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Protein

Pleiotropic ABC efflux transporter of multiple drugs

Gene

PDR5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Active efflux of weakly charged organic compounds of 90 cubic Angstroms to 300 cubic Angstroms surface volume. Confers resistance to numerous chemicals including cycloheximide, sulfomethuron methyl, steroids, antiseptics, antibiotics, anticancer, herbicides, mycotoxins, insecticides, ionophores, alkaloids, flavonoids, phenothiazines, organotin compounds, carbazoles, lysosomotropic aminoesters, detergents, rhodamines and other fluorophores, azoles and other antifungals. Exhibits nucleoside triphosphatase activity.14 Publications

Enzyme regulationi

FK506, isonitrile, enniatin, RU49953, kitasatospora E420, staurosporine CGP42700, prenyl-flavonoids, D-octapeptides were found to be inhibitors in vivo. Vanadate and oligomycin were found to be inhibitors in vitro.

Kineticsi

Activity measured in plasma membranes.

  1. KM=0.5 mM for MgATP1 Publication
  1. Vmax=2.5 µmol/min/mg enzyme1 Publication

pH dependencei

Optimum pH is 7.0.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi905 – 9128ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • xenobiotic-transporting ATPase activity Source: SGD

GO - Biological processi

  • cellular cation homeostasis Source: SGD
  • cellular response to drug Source: GO_Central
  • drug export Source: InterPro
  • drug transport Source: SGD
  • response to antibiotic Source: UniProtKB-KW
  • response to cycloheximide Source: UniProtKB-KW
  • response to drug Source: SGD
Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Cycloheximide resistance, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33670-MONOMER.

Protein family/group databases

TCDBi3.A.1.205.1. the atp-binding cassette (abc) superfamily.

Chemistry

SwissLipidsiSLP:000000523.

Names & Taxonomyi

Protein namesi
Recommended name:
Pleiotropic ABC efflux transporter of multiple drugs
Alternative name(s):
Pleiotropic drug resistance protein 5
Suppressor of toxicity of sporidesmin
Gene namesi
Name:PDR5
Synonyms:LEM1, STS1, YDR1
Ordered Locus Names:YOR153W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR153W.
SGDiS000005679. PDR5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 517517CytoplasmicSequence analysisAdd
BLAST
Transmembranei518 – 54225HelicalSequence analysisAdd
BLAST
Topological domaini543 – 55816ExtracellularSequence analysisAdd
BLAST
Transmembranei559 – 57921HelicalSequence analysisAdd
BLAST
Topological domaini580 – 61132CytoplasmicSequence analysisAdd
BLAST
Transmembranei612 – 62817HelicalSequence analysisAdd
BLAST
Topological domaini629 – 6313ExtracellularSequence analysis
Transmembranei632 – 65019HelicalSequence analysisAdd
BLAST
Topological domaini651 – 66515CytoplasmicSequence analysisAdd
BLAST
Transmembranei666 – 68520HelicalSequence analysisAdd
BLAST
Topological domaini686 – 77489ExtracellularSequence analysisAdd
BLAST
Transmembranei775 – 79319HelicalSequence analysisAdd
BLAST
Topological domaini794 – 1237444CytoplasmicSequence analysisAdd
BLAST
Transmembranei1238 – 126023HelicalSequence analysisAdd
BLAST
Topological domaini1261 – 129131ExtracellularSequence analysisAdd
BLAST
Transmembranei1292 – 131322HelicalSequence analysisAdd
BLAST
Topological domaini1314 – 132411CytoplasmicSequence analysisAdd
BLAST
Transmembranei1325 – 134925HelicalSequence analysisAdd
BLAST
Topological domaini1350 – 13545ExtracellularSequence analysis
Transmembranei1355 – 137925HelicalSequence analysisAdd
BLAST
Topological domaini1380 – 13889CytoplasmicSequence analysis
Transmembranei1389 – 140719HelicalSequence analysisAdd
BLAST
Topological domaini1408 – 147669ExtracellularSequence analysisAdd
BLAST
Transmembranei1477 – 149923HelicalSequence analysisAdd
BLAST
Topological domaini1500 – 151112CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Biotechnological usei

