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Protein

Protein BCK2

Gene

BCK2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Dosage dependent suppressor of PKC1 deletion and MPK1 deletion. Involved in cell lysis.

GO - Biological processi

  • G1/S transition of mitotic cell cycle Source: SGD
  • positive regulation of gene expression Source: SGD
  • regulation of cell cycle Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30328-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BCK2
Alternative name(s):
Bypass of kinase C protein
Gene namesi
Name:BCK2
Synonyms:CTR7
Ordered Locus Names:YER167W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome V

Organism-specific databases

CYGDiYER167w.
EuPathDBiFungiDB:YER167W.
SGDiS000000969. BCK2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 851851Protein BCK2PRO_0000064883Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei334 – 3341Phosphoserine1 Publication
Modified residuei757 – 7571Phosphoserine2 Publications
Modified residuei761 – 7611Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP33306.
PaxDbiP33306.
PeptideAtlasiP33306.
PRIDEiP33306.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FUS3P168922EBI-3480,EBI-7193
KEL1P388532EBI-3480,EBI-9619
KIN2P131864EBI-3480,EBI-9723
KSS1P146814EBI-3480,EBI-9945

Protein-protein interaction databases

BioGridi36920. 92 interactions.
DIPiDIP-6406N.
IntActiP33306. 14 interactions.
MINTiMINT-4484608.

Structurei

3D structure databases

ProteinModelPortaliP33306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG44363.
InParanoidiP33306.
OMAiAFSKMFT.
OrthoDBiEOG7ZSJ2D.

Sequencei

Sequence statusi: Complete.

P33306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKNSHHHRS SSVNSTKSRS TESTNKWKIP HYYRRSASGS TQASPDRNSS
60 70 80 90 100
TGSCSTPVLP TMNVMSSPKK VLLEDPRDNH TKAKKSSRKK SGEMVFVNYT
110 120 130 140 150
VQDTANENDT DLQTQPVSVP APKAKLKKKS SKRRMLKIFG SSKNEHIEDI
160 170 180 190 200
VEEQPMVLQM DSESKPLSGT PISESGIDAS SLTTKRSYNS FLKHNRLNGK
210 220 230 240 250
TPFSGNLSFP SLNMMGNTTD LPIDNNDFCS EKEVVPKSTH DPSLAKPPSR
260 270 280 290 300
FTESETNSTP NLSSIPLMNT KNTRLKYNKV APQSSDRQKS QESGLYHSTE
310 320 330 340 350
SFNFKDQNYS NNKSSLSLNS DLSTPHFAKH SPDSPRTSRS FNCGDSQSKV
360 370 380 390 400
KLPEENDASI AFSKMFTRKR ANTGGSTCSL ASPTIAQTIQ QSNIKVNKLP
410 420 430 440 450
TQRTTSVGSL SSMSNRYSPI RVASPGRARS ATRGSSLYRL SRDLNSLPSV
460 470 480 490 500
TDLPEMDSTT PVNEIFLDGQ PQHKSGSVKG GHRKKQESIS DAQRIQHSNS
510 520 530 540 550
YITTPSSSLV TPPYYMTGYT LPSSASASST PNVLETHNMN FVPSTSTVTS
560 570 580 590 600
YRPSSNFSSF DKEYSNENDA SGEFSAFNTP MENIPALKGI PRSTLEENEE
610 620 630 640 650
EDVLVQDIPN TAHFQRRDIM GMDTHRKDDS LDFNSLMPHG STTSSSIVDS
660 670 680 690 700
VMTNSISTTT SNATGNYFQD QDKYTLVNTG LGLSDANLDH FIRSQWKHAS
710 720 730 740 750
RSESNNNTGN RVSYSGSTPN NVDTTKTNLQ VYTEFDFENP ESFFHEQSKL
760 770 780 790 800
LGEMGHSNNN SNSAINMNEP KSADTYIGNI SPDTSATVSL GDLMGSNVSN
810 820 830 840 850
NSERNFYDGH TFVPQYQANS SVENSNNQNA APIANNDIDN NLQSFYFDNS

N
Length:851
Mass (Da):93,738
Last modified:February 1, 1995 - v2
Checksum:i9F824F2701FC452D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 52NS → HC in AAA34452 (PubMed:8395014).Curated
Sequence conflicti100 – 1001T → A in AAA34452 (PubMed:8395014).Curated
Sequence conflicti167 – 1671L → F in AAA34452 (PubMed:8395014).Curated
Sequence conflicti812 – 8121F → C in AAA34452 (PubMed:8395014).Curated
Sequence conflicti827 – 8271N → K in AAA34452 (PubMed:8395014).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10242 Genomic DNA. Translation: AAA34452.1.
U18922 Genomic DNA. Translation: AAB64694.1.
BK006939 Genomic DNA. Translation: DAA07829.1.
PIRiS50670.
RefSeqiNP_011094.3. NM_001179057.3.

Genome annotation databases

EnsemblFungiiYER167W; YER167W; YER167W.
GeneIDi856914.
KEGGisce:YER167W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10242 Genomic DNA. Translation: AAA34452.1.
U18922 Genomic DNA. Translation: AAB64694.1.
BK006939 Genomic DNA. Translation: DAA07829.1.
PIRiS50670.
RefSeqiNP_011094.3. NM_001179057.3.

3D structure databases

ProteinModelPortaliP33306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36920. 92 interactions.
DIPiDIP-6406N.
IntActiP33306. 14 interactions.
MINTiMINT-4484608.

Proteomic databases

MaxQBiP33306.
PaxDbiP33306.
PeptideAtlasiP33306.
PRIDEiP33306.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER167W; YER167W; YER167W.
GeneIDi856914.
KEGGisce:YER167W.

Organism-specific databases

CYGDiYER167w.
EuPathDBiFungiDB:YER167W.
SGDiS000000969. BCK2.

Phylogenomic databases

eggNOGiNOG44363.
InParanoidiP33306.
OMAiAFSKMFT.
OrthoDBiEOG7ZSJ2D.

Enzyme and pathway databases

BioCyciYEAST:G3O-30328-MONOMER.

Miscellaneous databases

NextBioi983362.
PROiP33306.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathway."
    Lee K.S., Hines L.K., Levin D.E.
    Mol. Cell. Biol. 13:5843-5853(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-757, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-757 AND SER-761, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBCK2_YEAST
AccessioniPrimary (citable) accession number: P33306
Secondary accession number(s): D3DM75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: July 22, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.