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P33413

- DUR3_YEAST

UniProt

P33413 - DUR3_YEAST

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Protein

Urea active transporter

Gene

DUR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for active transport of urea.

GO - Molecular functioni

  1. putrescine transmembrane transporter activity Source: SGD
  2. spermidine transmembrane transporter activity Source: SGD
  3. urea transmembrane transporter activity Source: SGD

GO - Biological processi

  1. putrescine transport Source: SGD
  2. spermidine transport Source: SGD
  3. urea catabolic process Source: SGD
  4. urea transmembrane transport Source: GOC
  5. urea transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31036-MONOMER.

Protein family/group databases

TCDBi2.A.21.6.1. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Urea active transporter
Gene namesi
Name:DUR3
Ordered Locus Names:YHL016C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHL016c.
SGDiS000001008. DUR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei15 – 3521HelicalSequence AnalysisAdd
BLAST
Topological domaini36 – 8550ExtracellularSequence AnalysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence AnalysisAdd
BLAST
Topological domaini107 – 13024CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence AnalysisAdd
BLAST
Topological domaini152 – 16615ExtracellularSequence AnalysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST
Topological domaini188 – 1892CytoplasmicSequence Analysis
Transmembranei190 – 21021HelicalSequence AnalysisAdd
BLAST
Topological domaini211 – 25343ExtracellularSequence AnalysisAdd
BLAST
Transmembranei254 – 27421HelicalSequence AnalysisAdd
BLAST
Topological domaini275 – 29521CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei296 – 31621HelicalSequence AnalysisAdd
BLAST
Topological domaini317 – 34327ExtracellularSequence AnalysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence AnalysisAdd
BLAST
Topological domaini365 – 40339CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei404 – 42421HelicalSequence AnalysisAdd
BLAST
Topological domaini425 – 4251ExtracellularSequence Analysis
Transmembranei426 – 44621HelicalSequence AnalysisAdd
BLAST
Topological domaini447 – 4548CytoplasmicSequence Analysis
Transmembranei455 – 47521HelicalSequence AnalysisAdd
BLAST
Topological domaini476 – 49621ExtracellularSequence AnalysisAdd
BLAST
Transmembranei497 – 51721HelicalSequence AnalysisAdd
BLAST
Topological domaini518 – 618101CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei619 – 63921HelicalSequence AnalysisAdd
BLAST
Topological domaini640 – 65011ExtracellularSequence AnalysisAdd
BLAST
Transmembranei651 – 67121HelicalSequence AnalysisAdd
BLAST
Topological domaini672 – 73564CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Urea active transporterPRO_0000105397Add
BLAST

Proteomic databases

PaxDbiP33413.

Expressioni

Inductioni

By allophanate or its non-metabolized analog oxalurate. Sensitive to nitrogen catabolite repression.

Gene expression databases

GenevestigatoriP33413.

Interactioni

Subunit structurei

May polymerize.

Protein-protein interaction databases

BioGridi36407. 24 interactions.
IntActiP33413. 16 interactions.
STRINGi4932.YHL016C.

