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P33283

- PYRF_CANGA

UniProt

P33283 - PYRF_CANGA

Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371SubstrateBy similarity
    Active sitei93 – 931Proton donorPROSITE-ProRule annotation
    Binding sitei217 – 2171SubstrateBy similarity
    Binding sitei235 – 2351SubstrateBy similarity

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: CGD

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: CGD
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
    3. uracil biosynthetic process Source: CGD

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMP decarboxylase
    Short name:
    OMPDCase
    Short name:
    OMPdecase
    Uridine 5'-monophosphate synthase
    Short name:
    UMP synthase
    Gene namesi
    Name:URA3
    Ordered Locus Names:CAGL0I03080g
    OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
    Taxonomic identifieri284593 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
    ProteomesiUP000002428: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: CGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265Orotidine 5'-phosphate decarboxylasePRO_0000134649Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP33283.
    SMRiP33283. Positions 1-264.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni59 – 613Substrate bindingBy similarity
    Regioni91 – 10010Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family.Curated

    Phylogenomic databases

    KOiK01591.
    OMAiMGQQYRT.
    OrthoDBiEOG7CVQ76.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33283-1 [UniParc]FASTAAdd to Basket

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    MSSASYLQRA EAHPSPVASK LLKLMHEKKT NLCASLDVTT TSELLKLVDT    50
    LGPYICLLKT HVDILSDFSF ENTVKPLKEM AAKHNFLIFE DRKFADIGNT 100
    VKLQYTSGVY KIAEWADITN AHGVTGQGIV TGLKQGAEET TNEPRGLLML 150
    AELSSKGSLA HGEYTKGTVD IAKSDKDFVI GFIAQKDMGG RDEGFDWLIM 200
    TPGVGLDDKG DALGQQYRTV DEVFSTGTDI IIVGRGLFAK GRDPKTEGER 250
    YRKAGWDAYL KRIGN 265
    Length:265
    Mass (Da):29,054
    Last modified:February 1, 1994 - v1
    Checksum:i19F42505E26EF136
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13661 Genomic DNA. Translation: AAA34325.1.
    CR380955 Genomic DNA. Translation: CAG60321.1.
    RefSeqiXP_447384.1. XM_447384.1.

    Genome annotation databases

    GeneIDi2889164.
    KEGGicgr:CAGL0I03080g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13661 Genomic DNA. Translation: AAA34325.1 .
    CR380955 Genomic DNA. Translation: CAG60321.1 .
    RefSeqi XP_447384.1. XM_447384.1.

    3D structure databases

    ProteinModelPortali P33283.
    SMRi P33283. Positions 1-264.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2889164.
    KEGGi cgr:CAGL0I03080g.

    Phylogenomic databases

    KOi K01591.
    OMAi MGQQYRT.
    OrthoDBi EOG7CVQ76.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A system for gene cloning and manipulation in the yeast Candida glabrata."
      Zhou P., Szczypka M.S., Young R.J., Thiele D.J.
      Gene 142:135-140(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 85/038.
    2. "Genome evolution in yeasts."
      Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
      , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
      Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

    Entry informationi

    Entry nameiPYRF_CANGA
    AccessioniPrimary (citable) accession number: P33283
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3