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Protein

Mannosyl phosphorylinositol ceramide synthase SUR1

Gene

SUR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the synthesis of mannosyl phosphorylinositol ceramide. Catalyzes the addition of mannosyl to phosphorylinositol ceramide. Suppressor of RVS161 mutation.1 Publication

GO - Molecular functioni

  • mannosyltransferase activity Source: SGD
  • transferase activity, transferring glycosyl groups Source: SGD

GO - Biological processi

  • glycosphingolipid biosynthetic process Source: SGD
  • mannosyl-inositol phosphorylceramide biosynthetic process Source: GO_Central
  • mannosyl-inositol phosphorylceramide metabolic process Source: SGD
  • sphingolipid biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-703.
YEAST:MONOMER3O-703.

Protein family/group databases

CAZyiGT32. Glycosyltransferase Family 32.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannosyl phosphorylinositol ceramide synthase SUR1 (EC:2.4.-.-)
Gene namesi
Name:SUR1
Synonyms:BCL21, CSG1, LPE15
Ordered Locus Names:YPL057C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL057C.
SGDiS000005978. SUR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 269ExtracellularSequence analysisAdd BLAST242
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Topological domaini291 – 382CytoplasmicSequence analysisAdd BLAST92

GO - Cellular componenti

  • Golgi membrane Source: GO_Central
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000723141 – 382Mannosyl phosphorylinositol ceramide synthase SUR1Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei349PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP33300.
PRIDEiP33300.

PTM databases

iPTMnetiP33300.

Interactioni

Subunit structurei

Heterodimer of SUR1 and CSG2.1 Publication

Protein-protein interaction databases

BioGridi36123. 365 interactors.
DIPiDIP-4557N.
IntActiP33300. 3 interactors.
MINTiMINT-485923.

Structurei

3D structure databases

ProteinModelPortaliP33300.
SMRiP33300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 32 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000007232.
HOGENOMiHOG000200927.
InParanoidiP33300.
OMAiGSSWHMD.
OrthoDBiEOG092C2XIG.

Family and domain databases

InterProiIPR007577. GlycoTrfase_DXD_sugar-bd_CS.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF04488. Gly_transf_sug. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

P33300-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKELKYLIC FNILLLLSII YYTFDLLTLC IDDTVKDAIL EEDLNPDAPP
60 70 80 90 100
KPQLIPKIIH QTYKTEDIPE HWKEGRQKCL DLHPDYKYIL WTDEMAYEFI
110 120 130 140 150
KEEYPWFLDT FENYKYPIER ADAIRYFILS HYGGVYIDLD DGCERKLDPL
160 170 180 190 200
LAFPAFLRKT SPLGVSNDVM GSVPRHPFFL KALKSLKHYD KYWFIPYMTI
210 220 230 240 250
MGSTGPLFLS VIWKQYKRWR IPKNGTVRIL QPAYYKMHSY SFFSITKGSS
260 270 280 290 300
WHLDDAKLMK ALENHILSCV VTGFIFGFFI LYGEFTFYCW LCSKNFSNLT
310 320 330 340 350
KNWKLNAIKV RFVTILNSLG LRLKLSKSTS DTASATLLAR QQKRLRKDSN
360 370 380
TNIVLLKSSR KSDVYDLEKN DSSKYSLGNN SS
Length:382
Mass (Da):44,808
Last modified:February 1, 1994 - v1
Checksum:i5A9AAB5F9A4069E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96648 Genomic DNA. Translation: AAA68909.1.
D26581 Genomic DNA. Translation: BAA05628.1.
U39205 Genomic DNA. Translation: AAB68308.1.
BK006949 Genomic DNA. Translation: DAA11373.1.
PIRiS41798.
RefSeqiNP_015268.1. NM_001183871.1.

Genome annotation databases

EnsemblFungiiYPL057C; YPL057C; YPL057C.
GeneIDi856050.
KEGGisce:YPL057C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96648 Genomic DNA. Translation: AAA68909.1.
D26581 Genomic DNA. Translation: BAA05628.1.
U39205 Genomic DNA. Translation: AAB68308.1.
BK006949 Genomic DNA. Translation: DAA11373.1.
PIRiS41798.
RefSeqiNP_015268.1. NM_001183871.1.

3D structure databases

ProteinModelPortaliP33300.
SMRiP33300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36123. 365 interactors.
DIPiDIP-4557N.
IntActiP33300. 3 interactors.
MINTiMINT-485923.

Protein family/group databases

CAZyiGT32. Glycosyltransferase Family 32.

PTM databases

iPTMnetiP33300.

Proteomic databases

MaxQBiP33300.
PRIDEiP33300.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL057C; YPL057C; YPL057C.
GeneIDi856050.
KEGGisce:YPL057C.

Organism-specific databases

EuPathDBiFungiDB:YPL057C.
SGDiS000005978. SUR1.

Phylogenomic databases

GeneTreeiENSGT00390000007232.
HOGENOMiHOG000200927.
InParanoidiP33300.
OMAiGSSWHMD.
OrthoDBiEOG092C2XIG.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-703.
YEAST:MONOMER3O-703.

Miscellaneous databases

PROiP33300.

Family and domain databases

InterProiIPR007577. GlycoTrfase_DXD_sugar-bd_CS.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF04488. Gly_transf_sug. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSUR1_YEAST
AccessioniPrimary (citable) accession number: P33300
Secondary accession number(s): D6W3V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.