Strains lacking PDR5 are used for toxicity tests. Strains overexpressing PDR5 are used for screening antifungal sensitizers.3 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi183 – 1831L → P: Activates ER-associated degradation.
Mutagenesisi257 – 2571T → I: Alters drug specificity.
Mutagenesisi302 – 3021G → D: Confers generalized drug resistance.
Mutagenesisi648 – 6481S → F: Alters drug specificity.
Mutagenesisi905 – 9051G → S: Inactivates drug transport.
Mutagenesisi908 – 9081G → S: Inactivates drug transport.
Mutagenesisi1009 – 10091G → C: Confers generalized drug resistance.
Mutagenesisi1040 – 10401G → D: Alters drug specificity.
Mutagenesisi1048 – 10481S → V: Alters drug specificity.
Mutagenesisi1289 – 12891E → K: Alters drug specificity.
Mutagenesisi1311 – 13111Y → S: Alters drug specificity.
Mutagenesisi1360 – 13601S → F: Alters drug specificity.
Mutagenesisi1393 – 13931T → I: Alters drug specificity.
Mutagenesisi1427 – 14271C → Y: Activates ER-associated degradation.

Chemistry

ChEMBLiCHEMBL1697658.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15111511Pleiotropic ABC efflux transporter of multiple drugsPRO_0000093442Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221PhosphoserineCombined sources
Modified residuei49 – 491PhosphothreonineCombined sources
Modified residuei51 – 511PhosphothreonineCombined sources
Modified residuei54 – 541PhosphoserineCombined sources
Modified residuei58 – 581PhosphoserineCombined sources
Modified residuei61 – 611PhosphoserineCombined sources
Glycosylationi734 – 7341N-linked (GlcNAc...)Sequence analysis
Cross-linki825 – 825Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Modified residuei837 – 8371PhosphoserineCombined sources
Modified residuei840 – 8401PhosphoserineCombined sources
Modified residuei841 – 8411PhosphoserineCombined sources
Modified residuei849 – 8491PhosphoserineCombined sources
Modified residuei850 – 8501PhosphoserineCombined sources
Modified residuei854 – 8541PhosphoserineCombined sources
Glycosylationi1447 – 14471N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Ubiquitinylation mediates endocytosis and vacuolar degradation. Phosphorylation by casein kinase I stabilizes the protein half-life.3 Publications

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP33302.

PTM databases

iPTMnetiP33302.

Expressioni

Inductioni

Expressed during exponential growth. Transcription is transiently activated within 40 min after induction by benomyl and other toxic chemicals. Multidrug resistance and PDR5 mRNA level are activated by the transcription regulators PDR1, PDR3, YAP1, YAP2, STB5 and by the mitochondrial rho zero mutation. Mutations or deletion in the PDR1 or PDR3 transcription factors strongly activate PDR5 mRNA and PDR5 translation. The transcription regulator RDR1 represses PDR5 expression.6 Publications

Interactioni

Protein-protein interaction databases

BioGridi34549. 103 interactions.
DIPiDIP-6776N.
IntActiP33302. 18 interactions.
MINTiMINT-636136.

Chemistry

BindingDBiP33302.

Structurei

3D structure databases

ProteinModelPortaliP33302.
SMRiP33302. Positions 173-421, 883-1196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini161 – 410250ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini869 – 1112244ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi784 – 7874Poly-Phe

Domaini

The N-terminal ABC transporter domain (positions 161 to 410) contains degenerated Walker A and B ATP-binding motifs, suggesting that it may be less efficient in ATP binding or not functional at all. This is a distinctive feature of the PDR subfamily.1 Publication
The unusual length of the two extracellular loops at positions 686 to 774 and 1408 to 1476 is another specific feature of the PDR subfamily which may have an important role for function.1 Publication

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000075308.
HOGENOMiHOG000162078.
InParanoidiP33302.
KOiK08711.
OrthoDBiEOG7N903S.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR029481. ABC_trans_N.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR005285. Drug-R_PDR/CDR.
IPR027417. P-loop_NTPase.
IPR010929. PDR_CDR_ABC.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF14510. ABC_trans_N. 1 hit.
PF06422. PDR_CDR. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00956. 3a01205. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEAKLNNNV NDVTSYSSAS SSTENAADLH NYNGFDEHTE ARIQKLARTL
60 70 80 90 100
TAQSMQNSTQ SAPNKSDAQS IFSSGVEGVN PIFSDPEAPG YDPKLDPNSE
110 120 130 140 150
NFSSAAWVKN MAHLSAADPD FYKPYSLGCA WKNLSASGAS ADVAYQSTVV
160 170 180 190 200
NIPYKILKSG LRKFQRSKET NTFQILKPMD GCLNPGELLV VLGRPGSGCT
210 220 230 240 250
TLLKSISSNT HGFDLGADTK ISYSGYSGDD IKKHFRGEVV YNAEADVHLP
260 270 280 290 300
HLTVFETLVT VARLKTPQNR IKGVDRESYA NHLAEVAMAT YGLSHTRNTK
310 320 330 340 350
VGNDIVRGVS GGERKRVSIA EVSICGSKFQ CWDNATRGLD SATALEFIRA
360 370 380 390 400
LKTQADISNT SATVAIYQCS QDAYDLFNKV CVLDDGYQIY YGPADKAKKY
410 420 430 440 450
FEDMGYVCPS RQTTADFLTS VTSPSERTLN KDMLKKGIHI PQTPKEMNDY
460 470 480 490 500
WVKSPNYKEL MKEVDQRLLN DDEASREAIK EAHIAKQSKR ARPSSPYTVS
510 520 530 540 550
YMMQVKYLLI RNMWRLRNNI GFTLFMILGN CSMALILGSM FFKIMKKGDT
560 570 580 590 600
STFYFRGSAM FFAILFNAFS SLLEIFSLYE ARPITEKHRT YSLYHPSADA
610 620 630 640 650
FASVLSEIPS KLIIAVCFNI IFYFLVDFRR NGGVFFFYLL INIVAVFSMS
660 670 680 690 700
HLFRCVGSLT KTLSEAMVPA SMLLLALSMY TGFAIPKKKI LRWSKWIWYI
710 720 730 740 750
NPLAYLFESL LINEFHGIKF PCAEYVPRGP AYANISSTES VCTVVGAVPG
760 770 780 790 800
QDYVLGDDFI RGTYQYYHKD KWRGFGIGMA YVVFFFFVYL FLCEYNEGAK
810 820 830 840 850
QKGEILVFPR SIVKRMKKRG VLTEKNANDP ENVGERSDLS SDRKMLQESS
860 870 880 890 900
EEESDTYGEI GLSKSEAIFH WRNLCYEVQI KAETRRILNN VDGWVKPGTL
910 920 930 940 950
TALMGASGAG KTTLLDCLAE RVTMGVITGD ILVNGIPRDK SFPRSIGYCQ
960 970 980 990 1000
QQDLHLKTAT VRESLRFSAY LRQPAEVSIE EKNRYVEEVI KILEMEKYAD
1010 1020 1030 1040 1050
AVVGVAGEGL NVEQRKRLTI GVELTAKPKL LVFLDEPTSG LDSQTAWSIC
1060 1070 1080 1090 1100
QLMKKLANHG QAILCTIHQP SAILMQEFDR LLFMQRGGKT VYFGDLGEGC
1110 1120 1130 1140 1150
KTMIDYFESH GAHKCPADAN PAEWMLEVVG AAPGSHANQD YYEVWRNSEE
1160 1170 1180 1190 1200
YRAVQSELDW MERELPKKGS ITAAEDKHEF SQSIIYQTKL VSIRLFQQYW
1210 1220 1230 1240 1250
RSPDYLWSKF ILTIFNQLFI GFTFFKAGTS LQGLQNQMLA VFMFTVIFNP
1260 1270 1280 1290 1300
ILQQYLPSFV QQRDLYEARE RPSRTFSWIS FIFAQIFVEV PWNILAGTIA
1310 1320 1330 1340 1350
YFIYYYPIGF YSNASAAGQL HERGALFWLF SCAFYVYVGS MGLLVISFNQ
1360 1370 1380 1390 1400
VAESAANLAS LLFTMSLSFC GVMTTPSAMP RFWIFMYRVS PLTYFIQALL
1410 1420 1430 1440 1450
AVGVANVDVK CADYELLEFT PPSGMTCGQY MEPYLQLAKT GYLTDENATD
1460 1470 1480 1490 1500
TCSFCQISTT NDYLANVNSF YSERWRNYGI FICYIAFNYI AGVFFYWLAR
1510
VPKKNGKLSK K
Length:1,511
Mass (Da):170,438
Last modified:February 1, 1994 - v1
Checksum:i4540DC0BF04744BA
GO

