ID PRP8_YEAST Reviewed; 2413 AA. AC P33334; D3DLB4; DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1994, sequence version 1. DT 27-MAR-2024, entry version 208. DE RecName: Full=Pre-mRNA-splicing factor 8; GN Name=PRP8; Synonyms=DBF3, DNA39, RNA8, SLT21, USA2; GN OrderedLocusNames=YHR165C; OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=559292; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=7785334; DOI=10.1002/yea.320110406; RA Hodges P.E., Jackson S.P., Brown J.D., Beggs J.D.; RT "Extraordinary sequence conservation of the PRP8 splicing factor."; RL Yeast 11:337-342(1995). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=7838707; DOI=10.1093/nar/22.25.5555; RA Shea J.E., Toyn J.H., Johnston L.H.; RT "The budding yeast U5 snRNP Prp8 is a highly conserved protein which links RT RNA splicing with cell cycle progression."; RL Nucleic Acids Res. 22:5555-5564(1994). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 204508 / S288c; RX PubMed=8091229; DOI=10.1126/science.8091229; RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J., RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., RA Waterston R., Wilson R., Vaudin M.; RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome RT VIII."; RL Science 265:2077-2082(1994). RN [4] RP GENOME REANNOTATION. RC STRAIN=ATCC 204508 / S288c; RX PubMed=24374639; DOI=10.1534/g3.113.008995; RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.; RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now."; RL G3 (Bethesda) 4:389-398(2014). RN [5] RP FUNCTION, AND SUBCELLULAR LOCATION. RX PubMed=2835658; DOI=10.1128/mcb.8.3.1067-1075.1988; RA Jackson S.P., Lossky M., Beggs J.D.; RT "Cloning of the RNA8 gene of Saccharomyces cerevisiae, detection of the RT RNA8 protein, and demonstration that it is essential for nuclear pre-mRNA RT splicing."; RL Mol. Cell. Biol. 8:1067-1075(1988). RN [6] RP FUNCTION, AND INTERACTION WITH PRP40. RX PubMed=9150140; DOI=10.1016/s0092-8674(00)80221-4; RA Abovich N., Rosbash M.; RT "Cross-intron bridging interactions in the yeast commitment complex are RT conserved in mammals."; RL Cell 89:403-412(1997). RN [7] RP SUBUNIT, IDENTIFICATION IN THE U4/U5/U6 TRI-SNRNP COMPLEX, AND RP IDENTIFICATION BY MASS SPECTROMETRY. RX PubMed=10449419; DOI=10.1093/emboj/18.16.4535; RA Gottschalk A., Neubauer G., Banroques J., Mann M., Luehrmann R., RA Fabrizio P.; RT "Identification by mass spectrometry and functional analysis of novel RT proteins of the yeast [U4/U6.U5] tri-snRNP."; RL EMBO J. 18:4535-4548(1999). RN [8] RP FUNCTION. RX PubMed=10444596; DOI=10.1101/gad.13.15.1983; RA Siatecka M., Reyes J.L., Konarska M.M.; RT "Functional interactions of Prp8 with both splice sites at the spliceosomal RT catalytic center."; RL Genes Dev. 13:1983-1993(1999). RN [9] RP INTERACTION WITH SNP1. RX PubMed=11425851; DOI=10.1074/jbc.m100022200; RA Awasthi S., Palmer R., Castro M., Mobarak C.D., Ruby S.W.; RT "New roles for the Snp1 and Exo84 proteins in yeast pre-mRNA splicing."; RL J. Biol. Chem. 276:31004-31015(2001). RN [10] RP IDENTIFICATION IN THE CWC COMPLEX, AND IDENTIFICATION BY MASS SPECTROMETRY. RX PubMed=11884590; DOI=10.1128/mcb.22.7.2011-2024.2002; RA Ohi M.D., Link A.J., Ren L., Jennings J.L., McDonald W.H., Gould K.L.; RT "Proteomics analysis reveals stable multiprotein complexes in both fission RT and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA RT splicing factors, and snRNAs."; RL Mol. Cell. Biol. 22:2011-2024(2002). RN [11] RP IDENTIFICATION BY MASS SPECTROMETRY. RX PubMed=14690591; DOI=10.1016/s1097-2765(03)00476-3; RA Hazbun T.R., Malmstroem L., Anderson S., Graczyk B.J., Fox B., Riffle M., RA Sundin B.A., Aranda J.D., McDonald W.H., Chiu C.-H., Snydsman B.E., RA Bradley P., Muller E.G.D., Fields S., Baker D., Yates J.R. III, Davis T.N.; RT "Assigning function to yeast proteins by integration of technologies."; RL Mol. Cell 12:1353-1365(2003). RN [12] RP FUNCTION. RX PubMed=12773561; DOI=10.1128/mcb.23.12.4174-4186.2003; RA McPheeters D.S., Muhlenkamp P.; RT "Spatial organization of protein-RNA interactions in the branch site-3' RT splice site region during pre-mRNA splicing in yeast."; RL Mol. Cell. Biol. 23:4174-4186(2003). RN [13] RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. RX PubMed=14562106; DOI=10.1038/nature02046; RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., RA O'Shea E.K., Weissman J.S.; RT "Global analysis of protein expression in yeast."; RL Nature 425:737-741(2003). RN [14] RP FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION. RX PubMed=17934474; DOI=10.1038/nsmb1303; RA Boon K.L., Grainger R.J., Ehsani P., Barrass J.D., Auchynnikava T., RA Inglehearn C.F., Beggs J.D.; RT "prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP RT maturation defect in yeast."; RL Nat. Struct. Mol. Biol. 14:1077-1083(2007). RN [15] RP MUTAGENESIS OF ASP-1853 AND ASP-1854, AND LACK OF METAL-BINDING SITE. RX PubMed=18836455; DOI=10.1038/nsmb.1505; RA Ritchie D.B., Schellenberg M.J., Gesner E.M., Raithatha S.A., Stuart D.T., RA Macmillan A.M.; RT "Structural elucidation of a PRP8 core domain from the heart of the RT spliceosome."; RL Nat. Struct. Mol. Biol. 15:1199-1205(2008). RN [16] RP SUBUNIT, IDENTIFICATION IN THE U4/U5/U6 TRI-SNRNP COMPLEX, AND ELECTRON RP MICROSCOPY. RX PubMed=18953335; DOI=10.1038/nsmb.1506; RA Hacker I., Sander B., Golas M.M., Wolf E., Karagoz E., Kastner B., RA Stark H., Fabrizio P., Luhrmann R.; RT "Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri- RT snRNP by electron microscopy."; RL Nat. Struct. Mol. Biol. 15:1206-1212(2008). RN [17] RP FUNCTION, AND INTERACTION WITH BRR2. RX PubMed=19098916; DOI=10.1038/nsmb.1535; RA Maeder C., Kutach A.K., Guthrie C.; RT "ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the RT C terminus of Prp8."; RL Nat. Struct. Mol. Biol. 16:42-48(2009). RN [18] RP INTERACTION WITH CWC21 AND SNU114. RX PubMed=19854871; DOI=10.1261/rna.1908309; RA Grainger R.J., Barrass J.D., Jacquier A., Rain J.-C., Beggs J.D.; RT "Physical and genetic interactions of yeast Cwc21p, an ortholog of human RT SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome."; RL RNA 15:2161-2173(2009). RN [19] RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 2147-2413, AND LACK OF METAL RP BINDING. RX PubMed=17317632; DOI=10.1016/j.molcel.2007.01.023; RA Pena V., Liu S., Bujnicki J.M., Luehrmann R., Wahl M.C.; RT "Structure of a multipartite protein-protein interaction domain in splicing RT factor Prp8 and its link to retinitis pigmentosa."; RL Mol. Cell 25:615-624(2007). RN [20] RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1827-2092, LACK OF METAL BINDING, RP DOMAIN, AND MUTAGENESIS OF ASP-1853; ASP-1854; THR-1855; THR-1936 AND RP ARG-1937. RX PubMed=18843295; DOI=10.1038/emboj.2008.209; RA Pena V., Rozov A., Fabrizio P., Luehrmann R., Wahl M.C.; RT "Structure and function of an RNase H domain at the heart of the RT spliceosome."; RL EMBO J. 27:2929-2940(2008). RN [21] RP X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 1822-2095, LACK OF METAL BINDING, RP FUNCTION, AND MUTAGENESIS OF ASP-1853. RX PubMed=18779563; DOI=10.1073/pnas.0805960105; RA Yang K., Zhang L., Xu T., Heroux A., Zhao R.; RT "Crystal structure of the beta-finger domain of Prp8 reveals analogy to RT ribosomal proteins."; RL Proc. Natl. Acad. Sci. U.S.A. 105:13817-13822(2008). RN [22] RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1836-2092 IN COMPLEX WITH AAR2, RP AND INTERACTION WITH AAR2. RX PubMed=21764848; DOI=10.1101/gad.635911; RA Weber G., Cristao V.F., de Lima Alves F., Santos K.F., Holton N., RA Rappsilber J., Beggs J.D., Wahl M.C.; RT "Mechanism for Aar2p function as a U5 snRNP assembly factor."; RL Genes Dev. 25:1601-1612(2011). RN [23] RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 885-2413 IN COMPLEX WITH AAR2, RP FUNCTION, DOMAIN, INTERACTION WITH AAR2, AND MUTAGENESIS OF HIS-1658; RP GLU-1684; HIS-1687; ASP-1700 AND ASP-1735. RX PubMed=23354046; DOI=10.1038/nature11843; RA Galej W.P., Oubridge C., Newman A.J., Nagai K.; RT "Crystal structure of Prp8 reveals active site cavity of the spliceosome."; RL Nature 493:638-643(2013). CC -!- FUNCTION: Functions as a scaffold that mediates the ordered assembly of CC spliceosomal proteins and snRNAs. Required for association of BRR2 with CC the spliceosomal U5 snRNP, and the subsequent assembly of the U4/U6-U5 CC tri-snRNP complex. Functions as a scaffold that positions spliceosomal CC U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that CC splicing can occur. Interacts with both the 5' and the 3' splice site, CC as well as the branch region. Has a role in branch site-3' splice site CC selection. Associates with the branch site-3' splice 3'-exon region. CC Also has a role in cell cycle. {ECO:0000269|PubMed:10444596, CC ECO:0000269|PubMed:12773561, ECO:0000269|PubMed:17934474, CC ECO:0000269|PubMed:18779563, ECO:0000269|PubMed:19098916, CC ECO:0000269|PubMed:23354046, ECO:0000269|PubMed:2835658, CC ECO:0000269|PubMed:9150140}. CC -!- SUBUNIT: Component of the U4/U6-U5 tri-snRNP complex composed of the CC U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, CC PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, CC SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1. CC Belongs to the CWC complex (or CEF1-associated complex), a spliceosome CC sub-complex reminiscent of a late-stage spliceosome composed of the U2, CC U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CC CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, CC HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, CC PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, CC SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Interacts with PRP40 and SNP1. CC Interacts (via SCwid domain) with CWC21. Interacts (via SCwid domain) CC with SNU114 (via N-terminus). Interacts (via RNase H homology domain CC and MPN domain) with BRR2; this modulates BRR2 ATPase and helicase CC activity. Interacts (via RNase H homology domain) with AAR2. AAR2 and CC BRR2 compete for PRP8 binding, and during U5 snRNP maturation BRR2 CC displaces the initially bound AAR2. Is associated with snRNP U5, CC together with SNU114 and BRR2. {ECO:0000269|PubMed:10449419, CC ECO:0000269|PubMed:11425851, ECO:0000269|PubMed:11884590, CC ECO:0000269|PubMed:17934474, ECO:0000269|PubMed:18953335, CC ECO:0000269|PubMed:19098916, ECO:0000269|PubMed:19854871, CC ECO:0000269|PubMed:21764848, ECO:0000269|PubMed:23354046, CC ECO:0000269|PubMed:9150140}. CC -!- INTERACTION: CC P33334; P32357: AAR2; NbExp=11; IntAct=EBI-465, EBI-340; CC P33334; P32639: BRR2; NbExp=25; IntAct=EBI-465, EBI-861; CC P33334; P36006: MYO3; NbExp=4; IntAct=EBI-465, EBI-11670; CC P33334; Q04439: MYO5; NbExp=4; IntAct=EBI-465, EBI-11687; CC P33334; Q00916: SNP1; NbExp=3; IntAct=EBI-465, EBI-724; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17934474, CC ECO:0000269|PubMed:2835658}. CC -!- DOMAIN: The MPN (JAB/Mov34) domain has structural similarity with CC deubiquitinating enzymes, but lacks the residues that would bind the CC catalytic metal ion. CC -!- DOMAIN: Contains a region with structural similarity to reverse CC transcripase, presenting the classical thumb, fingers and palm CC architecture, but lacks enzyme activity, since the essential metal- CC binding residues are not conserved. CC -!- DOMAIN: Contains a region with structural similarity to type-2 CC restriction endonucleases, but the residues that would bind catalytic CC metal ions in endonucleases are instead involved in hydrogen bonds that CC stabilize a highly conserved loop. CC -!- DOMAIN: Contains a region with structural similarity to RNase H, but CC lacks RNase H activity. CC -!- MISCELLANEOUS: Present with 468 molecules/cell in log phase SD medium. CC {ECO:0000269|PubMed:14562106}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z24732; CAA80854.1; -; Genomic_DNA. DR EMBL; L29421; AAA67044.1; -; Genomic_DNA. DR EMBL; U00027; AAB68011.1; -; Genomic_DNA. DR EMBL; BK006934; DAA06858.1; -; Genomic_DNA. DR PIR; S34670; S34670. DR RefSeq; NP_012035.1; NM_001179296.1. DR PDB; 2OG4; X-ray; 2.00 A; A=2147-2397. DR PDB; 3E66; X-ray; 2.05 A; A/B=1822-2095. DR PDB; 3E9O; X-ray; 2.00 A; A=1836-2087. DR PDB; 3E9P; X-ray; 2.10 A; A/B=1833-2087. DR PDB; 3JCM; EM; 3.80 A; A=1-2413. DR PDB; 3SBG; X-ray; 3.28 A; A=1836-2397. DR PDB; 3SBT; X-ray; 1.80 A; A=1836-2092. DR PDB; 3ZEF; X-ray; 3.10 A; B/E=885-2413. DR PDB; 4BGD; X-ray; 3.10 A; C=2148-2395. DR PDB; 4I43; X-ray; 2.00 A; B=885-2413. DR PDB; 4ILG; X-ray; 2.10 A; B=1836-2090, C=2147-2413. DR PDB; 4ILH; X-ray; 1.85 A; A=1836-2090. DR PDB; 4ILJ; X-ray; 2.00 A; A/B=1836-2090. DR PDB; 5DCA; X-ray; 2.80 A; J=2148-2398. DR PDB; 5GAM; EM; 3.70 A; A=1-735. DR PDB; 5GAN; EM; 3.60 A; A=1-2413. DR PDB; 5GAO; EM; 3.60 A; A=2147-2413. DR PDB; 5GAP; EM; 3.60 A; A=1-2413. DR PDB; 5GM6; EM; 3.50 A; A=128-2413. DR PDB; 5GMK; EM; 3.40 A; A=1-2413. DR PDB; 5LJ3; EM; 3.80 A; A=1-2413. DR PDB; 5LJ5; EM; 3.80 A; A=1-2413. DR PDB; 5LQW; EM; 5.80 A; A=1-2413. DR PDB; 5M52; X-ray; 3.40 A; C/D=2147-2413. DR PDB; 5M5P; X-ray; 4.20 A; B/D=2147-2413. DR PDB; 5MPS; EM; 3.85 A; A=1-2413. DR PDB; 5MQ0; EM; 4.17 A; A=1-2413. DR PDB; 5NRL; EM; 7.20 A; A=1-2413. DR PDB; 5QY1; X-ray; 1.72 A; A=1836-2090. DR PDB; 5QY2; X-ray; 1.36 A; A=1836-2090. DR PDB; 5QY3; X-ray; 1.58 A; A=1836-2090. DR PDB; 5QY4; X-ray; 1.57 A; A=1836-2090. DR PDB; 5QY5; X-ray; 1.51 A; A=1836-2090. DR PDB; 5QY6; X-ray; 1.51 A; A=1836-2090. DR PDB; 5QY7; X-ray; 1.67 A; A=1836-2090. DR PDB; 5QY8; X-ray; 1.59 A; A=1836-2090. DR PDB; 5QY9; X-ray; 1.40 A; A=1836-2090. DR PDB; 5QYA; X-ray; 1.55 A; A=1836-2090. DR PDB; 5QYB; X-ray; 2.10 A; A=1836-2090. DR PDB; 5QYC; X-ray; 1.70 A; A=1836-2090. DR PDB; 5QYD; X-ray; 1.67 A; A=1836-2090. DR PDB; 5QYE; X-ray; 1.51 A; A=1836-2090. DR PDB; 5QYF; X-ray; 1.49 A; A=1836-2090. DR PDB; 5QYG; X-ray; 1.67 A; A=1836-2090. DR PDB; 5QYH; X-ray; 1.47 A; A=1836-2090. DR PDB; 5QYI; X-ray; 1.58 A; A=1836-2090. DR PDB; 5QYJ; X-ray; 1.51 A; A=1836-2090. DR PDB; 5QYK; X-ray; 1.63 A; A=1836-2090. DR PDB; 5QYL; X-ray; 1.56 A; A=1836-2090. DR PDB; 5QYM; X-ray; 1.47 A; A=1836-2090. DR PDB; 5QYN; X-ray; 1.65 A; A=1836-2090. DR PDB; 5QYO; X-ray; 1.58 A; A=1836-2090. DR PDB; 5QYP; X-ray; 1.61 A; A=1836-2090. DR PDB; 5QYQ; X-ray; 1.67 A; A=1836-2090. DR PDB; 5QYR; X-ray; 1.54 A; A=1836-2090. DR PDB; 5QYS; X-ray; 1.52 A; A=1836-2090. DR PDB; 5QYT; X-ray; 1.52 A; A=1836-2090. DR PDB; 5QYU; X-ray; 1.51 A; A=1836-2090. DR PDB; 5QYV; X-ray; 1.59 A; A=1836-2090. DR PDB; 5QYW; X-ray; 1.63 A; A=1836-2090. DR PDB; 5QYX; X-ray; 1.60 A; A=1836-2090. DR PDB; 5QYY; X-ray; 1.71 A; A=1836-2090. DR PDB; 5QYZ; X-ray; 1.37 A; A=1836-2090. DR PDB; 5QZ0; X-ray; 1.57 A; A=1836-2090. DR PDB; 5QZ1; X-ray; 1.58 A; A=1836-2090. DR PDB; 5QZ2; X-ray; 1.54 A; A=1836-2090. DR PDB; 5QZ3; X-ray; 1.53 A; A=1836-2090. DR PDB; 5QZ4; X-ray; 1.75 A; A=1836-2090. DR PDB; 5QZ5; X-ray; 1.51 A; A=1836-2090. DR PDB; 5QZ6; X-ray; 1.32 A; A=1836-2090. DR PDB; 5QZ7; X-ray; 1.48 A; A=1836-2090. DR PDB; 5QZ8; X-ray; 1.62 A; A=1836-2090. DR PDB; 5QZ9; X-ray; 1.43 A; A=1836-2090. DR PDB; 5QZA; X-ray; 1.51 A; A=1836-2090. DR PDB; 5QZB; X-ray; 1.69 A; A=1836-2090. DR PDB; 5QZC; X-ray; 1.72 A; A=1836-2090. DR PDB; 5QZD; X-ray; 1.59 A; A=1836-2090. DR PDB; 5QZE; X-ray; 1.55 A; A=1836-2090. DR PDB; 5QZF; X-ray; 1.68 A; A=1836-2090. DR PDB; 5QZG; X-ray; 1.55 A; A=1836-2090. DR PDB; 5QZH; X-ray; 1.77 A; A=1836-2090. DR