Structurei

3D structure databases

ProteinModelPortaliP33413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0591.
HOGENOMiHOG000106394.
InParanoidiP33413.
OMAiYGSSYVF.
OrthoDBiEOG754HZG.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33413-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGEFKPPLPQ GAGYAIVLGL GAVFAGMMVL TTYLLKRYQK EIITAEEFTT
60 70 80 90 100
AGRSVKTGLV AAAVVSSWIW CSTLLTSSTK EYADGIFGGY AYAAGACFQI
110 120 130 140 150
IAFAILAIKT KQMAPNAHTY LELVRTRYGK IGHGCYLFYA IATNILVTSM
160 170 180 190 200
LLTSGSAVFS DLTGMNTIAS CFLLPVGVVV YTLFGGIKAT FLTDYMHTCV
210 220 230 240 250
IIIIVLVFAF KVYATSDVLG SPGKVYDLVR EAAKRHPVDG NYQGEYMTMT
260 270 280 290 300
SKSAGILLII NLIGNFGTVF LDNGYWNKAI SASPAASLKA YAIGGLAWFA
310 320 330 340 350
VPSLISLTMG LACLAVETSP NFPTYPDPLT SFQANSGLVL PAAAIAIMGK
360 370 380 390 400
GGAVASLLMI FMAVTSAMSA ELIAVSSVFT YDIYREYIDP RASGKKLIYT
410 420 430 440 450
SHVACIFFGL AMSGFSVGLY YGGISMGYIY EMMGIIISSA VLPVVLTLCS
460 470 480 490 500
KDMNLVAAVV SPILGTGLAI MSWLVCTKSL YKELTVDTTF MDYPMLTGNL
510 520 530 540 550
VALLSPAIFI PILTYVFKPQ NFDWEKMKDI TRVDETAELV QADPDIQLYD
560 570 580 590 600
AEANDKEQEE ETNSLVSDSE KNDVRVNNEK LIEPNLGVVI SNAIFQEDDT
610 620 630 640 650
QLQNELDEEQ RELARGLKIA YFLCVFFALA FLVVWPMPMY GSKYIFSKKF
660 670 680 690 700
FTGWVVVMII WLFFSAFAVC IYPLWEGRHG IYTTLRGLYW DLSGQTYKLR
710 720 730
EWQNSNPQDL HVVTSQISAR AHRQSSHFGQ VDEII
Length:735
Mass (Da):80,617
Last modified:February 1, 1995 - v2
Checksum:iFD1252DB838BF5CF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 636GLVAAA → RLSGCS in AAA34582. (PubMed:8335627)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19875 Genomic DNA. Translation: AAA34582.1.
U11582 Genomic DNA. Translation: AAB65069.1.
AY693170 Genomic DNA. Translation: AAT93189.1.
BK006934 Genomic DNA. Translation: DAA06669.1.
PIRiS46830.
RefSeqiNP_011847.1. NM_001179096.1.

Genome annotation databases

EnsemblFungiiYHL016C; YHL016C; YHL016C.
GeneIDi856370.
KEGGisce:YHL016C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19875 Genomic DNA. Translation: AAA34582.1 .
U11582 Genomic DNA. Translation: AAB65069.1 .
AY693170 Genomic DNA. Translation: AAT93189.1 .
BK006934 Genomic DNA. Translation: DAA06669.1 .
PIRi S46830.
RefSeqi NP_011847.1. NM_001179096.1.

3D structure databases

ProteinModelPortali P33413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36407. 24 interactions.
IntActi P33413. 16 interactions.
STRINGi 4932.YHL016C.

Protein family/group databases

TCDBi 2.A.21.6.1. the solute:sodium symporter (sss) family.

Proteomic databases

PaxDbi P33413.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHL016C ; YHL016C ; YHL016C .
GeneIDi 856370.
KEGGi sce:YHL016C.

Organism-specific databases

CYGDi YHL016c.
SGDi S000001008. DUR3.

Phylogenomic databases

eggNOGi COG0591.
HOGENOMi HOG000106394.
InParanoidi P33413.
OMAi YGSSYVF.
OrthoDBi EOG754HZG.

Enzyme and pathway databases

BioCyci YEAST:G3O-31036-MONOMER.

Miscellaneous databases

NextBioi 981846.
PROi P33413.

Gene expression databases

Genevestigatori P33413.

Family and domain databases

InterProi IPR001734. Na/solute_symporter.
IPR019900. Na/solute_symporter_subgr.
[Graphical view ]
PANTHERi PTHR11819. PTHR11819. 1 hit.
Pfami PF00474. SSF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00813. sss. 1 hit.
PROSITEi PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of the urea active transporter gene (DUR3) in Saccharomyces cerevisiae."
    Elberry H.M., Majumdar M.L., Cunningham T.S., Sumrada R.A., Cooper T.G.
    J. Bacteriol. 175:4688-4698(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: TCY1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiDUR3_YEAST
AccessioniPrimary (citable) accession number: P33413
Secondary accession number(s): D3DKP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3