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P33272

- CP2BC_RAT

UniProt

P33272 - CP2BC_RAT

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Protein

Cytochrome P450 2B12

Gene

Cyp2b12

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme seems responsible for metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. arachidonic acid epoxygenase activity Source: RGD
  2. aromatase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. epoxygenase P450 pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2B12 (EC:1.14.14.1)
Alternative name(s):
CYPIIB12
Gene namesi
Name:Cyp2b12
Synonyms:Cyp2b-12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620088. Cyp2b12.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. intracellular membrane-bounded organelle Source: RGD
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Cytochrome P450 2B12PRO_0000051687Add
BLAST

Proteomic databases

PaxDbiP33272.

Expressioni

Tissue specificityi

Preputial gland, but not in liver.

Gene expression databases

GenevestigatoriP33272.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048784.

Structurei

3D structure databases

ProteinModelPortaliP33272.
SMRiP33272. Positions 29-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
KOiK07412.
PhylomeDBiP33272.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33272-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFGVLLLLT LTVGFLLFLV SQSQPKTHGH LPPGPRPLPF LGNLLQMNRR
60 70 80 90 100
GFLNSFMQLQ EKYGDVFTVH LGPRPVVILC GTDTIREALV DQAEAFSGRG
110 120 130 140 150
TVAVLHPVVQ GYGVIFATGE RWKTLRRFSL VTMKEFGMGK RSVDERIKEE
160 170 180 190 200
AQCLVEELKK YKGAPLNPTF LFQSIAANTI CSIVFGERFD YKDHQFLHLL
210 220 230 240 250
DLVYKTSVLM GSLSSQVFEL YSGFLKYFPG AHKQIFKNLQ EMLNYIGHIV
260 270 280 290 300
EKHRATLDPS APRDFIDTYL LRMEKEKSNH HTEFNHQNLV ISVLSLFFAG
310 320 330 340 350
TETTSTTLRC TFLIMLKYPH VAEKVQKEID QVIGSHRLPT PDDRTKMPYT
360 370 380 390 400
DAVIHEIQRF ADLTPIGLPH RVTKDTVFRG YLLPKNTEVY PILSSALHDP
410 420 430 440 450
RYFEQPDTFN PEHFLDANGA LKKSEAFLPF STGKRICLGE GIARNELFIF
460 470 480 490
FTAILQNFTL ASPVAPEDID LTPINIGVGK IPSPYQINFL SR
Length:492
Mass (Da):55,797
Last modified:February 1, 1994 - v1
Checksum:iA21B1D4F9D77445B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63545 mRNA. Translation: CAA45107.1.
PIRiS27160.
RefSeqiNP_058852.1. NM_017156.1.
UniGeneiRn.144570.

Genome annotation databases

GeneIDi29295.
KEGGirno:29295.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63545 mRNA. Translation: CAA45107.1 .
PIRi S27160.
RefSeqi NP_058852.1. NM_017156.1.
UniGenei Rn.144570.

3D structure databases

ProteinModelPortali P33272.
SMRi P33272. Positions 29-492.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000048784.

Proteomic databases

PaxDbi P33272.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29295.
KEGGi rno:29295.

Organism-specific databases

CTDi 29295.
RGDi 620088. Cyp2b12.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
KOi K07412.
PhylomeDBi P33272.

Miscellaneous databases

NextBioi 608695.

Gene expression databases

Genevestigatori P33272.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of a novel cytochrome CYP2B cDNA coding for a protein which is expressed in a sebaceous gland, but not in the liver."
    Friedberg T., Grassow M.A., Bartlomowicz-Oesch B., Siegert P., Arand M., Adesnik M., Oesch F.
    Biochem. J. 287:775-783(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP2BC_RAT
AccessioniPrimary (citable) accession number: P33272
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3