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Protein

Ethanolamine-phosphate cytidylyltransferase

Gene

ECT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ethanolamine-phosphate cytidylyltransferase which catalyzes the second step of phosphatidylethanolamine biosynthesis. Involved in the maintenance of plasma membrane and required for proper sporulation.2 Publications

Miscellaneous

Present with 4700 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine.

Pathwayi: phosphatidylethanolamine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes phosphatidylethanolamine from ethanolamine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ethanolamine kinase (EKI1)
  2. Ethanolamine-phosphate cytidylyltransferase (ECT1)
  3. Choline/ethanolaminephosphotransferase 1 (EPT1)
This subpathway is part of the pathway phosphatidylethanolamine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from ethanolamine, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

  • ethanolamine-phosphate cytidylyltransferase activity Source: SGD

GO - Biological processi

  • phosphatidylethanolamine biosynthetic process Source: SGD

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciYEAST:YGR007W-MONOMER
ReactomeiR-SCE-1483213 Synthesis of PE
UniPathwayiUPA00558; UER00742

Chemistry databases

SwissLipidsiSLP:000000067

Names & Taxonomyi

Protein namesi
Recommended name:
Ethanolamine-phosphate cytidylyltransferase (EC:2.7.7.14)
Alternative name(s):
CTP:phosphoethanolamine cytidylyltransferase
Phosphorylethanolamine transferase
Gene namesi
Name:ECT1
Synonyms:MUQ1
Ordered Locus Names:YGR007W
ORF Names:G3856
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR007W
SGDiS000003239 ECT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002084651 – 323Ethanolamine-phosphate cytidylyltransferaseAdd BLAST323

Proteomic databases

MaxQBiP33412
PaxDbiP33412
PRIDEiP33412

Expressioni

Inductioni

By isooctane.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi33251, 47 interactors
STRINGi4932.YGR007W

Structurei

3D structure databases

ProteinModelPortaliP33412
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytidylyltransferase family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000075065
HOGENOMiHOG000187618
InParanoidiP33412
KOiK00967
OMAiCHGKTEI
OrthoDBiEOG092C3LI1

Family and domain databases

Gene3Di3.40.50.620, 2 hits
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01467 CTP_transf_like, 2 hits
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit

Sequencei

Sequence statusi: Complete.

P33412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVNLDPDKV WIDGCFDFTH HGHAGAILQA RRTVSKENGK LFCGVHTDED
60 70 80 90 100
IQHNKGTPVM NSSERYEHTR SNRWCSEVVE AAPYVTDPNW MDKYQCQYVV
110 120 130 140 150
HGDDITIDAN GEDCYKLVKE MGRFKVVKRT YGVSTTEIIH RILTKKSLPP
160 170 180 190 200
THPDYYPTTQ ELSFYSVAQD AVSKHCYVFQ RDLDNVLVNG GYKFDAEDCV
210 220 230 240 250
YVDGDFDLFH MGDIDQLRKL KMDLHPDKKL IVGITTSDYS STIMTMKERV
260 270 280 290 300
LSVLSCKYVD AVIIDADATS MSQYNCEKYH IGTAVLTAAG KFSEYLTKEL
310 320
IVKRVESQRE VYIARNQKKG MSI
Length:323
Mass (Da):36,863
Last modified:February 1, 1994 - v1
Checksum:i9BC6DF97007EB689
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti252S → I in BAA09310 (PubMed:8982874).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03536 Genomic DNA Translation: AAA34916.1
D50644 Genomic DNA Translation: BAA09310.1
Z72792 Genomic DNA Translation: CAA96990.1
AY557830 Genomic DNA Translation: AAS56156.1
BK006941 Genomic DNA Translation: DAA08105.1
PIRiB48067
RefSeqiNP_011521.1, NM_001181136.1

Genome annotation databases

EnsemblFungiiYGR007W; YGR007W; YGR007W
GeneIDi852890
KEGGisce:YGR007W

Similar proteinsi

Entry informationi

Entry nameiECT1_YEAST
AccessioniPrimary (citable) accession number: P33412
Secondary accession number(s): D6VUE4, Q05725
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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