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Protein

Synaptobrevin homolog 2

Gene

SNC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SNC1 and SNC2 are vesicle-targeting proteins essential for normal secretory traffic between the Golgi and the plasma membrane. They may also be involved in vesicle fusion.

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • SNAP receptor activity Source: SGD
  • SNARE binding Source: GO_Central

GO - Biological processi

  • endocytosis Source: SGD
  • exocytosis Source: SGD
  • Golgi to plasma membrane transport Source: SGD
  • vesicle fusion Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-33804-MONOMER
ReactomeiR-SCE-6798695 Neutrophil degranulation
R-SCE-8856825 Cargo recognition for clathrin-mediated endocytosis

Protein family/group databases

TCDBi1.F.1.1.2 the synaptosomal vesicle fusion pore (svf-pore) family

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptobrevin homolog 2
Gene namesi
Name:SNC2
Ordered Locus Names:YOR327C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YOR327C
SGDiS000005854 SNC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 93CytoplasmicSequence analysisAdd BLAST93
Transmembranei94 – 112Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST19
Topological domaini113 – 115VesicularSequence analysis3

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002067451 – 115Synaptobrevin homolog 2Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphoserineCombined sources1
Cross-linki62Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Lipidationi94S-palmitoyl cysteine1 Publication1

Post-translational modificationi

Palmitoylated by SWF1.2 Publications

Keywords - PTMi

Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP33328
PaxDbiP33328
PRIDEiP33328
TopDownProteomicsiP33328

PTM databases

iPTMnetiP33328
SwissPalmiP33328

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SSO1P328672EBI-17512,EBI-2206525

GO - Molecular functioni

  • SNAP receptor activity Source: SGD
  • SNARE binding Source: GO_Central

Protein-protein interaction databases

BioGridi34712, 297 interactors
DIPiDIP-4667N
IntActiP33328, 12 interactors
MINTiP33328
STRINGi4932.YOR327C

Structurei

3D structure databases

ProteinModelPortaliP33328
SMRiP33328
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 87v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074449
HOGENOMiHOG000042711
InParanoidiP33328
KOiK08513
OMAiVPYDPYI
OrthoDBiEOG092C4MCV

Family and domain databases

InterProiView protein in InterPro
IPR001388 Synaptobrevin
IPR016444 Synaptobrevin/VAMP
PfamiView protein in Pfam
PF00957 Synaptobrevin, 1 hit
PIRSFiPIRSF005409 Synaptobrevin_euk, 1 hit
PRINTSiPR00219 SYNAPTOBREVN
PROSITEiView protein in PROSITE
PS00417 SYNAPTOBREVIN, 1 hit
PS50892 V_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

P33328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSVPYDPY VPPEESNSGA NPNSQNKTAA LRQEIDDTVG IMRDNINKVA
60 70 80 90 100
ERGERLTSIE DKADNLAISA QGFKRGANRV RKQMWWKDLK MRMCLFLVVI
110
ILLVVIIVPI VVHFS
Length:115
Mass (Da):12,957
Last modified:October 1, 1996 - v2
Checksum:i815F027FAD8A599B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115S → T in AAA19816 (PubMed:8374953).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16243 Unassigned DNA Translation: AAA19816.1
Z49821 Genomic DNA Translation: CAA89974.1
Z75235 Genomic DNA Translation: CAA99647.1
BK006948 Genomic DNA Translation: DAA11090.1
PIRiS62059
RefSeqiNP_014972.3, NM_001183747.3

Genome annotation databases

EnsemblFungiiYOR327C; YOR327C; YOR327C
GeneIDi854505
KEGGisce:YOR327C

Entry informationi

Entry nameiSNC2_YEAST
AccessioniPrimary (citable) accession number: P33328
Secondary accession number(s): D6W324
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

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