Sequence cautioni

The sequence BAA05547.1 differs from that shown. Reason: Frameshift at position 61. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1711N → L in BAA05547 (PubMed:7882421).Curated
Sequence conflicti190 – 1901V → I in BAA05547 (PubMed:7882421).Curated
Sequence conflicti214 – 2141D → T in BAA05547 (PubMed:7882421).Curated
Sequence conflicti308 – 3081G → V in BAA05547 (PubMed:7882421).Curated
Sequence conflicti340 – 3456Missing in BAA05547 (PubMed:7882421).Curated
Sequence conflicti476 – 4761R → H in BAA05547 (PubMed:7882421).Curated
Sequence conflicti648 – 6481Missing in BAA05547 (PubMed:7882421).Curated
Sequence conflicti770 – 7701D → H in BAA05547 (PubMed:7882421).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26548 Genomic DNA. Translation: BAA05547.1. Frameshift.
X74113 Genomic DNA. Translation: CAA52212.1.
L19922 Genomic DNA. Translation: AAB53769.1.
U55020 Genomic DNA. Translation: AAC49639.1.
Z75061 Genomic DNA. Translation: CAA99359.1.
BK006948 Genomic DNA. Translation: DAA10926.1.
PIRiA53151.
RefSeqiNP_014796.3. NM_001183572.3.

Genome annotation databases

EnsemblFungiiYOR153W; YOR153W; YOR153W.
GeneIDi854324.
KEGGisce:YOR153W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26548 Genomic DNA. Translation: BAA05547.1. Frameshift.
X74113 Genomic DNA. Translation: CAA52212.1.
L19922 Genomic DNA. Translation: AAB53769.1.
U55020 Genomic DNA. Translation: AAC49639.1.
Z75061 Genomic DNA. Translation: CAA99359.1.
BK006948 Genomic DNA. Translation: DAA10926.1.
PIRiA53151.
RefSeqiNP_014796.3. NM_001183572.3.

3D structure databases

ProteinModelPortaliP33302.
SMRiP33302. Positions 173-421, 883-1196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34549. 103 interactions.
DIPiDIP-6776N.
IntActiP33302. 18 interactions.
MINTiMINT-636136.

Chemistry

BindingDBiP33302.
ChEMBLiCHEMBL1697658.
SwissLipidsiSLP:000000523.

Protein family/group databases

TCDBi3.A.1.205.1. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiP33302.

Proteomic databases

MaxQBiP33302.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR153W; YOR153W; YOR153W.
GeneIDi854324.
KEGGisce:YOR153W.

Organism-specific databases

EuPathDBiFungiDB:YOR153W.
SGDiS000005679. PDR5.

Phylogenomic databases

GeneTreeiENSGT00550000075308.
HOGENOMiHOG000162078.
InParanoidiP33302.
KOiK08711.
OrthoDBiEOG7N903S.

Enzyme and pathway databases

BioCyciYEAST:G3O-33670-MONOMER.

