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Protein

ATP-dependent permease MDL2, mitochondrial

Gene

MDL2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 3390 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi481 – 488ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34152-MONOMER
ReactomeiR-SCE-1369007 Mitochondrial ABC transporters
R-SCE-382556 ABC-family proteins mediated transport
R-SCE-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Protein family/group databases

TCDBi3.A.1.212.2 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent permease MDL2, mitochondrial
Alternative name(s):
Multidrug resistance-like protein 2
Gene namesi
Name:MDL2
Synonyms:SSH1
Ordered Locus Names:YPL270W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL270W
SGDiS000006191 MDL2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei123 – 143HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei170 – 192HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei257 – 277HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 90MitochondrionSequence analysisAdd BLAST90
ChainiPRO_000004533191 – 773ATP-dependent permease MDL2, mitochondrialAdd BLAST683

Proteomic databases

MaxQBiP33311
PaxDbiP33311
PRIDEiP33311

Interactioni

Protein-protein interaction databases

BioGridi35943, 267 interactors
DIPiDIP-4226N
IntActiP33311, 5 interactors
MINTiP33311
STRINGi4932.YPL270W

Structurei

3D structure databases

ProteinModelPortaliP33311
SMRiP33311
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 413ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST295
Domaini493 – 733ABC transporterPROSITE-ProRule annotationAdd BLAST241

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074497
InParanoidiP33311
KOiK02021
OMAiKSAWKSQ
OrthoDBiEOG092C3H79

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR013305 ABC_Tap-like
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030279 Mdl1/Mdl2
IPR027417 P-loop_NTPase
PANTHERiPTHR43394:SF2 PTHR43394:SF2, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR00958 3a01208, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33311-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNGRLPLLR LGICRNMLSR PRLAKLPSIR FRSLVTPSSS QLIPLSRLCL
60 70 80 90 100
RSPAVGKSLI LQSFRCNSSK TVPETSLPSA SPISKGSARS AHAKEQSKTD
110 120 130 140 150
DYKDIIRLFM LAKRDWKLLL TAILLLTISC SIGMSIPKVI GIVLDTLKTS
160 170 180 190 200
SGSDFFDLKI PIFSLPLYEF LSFFTVALLI GCAANFGRFI LLRILSERVV
210 220 230 240 250
ARLRANVIKK TLHQDAEFFD NHKVGDLISR LGSDAYVVSR SMTQKVSDGV
260 270 280 290 300
KALICGVVGV GMMCSLSPQL SILLLFFTPP VLFSASVFGK QIRNTSKDLQ
310 320 330 340 350
EATGQLTRVA EEQLSGIKTV QSFVAEGNEL SRYNVAIRDI FQVGKTAAFT
360 370 380 390 400
NAKFFTTTSL LGDLSFLTVL AYGSYLVLQS QLSIGDLTAF MLYTEYTGNA
410 420 430 440 450
VFGLSTFYSE IMQGAGAASR LFELTDRKPS ISPTVGHKYK PDRGVIEFKD
460 470 480 490 500
VSFSYPTRPS VQIFKNLNFK IAPGSSVCIV GPSGRGKSTI ALLLLRYYNP
510 520 530 540 550
TTGTITIDNQ DISKLNCKSL RRHIGIVQQE PVLMSGTIRD NITYGLTYTP
560 570 580 590 600
TKEEIRSVAK QCFCHNFITK FPNTYDTVIG PHGTLLSGGQ KQRIAIARAL
610 620 630 640 650
IKKPTILILD EATSALDVES EGAINYTFGQ LMKSKSMTIV SIAHRLSTIR
660 670 680 690 700
RSENVIVLGH DGSVVEMGKF KELYANPTSA LSQLLNEKAA PGPSDQQLQI
710 720 730 740 750
EKVIEKEDLN ESKEHDDQKK DDNDDNDNNH DNDSNNQSPE TKDNNSDDIE
760 770
KSVEHLLKDA AKEANPIKIT PQP
Length:773
Mass (Da):85,137
Last modified:December 20, 2005 - v3
Checksum:i58B1DF92D60E1E58
GO

Sequence cautioni

The sequence AAA20682 differs from that shown. Reason: Frameshift at position 754.Curated
The sequence AAT93160 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA98006 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56G → A in AAA20682 (PubMed:7912468).Curated1
Sequence conflicti265S → C in AAA20682 (PubMed:7912468).Curated1
Sequence conflicti752S → C in AAA20682 (PubMed:7912468).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16959 Genomic DNA Translation: AAA20682.1 Frameshift.
Z73626 Genomic DNA Translation: CAA98006.1 Different initiation.
AY693141 Genomic DNA Translation: AAT93160.1 Different initiation.
BK006949 Genomic DNA Translation: DAA11166.1
PIRiS65303
RefSeqiNP_015053.2, NM_001184084.1

Genome annotation databases

EnsemblFungiiYPL270W; YPL270W; YPL270W
GeneIDi855858
KEGGisce:YPL270W

Similar proteinsi

Entry informationi

Entry nameiMDL2_YEAST
AccessioniPrimary (citable) accession number: P33311
Secondary accession number(s): D6W3A0, Q08983
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health