P33374 (MBHL_ALCHY) Reviewed, UniProtKB/Swiss-Prot
Last modified
September 21, 2011.
Version 63.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Uptake hydrogenase large subunit EC=1.12.99.6 Alternative name(s): Hydrogenlyase Membrane-bound hydrogenase large subunit | ||
| Gene names |
| ||
| Organism | Alcaligenes hydrogenophilus | ||
| Taxonomic identifier | 516 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Alcaligenes |
Protein attributes
| Sequence length | 621 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | This enzyme recycles the H2 produced by nitrogenase to increase the production of ATP and to protect nitrogenase against inhibition or damage by O2 under carbon- or phosphate-limited conditions. |
| Catalytic activity | H2 + A = AH2. |
| Cofactor | Binds 1 nickel ion per subunit By similarity. |
| Subunit structure | Heterodimer of a large and a small subunit. |
| Subcellular location | |
| Sequence similarities | Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Ligand | Metal-binding Nickel |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Cellular component | plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ferredoxin hydrogenase activity Inferred from electronic annotation. Source: InterPro hydrogenase (acceptor) activityInferred from electronic annotation. Source: EC nickel cation bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Nucleotide sequences of membrane-bound hydrogenase gene in Alcaligenes hydrogenophilus." Yagi K., Seto T., Terakado M., Umeda F., Doi T., Imanishi T., Miura Y. Chem. Pharm. Bull. 40:3292-3296(1992) [PubMed: 1294332] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | S56898 Genomic DNA. Translation: AAB25780.1. Sequence problems. |
| PIR | JH0776. |
3D structure databases | |
| ProteinModelPortal | P33374. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| InterPro | IPR001501. Ni-dep_hyd_lsu. IPR018194. Ni-dep_hyd_lsu_Ni_BS. [Graphical view] |
| Pfam | PF00374. NiFeSe_Hases. 1 hit. [Graphical view] |
| PROSITE | PS00507. NI_HGENASE_L_1. 1 hit. PS00508. NI_HGENASE_L_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MBHL_ALCHY | ||||||||
| Accession | Primary (citable) accession number: P33374 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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