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Protein

Protein SGE1

Gene

SGE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Drug export permease. Multi-copy suppressor of loss-of-function mutation of GAL11. Involved specifically in transcription of GAL4-dependent genes. Can link GAL4 with the basal transcription machinery if GAL11 is missing. Confers resistance to 10-N-nonyl acridine orange (NAO) and in general to cationic dyes.

GO - Molecular functioni

  • drug transmembrane transporter activity Source: SGD

GO - Biological processi

  • drug transport Source: SGD
  • response to drug Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-34318-MONOMER

Protein family/group databases

TCDBi2.A.1.3.54 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SGE1
Alternative name(s):
10-N-nonyl acridine orange resistance protein
Crystal violet resistance protein
Gene namesi
Name:SGE1
Synonyms:NOR1
Ordered Locus Names:YPR198W
ORF Names:P9677.3
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR198W
SGDiS000006402 SGE1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 41ExtracellularSequence analysisAdd BLAST12
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 79CytoplasmicSequence analysisAdd BLAST17
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 103ExtracellularSequence analysis3
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 131CytoplasmicSequence analysis7
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 162ExtracellularSequence analysis10
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 227CytoplasmicSequence analysisAdd BLAST44
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 255ExtracellularSequence analysis7
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 300CytoplasmicSequence analysisAdd BLAST24
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 341ExtracellularSequence analysisAdd BLAST20
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 373CytoplasmicSequence analysisAdd BLAST11
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 399ExtracellularSequence analysis5
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Topological domaini421 – 443CytoplasmicSequence analysisAdd BLAST23
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Topological domaini465 – 508ExtracellularSequence analysisAdd BLAST44
Transmembranei509 – 529HelicalSequence analysisAdd BLAST21
Topological domaini530 – 543CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734221 – 543Protein SGE1Add BLAST543

Proteomic databases

MaxQBiP33335
PaxDbiP33335
PRIDEiP33335

Interactioni

Protein-protein interaction databases

BioGridi36368, 69 interactors
DIPiDIP-7575N
IntActiP33335, 3 interactors
MINTiP33335
STRINGi4932.YPR198W

Structurei

3D structure databases

ProteinModelPortaliP33335
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000006559
HOGENOMiHOG000247960
InParanoidiP33335
OMAiWGGRILD
OrthoDBiEOG092C1LCH

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 3 hits
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P33335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSTLSLTLC VISLLLTLFL AALDIVIVVT LYDTIGIKFH DFGNIGWLVT
60 70 80 90 100
GYALSNAVFM LLWGRLAEIL GTKECLMISV IVFEIGSLIS ALSNSMATLI
110 120 130 140 150
SGRVVAGFGG SGIESLAFVV GTSIVRENHR GIMITALAIS YVIAEGVGPF
160 170 180 190 200
IGGAFNEHLS WRWCFYINLP IGAFAFIILA FCNTSGEPHQ KMWLPSKIKK
210 220 230 240 250
IMNYDYGELL KASFWKNTFE VLVFKLDMVG IILSSAGFTL LMLGLSFGGN
260 270 280 290 300
NFPWNSGIII CFFTVGPILL LLFCAYDFHF LSLSGLHYDN KRIKPLLTWN
310 320 330 340 350
IASNCGIFTS SITGFLSCFA YELQSAYLVQ LYQLVFKKKP TLASIHLWEL
360 370 380 390 400
SIPAMIATMA IAYLNSKYGI IKPAIVFGVL CGIVGSGLFT LINGELSQSI
410 420 430 440 450
GYSILPGIAF GSIFQATLLS SQVQITSDDP DFQNKFIEVT AFNSFAKSLG
460 470 480 490 500
FAFGGNMGAM IFTASLKNQM RSSQLNIPQF TSVETLLAYS TEHYDGPQSS
510 520 530 540
LSKFINTAIH DVFYCALGCY ALSFFFGIFT SSKKTTISAK KQQ
Length:543
Mass (Da):59,426
Last modified:February 1, 1994 - v1
Checksum:i16A3D91DA0B950FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti429D → G in AAA65606 (Ref. 3) Curated1
Sequence conflicti447 – 486KSLGF…SVETL → NPWALRLEGYGGNDIHCITQ KPDALFPIKHTTIYVCRNT in AAA65606 (Ref. 3) CuratedAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11640 Genomic DNA Translation: AAA35043.1
U02077 Genomic DNA Translation: AAA52190.1
L24961 Genomic DNA Translation: AAA65606.1
X77765 Genomic DNA Translation: CAA54805.1
U25841 Genomic DNA Translation: AAB64626.1
BK006949 Genomic DNA Translation: DAA11612.1
PIRiS40888
RefSeqiNP_015524.1, NM_001184295.1

Genome annotation databases

EnsemblFungiiYPR198W; YPR198W; YPR198W
GeneIDi856327
KEGGisce:YPR198W

Similar proteinsi

Entry informationi

Entry nameiSGE1_YEAST
AccessioniPrimary (citable) accession number: P33335
Secondary accession number(s): D6W4J6, Q05720
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 20, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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