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Protein

Glycine betaine uptake system permease protein YehW

Gene

yehW

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Probably responsible for the translocation of the substrate across the membrane.1 Publication

Caution

Was originally thought to be part of an osmoprotectant uptake system (PubMed:15251200). However, it was shown later that the complex does not mediate osmotic stress protection (PubMed:26325238).2 Publications

GO - Molecular functioni

GO - Biological processi

  • amino acid transport Source: UniProtKB-KW
  • glycine betaine transport Source: EcoCyc
  • transmembrane transport Source: InterPro

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YEHW-MONOMER
MetaCyc:YEHW-MONOMER

Protein family/group databases

TCDBi3.A.1.12.15 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine betaine uptake system permease protein YehWCurated
Gene namesi
Name:yehW
Ordered Locus Names:b2128, JW2116
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12009 yehW

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicCurated8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 46PeriplasmicCuratedAdd BLAST17
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 101CytoplasmicCuratedAdd BLAST34
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Topological domaini123PeriplasmicCurated1
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 161CytoplasmicCuratedAdd BLAST17
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 206PeriplasmicCuratedAdd BLAST24
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 243Cytoplasmic1 PublicationAdd BLAST16

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000602551 – 243Glycine betaine uptake system permease protein YehWAdd BLAST243

Proteomic databases

PaxDbiP33359
PRIDEiP33359

Expressioni

Inductioni

Expression is sigma S-dependent. Induced by both osmotic shock and entry into stationary phase.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (YehX), two transmembrane proteins (YehW and YehY) and a solute-binding protein (YehZ).Curated

Protein-protein interaction databases

STRINGi316385.ECDH10B_2284

Structurei

3D structure databases

ProteinModelPortaliP33359
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 231ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST182

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105WJV Bacteria
COG1174 LUCA
HOGENOMiHOG000012909
InParanoidiP33359
KOiK05846
OMAiTAYVLQG
PhylomeDBiP33359

Family and domain databases

CDDicd06261 TM_PBP2, 1 hit
Gene3Di1.10.3720.10, 1 hit
InterProiView protein in InterPro
IPR000515 MetI-like
IPR035906 MetI-like_sf
PfamiView protein in Pfam
PF00528 BPD_transp_1, 1 hit
SUPFAMiSSF161098 SSF161098, 1 hit
PROSITEiView protein in PROSITE
PS50928 ABC_TM1, 1 hit

Sequencei

Sequence statusi: Complete.

P33359-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMLRDPLFW LIALFVALIF WLPYSQPLFA ALFPQLPRPV YQQESFAALA
60 70 80 90 100
LAHFWLVGIS SLFAVIIGTG AGIAVTRPWG AEFRPLVETI AAVGQTFPPV
110 120 130 140 150
AVLAIAVPVI GFGLQPAIIA LILYGVLPVL QATLAGLGAI DASVTEVAKG
160 170 180 190 200
MGMSRGQRVR KVELPLAAPV ILAGVRTSVI INIGTATIAS TVGASTLGTP
210 220 230 240
IIIGLSGFNT AYVIQGALLV ALAAIIADRL FERLVQALSQ HAK
Length:243
Mass (Da):25,515
Last modified:February 1, 1994 - v1
Checksum:i16D90AD1338083DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00007 Genomic DNA Translation: AAA60491.1
U00096 Genomic DNA Translation: AAC75189.1
AP009048 Genomic DNA Translation: BAE76605.1
PIRiG64980
RefSeqiNP_416632.1, NC_000913.3
WP_000783123.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75189; AAC75189; b2128
BAE76605; BAE76605; BAE76605
GeneIDi949028
KEGGiecj:JW2116
eco:b2128
PATRICifig|1411691.4.peg.116

Entry informationi

Entry nameiYEHW_ECOLI
AccessioniPrimary (citable) accession number: P33359
Secondary accession number(s): Q2MAV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
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