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Protein

L-lactate dehydrogenase 1

Gene

ldh1

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase 1 (ldh1), L-lactate dehydrogenase 2 (ldh2)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei89SubstrateBy similarity1
Binding sitei121NAD or substrateBy similarity1
Binding sitei152SubstrateBy similarity1
Active sitei176Proton acceptorBy similarity1
Binding sitei227SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 41NADBy similarityAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciLMON169963:G1GTA-216-MONOMER
UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase 1 (EC:1.1.1.27)
Short name:
L-LDH 1
Gene namesi
Name:ldh1
Synonyms:ldh
Ordered Locus Names:lmo0210
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001683651 – 313L-lactate dehydrogenase 1Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei218PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP33380

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi169963.lmo0210

Structurei

3D structure databases

ProteinModelPortaliP33380
SMRiP33380
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.Curated

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213793
KOiK00016
OMAiMDLMQTA
PhylomeDBiP33380

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

P33380-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDHQKIILV GDGAVGSSYA FACVNLSIGQ EFGIIDIDKD RTIGDAMDLS
60 70 80 90 100
HAVPFSTPKK IYSANYSDCH DADLVVVTAG TAQKPGETRL DLVNRNIKIM
110 120 130 140 150
KGIVDEVMAS GFDGIFLIAS NPVDILTYAT WKFSGLPKER VIGSGTSLDT
160 170 180 190 200
ARFRMSIADY LKVDARNVHG YILGEHGDTE FPAWSHTTVG GLPITEWISE
210 220 230 240 250
DEQGAMDTIF VSVRDAAYEI INKKGATFYG VAAALARITK AILNNENAIL
260 270 280 290 300
PLSVYLDGHY GMNDIYIGAP AVVNRQGVRH IVEMNLNDKE KEQMKNSADT
310
LKKVLDDAMK QID
Length:313
Mass (Da):34,192
Last modified:November 16, 2001 - v2
Checksum:iB05D3AEFAAADBBB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591974 Genomic DNA Translation: CAD00737.1
M82881 Genomic DNA Translation: AAA25274.1
PIRiAC1101
G43868
RefSeqiNP_463741.1, NC_003210.1
WP_003722739.1, NC_003210.1

Genome annotation databases

EnsemblBacteriaiCAD00737; CAD00737; CAD00737
GeneIDi987043
KEGGilmo:lmo0210
PATRICifig|169963.11.peg.215

Similar proteinsi

Entry informationi

Entry nameiLDH1_LISMO
AccessioniPrimary (citable) accession number: P33380
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 16, 2001
Last modified: April 25, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health