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P33345 (MOLR_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative molybdate metabolism regulator
Gene names
Name:yehH
Synonyms:molR
Ordered Locus Names:b4499
ORF Names:b2115/b2116/b2117
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length1264 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Function

Was originally thought to be involved in the regulation of molybdate metabolism (Ref.3), has also been implicated in selenate reduction (Ref.5).

Sequence similarities

To E.coli YehI.

Caution

Could be the product of a pseudogene.

Sequence caution

The sequence AAA60477.1 differs from that shown. Reason: Frameshift at positions 275 and 950.

The sequence U00096 differs from that shown. Reason: Frameshift at positions 275 and 950.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12641264Putative molybdate metabolism regulator
PRO_0000096531

Sequences

Sequence LengthMass (Da)Tools
P33345 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: FCB85A5933CCEFF4

FASTA1,264140,939
        10         20         30         40         50         60 
MRHFIYQDEK SHKFRAVEQQ GNELHISWGK VGTKGQSQIK SFSDAAAAAK AELKLIAEKV 

        70         80         90        100        110        120 
KKGYVEQAKD NSLQPSQTVT GSLKVADLST IIQEQPSFVA ETRAPDKNTD AVLPWLAKDI 

       130        140        150        160        170        180 
AVVFPPEVVH TTLSHRRFPG VPVQQADKLP QLRRLACSVS QRDNKTATFD FSACSLEWQN 

       190        200        210        220        230        240 
TVAQAISQID GLKTTQLPSP VMAVLTALEM KCTRYKVRED VMDQIVQEGG LEYATDVIIH 

       250        260        270        280        290        300 
LQQIDIEWDY ANNVIIILPS GIAPSYLEQY SRFEXRLRKH LSLTEESLWQ KCAQKLIAAI 

       310        320        330        340        350        360 
PHIPEWRQPL IALLLPEKPE IAHEIAQRLL GQKKLPSLEW LKIVATDEHI LASLEKYHEP 

       370        380        390        400        410        420 
YAIFDDYYCG AIWSATVLQE QGVAALPRFA PYAASDYCAD VLRHINHPFA LTLLIRVAGQ 

       430        440        450        460        470        480 
TKRCHDRMTK AIAAFPHAAM AALTELLGQK EENSWRIMLM TMLISQPALA EQVIPWLSTP 

       490        500        510        520        530        540 
AVAVLKSCQQ QLTQPSNHAS ADLLPAVVVS PPWLSKKKKS PIPVLDLAPL GIEPICYLTE 

       550        560        570        580        590        600 
EISNQLLAKY IWYSKHITVS HEESTTNLLA RMGFQRRIAG TYIKAPEAVV EAWLNEDYST 

       610        620        630        640        650        660 
LLSEFKVFHS PTGHYWQLGI LTTLPLEKAV KAWNALTLSP HTDTEYSMLH FGLKGLPGLV 

       670        680        690        700        710        720 
NSLARYPQEA LPITNYFAAS ELAPAVARAF NKLKTLRENA RSWLLKYPEH ALTGLLPAAP 

       730        740        750        760        770        780 
GKAGEAQDNA RAALRMLTEN GHQPLLQEIA RRYNQPEVTD AVNALLALDP LDNHPTKIPT 

       790        800        810        820        830        840 
LPAFYQPSLW TRPVLKANAQ SLPDSALLHL GEMLRFPQEE ALYPGLLQVK DVCSADSLAG 

       850        860        870        880        890        900 
FAWDLFTAWQ TAGAPSKESW AFTALGVLGN DDTARKLTPL IRAWPGESQH KRATVGLDIL 

       910        920        930        940        950        960 
AAIGSDIALM QLNGIAQKLK FKALQERAKE KIADIAESRE LTVAELEDRL APDLGLDDNG 

       970        980        990       1000       1010       1020 
SLLLDFGPRQ FTVSFDETLK PFVRDVSGSR LKDLPKPNKS DDETRANDAV NRYKLLKKDA 

      1030       1040       1050       1060       1070       1080 
RTIAAQQVAR LESAMCLRRR WSLENFQLFL VEHPLVRHLT RRLIWGVYSA ENQLLACFRV 

      1090       1100       1110       1120       1130       1140 
AEDNSSSTAD DDLFTLPEGD ISIGTPHVLE ISPTDAAAFG QLFADYELLP PFRQLDRNSY 

      1150       1160       1170       1180       1190       1200 
ALTEAERNAS ELTRWAGRKC PSGRVMGLAN KGWIKGEPQD GGWIGWMIKP LGRWSLIMEI 

      1210       1220       1230       1240       1250       1260 
DEGFAVGMSP AELSAEQLLS KLWLWEGKAE RYGWGSNSTQ EAQFSVIDAI TASELINDIE 


ALFE 

« Hide

References

« Hide 'large scale' references
[1]"Automated multiplex sequencing of the E.coli genome."
Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K., Church G.M.
Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / BHB2600.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Identification of a new gene, molR, essential for utilization of molybdate by Escherichia coli."
Lee J.H., Wendt J.C., Shanmugam K.T.
J. Bacteriol. 172:2079-2087(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
Strain: K12 / BW545.
[4]Healy F., Grunden A., Ray R.M., Shanmugam K.T.
Unpublished observations (FEB-1994)
Cited for: CHARACTERIZATION.
[5]"Involvement of a putative molybdenum enzyme in the reduction of selenate by Escherichia coli."
Bebien M., Kirsch J., Mejean V., Vermeglio A.
Microbiology 148:3865-3872(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: POTENTIAL INVOLVEMENT IN SELENATE REDUCTION.
Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00007 Genomic DNA. Translation: AAA60477.1. Frameshift.
U00096 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalP33345.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP33345. 8 interactions.

Proteomic databases

PRIDEP33345.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

EchoBASEEB1935.
EcoGeneEG11992. yehH.

Phylogenomic databases

HOGENOMHOG000122164.

Enzyme and pathway databases

BioCycEcoCyc:EG11992-MONOMER.
EcoCyc:G8208-MONOMER.
EcoCyc:G8209-MONOMER.

Gene expression databases

GenevestigatorP33345.

Family and domain databases

Gene3D2.20.140.10. 1 hit.
InterProIPR025406. DUF4132.
IPR008893. WGR_domain.
[Graphical view]
PfamPF13569. DUF4132. 1 hit.
PF05406. WGR. 1 hit.
[Graphical view]
SMARTSM00773. WGR. 1 hit.
[Graphical view]
SUPFAMSSF142921. SSF142921. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMOLR_ECOLI
AccessionPrimary (citable) accession number: P33345
Secondary accession number(s): P76427, P76428, P76429
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene