Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Synaptobrevin homolog 2

Gene

SNC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SNC1 and SNC2 are vesicle-targeting proteins essential for normal secretory traffic between the Golgi and the plasma membrane. They may also be involved in vesicle fusion.

GO - Molecular functioni

  • SNAP receptor activity Source: SGD
  • SNARE binding Source: GO_Central

GO - Biological processi

  • endocytosis Source: SGD
  • exocytosis Source: SGD
  • Golgi to plasma membrane transport Source: SGD
  • vesicle fusion Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33804-MONOMER.
ReactomeiR-SCE-6811440. Retrograde transport at the Trans-Golgi-Network.

Protein family/group databases

TCDBi1.F.1.1.2. the synaptosomal vesicle fusion pore (svf-pore) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptobrevin homolog 2
Gene namesi
Name:SNC2
Ordered Locus Names:YOR327C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR327C.
SGDiS000005854. SNC2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9393CytoplasmicSequence analysisAdd
BLAST
Transmembranei94 – 11219Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini113 – 1153VesicularSequence analysis

GO - Cellular componenti

  • endosome Source: SGD
  • integral component of membrane Source: UniProtKB-KW
  • SNARE complex Source: SGD
  • trans-Golgi network Source: SGD
  • transport vesicle membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 115115Synaptobrevin homolog 2PRO_0000206745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581PhosphoserineCombined sources
Cross-linki62 – 62Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources1 Publication
Lipidationi94 – 941S-palmitoyl cysteineCurated

Post-translational modificationi

Palmitoylated by SWF1.2 Publications

Keywords - PTMi

Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP33328.
TopDownProteomicsiP33328.

PTM databases

iPTMnetiP33328.
SwissPalmiP33328.

Interactioni

GO - Molecular functioni

  • SNAP receptor activity Source: SGD
  • SNARE binding Source: GO_Central

Protein-protein interaction databases

BioGridi34712. 133 interactions.
DIPiDIP-4667N.
IntActiP33328. 10 interactions.
MINTiMINT-477413.

Structurei

3D structure databases

ProteinModelPortaliP33328.
SMRiP33328. Positions 28-85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 8761v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074449.
HOGENOMiHOG000042711.
InParanoidiP33328.
KOiK08513.
OMAiYWWQNAR.
OrthoDBiEOG092C4MCV.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
InterProiIPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP.
[Graphical view]
PfamiPF00957. Synaptobrevin. 1 hit.
[Graphical view]
PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSVPYDPY VPPEESNSGA NPNSQNKTAA LRQEIDDTVG IMRDNINKVA
60 70 80 90 100
ERGERLTSIE DKADNLAISA QGFKRGANRV RKQMWWKDLK MRMCLFLVVI
110
ILLVVIIVPI VVHFS
Length:115
Mass (Da):12,957
Last modified:October 1, 1996 - v2
Checksum:i815F027FAD8A599B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti115 – 1151S → T in AAA19816 (PubMed:8374953).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16243 Unassigned DNA. Translation: AAA19816.1.
Z49821 Genomic DNA. Translation: CAA89974.1.
Z75235 Genomic DNA. Translation: CAA99647.1.
BK006948 Genomic DNA. Translation: DAA11090.1.
PIRiS62059.
RefSeqiNP_014972.3. NM_001183747.3.

Genome annotation databases

EnsemblFungiiYOR327C; YOR327C; YOR327C.
GeneIDi854505.
KEGGisce:YOR327C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16243 Unassigned DNA. Translation: AAA19816.1.
Z49821 Genomic DNA. Translation: CAA89974.1.
Z75235 Genomic DNA. Translation: CAA99647.1.
BK006948 Genomic DNA. Translation: DAA11090.1.
PIRiS62059.
RefSeqiNP_014972.3. NM_001183747.3.

3D structure databases

ProteinModelPortaliP33328.
SMRiP33328. Positions 28-85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34712. 133 interactions.
DIPiDIP-4667N.
IntActiP33328. 10 interactions.
MINTiMINT-477413.

Protein family/group databases

TCDBi1.F.1.1.2. the synaptosomal vesicle fusion pore (svf-pore) family.

PTM databases

iPTMnetiP33328.
SwissPalmiP33328.

Proteomic databases

MaxQBiP33328.
TopDownProteomicsiP33328.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR327C; YOR327C; YOR327C.
GeneIDi854505.
KEGGisce:YOR327C.

Organism-specific databases

EuPathDBiFungiDB:YOR327C.
SGDiS000005854. SNC2.

Phylogenomic databases

GeneTreeiENSGT00550000074449.
HOGENOMiHOG000042711.
InParanoidiP33328.
KOiK08513.
OMAiYWWQNAR.
OrthoDBiEOG092C4MCV.

Enzyme and pathway databases

BioCyciYEAST:G3O-33804-MONOMER.
ReactomeiR-SCE-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

PROiP33328.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
InterProiIPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP.
[Graphical view]
PfamiPF00957. Synaptobrevin. 1 hit.
[Graphical view]
PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNC2_YEAST
AccessioniPrimary (citable) accession number: P33328
Secondary accession number(s): D6W324
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.