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Protein

HTH-type transcriptional regulator MlrA

Gene

mlrA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator of the csg genes required for production of the curli (AgF).1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi6 – 2520H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12008-MONOMER.
ECOL316407:JW2115-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator MlrA
Alternative name(s):
MerR-like regulator A
Gene namesi
Name:mlrA
Synonyms:yehV
Ordered Locus Names:b2127, JW2115
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12008. mlrA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243HTH-type transcriptional regulator MlrAPRO_0000098144Add
BLAST

Proteomic databases

PaxDbiP33358.
PRIDEiP33358.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
gmrP773342EBI-1127668,EBI-548149
ydaMP773022EBI-1127668,EBI-544662

Protein-protein interaction databases

BioGridi4260445. 15 interactions.
IntActiP33358. 8 interactions.
STRINGi511145.b2127.

Structurei

3D structure databases

ProteinModelPortaliP33358.
SMRiP33358. Positions 1-128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 7270HTH merR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH merR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108XDN. Bacteria.
COG0789. LUCA.
HOGENOMiHOG000119656.
InParanoidiP33358.
OMAiLVVGWNV.
OrthoDBiEOG6HMXG6.

Family and domain databases

InterProiIPR009061. DNA-bd_dom_put.
IPR000551. MerR-type_HTH_dom.
[Graphical view]
PfamiPF13411. MerR_1. 1 hit.
[Graphical view]
SMARTiSM00422. HTH_MERR. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
PROSITEiPS00552. HTH_MERR_1. 1 hit.
PS50937. HTH_MERR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33358-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALYTIGEVA LLCDINPVTL RAWQRRYGLL KPQRTDGGHR LFNDADIDRI
60 70 80 90 100
REIKRWIDNG VQVSKVKMLL SNENVDVQNG WRDQQETLLT YLQSGNLHSL
110 120 130 140 150
RTWIKERGQD YPAQTLTTHL FIPLRRRLQC QQPTLQALLA ILDGVLINYI
160 170 180 190 200
AICLASARKK QGKDALVVGW NIQDTTRLWL EGWIASQQGW RIDVLAHSLN
210 220 230 240
QLRPELFEGR TLLVWCGENR TSAQQQQLTS WQEQGHDIFP LGI
Length:243
Mass (Da):28,046
Last modified:February 1, 1994 - v1
Checksum:i48F6D16051C04319
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288173 Genomic DNA. Translation: AAK84657.1.
AF288174 Genomic DNA. Translation: AAK84658.1.
U00007 Genomic DNA. Translation: AAA60490.1.
U00096 Genomic DNA. Translation: AAC75188.1.
AP009048 Genomic DNA. Translation: BAE76603.1.
PIRiF64980.
RefSeqiNP_416631.1. NC_000913.3.
WP_001240401.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75188; AAC75188; b2127.
BAE76603; BAE76603; BAE76603.
GeneIDi949029.
KEGGiecj:JW2115.
eco:b2127.
PATRICi32119591. VBIEscCol129921_2206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288173 Genomic DNA. Translation: AAK84657.1.
AF288174 Genomic DNA. Translation: AAK84658.1.
U00007 Genomic DNA. Translation: AAA60490.1.
U00096 Genomic DNA. Translation: AAC75188.1.
AP009048 Genomic DNA. Translation: BAE76603.1.
PIRiF64980.
RefSeqiNP_416631.1. NC_000913.3.
WP_001240401.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP33358.
SMRiP33358. Positions 1-128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260445. 15 interactions.
IntActiP33358. 8 interactions.
STRINGi511145.b2127.

Proteomic databases

PaxDbiP33358.
PRIDEiP33358.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75188; AAC75188; b2127.
BAE76603; BAE76603; BAE76603.
GeneIDi949029.
KEGGiecj:JW2115.
eco:b2127.
PATRICi32119591. VBIEscCol129921_2206.

Organism-specific databases

EchoBASEiEB1946.
EcoGeneiEG12008. mlrA.

Phylogenomic databases

eggNOGiENOG4108XDN. Bacteria.
COG0789. LUCA.
HOGENOMiHOG000119656.
InParanoidiP33358.
OMAiLVVGWNV.
OrthoDBiEOG6HMXG6.

Enzyme and pathway databases

BioCyciEcoCyc:EG12008-MONOMER.
ECOL316407:JW2115-MONOMER.

Miscellaneous databases

PROiP33358.

Family and domain databases

InterProiIPR009061. DNA-bd_dom_put.
IPR000551. MerR-type_HTH_dom.
[Graphical view]
PfamiPF13411. MerR_1. 1 hit.
[Graphical view]
SMARTiSM00422. HTH_MERR. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
PROSITEiPS00552. HTH_MERR_1. 1 hit.
PS50937. HTH_MERR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "MlrA, a novel regulator of curli (AgF) and extracellular matrix synthesis by Escherichia coli and Salmonella enterica serovar Typhimurium."
    Brown P.K., Dozois C.M., Nickerson C.A., Zuppardo A., Terlonge J., Curtiss R. III
    Mol. Microbiol. 41:349-363(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: ATCC 33694 / HB101 and Chi7122.
  2. "Automated multiplex sequencing of the E.coli genome."
    Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K., Church G.M.
    Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / BHB2600.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiMLRA_ECOLI
AccessioniPrimary (citable) accession number: P33358
Secondary accession number(s): Q2MAV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: January 20, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.