Miscellaneous databases

PROiP33302.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR029481. ABC_trans_N.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR005285. Drug-R_PDR/CDR.
IPR027417. P-loop_NTPase.
IPR010929. PDR_CDR_ABC.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF14510. ABC_trans_N. 1 hit.
PF06422. PDR_CDR. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00956. 3a01205. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Saccharomyces cerevisiae YDR1, which encodes a member of the ATP-binding cassette (ABC) superfamily, is required for multidrug resistance."
    Hirata D., Yano K., Miyahara K., Miyakawa T.
    Curr. Genet. 26:285-294(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 38626 / AH22 / NRRL Y-12843.
  2. "PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1."
    Balzi E., Wang M., Leterme S., van Dyck L., Goffeau A.
    J. Biol. Chem. 269:2206-2214(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, TOPOLOGY, DOMAINS.
    Strain: ATCC 204508 / S288c.
  3. "Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance."
    Bissinger P.H., Kuchler K.
    J. Biol. Chem. 269:4180-4186(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204510 / AB320.
  4. "Analysis of a 35.6 kb region on the right arm of Saccharomyces cerevisiae chromosome XV."
    Bordonne R., Camasses A., Madania A., Poch O., Tarassov I.A., Winsor B., Martin R.P.
    Yeast 13:73-83(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / FY1678.
  5. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  7. "The multidrug resistance gene PDR1 from Saccharomyces cerevisiae."
    Balzi E., Chen W., Ulaszewski S., Capieaux E., Goffeau A.
    J. Biol. Chem. 262:16871-16879(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANSCRIPTION REGULATION.
  8. "Interaction of the yeast pleiotropic drug resistance genes PDR1 and PDR5."
    Meyers S., Schauer W., Balzi E., Wagner M., Goffeau A., Golin J.
    Curr. Genet. 21:431-436(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANSCRIPTION REGULATION.
  9. "Loss of function mutation in the yeast multiple drug resistance gene PDR5 causes a reduction in chloramphenicol efflux."
    Leonard P.J., Rathod P.K., Golin J.
    Antimicrob. Agents Chemother. 38:2492-2494(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBSTRATES.
  10. "Solubilization and characterization of the overexpressed PDR5 multidrug resistance nucleotide triphosphatase of yeast."
    Decottignies A., Kolaczkowski M., Balzi E., Goffeau A.
    J. Biol. Chem. 269:12797-12803(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PURIFICATION, BIOPHYSICOCHEMICAL PROPERTIES.
  11. "Transcriptional control of the yeast PDR5 gene by the PDR3 gene product."
    Katzmann D.J., Burnett P.E., Golin J., Mahe Y., Moye-Rowley W.S.
    Mol. Cell. Biol. 14:4653-4661(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANSCRIPTION REGULATION.
  12. "Positive autoregulation of the yeast transcription factor Pdr3p, which is involved in control of drug resistance."
    Delahodde A., Delaveau T., Jacq C.
    Mol. Cell. Biol. 15:4043-4051(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANSCRIPTION REGULATION.
  13. "Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae."
    Egner R., Mahe Y., Pandjaitan R., Kuchler K.
    Mol. Cell. Biol. 15:5879-5887(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEGRADATION.
  14. "LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones."
    Kralli A., Bohen S.P., Yamamoto K.R.
    Proc. Natl. Acad. Sci. U.S.A. 92:4701-4705(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. "yAP-1- and yAP-2-mediated, heat shock-induced transcriptional activation of the multidrug resistance ABC transporter genes in Saccharomyces cerevisiae."
    Miyahara K., Hirata D., Miyakawa T.
    Curr. Genet. 29:103-105(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANSCRIPTION REGULATION.
  16. "The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole."
    Egner R., Kuchler K.
    FEBS Lett. 378:177-181(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEGRADATION.
  17. "The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance."
    Miyahara K., Mizunuma M., Hirata D., Tsuchiya E., Miyakawa T.
    FEBS Lett. 399:317-320(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  18. "An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones."
    Kralli A., Yamamoto K.R.
    J. Biol. Chem. 271:17152-17156(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INHIBITORS.
  19. "The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo."
    Mahe Y., Lemoine Y., Kuchler K.
    J. Biol. Chem. 271:25167-25172(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  20. "Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p."
    Kolaczkowski M., van der Rest M., Cybularz-Kolaczkowska A., Soumillion J.P., Konings W.N., Goffeau A.
