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P33273 (CP255_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C55

EC=1.14.14.1
Alternative name(s):
CYPIIC24
CYPIIC55
Cytochrome P450 2C24
Cytochrome P450-PROS2
Gene names
Name:Cyp2c55
Synonyms:Cyp2c-55, Cyp2c24
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Metabolizes arachidonic acid mainly to 19-hydroxyeicosatetraenoic acid (HETE) By similarity.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Cytochrome P450 2C55
PRO_0000051712

Sites

Metal binding4351Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict1251H → R in M86677. Ref.2
Sequence conflict3171T → I in M86677. Ref.2
Sequence conflict3881V → L in M86677. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P33273 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: 1E3098CC99043163

FASTA49055,991
        10         20         30         40         50         60 
MDPVLVLVLT LSCLLLLSLW RQSSGRGKLP PGPTPLPIIG NILQIDVKDI SKSFSYFSKI 

        70         80         90        100        110        120 
YGPVFTLYFG PKPTVVVHGY EAVKEALDDL GEEFSGRGSF PIVERMNNGL GLIFSNGTKW 

       130        140        150        160        170        180 
KELRHFSLMT LRNFGMGKRS IEDRIQEEAS CLVEELRKTN GSLCDPTFIL SCAPSNVICS 

       190        200        210        220        230        240 
VVFHNRFDYK DENFLNLMEK LNENFKILNS PWMQVCNALP AFIDYLPGSH NRVIKNFAEI 

       250        260        270        280        290        300 
KSYILRRVKE HQETLDMDNP RDFIDCFLIK MEQEKHNPRT EFTIESLMAT VSDVFVAGSE 

       310        320        330        340        350        360 
TTSTTLRYGL LLLLKHTEVT AKVQEEIDHV IGRHRRPCMQ DRTRMPYTDA MVHEIQRYIN 

       370        380        390        400        410        420 
LIPNNVPHAA TCNVRFRNYV IPKGTDLVTS LTSVLHDDKE FPNPEVFDPG HFLDENGNFK 

       430        440        450        460        470        480 
KSDYFMPFST GKRMCVGEAL ARMELFLLLT TIVQNFNLKS FVDTKDIDTT PMANTFGRVP 

       490 
PSYQLCFIPR 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.
[2]"cDNA cloning and regulation of a novel rat cytochrome P450 of the 2C gene subfamily (P450IIC24)."
Zaphiropoulos P.G.
Biochem. Biophys. Res. Commun. 180:645-651(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-490.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC121010 Genomic DNA. No translation available.
M86677 Genomic DNA. No translation available.
M86678 Genomic DNA. No translation available.
PIRJH0451.

3D structure databases

ProteinModelPortalP33273.
SMRP33273. Positions 30-489.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000015802.

Proteomic databases

PaxDbP33273.
PRIDEP33273.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD1311338. Cyp2c55.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036992.
HOVERGENHBG015789.
PhylomeDBP33273.

Gene expression databases

GenevestigatorP33273.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP255_RAT
AccessionPrimary (citable) accession number: P33273
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: April 3, 2007
Last modified: April 16, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families