PDB; 5QZI; X-ray; 1.51 A; A=1836-2090. DR PDB; 5QZJ; X-ray; 1.51 A; A=1836-2090. DR PDB; 5QZK; X-ray; 1.73 A; A=1836-2090. DR PDB; 5QZL; X-ray; 1.54 A; A=1836-2090. DR PDB; 5QZM; X-ray; 1.66 A; A=1836-2090. DR PDB; 5QZN; X-ray; 1.44 A; A=1836-2090. DR PDB; 5QZO; X-ray; 1.39 A; A=1836-2090. DR PDB; 5QZP; X-ray; 1.50 A; A=1836-2090. DR PDB; 5QZQ; X-ray; 2.11 A; A=1836-2090. DR PDB; 5QZR; X-ray; 1.59 A; A=1836-2090. DR PDB; 5QZS; X-ray; 1.58 A; A=1836-2090. DR PDB; 5QZT; X-ray; 1.53 A; A=1836-2090. DR PDB; 5QZU; X-ray; 1.54 A; A=1836-2090. DR PDB; 5QZV; X-ray; 2.11 A; A=1836-2090. DR PDB; 5QZW; X-ray; 1.36 A; A=1836-2090. DR PDB; 5QZX; X-ray; 1.55 A; A=1836-2090. DR PDB; 5QZY; X-ray; 1.66 A; A=1836-2090. DR PDB; 5QZZ; X-ray; 1.59 A; A=1836-2090. DR PDB; 5R00; X-ray; 1.72 A; A=1836-2090. DR PDB; 5R01; X-ray; 1.72 A; A=1836-2090. DR PDB; 5R02; X-ray; 1.66 A; A=1836-2090. DR PDB; 5R03; X-ray; 1.51 A; A=1836-2090. DR PDB; 5R04; X-ray; 1.34 A; A=1836-2090. DR PDB; 5R05; X-ray; 1.57 A; A=1836-2090. DR PDB; 5R06; X-ray; 1.67 A; A=1836-2090. DR PDB; 5R07; X-ray; 1.71 A; A=1836-2090. DR PDB; 5R08; X-ray; 1.70 A; A=1836-2090. DR PDB; 5R09; X-ray; 1.56 A; A=1836-2090. DR PDB; 5R0A; X-ray; 1.54 A; A=1836-2090. DR PDB; 5R0B; X-ray; 1.82 A; A=1836-2090. DR PDB; 5R0C; X-ray; 1.60 A; A=1836-2090. DR PDB; 5R0D; X-ray; 1.27 A; A=1836-2090. DR PDB; 5R0E; X-ray; 1.59 A; A=1836-2090. DR PDB; 5R0F; X-ray; 1.97 A; A=1836-2090. DR PDB; 5R0G; X-ray; 1.73 A; A=1836-2090. DR PDB; 5R0H; X-ray; 1.57 A; A=1836-2090. DR PDB; 5R0I; X-ray; 1.86 A; A=1836-2090. DR PDB; 5R0J; X-ray; 1.81 A; A=1836-2090. DR PDB; 5R0K; X-ray; 1.80 A; A=1836-2090. DR PDB; 5R0L; X-ray; 1.70 A; A=1836-2090. DR PDB; 5R0M; X-ray; 1.70 A; A=1836-2090. DR PDB; 5R0N; X-ray; 1.78 A; A=1836-2090. DR PDB; 5R0O; X-ray; 1.86 A; A=1836-2090. DR PDB; 5R0P; X-ray; 1.73 A; A=1836-2090. DR PDB; 5R0Q; X-ray; 1.91 A; A=1836-2090. DR PDB; 5R0R; X-ray; 1.73 A; A=1836-2090. DR PDB; 5R0S; X-ray; 1.81 A; A=1836-2090. DR PDB; 5R0T; X-ray; 1.96 A; A=1836-2090. DR PDB; 5R0U; X-ray; 1.86 A; A=1836-2090. DR PDB; 5R0V; X-ray; 1.81 A; A=1836-2090. DR PDB; 5R0W; X-ray; 1.86 A; A=1836-2090. DR PDB; 5R0X; X-ray; 1.84 A; A=1836-2090. DR PDB; 5R0Y; X-ray; 1.75 A; A=1836-2090. DR PDB; 5R0Z; X-ray; 1.86 A; A=1836-2090. DR PDB; 5R10; X-ray; 1.70 A; A=1836-2090. DR PDB; 5R11; X-ray; 1.82 A; A=1836-2090. DR PDB; 5R12; X-ray; 1.70 A; A=1836-2090. DR PDB; 5R13; X-ray; 1.87 A; A=1836-2090. DR PDB; 5R14; X-ray; 1.74 A; A=1836-2090. DR PDB; 5R15; X-ray; 1.79 A; A=1836-2090. DR PDB; 5R16; X-ray; 1.84 A; A=1836-2090. DR PDB; 5R17; X-ray; 1.87 A; A=1836-2090. DR PDB; 5R18; X-ray; 1.79 A; A=1836-2090. DR PDB; 5R19; X-ray; 1.70 A; A=1836-2090. DR PDB; 5R1A; X-ray; 1.73 A; A=1836-2090. DR PDB; 5R1B; X-ray; 1.89 A; A=1836-2090. DR PDB; 5R1C; X-ray; 1.91 A; A=1836-2090. DR PDB; 5R1D; X-ray; 1.82 A; A=1836-2090. DR PDB; 5R1E; X-ray; 1.70 A; A=1836-2090. DR PDB; 5R1F; X-ray; 1.80 A; A=1836-2090. DR PDB; 5R1G; X-ray; 1.81 A; A=1836-2090. DR PDB; 5R1H; X-ray; 2.06 A; A=1836-2090. DR PDB; 5R1I; X-ray; 2.01 A; A=1836-2090. DR PDB; 5R1J; X-ray; 1.96 A; A=1836-2090. DR PDB; 5R1K; X-ray; 1.99 A; A=1836-2090. DR PDB; 5R1L; X-ray; 1.94 A; A=1836-2090. DR PDB; 5R1M; X-ray; 1.90 A; A=1836-2090. DR PDB; 5R1N; X-ray; 1.94 A; A=1836-2090. DR PDB; 5R1O; X-ray; 1.90 A; A=1836-2090. DR PDB; 5R1P; X-ray; 1.95 A; A=1836-2090. DR PDB; 5R1Q; X-ray; 1.86 A; A=1836-2090. DR PDB; 5R1S; X-ray; 2.05 A; A=1836-2090. DR PDB; 5ST0; X-ray; 1.54 A; A=1836-2090. DR PDB; 5ST1; X-ray; 1.58 A; A=1836-2090. DR PDB; 5ST2; X-ray; 1.53 A; A=1836-2090. DR PDB; 5ST3; X-ray; 1.47 A; A=1836-2090. DR PDB; 5ST4; X-ray; 1.44 A; A=1836-2090. DR PDB; 5ST5; X-ray; 1.61 A; A=1836-2090. DR PDB; 5ST6; X-ray; 1.62 A; A=1836-2090. DR PDB; 5ST7; X-ray; 1.46 A; A=1836-2090. DR PDB; 5ST8; X-ray; 1.51 A; A=1836-2090. DR PDB; 5ST9; X-ray; 1.40 A; A=1836-2090. DR PDB; 5STA; X-ray; 1.58 A; A=1836-2090. DR PDB; 5STB; X-ray; 1.55 A; A=1836-2090. DR PDB; 5STC; X-ray; 1.44 A; A=1836-2090. DR PDB; 5STE; X-ray; 1.51 A; A=1836-2090. DR PDB; 5STF; X-ray; 1.45 A; A=1836-2090. DR PDB; 5STG; X-ray; 1.61 A; A=1836-2090. DR PDB; 5STH; X-ray; 1.67 A; A=1836-2090. DR PDB; 5STI; X-ray; 1.76 A; A=1836-2090. DR PDB; 5STJ; X-ray; 1.76 A; A=1836-2090. DR PDB; 5STK; X-ray; 1.80 A; A=1836-2090. DR PDB; 5STL; X-ray; 1.51 A; A=1836-2090. DR PDB; 5STM; X-ray; 1.65 A; A=1836-2090. DR PDB; 5STN; X-ray; 1.56 A; A=1836-2090. DR PDB; 5STO; X-ray; 1.55 A; A=1836-2090. DR PDB; 5STP; X-ray; 1.51 A; A=1836-2090. DR PDB; 5STQ; X-ray; 1.50 A; A=1836-2090. DR PDB; 5STR; X-ray; 1.45 A; A=1836-2090. DR PDB; 5STS; X-ray; 1.57 A; A=1836-2090. DR PDB; 5STT; X-ray; 1.49 A; A=1836-2090. DR PDB; 5STU; X-ray; 1.55 A; A=1836-2090. DR PDB; 5STV; X-ray; 1.50 A; A=1836-2090. DR PDB; 5STW; X-ray; 1.89 A; A=1836-2090. DR PDB; 5STX; X-ray; 1.50 A; A=1836-2090. DR PDB; 5STY; X-ray; 1.57 A; A=1836-2090. DR PDB; 5STZ; X-ray; 1.44 A; A=1836-2090. DR PDB; 5SU0; X-ray; 1.54 A; A=1836-2090. DR PDB; 5SU1; X-ray; 1.57 A; A=1836-2090. DR PDB; 5SU2; X-ray; 1.85 A; A=1836-2090. DR PDB; 5SU3; X-ray; 1.65 A; A=1836-2090. DR PDB; 5SU4; X-ray; 1.66 A; A=1836-2090. DR PDB; 5SU5; X-ray; 1.81 A; A=1836-2090. DR PDB; 5SU6; X-ray; 1.51 A; A=1836-2090. DR PDB; 5SU7; X-ray; 1.81 A; A=1836-2090. DR PDB; 5SU8; X-ray; 1.79 A; A=1836-2090. DR PDB; 5SU9; X-ray; 1.66 A; A=1836-2090. DR PDB; 5SUA; X-ray; 1.53 A; A=1836-2090. DR PDB; 5SUB; X-ray; 1.51 A; A=1836-2090. DR PDB; 5SUC; X-ray; 1.54 A; A=1836-2090. DR PDB; 5SUD; X-ray; 1.48 A; A=1836-2090. DR PDB; 5SUE; X-ray; 1.70 A; A=1836-2090. DR PDB; 5SUF; X-ray; 1.51 A; A=1836-2090. DR PDB; 5SUG; X-ray; 1.53 A; A=1836-2090. DR PDB; 5WSG; EM; 4.00 A; A=1-2413. DR PDB; 5Y88; EM; 3.70 A; A=1-2413. DR PDB; 5YLZ; EM; 3.60 A; A=1-2413. DR PDB; 5ZWM; EM; 3.40 A; A=1-2413. DR PDB; 5ZWO; EM; 3.90 A; A=1-2413. DR PDB; 6BK8; EM; 3.30 A; A=1-2413. DR PDB; 6EXN; EM; 3.70 A; A=1-2413. DR PDB; 6J6G; EM; 3.20 A; A=1-2413. DR PDB; 6J6H; EM; 3.60 A; A=1-2413. DR PDB; 6J6N; EM; 3.86 A; A=1-2413. DR PDB; 6J6Q; EM; 3.70 A; A=1-2413. DR PDB; 6TEO; X-ray; 3.10 A; B/D=315-555. DR PDB; 7B9V; EM; 2.80 A; A=1-2413. DR PDB; 7FJU; X-ray; 1.63 A; A=1836-2090. DR PDB; 7FJV; X-ray; 1.63 A; A=1836-2090. DR PDB; 7FJW; X-ray; 1.63 A; A=1836-2090. DR PDB; 7FJX; X-ray; 1.59 A; A=1836-2090. DR PDB; 7FJY; X-ray; 1.63 A; A=1836-2090. DR PDB; 7FJZ; X-ray; 1.54 A; A=1836-2090. DR PDB; 7FK0; X-ray; 1.69 A; A=1836-2090. DR PDB; 7FK1; X-ray; 1.76 A; A=1836-2090. DR PDB; 7FK2; X-ray; 1.35 A; A=1836-2090. DR PDB; 7FK3; X-ray; 1.59 A; A=1836-2090. DR PDB; 7FK4; X-ray; 1.59 A; A=1836-2090. DR PDB; 7FK5; X-ray; 1.53 A; A=1836-2090. DR PDB; 7FK6; X-ray; 1.61 A; A=1836-2090. DR PDB; 7FK7; X-ray; 1.72 A; A=1836-2090. DR PDB; 7FK8; X-ray; 1.67 A; A=1836-2090. DR PDB; 7FK9; X-ray; 1.35 A; A=1836-2090. DR PDB; 7FKA; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FKB; X-ray; 1.68 A; A=1836-2090. DR PDB; 7FKC; X-ray; 1.54 A; A=1836-2090. DR PDB; 7FKD; X-ray; 1.45 A; A=1836-2090. DR PDB; 7FKE; X-ray; 1.48 A; A=1836-2090. DR PDB; 7FKF; X-ray; 1.69 A; A=1836-2090. DR PDB; 7FKG; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FKH; X-ray; 1.44 A; A=1836-2090. DR PDB; 7FKI; X-ray; 1.47 A; A=1836-2090. DR PDB; 7FKJ; X-ray; 1.74 A; A=1836-2090. DR PDB; 7FKK; X-ray; 1.63 A; A=1836-2090. DR PDB; 7FKL; X-ray; 1.63 A; A=1836-2090. DR PDB; 7FKM; X-ray; 1.53 A; A=1836-2090. DR PDB; 7FKN; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FKO; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FKP; X-ray; 1.52 A; A=1836-2090. DR PDB; 7FKQ; X-ray; 1.68 A; A=1836-2090. DR PDB; 7FKR; X-ray; 1.69 A; A=1836-2090. DR PDB; 7FKS; X-ray; 1.58 A; A=1836-2090. DR PDB; 7FKT; X-ray; 1.44 A; A=1836-2090. DR PDB; 7FKU; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FKV; X-ray; 1.75 A; A=1836-2090. DR PDB; 7FKW; X-ray; 1.47 A; A=1836-2090. DR PDB; 7FKX; X-ray; 1.85 A; A=1836-2090. DR PDB; 7FKY; X-ray; 1.59 A; A=1836-2090. DR PDB; 7FKZ; X-ray; 1.58 A; A=1836-2090. DR PDB; 7FL0; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FL1; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FL2; X-ray; 1.58 A; A=1836-2090. DR PDB; 7FL3; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FL4; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FL5; X-ray; 1.89 A; A=1836-2090. DR PDB; 7FL6; X-ray; 1.58 A; A=1836-2090. DR PDB; 7FL7; X-ray; 1.72 A; A=1836-2090. DR PDB; 7FL8; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FL9; X-ray; 1.59 A; A=1836-2090. DR PDB; 7FLA; X-ray; 1.87 A; A=1836-2090. DR PDB; 7FLB; X-ray; 1.57 A; A=1836-2090. DR PDB; 7FLC; X-ray; 1.95 A; A=1836-2090. DR PDB; 7FLD; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FLE; X-ray; 1.57 A; A=1836-2090. DR PDB; 7FLF; X-ray; 1.54 A; A=1836-2090. DR PDB; 7FLG; X-ray; 1.58 A; A=1836-2090. DR PDB; 7FLH; X-ray; 1.67 A; A=1836-2090. DR PDB; 7FLI; X-ray; 1.75 A; A=1836-2090. DR PDB; 7FLJ; X-ray; 1.47 A; A=1836-2090. DR PDB; 7FLK; X-ray; 1.62 A; A=1836-2090. DR PDB; 7FLL; X-ray; 1.48 A; A=1836-2090. DR PDB; 7FLM; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FLN; X-ray; 1.57 A; A=1836-2090. DR PDB; 7FLO; X-ray; 1.58 A; A=1836-2090. DR PDB; 7FLP; X-ray; 1.58 A; A=1836-2090. DR PDB; 7FLQ; X-ray; 1.73 A; A=1836-2090. DR PDB; 7FLR; X-ray; 1.63 A; A=1836-2090. DR PDB; 7FLS; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FLT; X-ray; 1.73 A; A=1836-2090. DR PDB; 7FLU; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FLV; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FLW; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FLX; X-ray; 1.75 A; A=1836-2090. DR PDB; 7FLY; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FLZ; X-ray; 1.52 A; A=1836-2090. DR PDB; 7FM0; X-ray; 1.61 A; A=1836-2090. DR PDB; 7FM1; X-ray; 1.50 A; A=1836-2090. DR PDB; 7FM2; X-ray; 1.72 A; A=1836-2090. DR PDB; 7FM3; X-ray; 1.65 A; A=1836-2090. DR PDB; 7FM4; X-ray; 1.62 A; A=1836-2090. DR PDB; 7FM5; X-ray; 1.56 A; A=1836-2090. DR PDB; 7FM6; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FM7; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FM8; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FM9; X-ray; 1.59 A; A=1836-2090. DR PDB; 7FMA; X-ray; 1.41 A; A=1836-2090. DR PDB; 7FMB; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FMC; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FMD; X-ray; 1.68 A; A=1836-2090. DR PDB; 7FME; X-ray; 1.44 A; A=1836-2090. DR PDB; 7FMF; X-ray; 1.65 A; A=1836-2090. DR PDB; 7FMG; X-ray; 1.71 A; A=1836-2090. DR PDB; 7FMH; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FMI; X-ray; 1.34 A; A=1836-2090. DR PDB; 7FMJ; X-ray; 1.50 A; A=1836-2090. DR PDB; 7FMK; X-ray; 1.47 A; A=1836-2090. DR PDB; 7FML; X-ray; 1.58 A; A=1836-2090. DR PDB; 7FMM; X-ray; 1.69 A; A=1836-2090. DR PDB; 7FMN; X-ray; 1.60 A; A=1836-2090. DR PDB; 7FMO; X-ray; 1.67 A; A=1836-2090. DR PDB; 7FMP; X-ray; 1.72 A; A=1836-2090. DR PDB; 7FMQ; X-ray; 1.58 A; A=1836-2090. DR PDB; 7FMR; X-ray; 1.58 A; A=1836-2090. DR PDB; 7FMS; X-ray; 1.58 A; A=1836-2090. DR PDB; 7FMT; X-ray; 1.67 A; A=1836-2090. DR PDB; 7FMU; X-ray; 1.81 A; A=1836-2090. DR PDB; 7FMV; X-ray; 1.61 A; A=1836-2090. DR PDB; 7FMW; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FMX; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FMY; X-ray; 1.65 A; A=1836-2090. DR PDB; 7FMZ; X-ray; 1.67 A; A=1836-2090. DR PDB; 7FN0; X-ray; 1.59 A; A=1836-2090. DR PDB; 7FN1; X-ray; 1.44 A; A=1836-2090. DR PDB; 7FN2; X-ray; 1.62 A; A=1836-2090. DR PDB; 7FN3; X-ray; 1.63 A; A=1836-2090. DR PDB; 7FN4; X-ray; 1.72 A; A=1836-2090. DR PDB; 7FN5; X-ray; 1.69 A; A=1836-2090. DR PDB; 7FN6; X-ray; 1.50 A; A=1836-2090. DR PDB; 7FN7; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FN8; X-ray; 1.41 A; A=1836-2090. DR PDB; 7FN9; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FNA; X-ray; 1.69 A; A=1836-2090. DR PDB; 7FNB; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FNC; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FND; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FNE; X-ray; 1.57 A; A=1836-2090. DR PDB; 7FNF; X-ray; 1.54 A; A=1836-2090. DR PDB; 7FNG; X-ray; 1.60 A; A=1836-2090. DR PDB; 7FNH; X-ray; 1.57 A; A=1836-2090. DR PDB; 7FNI; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FNJ; X-ray; 1.57 A; A=1836-2090. DR PDB; 7FNK; X-ray; 1.57 A; A=1836-2090. DR PDB; 7FNL; X-ray; 1.67 A; A=1836-2090. DR PDB; 7FNM; X-ray; 1.72 A; A=1836-2090. DR PDB; 7FNN; X-ray; 1.65 A; A=1836-2090. DR PDB; 7FNO; X-ray; 1.65 A; A=1836-2090. DR PDB; 7FNP; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FNQ; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FNR; X-ray; 1.60 A; A=1836-2090. DR PDB; 7FNS; X-ray; 1.45 A; A=1836-2090. DR PDB; 7FNT; X-ray; 1.61 A; A=1836-2090. DR PDB; 7FNU; X-ray; 1.54 A; A=1836-2090. DR PDB; 7FNV; X-ray; 1.54 A; A=1836-2090. DR PDB; 7FNW; X-ray; 1.90 A; A=1836-2090. DR PDB; 7FNX; X-ray; 1.72 A; A=1836-2090. DR PDB; 7FNY; X-ray; 1.71 A; A=1836-2090. DR PDB; 7FNZ; X-ray; 1.66 A; A=1836-2090. DR PDB; 7FO0; X-ray; 1.83 A; A=1836-2090. DR PDB; 7FO1; X-ray; 1.50 A; A=1836-2090. DR PDB; 7FO2; X-ray; 2.01 A; A=1836-2090. DR PDB; 7FO3; X-ray; 1.59 A; A=1836-2090. DR PDB; 7FO4; X-ray; 1.53 A; A=1836-2090. DR PDB; 7FO5; X-ray; 1.71 A; A=1836-2090. DR PDB; 7FO6; X-ray; 1.57 A; A=1836-2090. DR PDB; 7FO7; X-ray; 1.45 A; A=1836-2090. DR PDB; 7FO8; X-ray; 1.72 A; A=1836-2090. DR PDB; 7FO9; X-ray; 1.67 A; A=1836-2090. DR PDB; 7FOA; X-ray; 1.67 A; A=1836-2090. DR PDB; 7FOB; X-ray; 1.72 A; A=1836-2090. DR PDB; 7FOC; X-ray; 1.90 A; A=1836-2090. DR PDB; 7FOD; X-ray; 1.59 A; A=1836-2090. DR PDB; 7FOE; X-ray; 1.65 A; A=1836-2090. DR PDB; 7FOF; X-ray; 1.77 A; A=1836-2090. DR PDB; 7FOG; X-ray; 1.41 A; A=1836-2090. DR PDB; 7FOH; X-ray; 1.69 A; A=1836-2090. DR PDB; 7FOI; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FOJ; X-ray; 1.65 A; A=1836-2090. DR PDB; 7FOK; X-ray; 1.72 A; A=1836-2090. DR PDB; 7FOL; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FOM; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FON; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FOO; X-ray; 1.59 A; A=1836-2090. DR PDB; 7FOP; X-ray; 1.66 A; A=1836-2090. DR PDB; 7FOQ; X-ray; 1.74 A; A=1836-2090. DR PDB; 7FOR; X-ray; 2.03 A; A=1836-2090. DR PDB; 7FOS; X-ray; 1.67 A; A=1836-2090. DR PDB; 7FOT; X-ray; 1.56 A; A=1836-2090. DR PDB; 7FOU; X-ray; 1.59 A; A=1836-2090. DR PDB; 7FOV; X-ray; 1.48 A; A=1836-2090. DR PDB; 7FOW; X-ray; 1.51 A; A=1836-2090. DR PDB; 7FOX; X-ray; 1.47 A; A=1836-2090. DR PDB; 7FOY; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FOZ; X-ray; 1.83 A; A=1836-2090. DR PDB; 7FP0; X-ray; 1.54 A; A=1836-2090. DR PDB; 7FP1; X-ray; 1.43 A; A=1836-2090. DR PDB; 7FP2; X-ray; 1.64 A; A=1836-2090. DR PDB; 7FP3; X-ray; 1.76 A; A=1836-2090. DR PDB; 7FP4; X-ray; 1.45 A; A=1836-2090. DR PDB; 7FP5; X-ray; 1.53 A; A=1836-2090. DR PDB; 7FP6; X-ray; 1.61 A; A=1836-2090. DR PDB; 7FP7; X-ray; 1.47 A; A=1836-2090. DR PDB; 7FP8; X-ray; 1.59 A; A=1836-2090. DR PDB; 7FP9; X-ray; 1.90 A; A=1836-2090. DR PDB; 7FPA; X-ray; 1.86 A; A=1836-2090. DR PDB; 7FPB; X-ray; 2.02 A; A=1836-2090. DR PDB; 7FPC; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FPD; X-ray; 1.61 A; A=1836-2090. DR PDB; 7FPE; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FPF; X-ray; 1.55 A; A=1836-2090. DR PDB; 7FPG; X-ray; 1.60 A; A=1836-2090. DR PDB; 7FPH; X-ray; 1.91 A; A=1836-2090. DR PDB; 7FPI; X-ray; 1.63 A; A=1836-2090. DR PDB; 7FPJ; X-ray; 1.59 A; A=1836-2090. DR PDB; 7FPK; X-ray; 1.59 A; A=1836-2090. DR PDBsum; 2OG4; -. DR PDBsum; 3E66; -. DR PDBsum; 3E9O; -. DR PDBsum; 3E9P; -. DR PDBsum; 3JCM; -. DR PDBsum; 3SBG; -. DR PDBsum; 3SBT; -. DR PDBsum; 3ZEF; -. DR PDBsum; 4BGD; -. DR PDBsum; 4I43; -. DR PDBsum; 4ILG; -. DR PDBsum; 4ILH; -. DR PDBsum; 4ILJ; -. DR PDBsum; 5DCA; -. DR PDBsum; 5GAM; -. DR PDBsum; 5GAN; -. DR PDBsum; 5GAO; -. DR PDBsum; 5GAP; -. DR PDBsum; 5GM6; -. DR PDBsum; 5GMK; -. DR PDBsum; 5LJ3; -. DR PDBsum; 5LJ5; -. DR PDBsum; 5LQW; -. DR PDBsum; 5M52; -. DR PDBsum; 5M5P; -. DR PDBsum; 5MPS; -. DR PDBsum; 5MQ0; -. DR PDBsum; 5NRL; -. DR PDBsum; 5QY1; -. DR PDBsum; 5QY2; -. DR PDBsum; 5QY3; -. DR PDBsum; 5QY4; -. DR PDBsum; 5QY5; -. DR PDBsum; 5QY6; -. DR PDBsum; 5QY7; -. DR PDBsum; 5QY8; -. DR PDBsum; 5QY9; -. DR PDBsum; 5QYA; -. DR PDBsum; 5QYB; -. DR PDBsum; 5QYC; -. DR PDBsum; 5QYD; -. DR PDBsum; 5QYE; -. DR PDBsum; 5QYF; -. DR PDBsum; 5QYG; -. DR PDBsum; 5QYH; -. DR PDBsum; 5QYI; -. DR PDBsum; 5QYJ; -. DR PDBsum; 5QYK; -. DR PDBsum; 5QYL; -. DR PDBsum; 5QYM; -. DR PDBsum; 5QYN; -. DR PDBsum; 5QYO; -. DR PDBsum; 5QYP; -. DR PDBsum; 5QYQ; -. DR PDBsum; 5QYR; -. DR PDBsum; 5QYS; -. DR PDBsum; 5QYT; -. DR PDBsum; 5QYU; -. DR PDBsum; 5QYV; -. DR PDBsum; 5QYW; -. DR PDBsum; 5QYX; -. DR PDBsum; 5QYY; -. DR PDBsum; 5QYZ; -. DR PDBsum; 5QZ0; -. DR PDBsum; 5QZ1; -. DR PDBsum; 5QZ2; -. DR PDBsum; 5QZ3; -. DR PDBsum; 5QZ4; -. DR PDBsum; 5QZ5; -. DR PDBsum; 5QZ6; -. DR PDBsum; 5QZ7; -. DR PDBsum; 5QZ8; -. DR PDBsum; 5QZ9; -. DR PDBsum; 5QZA; -. DR PDBsum; 5QZB; -. DR PDBsum; 5QZC; -. DR PDBsum; 5QZD; -. DR PDBsum; 5QZE; -. DR PDBsum; 5QZF; -. DR PDBsum; 5QZG; -. DR PDBsum; 5QZH; -. DR PDBsum; 5QZI; -. DR PDBsum; 5QZJ; -. DR PDBsum; 5QZK; -. DR PDBsum; 5QZL; -. DR PDBsum; 5QZM; -. DR PDBsum; 5QZN; -. DR PDBsum; 5QZO; -. DR PDBsum; 5QZP; -. DR PDBsum; 5QZQ; -. DR PDBsum; 5QZR; -. DR PDBsum; 5QZS; -. DR PDBsum; 5QZT; -. DR PDBsum; 5QZU; -. DR PDBsum; 5QZV; -. DR PDBsum; 5QZW; -. DR PDBsum; 5QZX; -. DR PDBsum; 5QZY; -. DR PDBsum; 5QZZ; -. DR PDBsum; 5R00; -. DR PDBsum; 5R01; -. DR PDBsum; 5R02; -. DR PDBsum; 5R03; -. DR PDBsum; 5R04; -. DR PDBsum; 5R05; -. DR PDBsum; 5R06; -. DR PDBsum; 5R07; -. DR PDBsum; 5R08; -. DR PDBsum; 5R09; -. DR PDBsum; 5R0A; -. DR PDBsum; 5R0B; -. DR PDBsum; 5R0C; -. DR PDBsum; 5R0D; -. DR PDBsum; 5R0E; -. DR PDBsum; 5R0F; -. DR PDBsum; 5R0G; -. DR PDBsum; 5R0H; -. DR PDBsum; 5R0I; -. DR PDBsum; 5R0J; -. DR PDBsum; 5R0K; -. DR PDBsum; 5R0L; -. DR PDBsum; 5R0M; -. DR PDBsum; 5R0N; -. DR PDBsum; 5R0O; -. DR PDBsum; 5R0P; -. DR PDBsum; 5R0Q; -. DR PDBsum; 5R0R; -. DR PDBsum; 5R0S; -. DR PDBsum; 5R0T; -. DR PDBsum; 5R0U; -. DR PDBsum; 5R0V; -. DR PDBsum; 5R0W; -. DR PDBsum; 5R0X; -. DR PDBsum; 5R0Y; -. DR PDBsum; 5R0Z; -. DR PDBsum; 5R10; -. DR PDBsum; 5R11; -. DR PDBsum; 5R12; -. DR PDBsum; 5R13; -. DR PDBsum; 5R14; -. DR PDBsum; 5R15; -. DR PDBsum; 5R16; -. DR PDBsum; 5R17; -. DR PDBsum; 5R18; -. DR PDBsum; 5R19; -. DR PDBsum; 5R1A; -. DR PDBsum; 5R1B; -. DR PDBsum; 5R1C; -. DR PDBsum; 5R1D; -. DR PDBsum; 5R1E; -. DR PDBsum; 5R1F; -. DR PDBsum; 5R1G; -. DR PDBsum; 5R1H; -. DR PDBsum; 5R1I; -. DR PDBsum; 5R1J; -. DR PDBsum; 5R1K; -. DR PDBsum; 5R1L; -. DR PDBsum; 5R1M; -. DR PDBsum; 5R1N; -. DR PDBsum; 5R1O; -. DR PDBsum; 5R1P; -. DR PDBsum; 5R1Q; -. DR PDBsum; 5R1S; -. DR PDBsum; 5ST0; -. DR PDBsum; 5ST1; -. DR PDBsum; 5ST2; -. DR PDBsum; 5ST3; -. DR PDBsum; 5ST4; -. DR PDBsum; 5ST5; -. DR PDBsum; 5ST6; -. DR PDBsum; 5ST7; -. DR PDBsum; 5ST8; -. DR PDBsum; 5ST9; -. DR PDBsum; 5STA; -. DR PDBsum; 5STB; -. DR PDBsum; 5STC; -. DR PDBsum; 5STE; -. DR PDBsum; 5STF; -. DR PDBsum; 5STG; -. DR PDBsum; 5STH; -. DR PDBsum; 5STI; -. DR PDBsum; 5STJ; -. DR PDBsum; 5STK; -. DR PDBsum; 5STL; -. DR PDBsum; 5STM; -. DR PDBsum; 5STN; -. DR PDBsum; 5STO; -. DR PDBsum; 5STP; -. DR PDBsum; 5STQ; -. DR PDBsum; 5STR; -. DR PDBsum; 5STS; -. DR PDBsum; 5STT; -. DR PDBsum; 5STU; -. DR PDBsum; 5STV; -. DR PDBsum; 5STW; -. DR PDBsum; 5STX; -. DR PDBsum; 5STY; -. DR PDBsum; 5STZ; -. DR PDBsum; 5SU0; -. DR PDBsum; 5SU1; -. DR PDBsum; 5SU2; -. DR PDBsum; 5SU3; -. DR PDBsum; 5SU4; -. DR PDBsum; 5SU5; -. DR PDBsum; 5SU6; -. DR PDBsum; 5SU7; -. DR PDBsum; 5SU8; -. DR PDBsum; 5SU9; -. DR PDBsum; 5SUA; -. DR PDBsum; 5SUB; -. DR PDBsum; 5SUC; -. DR PDBsum; 5SUD; -. DR PDBsum; 5SUE; -. DR PDBsum; 5SUF; -. DR PDBsum; 5SUG; -. DR PDBsum; 5WSG; -. DR PDBsum; 5Y88; -. DR PDBsum; 5YLZ; -. DR PDBsum; 5ZWM; -. DR PDBsum; 5ZWO; -. DR PDBsum; 6BK8; -. DR PDBsum; 6EXN; -. DR PDBsum; 6J6G; -. DR PDBsum; 6J6H; -. DR PDBsum; 6J6N; -. DR PDBsum; 6J6Q; -. DR PDBsum; 6TEO; -. DR PDBsum; 7B9V; -. DR PDBsum; 7FJU; -. DR PDBsum; 7FJV; -. DR PDBsum; 7FJW; -. DR PDBsum; 7FJX; -. DR PDBsum; 7FJY; -. DR PDBsum; 7FJZ; -. DR PDBsum; 7FK0; -. DR PDBsum; 7FK1; -. DR PDBsum; 7FK2; -. DR PDBsum; 7FK3; -. DR PDBsum; 7FK4; -. DR PDBsum; 7FK5; -. DR PDBsum; 7FK6; -. DR PDBsum; 7FK7; -. DR PDBsum; 7FK8; -. DR PDBsum; 7FK9; -. DR PDBsum; 7FKA; -. DR PDBsum; 7FKB; -. DR PDBsum; 7FKC; -. DR PDBsum; 7FKD; -. DR PDBsum; 7FKE; -. DR PDBsum; 7FKF; -. DR PDBsum; 7FKG; -. DR PDBsum; 7FKH; -. DR PDBsum; 7FKI; -. DR PDBsum; 7FKJ; -. DR PDBsum; 7FKK; -. DR PDBsum; 7FKL; -. DR PDBsum; 7FKM; -. DR PDBsum; 7FKN; -. DR PDBsum; 7FKO; -. DR PDBsum; 7FKP; -. DR PDBsum; 7FKQ; -. DR PDBsum; 7FKR; -. DR PDBsum; 7FKS; -. DR PDBsum; 7FKT; -. DR PDBsum; 7FKU; -. DR PDBsum; 7FKV; -. DR PDBsum; 7FKW; -. DR PDBsum; 7FKX; -. DR PDBsum; 7FKY; -. DR PDBsum; 7FKZ; -. DR PDBsum; 7FL0; -. DR PDBsum; 7FL1; -. DR PDBsum; 7FL2; -. DR PDBsum; 7FL3; -. DR PDBsum; 7FL4; -. DR PDBsum; 7FL5; -. DR PDBsum; 7FL6; -. DR PDBsum; 7FL7; -. DR PDBsum; 7FL8; -. DR PDBsum; 7FL9; -. DR PDBsum; 7FLA; -. DR PDBsum; 7FLB; -. DR PDBsum; 7FLC; -. DR PDBsum; 7FLD; -. DR PDBsum; 7FLE; -. DR PDBsum; 7FLF; -. DR PDBsum; 7FLG; -. DR PDBsum; 7FLH; -. DR PDBsum; 7FLI; -. DR PDBsum; 7FLJ; -. DR PDBsum; 7FLK; -. DR PDBsum; 7FLL; -. DR PDBsum; 7FLM; -. DR PDBsum; 7FLN; -. DR PDBsum; 7FLO; -. DR PDBsum; 7FLP; -. DR PDBsum; 7FLQ; -. DR PDBsum; 7FLR; -. DR PDBsum; 7FLS; -. DR PDBsum; 7FLT; -. DR PDBsum; 7FLU; -. DR PDBsum; 7FLV; -. DR PDBsum; 7FLW; -. DR PDBsum; 7FLX; -. DR PDBsum; 7FLY; -. DR PDBsum; 7FLZ; -. DR PDBsum; 7FM0; -. DR PDBsum; 7FM1; -. DR PDBsum; 7FM2; -. DR PDBsum; 7FM3; -. DR PDBsum; 7FM4; -. DR PDBsum; 7FM5; -. DR PDBsum; 7FM6; -. DR PDBsum; 7FM7; -. DR PDBsum; 7FM8; -. DR PDBsum; 7FM9; -. DR PDBsum; 7FMA; -. DR PDBsum; 7FMB; -. DR PDBsum; 7FMC; -. DR PDBsum; 7FMD; -. DR PDBsum; 7FME; -. DR PDBsum; 7FMF; -. DR PDBsum; 7FMG; -. DR PDBsum; 7FMH; -. DR PDBsum; 7FMI; -. DR PDBsum; 7FMJ; -. DR PDBsum; 7FMK; -. DR PDBsum; 7FML; -. DR PDBsum; 7FMM; -. DR PDBsum; 7FMN; -. DR PDBsum; 7FMO; -. DR PDBsum; 7FMP; -. DR PDBsum; 7FMQ; -. DR PDBsum; 7FMR; -. DR PDBsum; 7FMS; -. DR PDBsum; 7FMT; -. DR PDBsum; 7FMU; -. DR PDBsum; 7FMV; -. DR PDBsum; 7FMW; -. DR PDBsum; 7FMX; -. DR PDBsum; 7FMY; -. DR PDBsum; 7FMZ; -. DR PDBsum; 7FN0; -. DR PDBsum; 7FN1; -. DR PDBsum; 7FN2; -. DR PDBsum; 7FN3; -. DR PDBsum; 7FN4; -. DR PDBsum; 7FN5; -. DR PDBsum; 7FN6; -. DR PDBsum; 7FN7; -. DR PDBsum; 7FN8; -. DR PDBsum; 7FN9; -. DR PDBsum; 7FNA; -. DR PDBsum; 7FNB; -. DR PDBsum; 7FNC; -. DR PDBsum; 7FND; -. DR PDBsum; 7FNE; -. DR PDBsum; 7FNF; -. DR PDBsum; 7FNG; -. DR PDBsum; 7FNH; -. DR PDBsum; 7FNI; -. DR PDBsum; 7FNJ; -. DR PDBsum; 7FNK; -. DR PDBsum; 7FNL; -. DR PDBsum; 7FNM; -. DR PDBsum; 7FNN; -. DR PDBsum; 7FNO; -. DR PDBsum; 7FNP; -. DR PDBsum; 7FNQ; -. DR PDBsum; 7FNR; -. DR PDBsum; 7FNS; -. DR PDBsum; 7FNT; -. DR PDBsum; 7FNU; -. DR PDBsum; 7FNV; -. DR PDBsum; 7FNW; -. DR PDBsum; 7FNX; -. DR PDBsum; 7FNY; -. DR PDBsum; 7FNZ; -. DR PDBsum; 7FO0; -. DR PDBsum; 7FO1; -. DR PDBsum; 7FO2; -. DR PDBsum; 7FO3; -. DR PDBsum; 7FO4; -. DR PDBsum; 7FO5; -. DR PDBsum; 7FO6; -. DR PDBsum; 7FO7; -. DR PDBsum; 7FO8; -. DR PDBsum; 7FO9; -. DR PDBsum; 7FOA; -. DR PDBsum; 7FOB; -. DR PDBsum; 7FOC; -. DR PDBsum; 7FOD; -. DR PDBsum; 7FOE; -. DR PDBsum; 7FOF; -. DR PDBsum; 7FOG; -. DR PDBsum; 7FOH; -. DR PDBsum; 7FOI; -. DR PDBsum; 7FOJ; -. DR PDBsum; 7FOK; -. DR PDBsum; 7FOL; -. DR PDBsum; 7FOM; -. DR PDBsum; 7FON; -. DR PDBsum; 7FOO; -. DR PDBsum; 7FOP; -. DR PDBsum; 7FOQ; -. DR PDBsum; 7FOR; -. DR PDBsum; 7FOS; -. DR PDBsum; 7FOT; -. DR PDBsum; 7FOU; -. DR PDBsum; 7FOV; -. DR PDBsum; 7FOW; -. DR PDBsum; 7FOX; -. DR PDBsum; 7FOY; -. DR PDBsum; 7FOZ; -. DR PDBsum; 7FP0; -. DR PDBsum; 7FP1; -. DR PDBsum; 7FP2; -. DR PDBsum; 7FP3; -. DR PDBsum; 7FP4; -. DR PDBsum; 7FP5; -. DR PDBsum; 7FP6; -. DR PDBsum; 7FP7; -. DR PDBsum; 7FP8; -. DR PDBsum; 7FP9; -. DR PDBsum; 7FPA; -. DR PDBsum; 7FPB; -. DR PDBsum; 7FPC; -. DR PDBsum; 7FPD; -. DR PDBsum; 7FPE; -. DR PDBsum; 7FPF; -. DR PDBsum; 7FPG; -. DR PDBsum; 7FPH; -. DR PDBsum; 7FPI; -. DR PDBsum; 7FPJ; -. DR PDBsum; 7FPK; -. DR AlphaFoldDB; P33334; -. DR EMDB; EMD-0686; -. DR EMDB; EMD-0687; -. DR EMDB; EMD-0691; -. DR EMDB; EMD-0692; -. DR EMDB; EMD-12106; -. DR EMDB; EMD-3539; -. DR EMDB; EMD-3541; -. DR EMDB; EMD-3683; -. DR EMDB; EMD-3979; -. DR EMDB; EMD-4055; -. DR EMDB; EMD-4057; -. DR EMDB; EMD-6817; -. DR EMDB; EMD-6839; -. DR EMDB; EMD-6972; -. DR EMDB; EMD-6974; -. DR EMDB; EMD-7109; -. DR EMDB; EMD-8011; -. DR EMDB; EMD-8012; -. DR EMDB; EMD-8013; -. DR EMDB; EMD-8014; -. DR EMDB; EMD-9524; -. DR EMDB; EMD-9525; -. DR SMR; P33334; -. DR BioGRID; 36599; 257. DR ComplexPortal; CPX-1651; PRP19-associated complex. DR ComplexPortal; CPX-25; U4/U6.U5 tri-small nuclear ribonucleoprotein complex. DR ComplexPortal; CPX-29; U5 small nuclear ribonucleoprotein complex. DR ComplexPortal; CPX-30; U5 small nuclear ribonucleoprotein complex, AAR2 variant. DR DIP; DIP-2427N; -. DR IntAct; P33334; 66. DR MINT; P33334; -. DR STRING; 4932.YHR165C; -. DR CarbonylDB; P33334; -. DR GlyGen; P33334; 4 sites, 1 O-linked glycan (4 sites). DR iPTMnet; P33334; -. DR MaxQB; P33334; -. DR PaxDb; 4932-YHR165C; -. DR PeptideAtlas; P33334; -. DR EnsemblFungi; YHR165C_mRNA; YHR165C; YHR165C. DR GeneID; 856570; -. DR KEGG; sce:YHR165C; -. DR AGR; SGD:S000001208; -. DR SGD; S000001208; PRP8. DR VEuPathDB; FungiDB:YHR165C; -. DR eggNOG; KOG1795; Eukaryota. DR GeneTree; ENSGT00390000015210; -. DR HOGENOM; CLU_000380_3_0_1; -. DR InParanoid; P33334; -. DR OMA; ANKWNTS; -. DR OrthoDB; 246127at2759; -. DR BioCyc; YEAST:G3O-31199-MONOMER; -. DR BRENDA; 3.1.13.2; 984. DR BioGRID-ORCS; 856570; 3 hits in 10 CRISPR screens. DR EvolutionaryTrace; P33334; -. DR PRO; PR:P33334; -. DR Proteomes; UP000002311; Chromosome VIII. DR RNAct; P33334; Protein. DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central. DR GO; GO:0005737; C:cytoplasm; NAS:ComplexPortal. DR GO; GO:0005634; C:nucleus; IDA:SGD. DR GO; GO:0005681; C:spliceosomal complex; NAS:ComplexPortal. DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IDA:SGD. DR GO; GO:0005682; C:U5 snRNP; IDA:SGD. DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro. DR GO; GO:0003729; F:mRNA binding; HDA:SGD. DR GO; GO:0097157; F:pre-mRNA intronic binding; IDA:SGD. DR GO; GO:0030619; F:U1 snRNA binding; IDA:SGD. DR GO; GO:0030620; F:U2 snRNA binding; IDA:SGD. DR GO; GO:0030623; F:U5 snRNA binding; IDA:SGD. DR GO; GO:0017070; F:U6 snRNA binding; IDA:SGD. DR GO; GO:0000350; P:generation of catalytic spliceosome for second transesterification step; IMP:SGD. DR GO; GO:0000389; P:mRNA 3'-splice site recognition; IMP:SGD. DR GO; GO:0000395; P:mRNA 5'-splice site recognition; IMP:SGD. DR GO; GO:0000398; P:mRNA splicing, via spliceosome; NAS:ComplexPortal. DR GO; GO:0000387; P:spliceosomal snRNP assembly; NAS:ComplexPortal. DR GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IDA:SGD. DR CDD; cd08056; MPN_PRP8; 1. DR CDD; cd13838; RNase_H_like_Prp8_IV; 1. DR DisProt; DP02722; -. DR Gene3D; 1.20.80.40; -; 1. DR Gene3D; 3.30.420.230; -; 1. DR Gene3D; 3.90.1570.40; -; 1. DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1. DR Gene3D; 3.30.43.40; Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain; 1. DR InterPro; IPR000555; JAMM/MPN+_dom. DR InterPro; IPR037518; MPN. DR InterPro; IPR012591; PRO8NT. DR InterPro; IPR012592; PROCN. DR InterPro; IPR012984; PROCT. DR InterPro; IPR027652; PRP8. DR InterPro; IPR021983; PRP8_domainIV. DR InterPro; IPR043173; Prp8_domainIV_fingers. DR InterPro; IPR043172; Prp8_domainIV_palm. DR InterPro; IPR019581; Prp8_U5-snRNA-bd. DR InterPro; IPR042516; Prp8_U5-snRNA-bd_sf. DR InterPro; IPR019580; Prp8_U6-snRNA-bd. DR InterPro; IPR012337; RNaseH-like_sf. DR InterPro; IPR019582; RRM_spliceosomal_PrP8. DR PANTHER; PTHR11140; PRE-MRNA SPLICING FACTOR PRP8; 1. DR PANTHER; PTHR11140:SF0; PRE-MRNA-PROCESSING-SPLICING FACTOR 8; 1. DR Pfam; PF08082; PRO8NT; 1. DR Pfam; PF08083; PROCN; 1. DR Pfam; PF08084; PROCT; 1. DR Pfam; PF12134; PRP8_domainIV; 1. DR Pfam; PF10598; RRM_4; 1. DR Pfam; PF10597; U5_2-snRNA_bdg; 1. DR Pfam; PF10596; U6-snRNA_bdg; 1. DR SMART; SM00232; JAB_MPN; 1. DR SUPFAM; SSF53098; Ribonuclease H-like; 2. DR PROSITE; PS50249; MPN; 1. PE 1: Evidence at protein level; KW 3D-structure; mRNA processing; mRNA splicing; Nucleus; Reference proteome; KW Ribonucleoprotein; RNA-binding; Spliceosome. FT CHAIN 1..2413 FT /note="Pre-mRNA-splicing factor 8" FT /id="PRO_0000097042" FT DOMAIN 2182..2311 FT /note="MPN" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182" FT REGION 1..60 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 253..543 FT /note="SNU114/CWC21 interacting domain (SCwid)" FT REGION 885..1375 FT /note="Reverse transcriptase homology domain" FT REGION 1376..1649 FT /note="Linker" FT REGION 1585..1598 FT /note="Important for branch point selection" FT REGION 1653..1824 FT /note="Restriction endonuclease homology domain" FT REGION 1839..2092 FT /note="RNase H homology domain" FT COMPBIAS 1..31 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MUTAGEN 1658 FT /note="H->S: No effect on viability." FT /evidence="ECO:0000269|PubMed:23354046" FT MUTAGEN 1684 FT /note="E->Q: No effect on viability." FT /evidence="ECO:0000269|PubMed:23354046" FT MUTAGEN 1687 FT /note="H->S: No effect on viability." FT /evidence="ECO:0000269|PubMed:23354046" FT MUTAGEN 1700 FT /note="D->N: No effect on viability." FT /evidence="ECO:0000269|PubMed:23354046" FT MUTAGEN 1735 FT /note="D->N: No effect on viability." FT /evidence="ECO:0000269|PubMed:23354046" FT MUTAGEN 1853 FT /note="D->A: Alters protein folding. Severely impaired FT growth. Strongly reduced growth at 35 degrees Celsius; when FT associated with A-1854." FT /evidence="ECO:0000269|PubMed:18779563, FT ECO:0000269|PubMed:18836455, ECO:0000269|PubMed:18843295" FT MUTAGEN 1853 FT /note="D->N: Reduced growth at 30 degrees Celsius. Strongly FT reduced growth at 16 degrees Celsius." FT /evidence="ECO:0000269|PubMed:18779563, FT ECO:0000269|PubMed:18836455, ECO:0000269|PubMed:18843295" FT MUTAGEN 1854 FT /note="D->A: Reduced growth at 30 degrees Celsius. Strongly FT reduced growth at 16 degrees Celsius. Strongly reduced FT growth at 35 degrees Celsius; when associated with A-1853." FT /evidence="ECO:0000269|PubMed:18836455, FT ECO:0000269|PubMed:18843295" FT MUTAGEN 1854 FT /note="D->N: Reduced growth at 30 degrees Celsius. Strongly FT reduced growth at 16 degrees Celsius." FT /evidence="ECO:0000269|PubMed:18836455, FT ECO:0000269|PubMed:18843295" FT MUTAGEN 1855 FT /note="T->A: Reduced growth at 30 degrees Celsius. Strongly FT reduced growth at 16 degrees Celsius." FT /evidence="ECO:0000269|PubMed:18843295" FT MUTAGEN 1936 FT /note="T->A: Reduced growth at 30 degrees Celsius. Strongly FT reduced growth at 16 degrees Celsius." FT /evidence="ECO:0000269|PubMed:18843295" FT MUTAGEN 1937 FT /note="R->K: Severely impaired growth. Reduced growth at 30 FT degrees Celsius. Strongly reduced growth at 16 degrees FT Celsius." FT /evidence="ECO:0000269|PubMed:18843295" FT CONFLICT 388..420 FT /note="PHLYNSRPRSVRIPWYNNPVSCIIQNDEEYDTP -> LIYIIPGPVQCAYHG FT IIIQCRVLSRTMRSTTRL (in Ref. 2; AAA67044)" FT /evidence="ECO:0000305" FT CONFLICT 1132 FT /note="T -> S (in Ref. 2; AAA67044)" FT /evidence="ECO:0000305" FT CONFLICT 1575 FT /note="W -> C (in Ref. 2; AAA67044)" FT /evidence="ECO:0000305" FT HELIX 136..145 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 152..154 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 155..162 FT /evidence="ECO:0007829|PDB:6J6G" FT TURN 163..167 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 168..177 FT /evidence="ECO:0007829|PDB:6J6G" FT STRAND 188..194 FT /evidence="ECO:0007829|PDB:6J6G" FT STRAND 200..202 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 210..230 FT /evidence="ECO:0007829|PDB:6J6G" FT STRAND 239..242 FT /evidence="ECO:0007829|PDB:6J6G" FT STRAND 244..246 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 251..254 FT /evidence="ECO:0007829|PDB:6J6G" FT TURN 255..257 FT /evidence="ECO:0007829|PDB:6J6G" FT TURN 270..272 FT /evidence="ECO:0007829|PDB:6J6G" FT TURN 274..281 FT /evidence="ECO:0007829|PDB:6J6G" FT STRAND 282..284 FT /evidence="ECO:0007829|PDB:6J6G" FT TURN 285..288 FT /evidence="ECO:0007829|PDB:6BK8" FT TURN 290..292 FT /evidence="ECO:0007829|PDB:6J6G" FT STRAND 300..302 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 305..314 FT /evidence="ECO:0007829|PDB:6J6G" FT TURN 315..318 FT /evidence="ECO:0007829|PDB:6J6G" FT TURN 325..328 FT /evidence="ECO:0007829|PDB:6J6G" FT STRAND 329..332 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 333..341 FT /evidence="ECO:0007829|PDB:6J6G" FT STRAND 347..349 FT /evidence="ECO:0007829|PDB:6J6G" FT STRAND 366..368 FT /evidence="ECO:0007829|PDB:6J6G" FT TURN 370..372 FT /evidence="ECO:0007829|PDB:6TEO" FT HELIX 382..386 FT /evidence="ECO:0007829|PDB:6TEO" FT TURN 388..392 FT /evidence="ECO:0007829|PDB:6TEO" FT TURN 416..418 FT /evidence="ECO:0007829|PDB:6BK8" FT TURN 461..464 FT /evidence="ECO:0007829|PDB:6TEO" FT HELIX 473..480 FT /evidence="ECO:0007829|PDB:6TEO" FT TURN 484..487 FT /evidence="ECO:0007829|PDB:6TEO" FT STRAND 489..491 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 496..507 FT /evidence="ECO:0007829|PDB:6TEO" FT STRAND 512..516 FT /evidence="ECO:0007829|PDB:6TEO" FT HELIX 519..532 FT /evidence="ECO:0007829|PDB:6TEO" FT TURN 541..544 FT /evidence="ECO:0007829|PDB:5GMK" FT HELIX 547..552 FT /evidence="ECO:0007829|PDB:6J6G" FT STRAND 557..563 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 564..585 FT /evidence="ECO:0007829|PDB:6J6G" FT STRAND 591..593 FT /evidence="ECO:0007829|PDB:6J6G" FT STRAND 599..603 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 607..612 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 617..640 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 646..657 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 660..663 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 666..668 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 671..673 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 674..691 FT /evidence="ECO:0007829|PDB:6J6G" FT TURN 692..694 FT /evidence="ECO:0007829|PDB:6J6G" FT STRAND 697..699 FT /evidence="ECO:0007829|PDB:5GMK" FT HELIX 705..735 FT /evidence="ECO:0007829|PDB:6J6G" FT TURN 747..749 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 750..769 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 778..794 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 806..836 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 842..870 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 885..892 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 908..924 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 931..945 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 947..960 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 967..969 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 975..983 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 986..1005 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1013..1015 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1017..1019 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 1021..1033 FT /evidence="ECO:0007829|PDB:4I43" FT TURN 1036..1039 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1042..1044 FT /evidence="ECO:0007829|PDB:6J6G" FT STRAND 1046..1053 FT /evidence="ECO:0007829|PDB:4I43" FT TURN 1056..1060 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1063..1071 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1076..1085 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1087..1092 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1095..1098 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1110..1135 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1138..1140 FT /evidence="ECO:0007829|PDB:3ZEF" FT HELIX 1150..1154 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1156..1164 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1167..1174 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1176..1189 FT /evidence="ECO:0007829|PDB:4I43" FT TURN 1197..1200 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1205..1207 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 1209..1211 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1217..1231 FT /evidence="ECO:0007829|PDB:4I43" FT TURN 1236..1238 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1243..1245 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1246..1252 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1258..1262 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1265..1271 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1272..1274 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1275..1277 FT /evidence="ECO:0007829|PDB:6J6G" FT STRAND 1283..1289 FT /evidence="ECO:0007829|PDB:4I43" FT TURN 1291..1293 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1295..1304 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1306..1320 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1328..1346 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1348..1351 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1354..1375 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1380..1382 FT /evidence="ECO:0007829|PDB:6BK8" FT HELIX 1385..1389 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1392..1394 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1409..1412 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1414..1417 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1422..1425 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1427..1429 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1434..1436 FT /evidence="ECO:0007829|PDB:3ZEF" FT HELIX 1440..1443 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1447..1470 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1477..1479 FT /evidence="ECO:0007829|PDB:4I43" FT TURN 1480..1482 FT /evidence="ECO:0007829|PDB:4I43" FT TURN 1487..1490 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1491..1495 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1499..1502 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1508..1514 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1515..1517 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1530..1533 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1540..1549 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1552..1558 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1559..1561 FT /evidence="ECO:0007829|PDB:5GMK" FT HELIX 1563..1565 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1568..1575 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 1581..1585 FT /evidence="ECO:0007829|PDB:6BK8" FT HELIX 1592..1595 FT /evidence="ECO:0007829|PDB:6BK8" FT HELIX 1598..1600 FT /evidence="ECO:0007829|PDB:6BK8" FT HELIX 1603..1614 FT /evidence="ECO:0007829|PDB:4I43" FT TURN 1617..1619 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1624..1626 FT /evidence="ECO:0007829|PDB:6J6G" FT STRAND 1628..1630 FT /evidence="ECO:0007829|PDB:6J6G" FT STRAND 1633..1636 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1641..1648 FT /evidence="ECO:0007829|PDB:4I43" FT TURN 1649..1652 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1653..1670 FT /evidence="ECO:0007829|PDB:4I43" FT TURN 1671..1677 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1678..1683 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1690..1692 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1700..1711 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1726..1739 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1743..1745 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1748..1759 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1763..1766 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1768..1778 FT /evidence="ECO:0007829|PDB:4I43" FT TURN 1779..1782 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1783..1788 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1794..1808 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 1810..1822 FT /evidence="ECO:0007829|PDB:4I43" FT STRAND 1825..1827 FT /evidence="ECO:0007829|PDB:6J6G" FT HELIX 1837..1844 FT /evidence="ECO:0007829|PDB:5R0D" FT STRAND 1845..1847 FT /evidence="ECO:0007829|PDB:5R0D" FT STRAND 1849..1853 FT /evidence="ECO:0007829|PDB:5R0D" FT STRAND 1857..1864 FT /evidence="ECO:0007829|PDB:5R0D" FT STRAND 1866..1868 FT /evidence="ECO:0007829|PDB:5STQ" FT STRAND 1870..1875 FT /evidence="ECO:0007829|PDB:5R0D" FT STRAND 1877..1882 FT /evidence="ECO:0007829|PDB:5R0D" FT TURN 1884..1886 FT /evidence="ECO:0007829|PDB:5R0D" FT STRAND 1888..1894 FT /evidence="ECO:0007829|PDB:5R0D" FT HELIX 1896..1899 FT /evidence="ECO:0007829|PDB:5R0D" FT HELIX 1905..1923 FT /evidence="ECO:0007829|PDB:5R0D" FT HELIX 1926..1928 FT /evidence="ECO:0007829|PDB:5R0D" FT STRAND 1931..1937 FT /evidence="ECO:0007829|PDB:5R0D" FT HELIX 1938..1940 FT /evidence="ECO:0007829|PDB:5R0D" FT HELIX 1941..1947 FT /evidence="ECO:0007829|PDB:5R0D" FT TURN 1948..1950 FT /evidence="ECO:0007829|PDB:5R0D" FT STRAND 1954..1957 FT /evidence="ECO:0007829|PDB:5R0D" FT STRAND 1959..1961 FT /evidence="ECO:0007829|PDB:5QZ6" FT HELIX 1965..1970 FT /evidence="ECO:0007829|PDB:5R0D" FT HELIX 1972..1980 FT /evidence="ECO:0007829|PDB:5R0D" FT STRAND 1985..1990 FT /evidence="ECO:0007829|PDB:5R0D" FT TURN 1991..1994 FT /evidence="ECO:0007829|PDB:5R0D" FT HELIX 1995..1997 FT /evidence="ECO:0007829|PDB:5R0D" FT HELIX 2001..2017 FT /evidence="ECO:0007829|PDB:5R0D" FT HELIX 2019..2027 FT /evidence="ECO:0007829|PDB:5R0D" FT STRAND 2028..2032 FT /evidence="ECO:0007829|PDB:7FNC" FT STRAND 2039..2041 FT /evidence="ECO:0007829|PDB:5R0D" FT HELIX 2045..2067 FT /evidence="ECO:0007829|PDB:5R0D" FT HELIX 2071..2073 FT /evidence="ECO:0007829|PDB:7FMI" FT HELIX 2076..2083 FT /evidence="ECO:0007829|PDB:7FMI" FT STRAND 2088..2090 FT /evidence="ECO:0007829|PDB:6BK8" FT HELIX 2091..2105 FT /evidence="ECO:0007829|PDB:6BK8" FT HELIX 2149..2159 FT /evidence="ECO:0007829|PDB:2OG4" FT HELIX 2160..2167 FT /evidence="ECO:0007829|PDB:2OG4" FT STRAND 2168..2171 FT /evidence="ECO:0007829|PDB:2OG4" FT STRAND 2178..2180 FT /evidence="ECO:0007829|PDB:5DCA" FT STRAND 2182..2186 FT /evidence="ECO:0007829|PDB:2OG4" FT HELIX 2187..2195 FT /evidence="ECO:0007829|PDB:2OG4" FT STRAND 2199..2201 FT /evidence="ECO:0007829|PDB:2OG4" FT STRAND 2204..2211 FT /evidence="ECO:0007829|PDB:2OG4" FT STRAND 2218..2225 FT /evidence="ECO:0007829|PDB:2OG4" FT STRAND 2229..2231 FT /evidence="ECO:0007829|PDB:2OG4" FT STRAND 2236..2238 FT /evidence="ECO:0007829|PDB:2OG4" FT STRAND 2245..2247 FT /evidence="ECO:0007829|PDB:3ZEF" FT STRAND 2254..2264 FT /evidence="ECO:0007829|PDB:2OG4" FT HELIX 2271..2281 FT /evidence="ECO:0007829|PDB:2OG4" FT TURN 2282..2284 FT /evidence="ECO:0007829|PDB:2OG4" FT STRAND 2289..2296 FT /evidence="ECO:0007829|PDB:2OG4" FT STRAND 2299..2307 FT /evidence="ECO:0007829|PDB:2OG4" FT HELIX 2309..2316 FT /evidence="ECO:0007829|PDB:2OG4" FT TURN 2317..2320 FT /evidence="ECO:0007829|PDB:3SBG" FT TURN 2323..2325 FT /evidence="ECO:0007829|PDB:4BGD" FT HELIX 2331..2333 FT /evidence="ECO:0007829|PDB:2OG4" FT STRAND 2334..2345 FT /evidence="ECO:0007829|PDB:2OG4" FT STRAND 2348..2352 FT /evidence="ECO:0007829|PDB:2OG4" FT HELIX 2360..2362 FT /evidence="ECO:0007829|PDB:4I43" FT HELIX 2363..2365 FT /evidence="ECO:0007829|PDB:2OG4" FT STRAND 2374..2376 FT /evidence="ECO:0007829|PDB:2OG4" FT HELIX 2385..2387 FT /evidence="ECO:0007829|PDB:2OG4" FT HELIX 2389..2396 FT /evidence="ECO:0007829|PDB:5DCA" FT TURN 2406..2408 FT /evidence="ECO:0007829|PDB:5M52" SQ SEQUENCE 2413 AA; 279504 MW; 8F4F6F89D34D3508 CRC64; MSGLPPPPPG FEEDSDLALP PPPPPPPGYE IEELDNPMVP SSVNEDTFLP PPPPPPSNFE INAEEIVDFT LPPPPPPPGL DELETKAEKK VELHGKRKLD IGKDTFVTRK SRKRAKKMTK KAKRSNLYTP KAEMPPEHLR KIINTHSDMA SKMYNTDKKA FLGALKYLPH AILKLLENMP HPWEQAKEVK VLYHTSGAIT FVNETPRVIE PVYTAQWSAT WIAMRREKRD RTHFKRMRFP PFDDDEPPLS YEQHIENIEP LDPINLPLDS QDDEYVKDWL YDSRPLEEDS KKVNGTSYKK WSFDLPEMSN LYRLSTPLRD EVTDKNYYYL FDKKSFFNGK ALNNAIPGGP KFEPLYPREE EEDYNEFNSI DRVIFRVPIR SEYKVAFPHL YNSRPRSVRI PWYNNPVSCI IQNDEEYDTP ALFFDPSLNP IPHFIDNNSS LNVSNTKENG DFTLPEDFAP LLAEEEELIL PNTKDAMSLY HSPFPFNRTK GKMVRAQDVA LAKKWFLQHP DEEYPVKVKV SYQKLLKNYV LNELHPTLPT NHNKTKLLKS LKNTKYFQQT TIDWVEAGLQ LCRQGHNMLN LLIHRKGLTY LHLDYNFNLK PTKTLTTKER KKSRLGNSFH LMRELLKMMK LIVDTHVQFR LGNVDAFQLA DGIHYILNHI GQLTGIYRYK YKVMHQIRAC KDLKHIIYYK FNKNLGKGPG CGFWQPAWRV WLNFLRGTIP LLERYIGNLI TRQFEGRSNE IVKTTTKQRL DAYYDLELRN SVMDDILEMM PESIRQKKAR TILQHLSEAW RCWKANIPWD VPGMPAPIKK IIERYIKSKA DAWVSAAHYN RERIKRGAHV EKTMVKKNLG RLTRLWIKNE QERQRQIQKN GPEITPEEAT TIFSVMVEWL ESRSFSPIPF PPLTYKNDTK ILVLALEDLK DVYASKVRLN ASEREELALI EEAYDNPHDT LNRIKKYLLT QRVFKPVDIT MMENYQNISP VYSVDPLEKI TDAYLDQYLW YEADQRKLFP NWIKPSDSEI PPLLVYKWTQ GINNLSEIWD VSRGQSAVLL ETTLGEMAEK IDFTLLNRLL RLIVDPNIAD YITAKNNVVI NFKDMSHVNK YGLIRGLKFA SFIFQYYGLV IDLLLLGQER ATDLAGPANN PNEFMQFKSK EVEKAHPIRL YTRYLDRIYM LFHFEEDEGE ELTDEYLAEN PDPNFENSIG YNNRKCWPKD SRMRLIRQDV NLGRAVFWEI QSRVPTSLTS IKWENAFVSV YSKNNPNLLF SMCGFEVRIL PRQRMEEVVS NDEGVWDLVD ERTKQRTAKA YLKVSEEEIK KFDSRIRGIL MASGSTTFTK VAAKWNTSLI SLFTYFREAI VATEPLLDIL VKGETRIQNR VKLGLNSKMP TRFPPAVFYT PKELGGLGMI SASHILIPAS DLSWSKQTDT GITHFRAGMT HEDEKLIPTI FRYITTWENE FLDSQRVWAE YATKRQEAIQ QNRRLAFEEL EGSWDRGIPR ISTLFQRDRH TLAYDRGHRI RREFKQYSLE RNSPFWWTNS HHDGKLWNLN AYRTDVIQAL GGIETILEHT LFKGTGFNSW EGLFWEKASG FEDSMQFKKL THAQRTGLSQ IPNRRFTLWW SPTINRANVY VGFLVQLDLT GIFLHGKIPT LKISLIQIFR AHLWQKIHES IVFDICQILD GELDVLQIES VTKETVHPRK SYKMNSSAAD ITMESVHEWE VSKPSLLHET NDSFKGLITN KMWFDVQLRY GDYDSHDISR YVRAKFLDYT TDNVSMYPSP TGVMIGIDLA YNMYDAYGNW FNGLKPLIQN SMRTIMKANP ALYVLRERIR KGLQIYQSSV QEPFLNSSNY AELFNNDIKL FVDDTNVYRV TVHKTFEGNV ATKAINGCIF TLNPKTGHLF LKIIHTSVWA GQKRLSQLAK WKTAEEVSAL VRSLPKEEQP KQIIVTRKAM LDPLEVHMLD FPNIAIRPTE LRLPFSAAMS IDKLSDVVMK ATEPQMVLFN IYDDWLDRIS SYTAFSRLTL LLRALKTNEE SAKMILLSDP TITIKSYHLW PSFTDEQWIT IESQMRDLIL TEYGRKYNVN ISALTQTEIK DIILGQNIKA PSVKRQKMAE LEAARSEKQN DEEAAGASTV MKTKTINAQG EEIVVVASAD YESQTFSSKN EWRKSAIANT LLYLRLKNIY VSADDFVEEQ NVYVLPKNLL KKFIEISDVK IQVAAFIYGM SAKDHPKVKE IKTVVLVPQL GHVGSVQISN IPDIGDLPDT EGLELLGWIH TQTEELKFMA ASEVATHSKL FADKKRDCID ISIFSTPGSV SLSAYNLTDE GYQWGEENKD IMNVLSEGFE PTFSTHAQLL LSDRITGNFI IPSGNVWNYT FMGTAFNQEG DYNFKYGIPL EFYNEMHRPV HFLQFSELAG DEELEAEQID VFS //