Reviewed,
UniProtKB/Swiss-Prot P33431 (SODC_CAVPO)
Last modified
November 3, 2009.
Version 73.
History...
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90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Superoxide dismutase [Cu-Zn] EC=1.15.1.1 | ||
| Gene names |
| ||
| Organism | Cavia porcellus (Guinea pig) | ||
| Taxonomic identifier | 10141 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia |
Protein attributes
| Sequence length | 153 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. |
| Catalytic activity | 2 superoxide + 2 H+ = O2 + H2O2. |
| Cofactor | Binds 1 copper ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity. |
| Subunit structure | Homodimer. |
| Subcellular location | |
| Sequence similarities | Belongs to the Cu-Zn superoxide dismutase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.2 | ||||||||
| Chain | 2 – 153 | 152 | Superoxide dismutase [Cu-Zn] | PRO_0000164053 | |||||||
Sites | |||||||||||
| Metal binding | 46 | 1 | Copper; catalytic By similarity | ||||||||
| Metal binding | 48 | 1 | Copper; catalytic By similarity | ||||||||
| Metal binding | 63 | 1 | Copper; catalytic By similarity | ||||||||
| Metal binding | 63 | 1 | Zinc; structural By similarity | ||||||||
| Metal binding | 71 | 1 | Zinc; structural By similarity | ||||||||
| Metal binding | 80 | 1 | Zinc; structural By similarity | ||||||||
| Metal binding | 83 | 1 | Zinc; structural By similarity | ||||||||
| Metal binding | 120 | 1 | Copper; catalytic By similarity | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 2 | 1 | N-acetylalanine | ||||||||
| Modified residue | 70 | 1 | N6-acetyllysine By similarity | ||||||||
| Modified residue | 98 | 1 | Phosphoserine By similarity | ||||||||
| Modified residue | 122 | 1 | N6-acetyllysine By similarity | ||||||||
| Disulfide bond | 57 ↔ 146 | By similarity | |||||||||
Experimental info | |||||||||||
| Sequence conflict | 103 – 104 | 2 | LI → IL AA sequence Ref.2 | ||||||||
Sequences
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References
| [1] | "Differential patterns of antioxidant enzyme mRNA expression in guinea pig lung and liver during development." Yuan H.T., Bingle C.D., Kelly F.J. Biochim. Biophys. Acta 1305:163-171(1996) [PubMed: 8597602] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Hartley. Tissue: Lung. |
| [2] | "Taxonomical classification of the guinea pig based on its Cu/Zn superoxide dismutase sequence." Wolf B., Reinecke K., Aumann K.-D., Brigelius-Flohe R., Flohe L. Biol. Chem. Hoppe-Seyler 374:641-649(1993) [PubMed: 8240718] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-153. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| U39844 mRNA. Translation: AAC52720.1. | |
| PIR | S36108. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1HL5 based on UniProtKB P00441. |
| SMR | P33431. Positions 4-153. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P33431. |
Genome annotation databases | |
| Ensembl | ENSCPOT00000014365; ENSCPOP00000012815; ENSCPOG00000014223; Cavia porcellus. [Genome view] |
Phylogenomic databases | |
| HOVERGEN | P33431. |
Enzyme and pathway databases | |
| BRENDA | 1.15.1.1. 44. |
Family and domain databases | |
| InterPro | IPR018152. SOD_Cu/Zn_BS. IPR001424. SOD_Cu_Zn. [Graphical view] |
| Gene3D | G3DSA:2.60.40.200. SOD_Cu_Zn. 1 hit. |
| PANTHER | PTHR10003. SOD_Cu_Zn. 1 hit. |
| Pfam | PF00080. Sod_Cu. 1 hit. [Graphical view] |
| PRINTS | PR00068. CUZNDISMTASE. |
| ProDom | PD000469. SOD_CU_ZN. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00087. SOD_CU_ZN_1. 1 hit. PS00332. SOD_CU_ZN_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SODC_CAVPO | ||||||||
| Accession | Primary (citable) accession number: P33431 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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