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P33363

- BGLX_ECOLI

UniProt

P33363 - BGLX_ECOLI

Protein

Periplasmic beta-glucosidase

Gene

bglX

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei287 – 2871By similarity

    GO - Molecular functioni

    1. beta-glucosidase activity Source: EcoliWiki
    2. glucosidase activity Source: EcoliWiki

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BioCyciEcoCyc:EG12013-MONOMER.
    ECOL316407:JW2120-MONOMER.
    MetaCyc:EG12013-MONOMER.

    Protein family/group databases

    CAZyiGH3. Glycoside Hydrolase Family 3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Periplasmic beta-glucosidase (EC:3.2.1.21)
    Alternative name(s):
    Beta-D-glucoside glucohydrolase
    Cellobiase
    Gentiobiase
    Gene namesi
    Name:bglX
    Synonyms:yohA
    Ordered Locus Names:b2132, JW2120
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG12013. bglX.

    Subcellular locationi

    GO - Cellular componenti

    1. outer membrane-bounded periplasmic space Source: EcoCyc
    2. periplasmic space Source: EcoliWiki

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 765745Periplasmic beta-glucosidasePRO_0000011781Add
    BLAST

    Proteomic databases

    PaxDbiP33363.
    PRIDEiP33363.

    Expressioni

    Gene expression databases

    GenevestigatoriP33363.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    nrdAP004521EBI-1114600,EBI-370018

    Protein-protein interaction databases

    DIPiDIP-9218N.
    IntActiP33363. 16 interactions.
    STRINGi511145.b2132.

    Structurei

    3D structure databases

    ProteinModelPortaliP33363.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1472.
    HOGENOMiHOG000031217.
    KOiK05349.
    OMAiMSLAMQP.
    OrthoDBiEOG6DNT6C.
    PhylomeDBiP33363.

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    3.40.50.1700. 1 hit.
    InterProiIPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR019800. Glyco_hydro_3_AS.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR30620. PTHR30620. 1 hit.
    PfamiPF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view]
    PRINTSiPR00133. GLHYDRLASE3.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 2 hits.
    PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P33363-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKWLCSVGIA VSLALQPALA DDLFGNHPLT PEARDAFVTE LLKKMTVDEK    50
    IGQLRLISVG PDNPKEAIRE MIKDGQVGAI FNTVTRQDIR AMQDQVMELS 100
    RLKIPLFFAY DVLHGQRTVF PISLGLASSF NLDAVKTVGR VSAYEAADDG 150
    LNMTWAPMVD VSRDPRWGRA SEGFGEDTYL TSTMGKTMVE AMQGKSPADR 200
    YSVMTSVKHF AAYGAVEGGK EYNTVDMSPQ RLFNDYMPPY KAGLDAGSGA 250
    VMVALNSLNG TPATSDSWLL KDVLRDQWGF KGITVSDHGA IKELIKHGTA 300
    ADPEDAVRVA LKSGINMSMS DEYYSKYLPG LIKSGKVTMA ELDDAARHVL 350
    NVKYDMGLFN DPYSHLGPKE SDPVDTNAES RLHRKEAREV ARESLVLLKN 400
    RLETLPLKKS ATIAVVGPLA DSKRDVMGSW SAAGVADQSV TVLTGIKNAV 450
    GENGKVLYAK GANVTSDKGI IDFLNQYEEA VKVDPRSPQE MIDEAVQTAK 500
    QSDVVVAVVG EAQGMAHEAS SRTDITIPQS QRDLIAALKA TGKPLVLVLM 550
    NGRPLALVKE DQQADAILET WFAGTEGGNA IADVLFGDYN PSGKLPMSFP 600
    RSVGQIPVYY SHLNTGRPYN ADKPNKYTSR YFDEANGALY PFGYGLSYTT 650
    FTVSDVKLSA PTMKRDGKVT ASVQVTNTGK REGATVVQMY LQDVTASMSR 700
    PVKQLKGFEK ITLKPGETQT VSFPIDIEAL KFWNQQMKYD AEPGKFNVFI 750
    GTDSARVKKG EFELL 765
    Length:765
    Mass (Da):83,460
    Last modified:February 1, 1995 - v2
    Checksum:i0E89B0AB42B8F8F3
    GO

    Sequence cautioni

    The sequence AAA60495.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15049 Genomic DNA. Translation: AAB38487.1.
    U00007 Genomic DNA. Translation: AAA60495.1. Different initiation.
    U00096 Genomic DNA. Translation: AAC75193.1.
    AP009048 Genomic DNA. Translation: BAE76609.1.
    PIRiC64981.
    RefSeqiNP_416636.1. NC_000913.3.
    YP_490371.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC75193; AAC75193; b2132.
    BAE76609; BAE76609; BAE76609.
    GeneIDi12931457.
    946682.
    KEGGiecj:Y75_p2094.
    eco:b2132.
    PATRICi32119603. VBIEscCol129921_2212.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15049 Genomic DNA. Translation: AAB38487.1 .
    U00007 Genomic DNA. Translation: AAA60495.1 . Different initiation.
    U00096 Genomic DNA. Translation: AAC75193.1 .
    AP009048 Genomic DNA. Translation: BAE76609.1 .
    PIRi C64981.
    RefSeqi NP_416636.1. NC_000913.3.
    YP_490371.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P33363.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-9218N.
    IntActi P33363. 16 interactions.
    STRINGi 511145.b2132.

    Protein family/group databases

    CAZyi GH3. Glycoside Hydrolase Family 3.

    Proteomic databases

    PaxDbi P33363.
    PRIDEi P33363.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC75193 ; AAC75193 ; b2132 .
    BAE76609 ; BAE76609 ; BAE76609 .
    GeneIDi 12931457.
    946682.
    KEGGi ecj:Y75_p2094.
    eco:b2132.
    PATRICi 32119603. VBIEscCol129921_2212.

    Organism-specific databases

    EchoBASEi EB1951.
    EcoGenei EG12013. bglX.

    Phylogenomic databases

    eggNOGi COG1472.
    HOGENOMi HOG000031217.
    KOi K05349.
    OMAi MSLAMQP.
    OrthoDBi EOG6DNT6C.
    PhylomeDBi P33363.

    Enzyme and pathway databases

    BioCyci EcoCyc:EG12013-MONOMER.
    ECOL316407:JW2120-MONOMER.
    MetaCyc:EG12013-MONOMER.

    Miscellaneous databases

    PROi P33363.

    Gene expression databases

    Genevestigatori P33363.

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    3.40.50.1700. 1 hit.
    InterProi IPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR019800. Glyco_hydro_3_AS.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR30620. PTHR30620. 1 hit.
    Pfami PF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00133. GLHYDRLASE3.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 2 hits.
    PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Yang M., Luoh S., Goddard A., Reilly D., Henzel W., Bass S.
      Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    2. "Automated multiplex sequencing of the E.coli genome."
      Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K., Church G.M.
      Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / BHB2600.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

    Entry informationi

    Entry nameiBGLX_ECOLI
    AccessioniPrimary (citable) accession number: P33363
    Secondary accession number(s): Q2MAU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3