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Protein

Importin alpha re-exporter

Gene

CSE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Export receptor for importin alpha (SRP1). Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm.4 Publications

GO - Molecular functioni

  • nuclear export signal receptor activity Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic nuclear division Source: UniProtKB-KW
  • protein export from nucleus Source: SGD
  • protein import into nucleus Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30711-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Importin alpha re-exporter
Alternative name(s):
Chromosome segregation protein CSE1
Gene namesi
Name:CSE1
Ordered Locus Names:YGL238W
ORF Names:HRC135
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL238W.
SGDiS000003207. CSE1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central
  • nuclear envelope Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001172931 – 960Importin alpha re-exporterAdd BLAST960

Proteomic databases

MaxQBiP33307.
PRIDEiP33307.

PTM databases

iPTMnetiP33307.

Interactioni

Subunit structurei

Binds with high affinity to SRP1 only in the presence of RanGTP. The complex is dissociated by the RanGTP-binding protein YRB1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SRP1Q028212EBI-5168,EBI-1797

Protein-protein interaction databases

BioGridi33001. 43 interactors.
DIPiDIP-1131N.
IntActiP33307. 22 interactors.
MINTiMINT-404965.

Structurei

Secondary structure

1960
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 13Combined sources11
Helixi17 – 19Combined sources3
Helixi20 – 31Combined sources12
Helixi36 – 45Combined sources10
Helixi51 – 68Combined sources18
Beta strandi72 – 74Combined sources3
Beta strandi76 – 78Combined sources3
Helixi80 – 96Combined sources17
Helixi99 – 116Combined sources18
Turni118 – 120Combined sources3
Helixi124 – 129Combined sources6
Helixi139 – 151Combined sources13
Helixi152 – 154Combined sources3
Helixi161 – 188Combined sources28
Helixi197 – 217Combined sources21
Helixi223 – 227Combined sources5
Helixi229 – 240Combined sources12
Helixi245 – 247Combined sources3
Beta strandi253 – 255Combined sources3
Helixi258 – 276Combined sources19
Helixi278 – 298Combined sources21
Helixi303 – 305Combined sources3
Helixi306 – 320Combined sources15
Helixi323 – 326Combined sources4
Helixi327 – 329Combined sources3
Helixi332 – 341Combined sources10
Helixi343 – 347Combined sources5
Helixi351 – 353Combined sources3
Turni354 – 359Combined sources6
Helixi361 – 370Combined sources10
Helixi377 – 391Combined sources15
Helixi393 – 412Combined sources20
Turni415 – 417Combined sources3
Helixi419 – 433Combined sources15
Beta strandi434 – 436Combined sources3
Helixi452 – 459Combined sources8
Helixi461 – 465Combined sources5
