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Protein

Protein SLA2

Gene

SLA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for cellular morphogenesis and polarization of the cortical cytoskeleton. It might act in concert with proteins such as CDC42 and CDC43 to limit the region of cortical patch formation to the cortex of the bud. Required for the accumulation and/or maintenance of plasma membrane H+-ATPase on the cell surface.

Miscellaneous

Present with 40600 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • clathrin binding Source: InterPro
  • phospholipid binding Source: InterPro
  • protein binding, bridging Source: SGD

GO - Biological processi

  • actin cortical patch assembly Source: SGD
  • actin filament organization Source: SGD
  • bipolar cellular bud site selection Source: SGD
  • endocytosis Source: SGD
  • exocytosis Source: SGD
  • fungal-type cell wall organization Source: SGD

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33240-MONOMER
ReactomeiR-SCE-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SLA2
Alternative name(s):
Transmembrane protein MOP2
Gene namesi
Name:SLA2
Synonyms:END4, MOP2, UFG1
Ordered Locus Names:YNL243W
ORF Names:N1102
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL243W
SGDiS000005187 SLA2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei772 – 791HelicalPROSITE-ProRule annotationAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000719451 – 968Protein SLA2Add BLAST968

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei294PhosphothreonineCombined sources1
Modified residuei298PhosphothreonineCombined sources1
Modified residuei308PhosphoserineCombined sources1
Modified residuei555PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP33338
PaxDbiP33338
PRIDEiP33338

PTM databases

iPTMnetiP33338

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ENT1Q125182EBI-17323,EBI-31494

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • clathrin binding Source: InterPro
  • protein binding, bridging Source: SGD

Protein-protein interaction databases

BioGridi35596918 interactors.
DIPiDIP-973N
IntActiP33338 27 interactors.
MINTiP33338
STRINGi4932.YNL243W

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AHVelectron microscopy13.60F5-272[»]
ProteinModelPortaliP33338
SMRiP33338
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 127ENTHPROSITE-ProRule annotationAdd BLAST127
Domaini717 – 965I/LWEQPROSITE-ProRule annotationAdd BLAST249

Sequence similaritiesi

Belongs to the SLA2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074542
HOGENOMiHOG000193921
InParanoidiP33338
KOiK20040
OMAiNNRWTEG
OrthoDBiEOG092C1ATT

Family and domain databases

Gene3Di1.25.40.901 hit
InterProiView protein in InterPro
IPR011417 ANTH_dom
IPR013809 ENTH
IPR008942 ENTH_VHS
IPR035964 I/LWEQ_dom_sf
IPR002558 ILWEQ_dom
IPR030224 Sla2_fam
PANTHERiPTHR10407 PTHR10407, 1 hit
PfamiView protein in Pfam
PF07651 ANTH, 1 hit
PF01608 I_LWEQ, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD011820 ILWEQ, 1 hit
SMARTiView protein in SMART
SM00273 ENTH, 1 hit
SM00307 ILWEQ, 1 hit
SUPFAMiSSF109885 SSF109885, 1 hit
SSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50942 ENTH, 1 hit
PS50945 I_LWEQ, 1 hit

Sequencei

Sequence statusi: Complete.

P33338-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRIDSDLQK ALKKACSVEE TAPKRKHVRA CIVYTWDHQS SKAVFTTLKT
60 70 80 90 100
LPLANDEVQL FKMLIVLHKI IQEGHPSALA EAIRDRDWIR SLGRVHSGGS
110 120 130 140 150
SYSKLIREYV RYLVLKLDFH AHHRGFNNGT FEYEEYVSLV SVSDPDEGYE
160 170 180 190 200
TILDLMSLQD SLDEFSQIIF ASIQSERRNT ECKISALIPL IAESYGIYKF
210 220 230 240 250
ITSMLRAMHR QLNDAEGDAA LQPLKERYEL QHARLFEFYA DCSSVKYLTT
260 270 280 290 300
LVTIPKLPVD APDVFLINDV DESKEIKFKK REPSVTPART PARTPTPTPP
310 320 330 340 350
VVAEPAISPR PVSQRTTSTP TGYLQTMPTG ATTGMMIPTA TGAANAIFPQ
360 370 380 390 400
ATAQMQPDFW ANQQAQFANE QNRLEQERVQ QLQQQQAQQE LFQQQLQKAQ
410 420 430 440 450
QDMMNMQLQQ QNQHQNDLIA LTNQYEKDQA LLQQYDQRVQ QLESEITTMD
460 470 480 490 500
STASKQLANK DEQLTALQDQ LDVWERKYES LAKLYSQLRQ EHLNLLPRFK
510 520 530 540 550
KLQLKVNSAQ ESIQKKEQLE HKLKQKDLQM AELVKDRDRA RLELERSINN
560 570 580 590 600
AEADSAAATA AAETMTQDKM NPILDAILES GINTIQESVY NLDSPLSWSG
610 620 630 640 650
PLTPPTFLLS LLESTSENAT EFATSFNNLI VDGLAHGDQT EVIHCVSDFS
660 670 680 690 700
TSMATLVTNS KAYAVTTLPQ EQSDQILTLV KRCAREAQYF FEDLMSENLN
710 720 730 740 750
QVGDEEKTDI VINANVDMQE KLQELSLAIE PLLNIQSVKS NKETNPHSEL
760 770 780 790 800
VATADKIVKS SEHLRVDVPK PLLSLALMII DAVVALVKAA IQCQNEIATT
810 820 830 840 850
TSIPLNQFYL KNSRWTEGLI SAAKAVAGAT NVLITTASKL ITSEDNENTS
860 870 880 890 900
PEQFIVASKE VAASTIQLVA ASRVKTSIHS KAQDKLEHCS KDVTDACRSL
910 920 930 940 950
GNHVMGMIED DHSTSQQQQP LDFTSEHTLK TAEMEQQVEI LKLEQSLSNA
960
RKRLGEIRRH AYYNQDDD
Length:968
Mass (Da):108,911
Last modified:September 21, 2011 - v5
Checksum:iE592E09D8040C0E9
GO

Sequence cautioni

The sequence AAA19161 differs from that shown. Reason: Frameshift at positions 887 and 959.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52P → A in AAA74726 (PubMed:7896828).Curated1
Sequence conflicti344A → R in CAA96148 (PubMed:9169873).Curated1
Sequence conflicti344A → R in CAA96149 (PubMed:9169873).Curated1
Sequence conflicti560A → R in AAA19161 (Ref. 5) Curated1
Sequence conflicti915S → C in AAA19161 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22811 Genomic DNA Translation: CAA80464.1
L12352 Genomic DNA Translation: AAA74726.1
Z71519 Genomic DNA Translation: CAA96149.1
Z71518 Genomic DNA Translation: CAA96148.1
U07938 Unassigned DNA Translation: AAA19161.1 Frameshift.
Z69381 Genomic DNA Translation: CAA93355.1
BK006947 Genomic DNA Translation: DAA10316.2
PIRiS63211
RefSeqiNP_014156.2, NM_001183081.2

Genome annotation databases

EnsemblFungiiYNL243W; YNL243W; YNL243W
GeneIDi855478
KEGGisce:YNL243W

Similar proteinsi

Entry informationi

Entry nameiSLA2_YEAST
AccessioniPrimary (citable) accession number: P33338
Secondary accession number(s): D6W0V0, Q02434
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: September 21, 2011
Last modified: February 28, 2018
This is version 167 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome