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Protein

ATP-dependent permease MDL2, mitochondrial

Gene

MDL2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi481 – 488ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34152-MONOMER.
ReactomeiR-SCE-382556. ABC-family proteins mediated transport.
R-SCE-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Protein family/group databases

TCDBi3.A.1.212.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent permease MDL2, mitochondrial
Alternative name(s):
Multidrug resistance-like protein 2
Gene namesi
Name:MDL2
Synonyms:SSH1
Ordered Locus Names:YPL270W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL270W.
SGDiS000006191. MDL2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei123 – 143HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei170 – 192HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei257 – 277HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 90MitochondrionSequence analysisAdd BLAST90
ChainiPRO_000004533191 – 773ATP-dependent permease MDL2, mitochondrialAdd BLAST683

Proteomic databases

MaxQBiP33311.
PRIDEiP33311.

Interactioni

Protein-protein interaction databases

BioGridi35943. 71 interactors.
DIPiDIP-4226N.
IntActiP33311. 1 interactor.
MINTiMINT-509434.

Structurei

3D structure databases

ProteinModelPortaliP33311.
SMRiP33311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 413ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST295
Domaini493 – 733ABC transporterPROSITE-ProRule annotationAdd BLAST241

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074497.
InParanoidiP33311.
KOiK02021.
OMAiAIMENRT.
OrthoDBiEOG092C3H79.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013305. ABC_Tap-like.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030279. Mdl1/Mdl2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24221:SF198. PTHR24221:SF198. 2 hits.
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR00958. 3a01208. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33311-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNGRLPLLR LGICRNMLSR PRLAKLPSIR FRSLVTPSSS QLIPLSRLCL
60 70 80 90 100
RSPAVGKSLI LQSFRCNSSK TVPETSLPSA SPISKGSARS AHAKEQSKTD
110 120 130 140 150
DYKDIIRLFM LAKRDWKLLL TAILLLTISC SIGMSIPKVI GIVLDTLKTS
160 170 180 190 200
SGSDFFDLKI PIFSLPLYEF LSFFTVALLI GCAANFGRFI LLRILSERVV
210 220 230 240 250
ARLRANVIKK TLHQDAEFFD NHKVGDLISR LGSDAYVVSR SMTQKVSDGV
260 270 280 290 300
KALICGVVGV GMMCSLSPQL SILLLFFTPP VLFSASVFGK QIRNTSKDLQ
310 320 330 340 350
EATGQLTRVA EEQLSGIKTV QSFVAEGNEL SRYNVAIRDI FQVGKTAAFT
360 370 380 390 400
NAKFFTTTSL LGDLSFLTVL AYGSYLVLQS QLSIGDLTAF MLYTEYTGNA
410 420 430 440 450
VFGLSTFYSE IMQGAGAASR LFELTDRKPS ISPTVGHKYK PDRGVIEFKD
460 470 480 490 500
VSFSYPTRPS VQIFKNLNFK IAPGSSVCIV GPSGRGKSTI ALLLLRYYNP
510 520 530 540 550
TTGTITIDNQ DISKLNCKSL RRHIGIVQQE PVLMSGTIRD NITYGLTYTP
560 570 580 590 600
TKEEIRSVAK QCFCHNFITK FPNTYDTVIG PHGTLLSGGQ KQRIAIARAL
610 620 630 640 650
IKKPTILILD EATSALDVES EGAINYTFGQ LMKSKSMTIV SIAHRLSTIR
660 670 680 690 700
RSENVIVLGH DGSVVEMGKF KELYANPTSA LSQLLNEKAA PGPSDQQLQI
710 720 730 740 750
EKVIEKEDLN ESKEHDDQKK DDNDDNDNNH DNDSNNQSPE TKDNNSDDIE
760 770
KSVEHLLKDA AKEANPIKIT PQP
Length:773
Mass (Da):85,137
Last modified:December 20, 2005 - v3
Checksum:i58B1DF92D60E1E58
GO

Sequence cautioni

The sequence AAA20682 differs from that shown. Reason: Frameshift at position 754.Curated
The sequence AAT93160 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA98006 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56G → A in AAA20682 (PubMed:7912468).Curated1
Sequence conflicti265S → C in AAA20682 (PubMed:7912468).Curated1
Sequence conflicti752S → C in AAA20682 (PubMed:7912468).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16959 Genomic DNA. Translation: AAA20682.1. Frameshift.
Z73626 Genomic DNA. Translation: CAA98006.1. Different initiation.
AY693141 Genomic DNA. Translation: AAT93160.1. Different initiation.
BK006949 Genomic DNA. Translation: DAA11166.1.
PIRiS65303.
RefSeqiNP_015053.2. NM_001184084.1.

Genome annotation databases

EnsemblFungiiYPL270W; YPL270W; YPL270W.
GeneIDi855858.
KEGGisce:YPL270W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16959 Genomic DNA. Translation: AAA20682.1. Frameshift.
Z73626 Genomic DNA. Translation: CAA98006.1. Different initiation.
AY693141 Genomic DNA. Translation: AAT93160.1. Different initiation.
BK006949 Genomic DNA. Translation: DAA11166.1.
PIRiS65303.
RefSeqiNP_015053.2. NM_001184084.1.

3D structure databases

ProteinModelPortaliP33311.
SMRiP33311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35943. 71 interactors.
DIPiDIP-4226N.
IntActiP33311. 1 interactor.
MINTiMINT-509434.

Protein family/group databases

TCDBi3.A.1.212.2. the atp-binding cassette (abc) superfamily.

Proteomic databases

MaxQBiP33311.
PRIDEiP33311.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL270W; YPL270W; YPL270W.
GeneIDi855858.
KEGGisce:YPL270W.

Organism-specific databases

EuPathDBiFungiDB:YPL270W.
SGDiS000006191. MDL2.

Phylogenomic databases

GeneTreeiENSGT00550000074497.
InParanoidiP33311.
KOiK02021.
OMAiAIMENRT.
OrthoDBiEOG092C3H79.

Enzyme and pathway databases

BioCyciYEAST:G3O-34152-MONOMER.
ReactomeiR-SCE-382556. ABC-family proteins mediated transport.
R-SCE-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

PROiP33311.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013305. ABC_Tap-like.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030279. Mdl1/Mdl2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24221:SF198. PTHR24221:SF198. 2 hits.
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR00958. 3a01208. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDL2_YEAST
AccessioniPrimary (citable) accession number: P33311
Secondary accession number(s): D6W3A0, Q08983
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 20, 2005
Last modified: November 2, 2016
This is version 155 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3390 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.