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Protein

40S ribosomal protein S1-A

Gene

RPS1A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 92400 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eS1 in yeast.Curated

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: GO_Central
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32497-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S1-A1 PublicationUniRule annotation
Alternative name(s):
RP10A
Small ribosomal subunit protein eS1-A1 Publication
Gene namesi
Name:RPS1A1 PublicationUniRule annotation
Synonyms:PLC1, RPS10A
Ordered Locus Names:YLR441C
ORF Names:L9753.9
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR441C
SGDiS000004433 RPS1A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation1 Publication
ChainiPRO_00001535412 – 25540S ribosomal protein S1-AAdd BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine; partialUniRule annotation1 Publication1
Modified residuei245PhosphothreonineCombined sources1
Cross-linki248Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei254PhosphothreonineCombined sources1

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP33442
PaxDbiP33442
PRIDEiP33442
TopDownProteomicsiP33442

PTM databases

CarbonylDBiP33442
iPTMnetiP33442

Interactioni

Subunit structurei

Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). eS1 interacts directly with uS11 and eS26, which form part of the mRNA exit tunnel (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi31700, 198 interactors
DIPiDIP-4147N
IntActiP33442, 63 interactors
MINTiP33442
STRINGi4932.YLR441C

Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi75 – 77Combined sources3
Beta strandi93 – 98Combined sources6
Beta strandi116 – 118Combined sources3
Beta strandi151 – 153Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10S11-255[»]
3J6Yelectron microscopy6.10S11-255[»]
3J77electron microscopy6.20S11-255[»]
3J78electron microscopy6.30S11-255[»]
4U3MX-ray3.00S1/s12-255[»]
4U3NX-ray3.20S1/s12-255[»]
4U3UX-ray2.90S1/s12-255[»]
4U4NX-ray3.10S1/s12-255[»]
4U4OX-ray3.60S1/s12-255[»]
4U4QX-ray3.00S1/s12-255[»]
4U4RX-ray2.80S1/s12-255[»]
4U4UX-ray3.00S1/s12-255[»]
4U4YX-ray3.20S1/s12-255[»]
4U4ZX-ray3.10S1/s12-255[»]
4U50X-ray3.20S1/s12-255[»]
4U51X-ray3.20S1/s12-255[»]
4U52X-ray3.00S1/s12-255[»]
4U53X-ray3.30S1/s12-255[»]
4U55X-ray3.20S1/s12-255[»]
4U56X-ray3.45S1/s12-255[»]
4U6FX-ray3.10S1/s12-255[»]
4V88X-ray3.00AB/CB1-255[»]
4V8Yelectron microscopy4.30AB1-255[»]
4V8Zelectron microscopy6.60AB1-255[»]
4V92electron microscopy3.70B21-233[»]
5DATX-ray3.15S1/s12-255[»]
5DC3X-ray3.25S1/s12-255[»]
5DGEX-ray3.45S1/s12-255[»]
5DGFX-ray3.30S1/s12-255[»]
5DGVX-ray3.10S1/s12-255[»]
5FCIX-ray3.40S1/s12-255[»]
5FCJX-ray3.10S1/s12-255[»]
5I4LX-ray3.10S1/s120-235[»]
5JUOelectron microscopy4.00YA1-255[»]
5JUPelectron microscopy3.50YA1-255[»]
5JUSelectron microscopy4.20YA1-255[»]
5JUTelectron microscopy4.00YA1-255[»]
5JUUelectron microscopy4.00YA1-255[»]
5LL6electron microscopy3.90Q1-255[»]
5LYBX-ray3.25S1/s120-235[»]
5M1Jelectron microscopy3.30B220-233[»]
5MC6electron microscopy3.80Q1-255[»]
5MEIX-ray3.50C/s120-235[»]
5NDGX-ray3.70S1/s120-235[»]
5NDVX-ray3.30S1/s120-235[»]
5NDWX-ray3.70S1/s120-235[»]
5OBMX-ray3.40S1/s120-235[»]
5ON6X-ray3.10C/s120-235[»]
5TBWX-ray3.00C/s120-235[»]
5TGAX-ray3.30S1/s120-235[»]
5TGMX-ray3.50S1/s120-235[»]
5WYJelectron microscopy8.70SC1-255[»]
5WYKelectron microscopy4.50SC1-255[»]
6EMLelectron microscopy3.60Q1-255[»]
6FAIelectron microscopy3.40B1-255[»]
ProteinModelPortaliP33442
SMRiP33442
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic ribosomal protein eS1 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000018433
HOGENOMiHOG000105220
InParanoidiP33442
KOiK02984
OMAiMIRMFCI
OrthoDBiEOG092C4C2Y

Family and domain databases

HAMAPiMF_03122 Ribosomal_S3Ae_euk, 1 hit
InterProiView protein in InterPro
IPR027500 Ribosomal_S1/3_euk
IPR001593 Ribosomal_S3Ae
IPR018281 Ribosomal_S3Ae_CS
PfamiView protein in Pfam
PF01015 Ribosomal_S3Ae, 1 hit
SMARTiView protein in SMART
SM01397 Ribosomal_S3Ae, 1 hit
PROSITEiView protein in PROSITE
PS01191 RIBOSOMAL_S3AE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33442-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVGKNKRLS KGKKGQKKRV VDPFTRKEWF DIKAPSTFEN RNVGKTLVNK
60 70 80 90 100
STGLKSASDA LKGRVVEVCL ADLQGSEDHS FRKIKLRVDE VQGKNLLTNF
110 120 130 140 150
HGMDFTTDKL RSMVRKWQTL IEANVTVKTS DDYVLRIFAI AFTRKQANQV
160 170 180 190 200
KRHSYAQSSH IRAIRKVISE ILTKEVQGST LAQLTSKLIP EVINKEIENA
210 220 230 240 250
TKDIFPLQNI HVRKVKLLKQ PKFDVGALMA LHGEGSGEEK GKKVTGFKDE

VLETV
Length:255
Mass (Da):28,743
Last modified:January 23, 2007 - v2
Checksum:i2629D022EDBDE885
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65802 Genomic DNA Translation: CAA46676.1
X68556 Genomic DNA Translation: CAA48559.1
U21094 Genomic DNA Translation: AAB67521.1
AY693148 Genomic DNA Translation: AAT93167.1
X01420 Genomic DNA No translation available.
BK006945 Genomic DNA Translation: DAA09742.1
PIRiS21121
RefSeqiNP_013546.1, NM_001182329.1

Genome annotation databases

EnsemblFungiiYLR441C; YLR441C; YLR441C
GeneIDi851162
KEGGisce:YLR441C

Similar proteinsi

Entry informationi

Entry nameiRS3A1_YEAST
AccessioniPrimary (citable) accession number: P33442
Secondary accession number(s): D6VZ76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health