Helixi472 – 484Combined sources13
Helixi486 – 488Combined sources3
Helixi491 – 504Combined sources14
Helixi510 – 523Combined sources14
Beta strandi530 – 532Combined sources3
Beta strandi535 – 537Combined sources3
Helixi539 – 541Combined sources3
Turni542 – 545Combined sources4
Helixi546 – 558Combined sources13
Helixi564 – 567Combined sources4
Helixi571 – 584Combined sources14
Turni585 – 588Combined sources4
Helixi589 – 591Combined sources3
Helixi592 – 606Combined sources15
Helixi613 – 628Combined sources16
Helixi632 – 634Combined sources3
Helixi635 – 651Combined sources17
Turni655 – 657Combined sources3
Helixi658 – 671Combined sources14
Beta strandi672 – 674Combined sources3
Turni677 – 679Combined sources3
Helixi680 – 682Combined sources3
Helixi683 – 686Combined sources4
Helixi689 – 692Combined sources4
Turni695 – 697Combined sources3
Helixi698 – 712Combined sources15
Helixi713 – 715Combined sources3
Helixi720 – 730Combined sources11
Turni733 – 735Combined sources3
Helixi736 – 749Combined sources14
Helixi752 – 755Combined sources4
Helixi756 – 758Combined sources3
Helixi759 – 768Combined sources10
Helixi769 – 771Combined sources3
Helixi776 – 793Combined sources18
Helixi795 – 803Combined sources9
Helixi809 – 816Combined sources8
Helixi818 – 821Combined sources4
Helixi822 – 824Combined sources3
Helixi828 – 843Combined sources16
Helixi846 – 851Combined sources6
Helixi853 – 855Combined sources3
Helixi856 – 868Combined sources13
Helixi894 – 896Combined sources3
Helixi899 – 901Combined sources3
Turni914 – 916Combined sources3
Helixi917 – 932Combined sources16
Beta strandi934 – 936Combined sources3
Helixi937 – 941Combined sources5
Helixi942 – 944Combined sources3
Helixi947 – 957Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WA5X-ray2.00C1-960[»]
1Z3HX-ray3.10A/B1-960[»]
ProteinModelPortaliP33307.
SMRiP33307.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33307.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 33HEAT 1Add BLAST33
Domaini23 – 96Importin N-terminalPROSITE-ProRule annotationAdd BLAST74
Repeati34 – 73HEAT 2Add BLAST40
Repeati74 – 120HEAT 3Add BLAST47
Repeati121 – 157HEAT 4Add BLAST37
Repeati158 – 220HEAT 5Add BLAST63
Repeati221 – 278HEAT 6Add BLAST58
Repeati279 – 323HEAT 7Add BLAST45
Repeati324 – 392HEAT 8Add BLAST69
Repeati393 – 445HEAT 9Add BLAST53
Repeati446 – 489HEAT 10Add BLAST44
Repeati490 – 528HEAT 11Add BLAST39
Repeati529 – 586HEAT 12Add BLAST58
Repeati587 – 630HEAT 13Add BLAST44
Repeati631 – 674HEAT 14Add BLAST44
Repeati675 – 716HEAT 15Add BLAST42
Repeati717 – 751HEAT 16Add BLAST35
Repeati752 – 794HEAT 17Add BLAST43
Repeati795 – 826HEAT 18Add BLAST32
Repeati827 – 928HEAT 19; with insertAdd BLAST102
Repeati929 – 960HEAT 20Add BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi366 – 381Nuclear localization signalSequence analysisAdd BLAST16