    J. Biol. Chem. 271:31543-31548(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  21. "Camptothecin sensitivity is mediated by the pleiotropic drug resistance network in yeast."
    Reid R.J.D., Kauh E.A., Bjornsti M.-A.
    J. Biol. Chem. 272:12091-12099(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBSTRATES.
  22. "Clustered amino acid substitutions in the yeast transcription regulator Pdr3p increase pleiotropic drug resistance and identify a new central regulatory domain."
    Nourani A., Papajova D., Delahodde A., Jacq C., Subik J.
    Mol. Gen. Genet. 256:397-405(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANSCRIPTION REGULATION.
  23. "Molecular and phenotypic characterization of yeast PDR1 mutants that show hyperactive transcription of various ABC multidrug transporter genes."
    Carvajal E., van den Hazel H.B., Cybularz-Kolaczkowska A., Balzi E., Goffeau A.
    Mol. Gen. Genet. 256:406-415(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  24. "Complete inventory of the yeast ABC proteins."
    Decottignies A., Goffeau A.
    Nat. Genet. 15:137-145(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN FAMILY.
  25. "Role of ABC transporters in aureobasidin A resistance."
    Ogawa A., Hashida-Okado T., Endo M., Yoshioka H., Tsuruo T., Takesako K., Kato I.
    Antimicrob. Agents Chemother. 42:755-761(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBSTRATES.
  26. "Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome."
    Plemper R.K., Egner R., Kuchler K., Wolf D.H.
    J. Biol. Chem. 273:32848-32856(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRAFFICKING.
  27. "Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter."
    Egner R., Rosenthal F.E., Kralli A., Sanglard D., Kuchler K.
    Mol. Biol. Cell 9:523-543(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS.
  28. "In vivo characterization of the drug resistance profile of the major ABC transporters and other components of the yeast pleiotropic drug resistance network."
    Kolaczkowski M., Kolaczowska A., Luczynski J., Witek S., Goffeau A.
    Microb. Drug Resist. 4:143-158(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  29. "Casein kinase I-dependent phosphorylation and stability of the yeast multidrug transporter Pdr5p."
    Decottignies A., Owsianik G., Ghislain M.
    J. Biol. Chem. 274:37139-37146(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY CK1.
  30. "Chemical specificity of the PDR5 multidrug resistance gene product of Saccharomyces cerevisiae based on studies with tri-n-alkyltin chlorides."
    Golin J., Barkatt A., Cronin S., Eng G., May L.
    Antimicrob. Agents Chemother. 44:134-138(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBSTRATES.
  31. "Role of the PDR gene network in yeast susceptibility to the antifungal antibiotic mucidin."
    Michalkova-Papajova D., Obernauerova M., Subik J.
    Antimicrob. Agents Chemother. 44:418-420(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBSTRATES.
  32. "The transmembrane domain 10 of the yeast Pdr5p ABC antifungal efflux pump determines both substrate specificity and inhibitor susceptibility."
    Egner R., Bauer B.E., Kuchler K.
    Mol. Microbiol. 35:1255-1263(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY, MUTAGENESIS.
  33. "Genome microarray analysis of transcriptional activation in multidrug resistance yeast mutants."
    DeRisi J., van den Hazel B., Marc P., Balzi E., Brown P., Jacq C., Goffeau A.
    FEBS Lett. 470:156-160(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANSCRIPTION REGULATION.
  34. "Prenyl-flavonoids as potent inhibitors of the Pdr5p multidrug ABC transporter from Saccharomyces cerevisiae."
    Conseil G., Decottignies A., Jault J.-M., Comte G., Barron D., Goffeau A., Di Pietro A.
    Biochemistry 39:6910-6917(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INHIBITORS.
  35. "Protein kinase C effectors bind to multidrug ABC transporters and inhibit their activity."
    Conseil G., Perez-Victoria J.M., Jault J.-M., Gamarro F., Goffeau A., Hofmann J., Di Pietro A.
    Biochemistry 40:2564-2571(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INHIBITORS.
  36. "A novel screening for inhibitors of a pleiotropic drug resistant pump, Pdr5, in Saccharomyces cerevisiae."
    Hiraga K., Wanigasekera A., Sugi H., Hamanaka N., Oda K.
    Biosci. Biotechnol. Biochem. 65:1589-1595(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: BIOTECHNOLOGY.
  37. "Purification and some properties of an inhibitor for a yeast pleiotropic drug resistant pump from Kitasatospora sp. E-420."
    Wanigasekera A., Hiraga K., Hamanaka N., Oda K.
    Biosci. Biotechnol. Biochem. 65:2353-2357(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INHIBITORS.
  38. "The ABC transporter Pdr5p mediates the efflux of nonsteroidal ecdysone agonists in Saccharomyces cerevisiae."
    Hu W., Feng Q., Palli S.R., Krell P.J., Arif B.M., Retnakaran A.
    Eur. J. Biochem. 268:3416-3422(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBSTRATES.
