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Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Orotidine 5'-phosphate decarboxylase (URA3)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37SubstrateBy similarity1
Active sitei93Proton donorPROSITE-ProRule annotation1
Binding sitei217SubstrateBy similarity1
Binding sitei235SubstrateBy similarity1

GO - Molecular functioni

  • orotidine-5'-phosphate decarboxylase activity Source: CGD

GO - Biological processi

  • 'de novo' pyrimidine nucleobase biosynthetic process Source: CGD
  • 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  • uracil biosynthetic process Source: CGD

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
Ordered Locus Names:CAGL0I03080g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome I

Organism-specific databases

CGDiCAL0130376. URA3.
EuPathDBiFungiDB:CAGL0I03080g.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: CGD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001346491 – 265Orotidine 5'-phosphate decarboxylaseAdd BLAST265

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_447384.1.

Structurei

3D structure databases

ProteinModelPortaliP33283.
SMRiP33283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni59 – 61Substrate bindingBy similarity3
Regioni91 – 100Substrate bindingBy similarity10

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG1377. Eukaryota.
COG0284. LUCA.
InParanoidiP33283.
KOiK01591.
OMAiMGQQYRT.
OrthoDBiEOG092C3SZ1.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
PfamiView protein in Pfam
PF00215. OMPdecase. 1 hit.
SMARTiView protein in SMART
SM00934. OMPdecase. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiView protein in PROSITE
PS00156. OMPDECASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P33283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSASYLQRA EAHPSPVASK LLKLMHEKKT NLCASLDVTT TSELLKLVDT
60 70 80 90 100
LGPYICLLKT HVDILSDFSF ENTVKPLKEM AAKHNFLIFE DRKFADIGNT
110 120 130 140 150
VKLQYTSGVY KIAEWADITN AHGVTGQGIV TGLKQGAEET TNEPRGLLML
160 170 180 190 200
AELSSKGSLA HGEYTKGTVD IAKSDKDFVI GFIAQKDMGG RDEGFDWLIM
210 220 230 240 250
TPGVGLDDKG DALGQQYRTV DEVFSTGTDI IIVGRGLFAK GRDPKTEGER
260
YRKAGWDAYL KRIGN
Length:265
Mass (Da):29,054
Last modified:February 1, 1994 - v1
Checksum:i19F42505E26EF136
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13661 Genomic DNA. Translation: AAA34325.1.
CR380955 Genomic DNA. Translation: CAG60321.1.
RefSeqiXP_447384.1. XM_447384.1.

Genome annotation databases

EnsemblFungiiCAG60321; CAG60321; CAGL0I03080g.
KEGGicgr:CAGL0I03080g.

Similar proteinsi

Entry informationi

Entry nameiPYRF_CANGA
AccessioniPrimary (citable) accession number: P33283
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: August 30, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families