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P33413

- DUR3_YEAST

UniProt

P33413 - DUR3_YEAST

Protein

Urea active transporter

Gene

DUR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Required for active transport of urea.

    GO - Molecular functioni

    1. putrescine transmembrane transporter activity Source: SGD
    2. spermidine transmembrane transporter activity Source: SGD
    3. urea transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. putrescine transport Source: SGD
    2. spermidine transport Source: SGD
    3. urea catabolic process Source: SGD
    4. urea transmembrane transport Source: GOC
    5. urea transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31036-MONOMER.

    Protein family/group databases

    TCDBi2.A.21.6.1. the solute:sodium symporter (sss) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Urea active transporter
    Gene namesi
    Name:DUR3
    Ordered Locus Names:YHL016C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHL016c.
    SGDiS000001008. DUR3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 735735Urea active transporterPRO_0000105397Add
    BLAST

    Proteomic databases

    PaxDbiP33413.

    Expressioni

    Inductioni

    By allophanate or its non-metabolized analog oxalurate. Sensitive to nitrogen catabolite repression.

    Gene expression databases

    GenevestigatoriP33413.

    Interactioni

    Subunit structurei

    May polymerize.

    Protein-protein interaction databases

    BioGridi36407. 24 interactions.
    IntActiP33413. 16 interactions.
    STRINGi4932.YHL016C.

    Structurei

    3D structure databases

    ProteinModelPortaliP33413.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1414CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini36 – 8550ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini107 – 13024CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini152 – 16615ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini188 – 1892CytoplasmicSequence Analysis
    Topological domaini211 – 25343ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini275 – 29521CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini317 – 34327ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini365 – 40339CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini425 – 4251ExtracellularSequence Analysis
    Topological domaini447 – 4548CytoplasmicSequence Analysis
    Topological domaini476 – 49621ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini518 – 618101CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini640 – 65011ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini672 – 73564CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei131 – 15121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 21021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei254 – 27421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei296 – 31621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei344 – 36421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei404 – 42421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei426 – 44621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei455 – 47521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei497 – 51721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei619 – 63921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei651 – 67121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0591.
    HOGENOMiHOG000106394.
    OMAiYGSSYVF.
    OrthoDBiEOG754HZG.

    Family and domain databases

    InterProiIPR001734. Na/solute_symporter.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view]
    PANTHERiPTHR11819. PTHR11819. 1 hit.
    PfamiPF00474. SSF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00813. sss. 1 hit.
    PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33413-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEFKPPLPQ GAGYAIVLGL GAVFAGMMVL TTYLLKRYQK EIITAEEFTT    50
    AGRSVKTGLV AAAVVSSWIW CSTLLTSSTK EYADGIFGGY AYAAGACFQI 100
    IAFAILAIKT KQMAPNAHTY LELVRTRYGK IGHGCYLFYA IATNILVTSM 150
    LLTSGSAVFS DLTGMNTIAS CFLLPVGVVV YTLFGGIKAT FLTDYMHTCV 200
    IIIIVLVFAF KVYATSDVLG SPGKVYDLVR EAAKRHPVDG NYQGEYMTMT 250
    SKSAGILLII NLIGNFGTVF LDNGYWNKAI SASPAASLKA YAIGGLAWFA 300
    VPSLISLTMG LACLAVETSP NFPTYPDPLT SFQANSGLVL PAAAIAIMGK 350
    GGAVASLLMI FMAVTSAMSA ELIAVSSVFT YDIYREYIDP RASGKKLIYT 400
    SHVACIFFGL AMSGFSVGLY YGGISMGYIY EMMGIIISSA VLPVVLTLCS 450
    KDMNLVAAVV SPILGTGLAI MSWLVCTKSL YKELTVDTTF MDYPMLTGNL 500
    VALLSPAIFI PILTYVFKPQ NFDWEKMKDI TRVDETAELV QADPDIQLYD 550
    AEANDKEQEE ETNSLVSDSE KNDVRVNNEK LIEPNLGVVI SNAIFQEDDT 600
    QLQNELDEEQ RELARGLKIA YFLCVFFALA FLVVWPMPMY GSKYIFSKKF 650
    FTGWVVVMII WLFFSAFAVC IYPLWEGRHG IYTTLRGLYW DLSGQTYKLR 700
    EWQNSNPQDL HVVTSQISAR AHRQSSHFGQ VDEII 735
    Length:735
    Mass (Da):80,617
    Last modified:February 1, 1995 - v2
    Checksum:iFD1252DB838BF5CF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 636GLVAAA → RLSGCS in AAA34582. (PubMed:8335627)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19875 Genomic DNA. Translation: AAA34582.1.
    U11582 Genomic DNA. Translation: AAB65069.1.
    AY693170 Genomic DNA. Translation: AAT93189.1.
    BK006934 Genomic DNA. Translation: DAA06669.1.
    PIRiS46830.
    RefSeqiNP_011847.1. NM_001179096.1.

    Genome annotation databases

    EnsemblFungiiYHL016C; YHL016C; YHL016C.
    GeneIDi856370.
    KEGGisce:YHL016C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19875 Genomic DNA. Translation: AAA34582.1 .
    U11582 Genomic DNA. Translation: AAB65069.1 .
    AY693170 Genomic DNA. Translation: AAT93189.1 .
    BK006934 Genomic DNA. Translation: DAA06669.1 .
    PIRi S46830.
    RefSeqi NP_011847.1. NM_001179096.1.

    3D structure databases

    ProteinModelPortali P33413.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36407. 24 interactions.
    IntActi P33413. 16 interactions.
    STRINGi 4932.YHL016C.

    Protein family/group databases

    TCDBi 2.A.21.6.1. the solute:sodium symporter (sss) family.

    Proteomic databases

    PaxDbi P33413.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHL016C ; YHL016C ; YHL016C .
    GeneIDi 856370.
    KEGGi sce:YHL016C.

    Organism-specific databases

    CYGDi YHL016c.
    SGDi S000001008. DUR3.

    Phylogenomic databases

    eggNOGi COG0591.
    HOGENOMi HOG000106394.
    OMAi YGSSYVF.
    OrthoDBi EOG754HZG.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31036-MONOMER.

    Miscellaneous databases

    NextBioi 981846.
    PROi P33413.

    Gene expression databases

    Genevestigatori P33413.

    Family and domain databases

    InterProi IPR001734. Na/solute_symporter.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view ]
    PANTHERi PTHR11819. PTHR11819. 1 hit.
    Pfami PF00474. SSF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00813. sss. 1 hit.
    PROSITEi PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of the urea active transporter gene (DUR3) in Saccharomyces cerevisiae."
      Elberry H.M., Majumdar M.L., Cunningham T.S., Sumrada R.A., Cooper T.G.
      J. Bacteriol. 175:4688-4698(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: TCY1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiDUR3_YEAST
    AccessioniPrimary (citable) accession number: P33413
    Secondary accession number(s): D3DKP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3