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P33283 (PYRF_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
Ordered Locus Names:CAGL0I03080g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Orotidine 5'-phosphate decarboxylase
PRO_0000134649

Regions

Region59 – 613Substrate binding By similarity
Region91 – 10010Substrate binding By similarity

Sites

Active site931Proton donor By similarity
Binding site371Substrate By similarity
Binding site2171Substrate By similarity
Binding site2351Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P33283 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 19F42505E26EF136

FASTA26529,054
        10         20         30         40         50         60 
MSSASYLQRA EAHPSPVASK LLKLMHEKKT NLCASLDVTT TSELLKLVDT LGPYICLLKT 

        70         80         90        100        110        120 
HVDILSDFSF ENTVKPLKEM AAKHNFLIFE DRKFADIGNT VKLQYTSGVY KIAEWADITN 

       130        140        150        160        170        180 
AHGVTGQGIV TGLKQGAEET TNEPRGLLML AELSSKGSLA HGEYTKGTVD IAKSDKDFVI 

       190        200        210        220        230        240 
GFIAQKDMGG RDEGFDWLIM TPGVGLDDKG DALGQQYRTV DEVFSTGTDI IIVGRGLFAK 

       250        260 
GRDPKTEGER YRKAGWDAYL KRIGN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L13661 Genomic DNA. Translation: AAA34325.1.
CR380955 Genomic DNA. Translation: CAG60321.1.
RefSeqXP_447384.1. XM_447384.1.

3D structure databases

ProteinModelPortalP33283.
SMRP33283. Positions 1-264.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2889164.
KEGGcgr:CAGL0I03080g.

Phylogenomic databases

KOK01591.
OMAMGQQYRT.
OrthoDBEOG7CVQ76.

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_CANGA
AccessionPrimary (citable) accession number: P33283
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 13, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways