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Protein

Glycine betaine uptake system ATP-binding protein YehX

Gene

yehX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Probably responsible for energy coupling to the transport system.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 41ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • amino acid transport Source: UniProtKB-KW
  • glycine betaine transport Source: EcoCyc

Keywordsi

Molecular functionHydrolase
Biological processAmino-acid transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:YEHX-MONOMER.
MetaCyc:YEHX-MONOMER.

Protein family/group databases

TCDBi3.A.1.12.15. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine betaine uptake system ATP-binding protein YehXCurated (EC:3.6.3.-Curated)
Gene namesi
Name:yehX
Ordered Locus Names:b2129, JW2117
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12010. yehX.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000931671 – 308Glycine betaine uptake system ATP-binding protein YehXAdd BLAST308

Proteomic databases

PaxDbiP33360.
PRIDEiP33360.

Expressioni

Inductioni

Expression is sigma S-dependent. Induced by both osmotic shock and entry into stationary phase.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (YehX), two transmembrane proteins (YehW and YehY) and a solute-binding protein (YehZ).Curated

Protein-protein interaction databases

BioGridi4260448. 11 interactors.
DIPiDIP-11912N.
IntActiP33360. 8 interactors.
MINTiMINT-1228275.
STRINGi316385.ECDH10B_2285.

Structurei

3D structure databases

ProteinModelPortaliP33360.
SMRiP33360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 235ABC transporterPROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated

Phylogenomic databases

eggNOGiENOG4108IJ8. Bacteria.
COG1125. LUCA.
InParanoidiP33360.
KOiK05847.
PhylomeDBiP33360.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P33360-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEFSHVSKL FGAQKAVNDL NLNFQEGSFS VLIGTSGSGK STTLKMINRL
60 70 80 90 100
VEHDSGEIRF AGEEIRSLPV LELRRRMGYA IQSIGLFPHW SVAQNIATVP
110 120 130 140 150
QLQKWSRARI DDRIDELMAL LGLESNLRER YPHQLSGGQQ QRVGVARALA
160 170 180 190 200
ADPQVLLMDE PFGALDPVTR GALQQEMTRI HRLLGRTIVL VTHDIDEALR
210 220 230 240 250
LAEHLVLMDH GEVVQQGNPL TMLTRPANDF VRQFFGRSEL GVRLLSLRSV
260 270 280 290 300
ADYVRREERA DGEALAEEMT LRDALSLFVA RGCEVLPVVN MQGQPCGTLH

FQDLLVEA
Length:308
Mass (Da):34,425
Last modified:February 1, 1994 - v1
Checksum:i037C7C84E4EFB690
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00007 Genomic DNA. Translation: AAA60492.1.
U00096 Genomic DNA. Translation: AAC75190.1.
AP009048 Genomic DNA. Translation: BAE76606.1.
PIRiH64980.
RefSeqiNP_416633.1. NC_000913.3.
WP_000569315.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75190; AAC75190; b2129.
BAE76606; BAE76606; BAE76606.
GeneIDi946659.
KEGGiecj:JW2117.
eco:b2129.
PATRICifig|1411691.4.peg.115.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiYEHX_ECOLI
AccessioniPrimary (citable) accession number: P33360
Secondary accession number(s): Q2MAV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 5, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be part of an osmoprotectant uptake system (PubMed:15251200). However, it was shown later that the complex does not mediate osmotic stress protection (PubMed:26325238).2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families