P33422 (VP6_BTV2A) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein VP6

Alternative name(s):
Minor inner core protein VP6

Gene names

Name:

S9

Organism

Bluetongue virus 2 (isolate USA) (BTV 2)

Taxonomic identifier

10907 [NCBI]

Taxonomic lineage

Viruses › dsRNA viruses › Reoviridae › Sedoreovirinae › Orbivirus › Bluetongue virus › Bluetongue virus 2

Virus host

Antilocapra americana (Pronghorn) [TaxID: 9891]
Bos taurus (Bovine) [TaxID: 9913]
Capra hircus (Goat) [TaxID: 9925]
Culicoides variipennis [TaxID: 46212]
Ovis aries (Sheep) [TaxID: 9940]

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Surrounds and interacts with the genomic dsRNA. Possesses ss- and dsRNA-binding capacity. Its hydrophilic nature and capability to bind ss- and dsRNA suggest that it interacts with BTV genomic RNA.
Subcellular location	Virion. Note: Inner capsid.
Sequence similarities	Belongs to the orbivirus VP6 family.

Ontologies

Keywords
Cellular component	Virion
Gene Ontology (GO)
Cellular_component	viral capsid Inferred from electronic annotation. Source: InterPro
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Protein VP6		PRO_0000222721
Regions
	Compositional bias	60 – 102	43	Gly-rich

Sequences

	Sequence		Length	Mass (Da)
	P33422 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 60720F0E7D3FE834	FASTA	301	32,864
	10 20 30 40 50 60 MIDWAESESG KGDKVEPKEE NEAEESKDGE GTQSESGQKK ESSKEAEDAD VDRRVHTTVG 70 80 90 100 110 120 SGSGAKGFRE RANENVDRGD GKVCGGVGDV DAGVGTTGTN GGRWVVLTEE IARAIESKYG 130 140 150 160 170 180 TKIDVYRDEV PAQIIEVERS LQKELGISRE GVAEQTERLR DLRRKEKSET HARVAEKGRR 190 200 210 220 230 240 KQGKRVHGDA QKESTEDEKT PEEPTSVGIT IEGVMSQKKL LSMIGGVERK MAPIGARESA 250 260 270 280 290 300 VMLVSNSIKD VVRATAYFTA PTGDPHWKEV AREASKKKNI LAYTSTGGDV KTEFLHLIDH L

References

[1]	"Comparative sequence analyses of the cognate structural protein VP6 genes of five US bluetongue viruses." Hwang G.-Y., Chiou J.-F., Yang Y.-Y., Li J.K.-K. Virus Res. 24:315-323(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L08668 Genomic RNA. Translation: AAA42822.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001399. Orbi_VP6. [Graphical view]
Pfam	PF01516. Orbi_VP6. 1 hit. [Graphical view]
PRINTS	PR00902. VP6CAPSID.
ProtoNet	Search...

Entry information

Entry name

VP6_BTV2A

Accession

Primary (citable) accession number: P33422

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	April 3, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program