Sequence similaritiesi

Belongs to the XPO2/CSE1 family.Curated
Contains 20 HEAT repeats.Curated
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00550000074884.
HOGENOMiHOG000201317.
InParanoidiP33307.
KOiK18423.
OMAiKYINHYL.
OrthoDBiEOG092C0P3I.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR005043. CAS_CSE1_C.
IPR013713. Cse1.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03378. CAS_CSE1. 1 hit.
PF08506. Cse1. 1 hit.
PF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33307-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLETVAKF LAESVIASTA KTSERNLRQL ETQDGFGLTL LHVIASTNLP
60 70 80 90 100
LSTRLAGALF FKNFIKRKWV DENGNHLLPA NNVELIKKEI VPLMISLPNN
110 120 130 140 150
LQVQIGEAIS SIADSDFPDR WPTLLSDLAS RLSNDDMVTN KGVLTVAHSI
160 170 180 190 200
FKRWRPLFRS DELFLEIKLV LDVFTAPFLN LLKTVDEQIT ANENNKASLN
210 220 230 240 250
ILFDVLLVLI KLYYDFNCQD IPEFFEDNIQ VGMGIFHKYL SYSNPLLEDP
260 270 280 290 300
DETEHASVLI KVKSSIQELV QLYTTRYEDV FGPMINEFIQ ITWNLLTSIS
310 320 330 340 350
NQPKYDILVS KSLSFLTAVT RIPKYFEIFN NESAMNNITE QIILPNVTLR
360 370 380 390 400
EEDVELFEDD PIEYIRRDLE GSDTDTRRRA CTDFLKELKE KNEVLVTNIF
410 420 430 440 450
LAHMKGFVDQ YMSDPSKNWK FKDLYIYLFT ALAINGNITN AGVSSTNNLL
460 470 480 490 500
NVVDFFTKEI APDLTSNNIP HIILRVDAIK YIYTFRNQLT KAQLIELMPI
510 520 530 540 550
LATFLQTDEY VVYTYAAITI EKILTIRESN TSPAFIFHKE DISNSTEILL
560 570 580 590 600
KNLIALILKH GSSPEKLAEN EFLMRSIFRV LQTSEDSIQP LFPQLLAQFI
610 620 630 640 650
EIVTIMAKNP SNPRFTHYTF ESIGAILNYT QRQNLPLLVD SMMPTFLTVF
660 670 680 690 700
SEDIQEFIPY VFQIIAFVVE QSATIPESIK PLAQPLLAPN VWELKGNIPA
710 720 730 740 750
VTRLLKSFIK TDSSIFPDLV PVLGIFQRLI ASKAYEVHGF DLLEHIMLLI
760 770 780 790 800
DMNRLRPYIK QIAVLLLQRL QNSKTERYVK KLTVFFGLIS NKLGSDFLIH
810 820 830 840 850
FIDEVQDGLF QQIWGNFIIT TLPTIGNLLD RKIALIGVLN MVINGQFFQS
860 870 880 890 900
KYPTLISSTM NSIIETASSQ SIANLKNDYV DLDNLEEIST FGSHFSKLVS
910 920 930 940 950
ISEKPFDPLP EIDVNNGVRL YVAEALNKYN AISGNTFLNT ILPQLTQENQ
960
VKLNQLLVGN
Length:960
Mass (Da):109,356
Last modified:October 1, 1996 - v2
Checksum:i0A32D221DFC2C483
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti515Y → D in AAA34531 (PubMed:8336709).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14838 Genomic DNA. Translation: AAA34531.1.
Z72761 Genomic DNA. Translation: CAA96957.1.
Z49149 Genomic DNA. Translation: CAA89018.1.
BK006941 Genomic DNA. Translation: DAA07880.1.
PIRiA48083.
RefSeqiNP_011276.1. NM_001181104.1.

Genome annotation databases

EnsemblFungiiYGL238W; YGL238W; YGL238W.
GeneIDi852612.
KEGGisce:YGL238W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14838 Genomic DNA. Translation: AAA34531.1.
Z72761 Genomic DNA. Translation: CAA96957.1.
Z49149 Genomic DNA. Translation: CAA89018.1.
BK006941 Genomic DNA. Translation: DAA07880.1.
PIRiA48083.
RefSeqiNP_011276.1. NM_001181104.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WA5X-ray2.00C1-960[»]
1Z3HX-ray3.10A/B1-960[»]
ProteinModelPortaliP33307.
SMRiP33307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33001. 43 interactors.
DIPiDIP-1131N.
IntActiP33307. 22 interactors.
MINTiMINT-404965.

PTM databases

iPTMnetiP33307.

Proteomic databases

MaxQBiP33307.
PRIDEiP33307.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL238W; YGL238W; YGL238W.
GeneIDi852612.
KEGGisce:YGL238W.

Organism-specific databases

EuPathDBiFungiDB:YGL238W.
SGDiS000003207. CSE1.

Phylogenomic databases

GeneTreeiENSGT00550000074884.
HOGENOMiHOG000201317.
InParanoidiP33307.
KOiK18423.
OMAiKYINHYL.
OrthoDBiEOG092C0P3I.

Enzyme and pathway databases

BioCyciYEAST:G3O-30711-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP33307.
PROiP33307.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR005043. CAS_CSE1_C.
IPR013713. Cse1.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03378. CAS_CSE1. 1 hit.
PF08506. Cse1. 1 hit.
PF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSE1_YEAST
AccessioniPrimary (citable) accession number: P33307
Secondary accession number(s): D6VV96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 23500 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.