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Protein

Putative multidrug resistance outer membrane protein MdtQ

Gene

mdtQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciEcoCyc:EG12020-MONOMER.
EcoCyc:EG12021-MONOMER.
ECOL316407:JW5358-MONOMER.
ECOL316407:JW5838-MONOMER.

Protein family/group databases

TCDBi1.B.17.3.10. the outer membrane factor (omf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative multidrug resistance outer membrane protein MdtQ
Gene namesi
Name:mdtQ
Synonyms:yohG, yohH
Ordered Locus Names:b2139, JW5838/JW5358
ORF Names:b2138
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12020. mdtQ.

Subcellular locationi

  • Cell outer membrane Curated; Lipid-anchor PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121PROSITE-ProRule annotationAdd
BLAST
Chaini22 – 478457Putative multidrug resistance outer membrane protein MdtQPRO_0000031013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi22 – 221N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi22 – 221S-diacylglycerol cysteinePROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

BioGridi4260455. 240 interactions.
4260456. 22 interactions.
IntActiP33369. 1 interaction.
STRINGi316407.85675252.

Structurei

3D structure databases

ProteinModelPortaliP33369.
SMRiP33369. Positions 54-478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105ETP. Bacteria.
COG1538. LUCA.
HOGENOMiHOG000122243.
InParanoidiP33369.
OMAiRTYIEMS.
PhylomeDBiP33369.

Family and domain databases

InterProiIPR003423. OMP_efflux.
IPR010131. RND_efflux_OM_lipoprot_NodT.
[Graphical view]
PfamiPF02321. OEP. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01845. outer_NodT. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33369-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRDSFYPAI ACFPLLLMLA GCAPMHETRQ ALSQQTPAAQ VDTALPTALK
60 70 80 90 100
MVGQTXQWWL EYHDNQLTSL INNALQNAPD MQVAEQRIQL AEAQAKAVAT
110 120 130 140 150
QDGPQIDFSA DMERQKMSAE GLMGPFALND PAAGTTGPWY TNGTFGLTAG
160 170 180 190 200
WHLDIWGKNR AEVTARLGTV KARAAEREQT RQLLAGSVAR LYWEWQTQAA
210 220 230 240 250
LNTVLQQIEK EQNTIIATDR QLYQNGITSS VEGVETDINA SKTRQQLNDV
260 270 280 290 300
AGKMKIIEAR LSALTNNQTK SLKLKPVALP KVASQLPDEL GYSLLARRAD
310 320 330 340 350
LQAAHWYVES SLSTIDAAKA AFYPDINLMA FLQQDALHLS DLFRHSAQQM
360 370 380 390 400
GVTAGLTLPI FDSGRLNANL DIAKAESNLS IASYNKAVVE AVNDVARAAS
410 420 430 440 450
QVQTLAEKNQ HQAQIERDAL RVVGLAQARF NAGIIAGSRV SEARIPALRE
460 470
RANGLLLQGQ WLDASIQLTG ALGGGYKR
Length:478
Mass (Da):52,138
Last modified:December 1, 2000 - v2
Checksum:i32C92C44193C9CFF
GO

Sequence cautioni

The sequence AAA60501.1 differs from that shown. Reason: Frameshift at position 56. Produces two separate ORFs.Curated
The sequence AAA60502.1 differs from that shown. Reason: Frameshift at position 56. Produces two separate ORFs.Curated
The sequence BAE76615.1 differs from that shown. Reason: Frameshift at position 56. Produces two separate ORFs.Curated
The sequence BAE76616.1 differs from that shown. Reason: Frameshift at position 56. Produces two separate ORFs.Curated
The sequence U00096 differs from that shown. Reason: Frameshift at position 56. Produces two separate ORFs.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00007 Genomic DNA. Translation: AAA60501.1. Frameshift.
U00007 Genomic DNA. Translation: AAA60502.1. Sequence problems.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAE76615.1. Frameshift.
AP009048 Genomic DNA. Translation: BAE76616.1. Sequence problems.
PIRiA64982.
B64982.

Genome annotation databases

EnsemblBacteriaiBAE76615; BAE76615; BAE76615.
BAE76616; BAE76616; BAE76616.
KEGGiecj:JW5358.
ecj:JW5838.
PATRICi48663636. VBIEscCol107702_2163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00007 Genomic DNA. Translation: AAA60501.1. Frameshift.
U00007 Genomic DNA. Translation: AAA60502.1. Sequence problems.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAE76615.1. Frameshift.
AP009048 Genomic DNA. Translation: BAE76616.1. Sequence problems.
PIRiA64982.
B64982.

3D structure databases

ProteinModelPortaliP33369.
SMRiP33369. Positions 54-478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260455. 240 interactions.
4260456. 22 interactions.
IntActiP33369. 1 interaction.
STRINGi316407.85675252.

Protein family/group databases

TCDBi1.B.17.3.10. the outer membrane factor (omf) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE76615; BAE76615; BAE76615.
BAE76616; BAE76616; BAE76616.
KEGGiecj:JW5358.
ecj:JW5838.
PATRICi48663636. VBIEscCol107702_2163.

Organism-specific databases

EchoBASEiEB1956.
EcoGeneiEG12020. mdtQ.

Phylogenomic databases

eggNOGiENOG4105ETP. Bacteria.
COG1538. LUCA.
HOGENOMiHOG000122243.
InParanoidiP33369.
OMAiRTYIEMS.
PhylomeDBiP33369.

Enzyme and pathway databases

BioCyciEcoCyc:EG12020-MONOMER.
EcoCyc:EG12021-MONOMER.
ECOL316407:JW5358-MONOMER.
ECOL316407:JW5838-MONOMER.

Family and domain databases

InterProiIPR003423. OMP_efflux.
IPR010131. RND_efflux_OM_lipoprot_NodT.
[Graphical view]
PfamiPF02321. OEP. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01845. outer_NodT. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Automated multiplex sequencing of the E.coli genome."
    Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K., Church G.M.
    Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / BHB2600.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Rudd K.E.
    Unpublished observations (JUN-1999)
    Cited for: CONCEPTUAL TRANSLATION.
  5. "Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes."
    Sulavik M.C., Houseweart C., Cramer C., Jiwani N., Murgolo N., Greene J., DiDomenico B., Shaw K.J., Miller G.H., Hare R., Shimer G.
    Antimicrob. Agents Chemother. 45:1126-1136(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiMDTQ_ECOLI
AccessioniPrimary (citable) accession number: P33369
Secondary accession number(s): P33370, Q2MAU0, Q2MAU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 1, 2000
Last modified: January 20, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.