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Protein

Pyruvate decarboxylase

Gene

cfp

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

A 2-oxo acid = an aldehyde + CO2.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: pyruvate metabolism

This protein is involved in the pathway pyruvate metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway pyruvate metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33SubstrateBy similarity1
Binding sitei120SubstrateBy similarity1
Metal bindingi444MagnesiumBy similarity1
Metal bindingi471MagnesiumBy similarity1
Metal bindingi473Magnesium; via carbonyl oxygenBy similarity1
Binding sitei477SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Magnesium, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

UniPathwayiUPA00231.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate decarboxylase (EC:4.1.1.1)
Alternative name(s):
8-10 nm cytoplasmic filament-associated protein
P59NC
Gene namesi
Name:cfp
Synonyms:pdc-1
ORF Names:NCU02193
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 7, Linkage Group VII

Organism-specific databases

EuPathDBiFungiDB:NCU02193.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000356531 – 2Removed in mature form1 Publication2
ChainiPRO_00000356543 – 570Pyruvate decarboxylaseAdd BLAST568

Interactioni

Subunit structurei

Homopolymer.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-7533403,EBI-7533403

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

MINTiMINT-8291074.

Structurei

3D structure databases

ProteinModelPortaliP33287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni394 – 476Thiamine pyrophosphate bindingAdd BLAST83

Sequence similaritiesi

Belongs to the TPP enzyme family.Curated

Phylogenomic databases

HOGENOMiHOG000061335.
InParanoidiP33287.
KOiK01568.
OMAiYIEIPTN.
OrthoDBiEOG092C10AB.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR029061. THDP-binding.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR012110. TPP_enzyme.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PfamiPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
PIRSFiPIRSF036565. Pyruvt_ip_decrb. 1 hit.
SUPFAMiSSF52467. SSF52467. 1 hit.
SSF52518. SSF52518. 2 hits.
PROSITEiPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAQQQGKFT VGDYLAERLA QVGVRHHFVV PGDYNLILLD KLQAHPDLKE
60 70 80 90 100
VGCANELNCS LAAEGYARAN GISACVVTYS VGALSAFNGT GSAYAENLPL
110 120 130 140 150
VLISGSPNTN DPSQYHILHH TLGHPDYTYQ YEMAKKITCC AVAIPRAIDA
160 170 180 190 200
PRLIDRALRA AILARKPCYI EIPTNLAGAT CVRPGPISAI TDPITSDKSA
210 220 230 240 250
LEAAAKCAAE YLDGKLKPVI LVGPKAGRAG SEKELIEFAE AMGCAVALQP
260 270 280 290 300
AAKGMFPEDH KQFVGIFWGQ VSSDAADAMV HWADAMICVG AVFNDYSTVG
310 320 330 340 350
WTAVPNIPLM TVDMDHVTFP GAHFSRVRMC EFLSHLATQV TFNDSTMIEY
360 370 380 390 400
KRLKPDPPHV HTAEREEPLS RKEISRQVQE MLTDKTSLFV DTGDSWFNGI
410 420 430 440 450
QLKLPPGAKF EIEMQWGHIG WSIPAAFGYA LRHPDRHTIV LVGDGSFQVT
460 470 480 490 500
AQEVSQMVRF KVPITIMLIN NRGYTIEVEI HDGSYNKIKN WDYAMLVEAF
510 520 530 540 550
NSTDGHAKGL LANTAGELAD AIKVAESHKE GPTLIECTID QDDCSKELIT
560 570
WGHYVAAANA RPPRNMSVQE
Length:570
Mass (Da):62,263
Last modified:February 1, 1994 - v1
Checksum:iDF48B86C24EDAACF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09125 mRNA. Translation: AAA33567.1.
U65927 Genomic DNA. Translation: AAB17969.1.
CM002242 Genomic DNA. Translation: ESA42032.1.
S40298 mRNA. Translation: AAB22524.2.
PIRiJN0782.
RefSeqiXP_011395109.1. XM_011396807.1.

Genome annotation databases

EnsemblFungiiESA42032; ESA42032; NCU02193.
GeneIDi3875734.
KEGGincr:NCU02193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09125 mRNA. Translation: AAA33567.1.
U65927 Genomic DNA. Translation: AAB17969.1.
CM002242 Genomic DNA. Translation: ESA42032.1.
S40298 mRNA. Translation: AAB22524.2.
PIRiJN0782.
RefSeqiXP_011395109.1. XM_011396807.1.

3D structure databases

ProteinModelPortaliP33287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-8291074.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiESA42032; ESA42032; NCU02193.
GeneIDi3875734.
KEGGincr:NCU02193.

Organism-specific databases

EuPathDBiFungiDB:NCU02193.

Phylogenomic databases

HOGENOMiHOG000061335.
InParanoidiP33287.
KOiK01568.
OMAiYIEIPTN.
OrthoDBiEOG092C10AB.

Enzyme and pathway databases

UniPathwayiUPA00231.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR029061. THDP-binding.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR012110. TPP_enzyme.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PfamiPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
PIRSFiPIRSF036565. Pyruvt_ip_decrb. 1 hit.
SUPFAMiSSF52467. SSF52467. 1 hit.
SSF52518. SSF52518. 2 hits.
PROSITEiPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDC_NEUCR
AccessioniPrimary (citable) accession number: P33287
Secondary accession number(s): Q7RV97, V5IKN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.