SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P33413

- DUR3_YEAST

UniProt

P33413 - DUR3_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Urea active transporter
Gene
DUR3, YHL016C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for active transport of urea.

GO - Molecular functioni

  1. putrescine transmembrane transporter activity Source: SGD
  2. spermidine transmembrane transporter activity Source: SGD
  3. urea transmembrane transporter activity Source: SGD

GO - Biological processi

  1. putrescine transport Source: SGD
  2. spermidine transport Source: SGD
  3. urea catabolic process Source: SGD
  4. urea transmembrane transport Source: GOC
  5. urea transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31036-MONOMER.

Protein family/group databases

TCDBi2.A.21.6.1. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Urea active transporter
Gene namesi
Name:DUR3
Ordered Locus Names:YHL016C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHL016c.
SGDiS000001008. DUR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei15 – 3521Helical; Reviewed prediction
Add
BLAST
Topological domaini36 – 8550Extracellular Reviewed prediction
Add
BLAST
Transmembranei86 – 10621Helical; Reviewed prediction
Add
BLAST
Topological domaini107 – 13024Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei131 – 15121Helical; Reviewed prediction
Add
BLAST
Topological domaini152 – 16615Extracellular Reviewed prediction
Add
BLAST
Transmembranei167 – 18721Helical; Reviewed prediction
Add
BLAST
Topological domaini188 – 1892Cytoplasmic Reviewed prediction
Transmembranei190 – 21021Helical; Reviewed prediction
Add
BLAST
Topological domaini211 – 25343Extracellular Reviewed prediction
Add
BLAST
Transmembranei254 – 27421Helical; Reviewed prediction
Add
BLAST
Topological domaini275 – 29521Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei296 – 31621Helical; Reviewed prediction
Add
BLAST
Topological domaini317 – 34327Extracellular Reviewed prediction
Add
BLAST
Transmembranei344 – 36421Helical; Reviewed prediction
Add
BLAST
Topological domaini365 – 40339Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei404 – 42421Helical; Reviewed prediction
Add
BLAST
Topological domaini425 – 4251Extracellular Reviewed prediction
Transmembranei426 – 44621Helical; Reviewed prediction
Add
BLAST
Topological domaini447 – 4548Cytoplasmic Reviewed prediction
Transmembranei455 – 47521Helical; Reviewed prediction
Add
BLAST
Topological domaini476 – 49621Extracellular Reviewed prediction
Add
BLAST
Transmembranei497 – 51721Helical; Reviewed prediction
Add
BLAST
Topological domaini518 – 618101Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei619 – 63921Helical; Reviewed prediction
Add
BLAST
Topological domaini640 – 65011Extracellular Reviewed prediction
Add
BLAST
Transmembranei651 – 67121Helical; Reviewed prediction
Add
BLAST
Topological domaini672 – 73564Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Urea active transporter
PRO_0000105397Add
BLAST

Proteomic databases

PaxDbiP33413.

Expressioni

Inductioni

By allophanate or its non-metabolized analog oxalurate. Sensitive to nitrogen catabolite repression.

Gene expression databases

GenevestigatoriP33413.

Interactioni

Subunit structurei

May polymerize.

Protein-protein interaction databases

BioGridi36407. 24 interactions.
IntActiP33413. 16 interactions.
STRINGi4932.YHL016C.

Structurei

3D structure databases

ProteinModelPortaliP33413.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0591.
HOGENOMiHOG000106394.
OMAiYGSSYVF.
OrthoDBiEOG754HZG.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33413-1 [UniParc]FASTAAdd to Basket

