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Protein

Urea active transporter

Gene

DUR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for active transport of urea.

GO - Molecular functioni

  • putrescine transmembrane transporter activity Source: SGD
  • spermidine transmembrane transporter activity Source: SGD
  • symporter activity Source: GO_Central
  • urea transmembrane transporter activity Source: SGD

GO - Biological processi

  • putrescine transport Source: SGD
  • spermidine transport Source: SGD
  • urea catabolic process Source: SGD
  • urea transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31036-MONOMER.

Protein family/group databases

TCDBi2.A.21.6.1. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Urea active transporter
Gene namesi
Name:DUR3
Ordered Locus Names:YHL016C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHL016C.
SGDiS000001008. DUR3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 85ExtracellularSequence analysisAdd BLAST50
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 130CytoplasmicSequence analysisAdd BLAST24
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 166ExtracellularSequence analysisAdd BLAST15
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 189CytoplasmicSequence analysis2
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 253ExtracellularSequence analysisAdd BLAST43
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Topological domaini275 – 295CytoplasmicSequence analysisAdd BLAST21
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 343ExtracellularSequence analysisAdd BLAST27
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 403CytoplasmicSequence analysisAdd BLAST39
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Topological domaini425ExtracellularSequence analysis1
Transmembranei426 – 446HelicalSequence analysisAdd BLAST21
Topological domaini447 – 454CytoplasmicSequence analysis8
Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Topological domaini476 – 496ExtracellularSequence analysisAdd BLAST21
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21
Topological domaini518 – 618CytoplasmicSequence analysisAdd BLAST101
Transmembranei619 – 639HelicalSequence analysisAdd BLAST21
Topological domaini640 – 650ExtracellularSequence analysisAdd BLAST11
Transmembranei651 – 671HelicalSequence analysisAdd BLAST21
Topological domaini672 – 735CytoplasmicSequence analysisAdd BLAST64

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053971 – 735Urea active transporterAdd BLAST735

Proteomic databases

PRIDEiP33413.

PTM databases

iPTMnetiP33413.

Expressioni

Inductioni

By allophanate or its non-metabolized analog oxalurate. Sensitive to nitrogen catabolite repression.

Interactioni

Subunit structurei

May polymerize.

Protein-protein interaction databases

BioGridi36407. 24 interactors.
IntActiP33413. 16 interactors.

Structurei

3D structure databases

ProteinModelPortaliP33413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000106394.
InParanoidiP33413.
OMAiWALKRYQ.
OrthoDBiEOG092C1BV9.

Family and domain databases

InterProiIPR031155. DUR.
IPR001734. Na/solute_symporter.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PTHR11819:SF146. PTHR11819:SF146. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEFKPPLPQ GAGYAIVLGL GAVFAGMMVL TTYLLKRYQK EIITAEEFTT
60 70 80 90 100
AGRSVKTGLV AAAVVSSWIW CSTLLTSSTK EYADGIFGGY AYAAGACFQI
110 120 130 140 150
IAFAILAIKT KQMAPNAHTY LELVRTRYGK IGHGCYLFYA IATNILVTSM
160 170 180 190 200
LLTSGSAVFS DLTGMNTIAS CFLLPVGVVV YTLFGGIKAT FLTDYMHTCV
210 220 230 240 250
IIIIVLVFAF KVYATSDVLG SPGKVYDLVR EAAKRHPVDG NYQGEYMTMT
260 270 280 290 300
SKSAGILLII NLIGNFGTVF LDNGYWNKAI SASPAASLKA YAIGGLAWFA
310 320 330 340 350
VPSLISLTMG LACLAVETSP NFPTYPDPLT SFQANSGLVL PAAAIAIMGK
360 370 380 390 400
GGAVASLLMI FMAVTSAMSA ELIAVSSVFT YDIYREYIDP RASGKKLIYT
410 420 430 440 450
SHVACIFFGL AMSGFSVGLY YGGISMGYIY EMMGIIISSA VLPVVLTLCS
460 470 480 490 500
KDMNLVAAVV SPILGTGLAI MSWLVCTKSL YKELTVDTTF MDYPMLTGNL
510 520 530 540 550
VALLSPAIFI PILTYVFKPQ NFDWEKMKDI TRVDETAELV QADPDIQLYD
560 570 580 590 600
AEANDKEQEE ETNSLVSDSE KNDVRVNNEK LIEPNLGVVI SNAIFQEDDT
610 620 630 640 650
QLQNELDEEQ RELARGLKIA YFLCVFFALA FLVVWPMPMY GSKYIFSKKF
660 670 680 690 700
FTGWVVVMII WLFFSAFAVC IYPLWEGRHG IYTTLRGLYW DLSGQTYKLR
710 720 730
EWQNSNPQDL HVVTSQISAR AHRQSSHFGQ VDEII
Length:735
Mass (Da):80,617
Last modified:February 1, 1995 - v2
Checksum:iFD1252DB838BF5CF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58 – 63GLVAAA → RLSGCS in AAA34582 (PubMed:8335627).Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19875 Genomic DNA. Translation: AAA34582.1.
U11582 Genomic DNA. Translation: AAB65069.1.
AY693170 Genomic DNA. Translation: AAT93189.1.
BK006934 Genomic DNA. Translation: DAA06669.1.
PIRiS46830.
RefSeqiNP_011847.1. NM_001179096.1.

Genome annotation databases

EnsemblFungiiYHL016C; YHL016C; YHL016C.
GeneIDi856370.
KEGGisce:YHL016C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19875 Genomic DNA. Translation: AAA34582.1.
U11582 Genomic DNA. Translation: AAB65069.1.
AY693170 Genomic DNA. Translation: AAT93189.1.
BK006934 Genomic DNA. Translation: DAA06669.1.
PIRiS46830.
RefSeqiNP_011847.1. NM_001179096.1.

3D structure databases

ProteinModelPortaliP33413.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36407. 24 interactors.
IntActiP33413. 16 interactors.

Protein family/group databases

TCDBi2.A.21.6.1. the solute:sodium symporter (sss) family.

PTM databases

iPTMnetiP33413.

Proteomic databases

PRIDEiP33413.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHL016C; YHL016C; YHL016C.
GeneIDi856370.
KEGGisce:YHL016C.

Organism-specific databases

EuPathDBiFungiDB:YHL016C.
SGDiS000001008. DUR3.

Phylogenomic databases

HOGENOMiHOG000106394.
InParanoidiP33413.
OMAiWALKRYQ.
OrthoDBiEOG092C1BV9.

Enzyme and pathway databases

BioCyciYEAST:G3O-31036-MONOMER.

Miscellaneous databases

PROiP33413.

Family and domain databases

InterProiIPR031155. DUR.
IPR001734. Na/solute_symporter.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PTHR11819:SF146. PTHR11819:SF146. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDUR3_YEAST
AccessioniPrimary (citable) accession number: P33413
Secondary accession number(s): D3DKP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.