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Protein

Succinate/fumarate mitochondrial transporter

Gene

SFC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transports cytoplasmic succinate, derived from isocitrate by the action of isocitrate lyase in the cytosol, into the mitochondrial matrix in exchange for fumarate.

GO - Molecular functioni

  • succinate:fumarate antiporter activity Source: SGD

GO - Biological processi

  • fumarate transport Source: SGD
  • mitochondrial transport Source: GO_Central
  • succinate transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-31723-MONOMER

Protein family/group databases

TCDBi2.A.29.13.1 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate/fumarate mitochondrial transporter
Alternative name(s):
Regulator of acetyl-CoA synthase activity
Gene namesi
Name:SFC1
Synonyms:ACR1
Ordered Locus Names:YJR095W
ORF Names:J1921
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR095W
SGDiS000003856 SFC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei114 – 134Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei177 – 193Helical; Name=4Sequence analysisAdd BLAST17
Transmembranei219 – 235Helical; Name=5Sequence analysisAdd BLAST17
Transmembranei278 – 295Helical; Name=6Sequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906791 – 322Succinate/fumarate mitochondrial transporterAdd BLAST322

Proteomic databases

MaxQBiP33303
PaxDbiP33303
PRIDEiP33303
TopDownProteomicsiP33303

Expressioni

Inductioni

By ethanol or acetate as sole carbon sources. Repressed by glucose.

Interactioni

Protein-protein interaction databases

BioGridi33850, 70 interactors
DIPiDIP-8019N
IntActiP33303, 2 interactors
MINTiP33303
STRINGi4932.YJR095W

Structurei

3D structure databases

ProteinModelPortaliP33303
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 99Solcar 1Add BLAST92
Repeati111 – 202Solcar 2Add BLAST92
Repeati212 – 303Solcar 3Add BLAST92

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00910000146555
HOGENOMiHOG000168307
InParanoidiP33303
KOiK15100
OMAiAIRFTSF
OrthoDBiEOG092C3F38

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P33303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQKKKASHP AINLMAGGTA GLFEALCCHP LDTIKVRMQI YRRVAGIEHV
60 70 80 90 100
KPPGFIKTGR TIYQKEGFLA LYKGLGAVVI GIIPKMAIRF SSYEFYRTLL
110 120 130 140 150
VNKESGIVST GNTFVAGVGA GITEAVLVVN PMEVVKIRLQ AQHLTPSEPN
160 170 180 190 200
AGPKYNNAIH AAYTIVKEEG VSALYRGVSL TAARQATNQG ANFTVYSKLK
210 220 230 240 250
EFLQNYHQMD VLPSWETSCI GLISGAIGPF SNAPLDTIKT RLQKDKSISL
260 270 280 290 300
EKQSGMKKII TIGAQLLKEE GFRALYKGIT PRVMRVAPGQ AVTFTVYEYV
310 320
REHLENLGIF KKNDTPKPKP LK
Length:322
Mass (Da):35,340
Last modified:November 1, 1995 - v2
Checksum:iEC29718A0F5011A7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti300 – 322VREHL…PKPLK → RKGAFQKIWVYSRRMTHQSQ SH in CAA80973 (PubMed:7908717).CuratedAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25485 Genomic DNA Translation: CAA80973.1
Z49595 Genomic DNA Translation: CAA89624.1
AY692924 Genomic DNA Translation: AAT92943.1
BK006943 Genomic DNA Translation: DAA08880.1
PIRiS57116
RefSeqiNP_012629.1, NM_001181753.1

Genome annotation databases

EnsemblFungiiYJR095W; YJR095W; YJR095W
GeneIDi853558
KEGGisce:YJR095W

Similar proteinsi

Entry informationi

Entry nameiSFC1_YEAST
AccessioniPrimary (citable) accession number: P33303
Secondary accession number(s): D6VWR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

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