  39. "Saccharomyces cerevisiae multidrug resistance gene expression inversely correlates with the status of the F(0) component of the mitochondrial ATPase."
    Zhang X., Moye-Rowley W.S.
    J. Biol. Chem. 276:47844-47852(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: METABOLIC REGULATION.
  40. "The pleitropic drug ABC transporters from Saccharomyces cerevisiae."
    Rogers B., Decottignies A., Kolaczkowski M., Carvajal E., Balzi E., Goffeau A.
    J. Mol. Microbiol. Biotechnol. 3:207-214(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  41. "Zinc cluster protein Rdr1p is a transcriptional repressor of the PDR5 gene encoding a multidrug transporter."
    Hellauer K., Akache B., MacPherson S., Sirard E., Turcotte B.
    J. Biol. Chem. 277:17671-17676(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANSCRIPTION REGULATION.
  42. "New regulators of drug sensitivity in the family of yeast zinc cluster proteins."
    Akache B., Turcotte B.
    J. Biol. Chem. 277:21254-21260(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANSCRIPTION REGULATION.
  43. "Subproteomics: identification of plasma membrane proteins from the yeast Saccharomyces cerevisiae."
    Navarre C., Degand H., Bennett K.L., Crawford J.S., Moertz E., Boutry M.
    Proteomics 2:1706-1714(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  44. "Potent competitive inhibition of drug binding to the Saccharomyces cerevisiae ABC exporter Pdr5p by the hydrophobic estradiol-derivative RU49953."
    Conseil G., Perez-Victoria J.M., Renoir J.M., Goffeau A., Di Pietro A.
    Biochim. Biophys. Acta 1614:131-134(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INHIBITORS.
  45. "Phenothiazines as potent modulators of yeast multidrug resistance."
    Kolaczkowski M., Michalak K., Motohashi N.
    Int. J. Antimicrob. Agents 22:279-283(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INHIBITORS.
  46. "Studies with novel Pdr5p substrates demonstrate a strong size dependence for xenobiotic efflux."
    Golin J., Ambudkar S.V., Gottesman M.M., Habib A.D., Sczepanski J., Ziccardi W., May L.
    J. Biol. Chem. 278:5963-5969(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBSTRATES.
  47. "A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast."
    Hikkel I., Lucau-Danila A., Delaveau T., Marc P., Devaux F., Jacq C.
    J. Biol. Chem. 278:11427-11432(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANSCRIPTION REGULATION.
  48. "Three-dimensional reconstruction of the Saccharomyces cerevisiae multidrug resistance protein Pdr5p."
    Ferreira-Pereira A., Marco S., Decottignies A., Nader J., Goffeau A., Rigaud J.L.
    J. Biol. Chem. 278:11995-11999(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PURIFICATION, ELECTRON MICROSCOPY.
  49. "Antifungal activity of amiodarone is mediated by disruption of calcium homeostasis."
    Gupta S.S., Ton V.-K., Beaudry V., Rulli S., Cunningham K., Rao R.
    J. Biol. Chem. 278:28831-28839(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBSTRATES.
  50. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  51. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-825.
    Strain: SUB592.
  52. "A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery."
    Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.
    Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-825.
  53. "A yeast-based method for the detection of cyto and genotoxicity."
    Lichtenberg-Frate H., Schmitt M., Gellert G., Ludwig J.
    Toxicol. in Vitro 17:709-716(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: BIOTECHNOLOGY.
  54. "Chemosensitization of fluconazole resistance in Saccharomyces cerevisiae and pathogenic fungi by a D-octapeptide derivative."
    Niimi K., Harding D.R., Parshot R., King A., Lun D.J., Decottignies A., Niimi M., Lin S., Cannon R.D., Goffeau A., Monk B.C.
    Antimicrob. Agents Chemother. 48:1256-1271(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: BIOTECHNOLOGY.
  55. "The transporters Pdr5p and Snq2p mediate diazaborine resistance and are under the control of the gain-of-function allele PDR1-12."
    Wehrschutz-Sigl E., Jungwirth H., Bergler H., Hogenauer G.
    Eur. J. Biochem. 271:1145-1152(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBSTRATES.
  56. "Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase."
    Mamnun Y.M., Schuller C., Kuchler K.
    FEBS Lett. 559:111-117(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  57. "On the mechanism of constitutive Pdr1 activator-mediated PDR5 transcription in Saccharomyces cerevisiae: evidence for enhanced recruitment of coactivators and altered nucleosome structures."
    Gao C., Wang L., Milgrom E., Shen W.C.
    J. Biol. Chem. 279:42677-42686(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  58. "Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae."
    Hiraga K., Yamamoto S., Fukuda H., Hamanaka N., Oda K.
    Biochem. Biophys. Res. Commun. 328:1119-1125(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INHIBITORS.
  59. "A new function of isonitrile as an inhibitor of the Pdr5p multidrug ABC transporter in Saccharomyces cerevisiae."
    Yamamoto S., Hiraga K., Abiko A., Hamanaka N., Oda K.
    Biochem. Biophys. Res. Commun. 330:622-628(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INHIBITORS.
  60. "The role of hydrogen bond acceptor groups in the interaction of substrates with Pdr5p, a major yeast drug transporter."
    Hanson L., May L., Tuma P., Keeven J., Mehl P., Ferenz M., Ambudkar S.V., Golin J.
    Biochemistry 44:9703-9713(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBSTRATES.
  61. "Retrograde regulation of multidrug resistance in Saccharomyces cerevisiae."
    Moye-Rowley W.S.
    Gene 354:15-21(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: METABOLIC REGULATION.
  62. "Mutational analysis of the yeast multidrug resistance ABC transporter Pdr5p with altered drug specificity."
    Tutulan-Cunita A.C., Mikoshi M., Mizunuma M., Hirata D., Miyakawa T.
    Genes Cells 10:409-420(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS.
  63. "Activity of yeast multidrug resistance pumps during growth is controlled by carbon source and the composition of growth-depleted medium: DiS-C3(3) fluorescence assay."
    Malac J., Urbankova E., Sigler K., Gaskova D.
    Int. J. Biochem. Cell Biol. 37:2536-2543(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  64. "Regulation of the sphingoid long-chain base kinase Lcb4p by ergosterol and heme: studies in phytosphingosine-resistant mutants."
    Sano T., Kihara A., Kurotsu F., Iwaki S., Igarashi Y.
    J. Biol. Chem. 280:36674-36682(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBSTRATES.
  65. Cited for: INDUCTION.
  66. "Early transcriptional response of Saccharomyces cerevisiae to stress imposed by the herbicide 2,4-dichlorophenoxyacetic acid."
    Teixeira M.C., Fernandes A.R., Mira N.P., Becker J.D., Sa-Correia I.
    FEMS Yeast Res. 6:230-248(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  67. "Adaptive response to the antimalarial drug artesunate in yeast involves Pdr1p/Pdr3p-mediated transcriptional activation of the resistance determinants TPO1 and PDR5."
    Alenquer M., Tenreiro S., Sa-Correia I.
    FEMS Yeast Res. 6:1130-1139(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  68. "ELM1 is required for multidrug resistance in Saccharomyces cerevisiae."
    Souid A.K., Gao C., Wang L., Milgrom E., Shen W.C.
    Genetics 173:1919-1937(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: METABOLIC REGULATION, FUNCTION.
  69. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  70. "The yeast Pdr5p multidrug transporter: how does it recognize so many substrates?"
    Golin J., Ambudkar S.V., May L.
    Biochem. Biophys. Res. Commun. 356:1-5(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  71. Cited for: TRANSCRIPTION REGULATION.
  72. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-49; SER-54; SER-61; SER-837; SER-849; SER-850 AND SER-854, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  73. "Subcellular trafficking of the yeast plasma membrane ABC transporter, Pdr5, is impaired by a mutation in the N-terminal nucleotide-binding fold."
    de Thozee C.P., Cronin S., Goj A., Golin J., Ghislain M.
    Mol. Microbiol. 63:811-825(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRAFFICKING.
  74. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-837; SER-840 AND SER-841, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  75. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-837; SER-849 AND SER-850, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  76. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; THR-51; SER-54; SER-58; SER-849; SER-850 AND SER-854, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPDR5_YEAST
AccessioniPrimary (citable) accession number: P33302
Secondary accession number(s): D6W2L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 6, 2016
This is version 174 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 42000 molecules/cell in log phase SD medium in log phase SD medium.1 Publication
Full-sized PDR5 orthologs are found only in fungi and plants. Their topology and substrate specificity are distinct from mammalian MDR transporters.
This protein has been 'adopted' by Andre Goffeau from the Catholic University of Louvain (Belgium). The above-mentioned scientist has agreed to help us to curate information available on this protein. We are grateful to that person for committing precious time to help producing annotation useful to the whole community. However, that person is not responsible for any errors or omissions in this UniProtKB/Swiss-Prot entry. If you have found something wrong or missing in this entry you should submit an update report to: help@uniprot.org.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.