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Protein

Protein SLA2

Gene

SLA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for cellular morphogenesis and polarization of the cortical cytoskeleton. It might act in concert with proteins such as CDC42 and CDC43 to limit the region of cortical patch formation to the cortex of the bud. Required for the accumulation and/or maintenance of plasma membrane H+-ATPase on the cell surface.

GO - Molecular functioni

  • phospholipid binding Source: InterPro
  • protein binding, bridging Source: SGD

GO - Biological processi

  • actin filament organization Source: SGD
  • bipolar cellular bud site selection Source: SGD
  • endocytosis Source: SGD
  • exocytosis Source: SGD
  • fungal-type cell wall organization Source: SGD
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33240-MONOMER.
ReactomeiR-SCE-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SLA2
Alternative name(s):
Transmembrane protein MOP2
Gene namesi
Name:SLA2
Synonyms:END4, MOP2, UFG1
Ordered Locus Names:YNL243W
ORF Names:N1102
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL243W.
SGDiS000005187. SLA2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei772 – 79120HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  • actin cortical patch Source: SGD
  • cellular bud tip Source: UniProtKB-SubCell
  • incipient cellular bud site Source: SGD
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 968968Protein SLA2PRO_0000071945Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei294 – 2941PhosphothreonineCombined sources
Modified residuei298 – 2981PhosphothreonineCombined sources
Modified residuei308 – 3081PhosphoserineCombined sources
Modified residuei555 – 5551PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP33338.
PRIDEiP33338.

PTM databases

iPTMnetiP33338.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LAS17Q124463EBI-17323,EBI-10022

GO - Molecular functioni

  • protein binding, bridging Source: SGD

Protein-protein interaction databases

BioGridi35596. 112 interactions.
DIPiDIP-973N.
IntActiP33338. 26 interactions.
MINTiMINT-519732.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5AHVelectron microscopy13.60F5-272[»]
ProteinModelPortaliP33338.
SMRiP33338. Positions 5-272, 760-895.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 127127ENTHPROSITE-ProRule annotationAdd
BLAST
Domaini717 – 965249I/LWEQPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SLA2 family.Curated
Contains 1 ENTH (epsin N-terminal homology) domain.PROSITE-ProRule annotation
Contains 1 I/LWEQ domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074542.
HOGENOMiHOG000193921.
InParanoidiP33338.
KOiK20040.
OMAiRYDAQHH.
OrthoDBiEOG092C1ATT.

Family and domain databases

Gene3Di1.20.1410.10. 1 hit.
1.25.40.90. 1 hit.
InterProiIPR011417. ANTH_dom.
IPR013809. ENTH.
IPR008942. ENTH_VHS.
IPR002558. ILWEQ_dom.
IPR030224. Sla2_fam.
[Graphical view]
PANTHERiPTHR10407. PTHR10407. 1 hit.
PfamiPF07651. ANTH. 1 hit.
PF01608. I_LWEQ. 1 hit.
[Graphical view]
ProDomiPD011820. ILWEQ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00273. ENTH. 1 hit.
SM00307. ILWEQ. 1 hit.
[Graphical view]
SUPFAMiSSF109885. SSF109885. 1 hit.
SSF48464. SSF48464. 1 hit.
PROSITEiPS50942. ENTH. 1 hit.
PS50945. I_LWEQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33338-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRIDSDLQK ALKKACSVEE TAPKRKHVRA CIVYTWDHQS SKAVFTTLKT
60 70 80 90 100
LPLANDEVQL FKMLIVLHKI IQEGHPSALA EAIRDRDWIR SLGRVHSGGS
110 120 130 140 150
SYSKLIREYV RYLVLKLDFH AHHRGFNNGT FEYEEYVSLV SVSDPDEGYE
160 170 180 190 200
TILDLMSLQD SLDEFSQIIF ASIQSERRNT ECKISALIPL IAESYGIYKF
210 220 230 240 250
ITSMLRAMHR QLNDAEGDAA LQPLKERYEL QHARLFEFYA DCSSVKYLTT
260 270 280 290 300
LVTIPKLPVD APDVFLINDV DESKEIKFKK REPSVTPART PARTPTPTPP
310 320 330 340 350
VVAEPAISPR PVSQRTTSTP TGYLQTMPTG ATTGMMIPTA TGAANAIFPQ
360 370 380 390 400
ATAQMQPDFW ANQQAQFANE QNRLEQERVQ QLQQQQAQQE LFQQQLQKAQ
410 420 430 440 450
QDMMNMQLQQ QNQHQNDLIA LTNQYEKDQA LLQQYDQRVQ QLESEITTMD
460 470 480 490 500
STASKQLANK DEQLTALQDQ LDVWERKYES LAKLYSQLRQ EHLNLLPRFK
510 520 530 540 550
KLQLKVNSAQ ESIQKKEQLE HKLKQKDLQM AELVKDRDRA RLELERSINN
560 570 580 590 600
AEADSAAATA AAETMTQDKM NPILDAILES GINTIQESVY NLDSPLSWSG
610 620 630 640 650
PLTPPTFLLS LLESTSENAT EFATSFNNLI VDGLAHGDQT EVIHCVSDFS
660 670 680 690 700
TSMATLVTNS KAYAVTTLPQ EQSDQILTLV KRCAREAQYF FEDLMSENLN
710 720 730 740 750
QVGDEEKTDI VINANVDMQE KLQELSLAIE PLLNIQSVKS NKETNPHSEL
760 770 780 790 800
VATADKIVKS SEHLRVDVPK PLLSLALMII DAVVALVKAA IQCQNEIATT
810 820 830 840 850
TSIPLNQFYL KNSRWTEGLI SAAKAVAGAT NVLITTASKL ITSEDNENTS
860 870 880 890 900
PEQFIVASKE VAASTIQLVA ASRVKTSIHS KAQDKLEHCS KDVTDACRSL
910 920 930 940 950
GNHVMGMIED DHSTSQQQQP LDFTSEHTLK TAEMEQQVEI LKLEQSLSNA
960
RKRLGEIRRH AYYNQDDD
Length:968
Mass (Da):108,911
Last modified:September 21, 2011 - v5
Checksum:iE592E09D8040C0E9
GO

Sequence cautioni

The sequence AAA19161 differs from that shown. Reason: Frameshift at positions 887 and 959. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521P → A in AAA74726 (PubMed:7896828).Curated
Sequence conflicti344 – 3441A → R in CAA96148 (PubMed:9169873).Curated
Sequence conflicti344 – 3441A → R in CAA96149 (PubMed:9169873).Curated
Sequence conflicti560 – 5601A → R in AAA19161 (Ref. 5) Curated
Sequence conflicti915 – 9151S → C in AAA19161 (Ref. 5) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22811 Genomic DNA. Translation: CAA80464.1.
L12352 Genomic DNA. Translation: AAA74726.1.
Z71519 Genomic DNA. Translation: CAA96149.1.
Z71518 Genomic DNA. Translation: CAA96148.1.
U07938 Unassigned DNA. Translation: AAA19161.1. Frameshift.
Z69381 Genomic DNA. Translation: CAA93355.1.
BK006947 Genomic DNA. Translation: DAA10316.2.
PIRiS63211.
RefSeqiNP_014156.2. NM_001183081.2.

Genome annotation databases

EnsemblFungiiYNL243W; YNL243W; YNL243W.
GeneIDi855478.
KEGGisce:YNL243W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22811 Genomic DNA. Translation: CAA80464.1.
L12352 Genomic DNA. Translation: AAA74726.1.
Z71519 Genomic DNA. Translation: CAA96149.1.
Z71518 Genomic DNA. Translation: CAA96148.1.
U07938 Unassigned DNA. Translation: AAA19161.1. Frameshift.
Z69381 Genomic DNA. Translation: CAA93355.1.
BK006947 Genomic DNA. Translation: DAA10316.2.
PIRiS63211.
RefSeqiNP_014156.2. NM_001183081.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5AHVelectron microscopy13.60F5-272[»]
ProteinModelPortaliP33338.
SMRiP33338. Positions 5-272, 760-895.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35596. 112 interactions.
DIPiDIP-973N.
IntActiP33338. 26 interactions.
MINTiMINT-519732.

PTM databases

iPTMnetiP33338.

Proteomic databases

MaxQBiP33338.
PRIDEiP33338.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL243W; YNL243W; YNL243W.
GeneIDi855478.
KEGGisce:YNL243W.

Organism-specific databases

EuPathDBiFungiDB:YNL243W.
SGDiS000005187. SLA2.

Phylogenomic databases

GeneTreeiENSGT00550000074542.
HOGENOMiHOG000193921.
InParanoidiP33338.
KOiK20040.
OMAiRYDAQHH.
OrthoDBiEOG092C1ATT.

Enzyme and pathway databases

BioCyciYEAST:G3O-33240-MONOMER.
ReactomeiR-SCE-114608. Platelet degranulation.

Miscellaneous databases

PROiP33338.

Family and domain databases

Gene3Di1.20.1410.10. 1 hit.
1.25.40.90. 1 hit.
InterProiIPR011417. ANTH_dom.
IPR013809. ENTH.
IPR008942. ENTH_VHS.
IPR002558. ILWEQ_dom.
IPR030224. Sla2_fam.
[Graphical view]
PANTHERiPTHR10407. PTHR10407. 1 hit.
PfamiPF07651. ANTH. 1 hit.
PF01608. I_LWEQ. 1 hit.
[Graphical view]
ProDomiPD011820. ILWEQ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00273. ENTH. 1 hit.
SM00307. ILWEQ. 1 hit.
[Graphical view]
SUPFAMiSSF109885. SSF109885. 1 hit.
SSF48464. SSF48464. 1 hit.
PROSITEiPS50942. ENTH. 1 hit.
PS50945. I_LWEQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLA2_YEAST
AccessioniPrimary (citable) accession number: P33338
Secondary accession number(s): D6W0V0, Q02434
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: September 21, 2011
Last modified: September 7, 2016
This is version 154 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 40600 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.