« Hide

MGEFKPPLPQ GAGYAIVLGL GAVFAGMMVL TTYLLKRYQK EIITAEEFTT    50
AGRSVKTGLV AAAVVSSWIW CSTLLTSSTK EYADGIFGGY AYAAGACFQI 100
IAFAILAIKT KQMAPNAHTY LELVRTRYGK IGHGCYLFYA IATNILVTSM 150
LLTSGSAVFS DLTGMNTIAS CFLLPVGVVV YTLFGGIKAT FLTDYMHTCV 200
IIIIVLVFAF KVYATSDVLG SPGKVYDLVR EAAKRHPVDG NYQGEYMTMT 250
SKSAGILLII NLIGNFGTVF LDNGYWNKAI SASPAASLKA YAIGGLAWFA 300
VPSLISLTMG LACLAVETSP NFPTYPDPLT SFQANSGLVL PAAAIAIMGK 350
GGAVASLLMI FMAVTSAMSA ELIAVSSVFT YDIYREYIDP RASGKKLIYT 400
SHVACIFFGL AMSGFSVGLY YGGISMGYIY EMMGIIISSA VLPVVLTLCS 450
KDMNLVAAVV SPILGTGLAI MSWLVCTKSL YKELTVDTTF MDYPMLTGNL 500
VALLSPAIFI PILTYVFKPQ NFDWEKMKDI TRVDETAELV QADPDIQLYD 550
AEANDKEQEE ETNSLVSDSE KNDVRVNNEK LIEPNLGVVI SNAIFQEDDT 600
QLQNELDEEQ RELARGLKIA YFLCVFFALA FLVVWPMPMY GSKYIFSKKF 650
FTGWVVVMII WLFFSAFAVC IYPLWEGRHG IYTTLRGLYW DLSGQTYKLR 700
EWQNSNPQDL HVVTSQISAR AHRQSSHFGQ VDEII 735
Length:735
Mass (Da):80,617
Last modified:February 1, 1995 - v2
Checksum:iFD1252DB838BF5CF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 636GLVAAA → RLSGCS in AAA34582. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19875 Genomic DNA. Translation: AAA34582.1.
U11582 Genomic DNA. Translation: AAB65069.1.
AY693170 Genomic DNA. Translation: AAT93189.1.
BK006934 Genomic DNA. Translation: DAA06669.1.
PIRiS46830.
RefSeqiNP_011847.1. NM_001179096.1.

Genome annotation databases

EnsemblFungiiYHL016C; YHL016C; YHL016C.
GeneIDi856370.
KEGGisce:YHL016C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19875 Genomic DNA. Translation: AAA34582.1 .
U11582 Genomic DNA. Translation: AAB65069.1 .
AY693170 Genomic DNA. Translation: AAT93189.1 .
BK006934 Genomic DNA. Translation: DAA06669.1 .
PIRi S46830.
RefSeqi NP_011847.1. NM_001179096.1.

3D structure databases

ProteinModelPortali P33413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36407. 24 interactions.
IntActi P33413. 16 interactions.
STRINGi 4932.YHL016C.

Protein family/group databases

TCDBi 2.A.21.6.1. the solute:sodium symporter (sss) family.

Proteomic databases

PaxDbi P33413.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHL016C ; YHL016C ; YHL016C .
GeneIDi 856370.
KEGGi sce:YHL016C.

Organism-specific databases

CYGDi YHL016c.
SGDi S000001008. DUR3.

Phylogenomic databases

eggNOGi COG0591.
HOGENOMi HOG000106394.
OMAi YGSSYVF.
OrthoDBi EOG754HZG.

Enzyme and pathway databases

BioCyci YEAST:G3O-31036-MONOMER.

Miscellaneous databases

NextBioi 981846.
PROi P33413.

Gene expression databases

Genevestigatori P33413.

Family and domain databases

InterProi IPR001734. Na/solute_symporter.
IPR019900. Na/solute_symporter_subgr.
[Graphical view ]
PANTHERi PTHR11819. PTHR11819. 1 hit.
Pfami PF00474. SSF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00813. sss. 1 hit.
PROSITEi PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of the urea active transporter gene (DUR3) in Saccharomyces cerevisiae."
    Elberry H.M., Majumdar M.L., Cunningham T.S., Sumrada R.A., Cooper T.G.
    J. Bacteriol. 175:4688-4698(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: TCY1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiDUR3_YEAST
AccessioniPrimary (citable) accession number: P33413
Secondary accession number(s): D3DKP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi