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Protein

Serine/threonine-protein phosphatase PP-Z2

Gene

PPZ2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the maintenance of cell size and integrity in response to osmotic stress.

Miscellaneous

Present with 189 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi454Manganese 1By similarity1
Metal bindingi456Manganese 1By similarity1
Metal bindingi482Manganese 1By similarity1
Metal bindingi482Manganese 2By similarity1
Metal bindingi514Manganese 2By similarity1
Active sitei515Proton donorBy similarity1
Metal bindingi563Manganese 2By similarity1
Metal bindingi638Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular sodium ion homeostasis Source: SGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:YDR436W-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP-Z2 (EC:3.1.3.16)
Gene namesi
Name:PPZ2
Ordered Locus Names:YDR436W
ORF Names:D9461.22
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR436W
SGDiS000002844 PPZ2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00000588922 – 710Serine/threonine-protein phosphatase PP-Z2Add BLAST709

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1
Modified residuei55PhosphoserineBy similarity1
Modified residuei71PhosphoserineCombined sources1
Modified residuei161PhosphothreonineBy similarity1
Modified residuei203PhosphoserineCombined sources1
Modified residuei224PhosphoserineCombined sources1
Modified residuei271PhosphothreonineBy similarity1
Modified residuei275PhosphoserineBy similarity1
Modified residuei310PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiP33329
PaxDbiP33329
PRIDEiP33329

PTM databases

iPTMnetiP33329

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CAB3P360764EBI-13815,EBI-26778

Protein-protein interaction databases

BioGridi32492, 79 interactors
DIPiDIP-6355N
IntActiP33329, 15 interactors
MINTiP33329
STRINGi4932.YDR436W

Structurei

3D structure databases

ProteinModelPortaliP33329
SMRiP33329
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi346 – 353Poly-Ser8

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-Z subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00910000145027
HOGENOMiHOG000172697
InParanoidiP33329
KOiK06269
OMAiHYLTSHP
OrthoDBiEOG092C37EX

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR011159 PPPtase_PPZ/Ppq1
IPR006186 Ser/Thr-sp_prot-phosphatase
IPR031675 STPPase_N
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF16891 STPPase_N, 1 hit
PIRSFiPIRSF000909 PPPtase_PPZ, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33329-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNSGSKQHT KHNSKKDDHD GDRKKTLDLP PLTKSDTTHS LKSSRSLRSL
60 70 80 90 100
RSKRSEASLA SNVQAQTQPL SRRSSTLGNG NRNHRRSNNA PITPPNNHYL
110 120 130 140 150
TSHPSSSRRL SSSSRRSSMG NNNNSELPPS MIQMEPKSPI LKNSTSMHST
160 170 180 190 200
SSFNSYENAL TDDDDDRGDD GGESPSMAKV TRINTSSSAD RGSKRTPLRR
210 220 230 240 250
HNSLQPEKGV TGFSSTSSKL RRRSDNTLPA SYPLNAEAGG NGSDYFSNRS
260 270 280 290 300
NSHASSRKSS FGSTGNTAYS TPLHSPALRK MSSRDNDDSG DNVNGRGTSP
310 320 330 340 350
IPNLNIDKPS PSASSASKRE YLSAYPTLAH RDSSSSLSPR GKGQRSSSSS
360 370 380 390 400
SSSQRIYVSP PSPTGDFVHG SCADGDNGSR TNTMVEMKRK KPVRPVDIDE
410 420 430 440 450
IIQRLLDAGY AAKRTKNVCL KNSEIIQICH KARELFLAQP ALLELSPSVK
460 470 480 490 500
IVGDVHGQYA DLLRLFTKCG FPPMANYLFL GDYVDRGKQS LETILLLLCY
510 520 530 540 550
KIKYPENFFL LRGNHECANV TRVYGFYDEC KRRCNIKIWK TFVDTFNTLP
560 570 580 590 600
LAAIVTGKIF CVHGGLSPVL NSMDEIRHVS RPTDVPDFGL INDLLWSDPT
610 620 630 640 650
DSSNEWEDNE RGVSFCYNKV AINKFLNKFG FDLVCRAHMV VEDGYEFFND
660 670 680 690 700
RSLVTVFSAP NYCGEFDNWG AVMTVSEGLL CSFELLDPLD STALKQVMKK
710
GRQERKLANR
Length:710
Mass (Da):78,492
Last modified:January 23, 2007 - v4
Checksum:i3095F37046489AFB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti231S → T in AAA34899 (PubMed:8395014).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74136 Genomic DNA Translation: CAA52233.1
L10241 Genomic DNA Translation: AAA34899.1
U33007 Genomic DNA Translation: AAB64859.1
BK006938 Genomic DNA Translation: DAA12273.1
PIRiS35674
RefSeqiNP_010724.1, NM_001180744.1

Genome annotation databases

EnsemblFungiiYDR436W; YDR436W; YDR436W
GeneIDi852046
KEGGisce:YDR436W

Similar proteinsi

Entry informationi

Entry nameiPPZ2_YEAST
AccessioniPrimary (citable) accession number: P33329
Secondary accession number(s): D6VT63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 178 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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