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P33304

- AFR1_YEAST

UniProt

P33304 - AFR1_YEAST

Protein

Protein AFR1

Gene

AFR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Acts in conjunction with the alpha-factor receptor to promote morphogenesis and adaptation.

    GO - Molecular functioni

    1. receptor signaling protein activity Source: SGD

    GO - Biological processi

    1. cell morphogenesis involved in conjugation Source: SGD
    2. cell morphogenesis involved in conjugation with cellular fusion Source: SGD
    3. intracellular signal transduction Source: GOC
    4. pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: SGD
    5. regulation of G-protein coupled receptor protein signaling pathway Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29690-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein AFR1
    Gene namesi
    Name:AFR1
    Ordered Locus Names:YDR085C
    ORF Names:D4471
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDR085c.
    SGDiS000002492. AFR1.

    Subcellular locationi

    GO - Cellular componenti

    1. mating projection base Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 620620Protein AFR1PRO_0000064485Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei472 – 4721Phosphoserine1 Publication
    Modified residuei526 – 5261Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP33304.

    Expressioni

    Inductioni

    By pheromone (alpha-factor).

    Gene expression databases

    GenevestigatoriP33304.

    Interactioni

    Protein-protein interaction databases

    BioGridi32141. 19 interactions.
    DIPiDIP-824N.
    IntActiP33304. 6 interactions.
    MINTiMINT-599820.
    STRINGi4932.YDR085C.

    Structurei

    3D structure databases

    ProteinModelPortaliP33304.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    To yeast YER158C.Curated

    Phylogenomic databases

    eggNOGiNOG43797.
    OMAiNESARYF.
    OrthoDBiEOG7WT490.

    Sequencei

    Sequence statusi: Complete.

    P33304-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGSYLSAQE NQPIPERLIP RSNSTSNLFA LSSTFSKLNV RNDADYNYSN    50
    PNKKRHIYSG EIDCRSVTAA RKFPVRSCSM TAAQQRKRTA LFTVRERNSY 100
    HEGFNNDQDY VSQYQKPQYT FGVYKELTPY QLQRSKMKRS FQFPNGEIYK 150
    PKLDGKCTHS LKKPELNSRD SSLFKFSEKK GRNLSKDFVG PHNGTSVIHI 200
    PPNDTGYGVN SLELNTSVPS TIKSSVSSTS PISAVNTLTS LPESQTDDDD 250
    GYENKTVTIS YCFENTVNEK HGSHIEKLDL STKEKTKPTT NSGLFDRKKK 300
    TILGTEKYRC IKSQSKLKLG SVLKKLWRTS GNSNTKHGKK DTKRRRIPID 350
    DMVTHSDGNS EAENDIELMD ANLDGIEFDD DETLMDTDSI FDDLLSKEND 400
    KYDLRRRQLE IRQKLHETSH NDDGKVSFRD TEKHNVNEGL IDKTIIEEFS 450
    KLGEYIIDTR NQPPPRSSKR PSLDDNESAR YFYNISTDLR QSLSGPISLP 500
    MHVGNDMVNR LRNDWEYIRF EDRRNSLPDS SFDKVETPPK PIKKDVRFAK 550
    EVCLASTWSS NAYERANPEF IMNRHRLLWM MKVHPSMNSA MNEIKLELNS 600
    YKKNEMVVHE NSKCFTHYLI 620
    Length:620
    Mass (Da):71,364
    Last modified:February 1, 1994 - v1
    Checksum:iA9ABFBC9A26E62E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46796 Genomic DNA. Translation: CAA86807.1.
    L21702 Unassigned DNA. Translation: AAC37365.1.
    X82086 Genomic DNA. Translation: CAA57614.1.
    Z74381 Genomic DNA. Translation: CAA98905.1.
    AY723775 Genomic DNA. Translation: AAU09692.1.
    BK006938 Genomic DNA. Translation: DAA11932.1.
    PIRiS48772.
    RefSeqiNP_010370.1. NM_001180393.1.

    Genome annotation databases

    EnsemblFungiiYDR085C; YDR085C; YDR085C.
    GeneIDi851658.
    KEGGisce:YDR085C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46796 Genomic DNA. Translation: CAA86807.1 .
    L21702 Unassigned DNA. Translation: AAC37365.1 .
    X82086 Genomic DNA. Translation: CAA57614.1 .
    Z74381 Genomic DNA. Translation: CAA98905.1 .
    AY723775 Genomic DNA. Translation: AAU09692.1 .
    BK006938 Genomic DNA. Translation: DAA11932.1 .
    PIRi S48772.
    RefSeqi NP_010370.1. NM_001180393.1.

    3D structure databases

    ProteinModelPortali P33304.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32141. 19 interactions.
    DIPi DIP-824N.
    IntActi P33304. 6 interactions.
    MINTi MINT-599820.
    STRINGi 4932.YDR085C.

    Proteomic databases

    PaxDbi P33304.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDR085C ; YDR085C ; YDR085C .
    GeneIDi 851658.
    KEGGi sce:YDR085C.

    Organism-specific databases

    CYGDi YDR085c.
    SGDi S000002492. AFR1.

    Phylogenomic databases

    eggNOGi NOG43797.
    OMAi NESARYF.
    OrthoDBi EOG7WT490.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29690-MONOMER.

    Miscellaneous databases

    NextBioi 969260.

    Gene expression databases

    Genevestigatori P33304.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "AFR1 acts in conjunction with the alpha-factor receptor to promote morphogenesis and adaptation."
      Konopka J.B.
      Mol. Cell. Biol. 13:6876-6888(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC 204508 / S288c.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-472 AND SER-526, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAFR1_YEAST
    AccessioniPrimary (citable) accession number: P33304
    Secondary accession number(s): D6VS72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3