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Protein

Outer membrane usher protein YehB

Gene

yehB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the yehABCD fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Probably involved in the export and assembly of fimbrial subunits across the outer membrane.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • pilus assembly Source: GO_Central
  • transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Fimbrium biogenesis, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG11988-MONOMER.
ECOL316407:JW2096-MONOMER.

Protein family/group databases

TCDBi1.B.11.3.11. the outer membrane fimbrial usher porin (fup) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane usher protein YehB
Gene namesi
Name:yehB
Ordered Locus Names:b2109, JW2096
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11988. yehB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 826804Outer membrane usher protein YehBPRO_0000009331Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi809 ↔ 825Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP33341.
PRIDEiP33341.

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260435. 265 interactions.
DIPiDIP-11896N.
IntActiP33341. 2 interactions.
MINTiMINT-1263138.
STRINGi511145.b2109.

Structurei

3D structure databases

ProteinModelPortaliP33341.
SMRiP33341. Positions 53-788.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial export usher family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105CW0. Bacteria.
COG3188. LUCA.
HOGENOMiHOG000111415.
InParanoidiP33341.
KOiK07347.
OMAiGINTDNF.
OrthoDBiEOG6GJBP9.
PhylomeDBiP33341.

Family and domain databases

InterProiIPR000015. Fimb_usher.
IPR018030. Fimbrial_membr_usher_CS.
IPR025949. PapC-like_C.
IPR025885. PapC_N.
[Graphical view]
PANTHERiPTHR30451. PTHR30451. 1 hit.
PfamiPF13953. PapC_C. 1 hit.
PF13954. PapC_N. 1 hit.
PF00577. Usher. 1 hit.
[Graphical view]
PROSITEiPS01151. FIMBRIAL_USHER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33341-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRMTPLASA IVALLLGIEA YAAEETFDTH FMIGGMKDQQ VANIRLDDNQ
60 70 80 90 100
PLPGQYDIDI YVNKQWRGKY EIIVKDNPQE TCLSREVIKR LGINSDNFAS
110 120 130 140 150
GKQCLTFEQL VQGGSYTWDI GVFRLDFSVP QAWVEELESG YVPPENWERG
160 170 180 190 200
INAFYTSYYL SQYYSDYKAS GNNKSTYVRF NSGLNLLGWQ LHSDASFSKT
210 220 230 240 250
NNNPGVWKSN TLYLERGFAQ LLGTLRVGDM YTSSDIFDSV RFRGVRLFRD
260 270 280 290 300
MQMLPNSKQN FTPRVQGIAQ SNALVTIEQN GFVVYQKEVP PGPFAITDLQ
310 320 330 340 350
LAGGGADLDV SVKEADGSVT TYLVPYAAVP NMLQPGVSKY DLAAGRSHIE
360 370 380 390 400
GASKQSDFVQ AGYQYGFNNL LTLYGGSMVA NNYYAFTLGA GWNTRIGAIS
410 420 430 440 450
VDATKSHSKQ DNGDVFDGQS YQIAYNKFVS QTSTRFGLAA WRYSSRDYRT
460 470 480 490 500
FNDHVWANNK DNYRRDENDV YDIADYYQND FGRKNSFSAN MSQSLPEGWG
510 520 530 540 550
SVSLSTLWRD YWGRSGSSKD YQLSYSNNLR RISYTLAASQ AYDENHHEEK
560 570 580 590 600
RFNIFISIPF DWGDDVSTPR RQIYMSNSTT FDDQGFASNN TGLSGTVGSR
610 620 630 640 650
DQFNYGVNLS HQHQGNETTA GANLTWNAPV ATVNGSYSQS STYRQAGASV
660 670 680 690 700
SGGIVAWSGG VNLANRLSET FAVMNAPGIK DAYVNGQKYR TTNRNGVVIY
710 720 730 740 750
DGMTPYRENH LMLDVSQSDS EAELRGNRKI AAPYRGAVVL VNFDTDQRKP
760 770 780 790 800
WFIKALRADG QSLTFGYEVN DIHGHNIGVV GQGSQLFIRT NEVPPSVNVA
810 820
IDKQQGLSCT ITFGKEIDES RNYICQ
Length:826
Mass (Da):92,282
Last modified:February 1, 1994 - v1
Checksum:i1FA541B1A21675CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00007 Genomic DNA. Translation: AAA60473.1.
U00096 Genomic DNA. Translation: AAC75170.1.
AP009048 Genomic DNA. Translation: BAA15975.2.
PIRiD64978.
RefSeqiNP_416612.1. NC_000913.3.
WP_000945454.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75170; AAC75170; b2109.
BAA15975; BAA15975; BAA15975.
GeneIDi946617.
KEGGiecj:JW2096.
eco:b2109.
PATRICi32119551. VBIEscCol129921_2186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00007 Genomic DNA. Translation: AAA60473.1.
U00096 Genomic DNA. Translation: AAC75170.1.
AP009048 Genomic DNA. Translation: BAA15975.2.
PIRiD64978.
RefSeqiNP_416612.1. NC_000913.3.
WP_000945454.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP33341.
SMRiP33341. Positions 53-788.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260435. 265 interactions.
DIPiDIP-11896N.
IntActiP33341. 2 interactions.
MINTiMINT-1263138.
STRINGi511145.b2109.

Protein family/group databases

TCDBi1.B.11.3.11. the outer membrane fimbrial usher porin (fup) family.

Proteomic databases

PaxDbiP33341.
PRIDEiP33341.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75170; AAC75170; b2109.
BAA15975; BAA15975; BAA15975.
GeneIDi946617.
KEGGiecj:JW2096.
eco:b2109.
PATRICi32119551. VBIEscCol129921_2186.

Organism-specific databases

EchoBASEiEB1931.
EcoGeneiEG11988. yehB.

Phylogenomic databases

eggNOGiENOG4105CW0. Bacteria.
COG3188. LUCA.
HOGENOMiHOG000111415.
InParanoidiP33341.
KOiK07347.
OMAiGINTDNF.
OrthoDBiEOG6GJBP9.
PhylomeDBiP33341.

Enzyme and pathway databases

BioCyciEcoCyc:EG11988-MONOMER.
ECOL316407:JW2096-MONOMER.

Miscellaneous databases

PROiP33341.

Family and domain databases

InterProiIPR000015. Fimb_usher.
IPR018030. Fimbrial_membr_usher_CS.
IPR025949. PapC-like_C.
IPR025885. PapC_N.
[Graphical view]
PANTHERiPTHR30451. PTHR30451. 1 hit.
PfamiPF13953. PapC_C. 1 hit.
PF13954. PapC_N. 1 hit.
PF00577. Usher. 1 hit.
[Graphical view]
PROSITEiPS01151. FIMBRIAL_USHER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Automated multiplex sequencing of the E.coli genome."
    Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K., Church G.M.
    Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / BHB2600.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 307-826.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Escherichia coli K-12 possesses multiple cryptic but functional chaperone-usher fimbriae with distinct surface specificities."
    Korea C.G., Badouraly R., Prevost M.C., Ghigo J.M., Beloin C.
    Environ. Microbiol. 12:1957-1977(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYEHB_ECOLI
AccessioniPrimary (citable) accession number: P33341
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 13, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.