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P33304 (AFR1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein AFR1
Gene names
Name:AFR1
Ordered Locus Names:YDR085C
ORF Names:D4471
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length620 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts in conjunction with the alpha-factor receptor to promote morphogenesis and adaptation.

Induction

By pheromone (alpha-factor).

Sequence similarities

To yeast YER158C.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 620620Protein AFR1
PRO_0000064485

Amino acid modifications

Modified residue221Phosphoserine Ref.5
Modified residue4721Phosphoserine Ref.6
Modified residue5261Phosphoserine Ref.6

Sequences

Sequence LengthMass (Da)Tools
P33304 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: A9ABFBC9A26E62E5

FASTA62071,364
        10         20         30         40         50         60 
MEGSYLSAQE NQPIPERLIP RSNSTSNLFA LSSTFSKLNV RNDADYNYSN PNKKRHIYSG 

        70         80         90        100        110        120 
EIDCRSVTAA RKFPVRSCSM TAAQQRKRTA LFTVRERNSY HEGFNNDQDY VSQYQKPQYT 

       130        140        150        160        170        180 
FGVYKELTPY QLQRSKMKRS FQFPNGEIYK PKLDGKCTHS LKKPELNSRD SSLFKFSEKK 

       190        200        210        220        230        240 
GRNLSKDFVG PHNGTSVIHI PPNDTGYGVN SLELNTSVPS TIKSSVSSTS PISAVNTLTS 

       250        260        270        280        290        300 
LPESQTDDDD GYENKTVTIS YCFENTVNEK HGSHIEKLDL STKEKTKPTT NSGLFDRKKK 

       310        320        330        340        350        360 
TILGTEKYRC IKSQSKLKLG SVLKKLWRTS GNSNTKHGKK DTKRRRIPID DMVTHSDGNS 

       370        380        390        400        410        420 
EAENDIELMD ANLDGIEFDD DETLMDTDSI FDDLLSKEND KYDLRRRQLE IRQKLHETSH 

       430        440        450        460        470        480 
NDDGKVSFRD TEKHNVNEGL IDKTIIEEFS KLGEYIIDTR NQPPPRSSKR PSLDDNESAR 

       490        500        510        520        530        540 
YFYNISTDLR QSLSGPISLP MHVGNDMVNR LRNDWEYIRF EDRRNSLPDS SFDKVETPPK 

       550        560        570        580        590        600 
PIKKDVRFAK EVCLASTWSS NAYERANPEF IMNRHRLLWM MKVHPSMNSA MNEIKLELNS 

       610        620 
YKKNEMVVHE NSKCFTHYLI

« Hide

References

« Hide 'large scale' references
[1]"AFR1 acts in conjunction with the alpha-factor receptor to promote morphogenesis and adaptation."
Konopka J.B.
Mol. Cell. Biol. 13:6876-6888(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ATCC 204508 / S288c.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, MASS SPECTROMETRY.
Strain: YAL6B.
[6]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-472 AND SER-526, MASS SPECTROMETRY.
Strain: ADR376.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z46796 Genomic DNA. Translation: CAA86807.1.
L21702 Unassigned DNA. Translation: AAC37365.1.
X82086 Genomic DNA. Translation: CAA57614.1.
Z74381 Genomic DNA. Translation: CAA98905.1.
AY723775 Genomic DNA. Translation: AAU09692.1.
BK006938 Genomic DNA. Translation: DAA11932.1.
PIRS48772.
RefSeqNP_010370.1. NM_001180393.1.

3D structure databases

ProteinModelPortalP33304.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-824N.
IntActP33304. 5 interactions.
MINTMINT-599820.
STRING4932.YDR085C.

Proteomic databases

PaxDbP33304.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDR085C; YDR085C; YDR085C.
GeneID851658.
KEGGsce:YDR085C.

Organism-specific databases

CYGDYDR085c.
SGDS000002492. AFR1.

Phylogenomic databases

eggNOGNOG43797.
GeneTreeENSGT00530000068793.
OrthoDBEOG4C2MMD.

Enzyme and pathway databases

BioCycYEAST:G3O-29690-MONOMER.

Gene expression databases

GenevestigatorP33304.
GermOnlineYDR085C. Saccharomyces cerevisiae.

Family and domain databases

ProtoNetSearch...

Other

NextBio969260.

Entry information

Entry nameAFR1_YEAST
AccessionPrimary (citable) accession number: P33304
Secondary accession number(s): D6VS72
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 29, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Recent format changes

Overview of recent format changes

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome IV

Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents