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Protein

Cytochrome P450 4F1

Gene

Cyp4f1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

heme1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei328Heme (covalent; via 1 link)1 Publication1
Metal bindingi468Iron (heme axial ligand)1 Publication1

GO - Molecular functioni

  • arachidonic acid binding Source: RGD
  • arachidonic acid monooxygenase activity Source: RGD
  • aromatase activity Source: UniProtKB-EC
  • heme binding Source: RGD
  • iron ion binding Source: InterPro

GO - Biological processi

  • arachidonic acid metabolic process Source: RGD
  • icosanoid metabolic process Source: RGD
  • response to toxic substance Source: RGD

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Chemistry databases

SwissLipidsiSLP:000001703.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4F1 (EC:1.14.14.1)
Alternative name(s):
CYPIVF1
Cytochrome P450-A3
Gene namesi
Name:Cyp4f1
Synonyms:Cyp4f-1, Cyp4f2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70926. Cyp4f1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3509587.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518491 – 524Cytochrome P450 4F1Add BLAST524

Proteomic databases

PaxDbiP33274.
PRIDEiP33274.

Expressioni

Developmental stagei

The level of P450 4F1 is found to increase dramatically in hepatic tumors.

Interactioni

Protein-protein interaction databases

MINTiMINT-4569528.
STRINGi10116.ENSRNOP00000006533.

Structurei

3D structure databases

ProteinModelPortaliP33274.
SMRiP33274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiP33274.
PhylomeDBiP33274.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

P33274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQLSLSWLG LGPEVAFPWQ TLLLFGASWI LAQILTQIYA AYRNFRRLRG
60 70 80 90 100
FPQPPKRNWL MGHVGMVTPT EQGLKELTRL VGTYPQGFLM WIGPMVPVIT
110 120 130 140 150
LCHSDIVRSI LNASAAVALK DVIFYTILKP WLGDGLLVSA GDKWSRHRRM
160 170 180 190 200
LTPAFHFNIL KPYVKIFNDS TNIMHAKWKR LISEGSSRLD MFEHVSLMTL
210 220 230 240 250
DSLQKCVFSF DSNCQEKSSE YIAAILELSA LVAKRHQQPL LFMDLLYNLT
260 270 280 290 300
PDGMRFHKAC NLVHEFTDAV IRERRRTLPD QGLDEFLKSK AKSKTLDFID
310 320 330 340 350
VLLLTKDEDG KELSDEDIRA EADTFMFEGH DTTASGLSWI LYNLANDPEY
360 370 380 390 400
QERCRQEVQE LLRDRDPEEI EWDDLAQLPF LTMCIKESLR LHPPVTVISR
410 420 430 440 450
CCTQDILLPD GRTIPKGIIC LISIFGIHHN PSVWPDPEVY NPFRFDPENI
460 470 480 490 500
KDSSPLAFIP FSAGPRNCIG QTFAMSEMKV ALALTLLRFR LLPDDKEPRR
510 520
QPELILRAEG GLWLRVEPLT AGAQ
Length:524
Mass (Da):59,868
Last modified:February 1, 1994 - v1
Checksum:i572CEA2617CE632D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94548 mRNA. Translation: AAA41040.1.
AF200361 Genomic DNA. Translation: AAF20822.1.
PIRiS29723.
UniGeneiRn.5722.

Genome annotation databases

UCSCiRGD:70926. rat.

Similar proteinsi

Entry informationi

Entry nameiCP4F1_RAT
AccessioniPrimary (citable) accession number: P33274
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: August 30, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families