[»]
4U50X-ray3.20S1/s12-255[»]
4U51X-ray3.20S1/s12-255[»]
4U52X-ray3.00S1/s12-255[»]
4U53X-ray3.30S1/s12-255[»]
4U55X-ray3.20S1/s12-255[»]
4U56X-ray3.45S1/s12-255[»]
4U6FX-ray3.10S1/s12-255[»]
4V88X-ray3.00AB/CB1-255[»]
4V8Yelectron microscopy4.30AB1-255[»]
4V8Zelectron microscopy6.60AB1-255[»]
4V92electron microscopy3.70B21-233[»]
5DATX-ray3.15S1/s12-255[»]
5DC3X-ray3.25S1/s12-255[»]
5FCIX-ray3.40S1/s12-255[»]
5FCJX-ray3.10S1/s12-255[»]
5I4LX-ray3.10S1/s120-235[»]
5JUOelectron microscopy4.00YA1-255[»]
5JUPelectron microscopy3.50YA1-255[»]
5JUSelectron microscopy4.20YA1-255[»]
5JUTelectron microscopy4.00YA1-255[»]
5JUUelectron microscopy4.00YA1-255[»]
ProteinModelPortaliP33442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S3Ae family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00860000136309.
HOGENOMiHOG000105220.
InParanoidiP33442.
KOiK02984.
OMAiRQANQIK.
OrthoDBiEOG092C4C2Y.

Family and domain databases

HAMAPiMF_03122. Ribosomal_S3Ae_euk. 1 hit.
InterProiIPR027500. Ribosomal_S1/3_euk.
IPR001593. Ribosomal_S3Ae.
IPR018281. Ribosomal_S3Ae_CS.
[Graphical view]
PfamiPF01015. Ribosomal_S3Ae. 1 hit.
[Graphical view]
SMARTiSM01397. Ribosomal_S3Ae. 1 hit.
[Graphical view]
PROSITEiPS01191. RIBOSOMAL_S3AE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33442-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVGKNKRLS KGKKGQKKRV VDPFTRKEWF DIKAPSTFEN RNVGKTLVNK
60 70 80 90 100
STGLKSASDA LKGRVVEVCL ADLQGSEDHS FRKIKLRVDE VQGKNLLTNF
110 120 130 140 150
HGMDFTTDKL RSMVRKWQTL IEANVTVKTS DDYVLRIFAI AFTRKQANQV
160 170 180 190 200
KRHSYAQSSH IRAIRKVISE ILTKEVQGST LAQLTSKLIP EVINKEIENA
210 220 230 240 250
TKDIFPLQNI HVRKVKLLKQ PKFDVGALMA LHGEGSGEEK GKKVTGFKDE

VLETV
Length:255
Mass (Da):28,743
Last modified:January 23, 2007 - v2
Checksum:i2629D022EDBDE885
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65802 Genomic DNA. Translation: CAA46676.1.
X68556 Genomic DNA. Translation: CAA48559.1.
U21094 Genomic DNA. Translation: AAB67521.1.
AY693148 Genomic DNA. Translation: AAT93167.1.
X01420 Genomic DNA. No translation available.
BK006945 Genomic DNA. Translation: DAA09742.1.
PIRiS21121.
RefSeqiNP_013546.1. NM_001182329.1.

Genome annotation databases

EnsemblFungiiYLR441C; YLR441C; YLR441C.
GeneIDi851162.
KEGGisce:YLR441C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65802 Genomic DNA. Translation: CAA46676.1.
X68556 Genomic DNA. Translation: CAA48559.1.
U21094 Genomic DNA. Translation: AAB67521.1.
AY693148 Genomic DNA. Translation: AAT93167.1.
X01420 Genomic DNA. No translation available.
BK006945 Genomic DNA. Translation: DAA09742.1.
PIRiS21121.
RefSeqiNP_013546.1. NM_001182329.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10S11-255[»]
3J6Yelectron microscopy6.10S11-255[»]
3J77electron microscopy6.20S11-255[»]
3J78electron microscopy6.30S11-255[»]
3V88X-ray3.00B1-255[»]
4U3MX-ray3.00S1/s12-255[»]
4U3NX-ray3.20S1/s12-255[»]
4U3UX-ray2.90S1/s12-255[»]
4U4NX-ray3.10S1/s12-255[»]
4U4OX-ray3.60S1/s12-255[»]
4U4QX-ray3.00S1/s12-255[»]
4U4RX-ray2.80S1/s12-255[»]
4U4UX-ray3.00S1/s12-255[»]
4U4YX-ray3.20S1/s12-255[»]
4U4ZX-ray3.10S1/s12-255[»]
4U50X-ray3.20S1/s12-255[»]
4U51X-ray3.20S1/s12-255[»]
4U52X-ray3.00S1/s12-255[»]
4U53X-ray3.30S1/s12-255[»]
4U55X-ray3.20S1/s12-255[»]
4U56X-ray3.45S1/s12-255[»]
4U6FX-ray3.10S1/s12-255[»]
4V88X-ray3.00AB/CB1-255[»]
4V8Yelectron microscopy4.30AB1-255[»]
4V8Zelectron microscopy6.60AB1-255[»]
4V92electron microscopy3.70B21-233[»]
5DATX-ray3.15S1/s12-255[»]
5DC3X-ray3.25S1/s12-255[»]
5FCIX-ray3.40S1/s12-255[»]
5FCJX-ray3.10S1/s12-255[»]
5I4LX-ray3.10S1/s120-235[»]
5JUOelectron microscopy4.00YA1-255[»]
5JUPelectron microscopy3.50YA1-255[»]
5JUSelectron microscopy4.20YA1-255[»]
5JUTelectron microscopy4.00YA1-255[»]
5JUUelectron microscopy4.00YA1-255[»]
ProteinModelPortaliP33442.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31700. 72 interactors.
DIPiDIP-4147N.
IntActiP33442. 59 interactors.
MINTiMINT-8285687.

PTM databases

iPTMnetiP33442.

Proteomic databases

MaxQBiP33442.
PRIDEiP33442.
TopDownProteomicsiP33442.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR441C; YLR441C; YLR441C.
GeneIDi851162.
KEGGisce:YLR441C.

Organism-specific databases

EuPathDBiFungiDB:YLR441C.
SGDiS000004433. RPS1A.

Phylogenomic databases

GeneTreeiENSGT00860000136309.
HOGENOMiHOG000105220.
InParanoidiP33442.
KOiK02984.
OMAiRQANQIK.
OrthoDBiEOG092C4C2Y.

Enzyme and pathway databases

BioCyciYEAST:G3O-32497-MONOMER.

Miscellaneous databases

PROiP33442.

Family and domain databases

HAMAPiMF_03122. Ribosomal_S3Ae_euk. 1 hit.
InterProiIPR027500. Ribosomal_S1/3_euk.
IPR001593. Ribosomal_S3Ae.
IPR018281. Ribosomal_S3Ae_CS.
[Graphical view]
PfamiPF01015. Ribosomal_S3Ae. 1 hit.
[Graphical view]
SMARTiSM01397. Ribosomal_S3Ae. 1 hit.
[Graphical view]
PROSITEiPS01191. RIBOSOMAL_S3AE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS3A1_YEAST
AccessioniPrimary (citable) accession number: P33442
Secondary accession number(s): D6VZ76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 92400 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for S1 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.