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P33272

- CP2BC_RAT

UniProt

P33272 - CP2BC_RAT

Protein

Cytochrome P450 2B12

Gene

Cyp2b12

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme seems responsible for metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. arachidonic acid epoxygenase activity Source: RGD
    2. aromatase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. epoxygenase P450 pathway Source: RGD

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2B12 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIB12
    Gene namesi
    Name:Cyp2b12
    Synonyms:Cyp2b-12
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620088. Cyp2b12.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. intracellular membrane-bounded organelle Source: RGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 492492Cytochrome P450 2B12PRO_0000051687Add
    BLAST

    Proteomic databases

    PaxDbiP33272.

    Expressioni

    Tissue specificityi

    Preputial gland, but not in liver.

    Gene expression databases

    GenevestigatoriP33272.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000048784.

    Structurei

    3D structure databases

    ProteinModelPortaliP33272.
    SMRiP33272. Positions 29-492.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiP33272.
    KOiK07412.
    PhylomeDBiP33272.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01685. EP450ICYP2B.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33272-1 [UniParc]FASTAAdd to Basket

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    MEFGVLLLLT LTVGFLLFLV SQSQPKTHGH LPPGPRPLPF LGNLLQMNRR    50
    GFLNSFMQLQ EKYGDVFTVH LGPRPVVILC GTDTIREALV DQAEAFSGRG 100
    TVAVLHPVVQ GYGVIFATGE RWKTLRRFSL VTMKEFGMGK RSVDERIKEE 150
    AQCLVEELKK YKGAPLNPTF LFQSIAANTI CSIVFGERFD YKDHQFLHLL 200
    DLVYKTSVLM GSLSSQVFEL YSGFLKYFPG AHKQIFKNLQ EMLNYIGHIV 250
    EKHRATLDPS APRDFIDTYL LRMEKEKSNH HTEFNHQNLV ISVLSLFFAG 300
    TETTSTTLRC TFLIMLKYPH VAEKVQKEID QVIGSHRLPT PDDRTKMPYT 350
    DAVIHEIQRF ADLTPIGLPH RVTKDTVFRG YLLPKNTEVY PILSSALHDP 400
    RYFEQPDTFN PEHFLDANGA LKKSEAFLPF STGKRICLGE GIARNELFIF 450
    FTAILQNFTL ASPVAPEDID LTPINIGVGK IPSPYQINFL SR 492
    Length:492
    Mass (Da):55,797
    Last modified:February 1, 1994 - v1
    Checksum:iA21B1D4F9D77445B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63545 mRNA. Translation: CAA45107.1.
    PIRiS27160.
    RefSeqiNP_058852.1. NM_017156.1.
    UniGeneiRn.144570.

    Genome annotation databases

    GeneIDi29295.
    KEGGirno:29295.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63545 mRNA. Translation: CAA45107.1 .
    PIRi S27160.
    RefSeqi NP_058852.1. NM_017156.1.
    UniGenei Rn.144570.

    3D structure databases

    ProteinModelPortali P33272.
    SMRi P33272. Positions 29-492.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000048784.

    Proteomic databases

    PaxDbi P33272.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29295.
    KEGGi rno:29295.

    Organism-specific databases

    CTDi 29295.
    RGDi 620088. Cyp2b12.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    InParanoidi P33272.
    KOi K07412.
    PhylomeDBi P33272.

    Miscellaneous databases

    NextBioi 608695.

    Gene expression databases

    Genevestigatori P33272.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01685. EP450ICYP2B.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of a novel cytochrome CYP2B cDNA coding for a protein which is expressed in a sebaceous gland, but not in the liver."
      Friedberg T., Grassow M.A., Bartlomowicz-Oesch B., Siegert P., Arand M., Adesnik M., Oesch F.
      Biochem. J. 287:775-783(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCP2BC_RAT
    AccessioniPrimary (citable) accession number: P33272
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3