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P33272 (CP2BC_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2B12

EC=1.14.14.1
Alternative name(s):
CYPIIB12
Gene names
Name:Cyp2b12
Synonyms:Cyp2b-12
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme seems responsible for metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Preputial gland, but not in liver.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492Cytochrome P450 2B12
PRO_0000051687

Sites

Metal binding4371Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P33272 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: A21B1D4F9D77445B

FASTA49255,797
        10         20         30         40         50         60 
MEFGVLLLLT LTVGFLLFLV SQSQPKTHGH LPPGPRPLPF LGNLLQMNRR GFLNSFMQLQ 

        70         80         90        100        110        120 
EKYGDVFTVH LGPRPVVILC GTDTIREALV DQAEAFSGRG TVAVLHPVVQ GYGVIFATGE 

       130        140        150        160        170        180 
RWKTLRRFSL VTMKEFGMGK RSVDERIKEE AQCLVEELKK YKGAPLNPTF LFQSIAANTI 

       190        200        210        220        230        240 
CSIVFGERFD YKDHQFLHLL DLVYKTSVLM GSLSSQVFEL YSGFLKYFPG AHKQIFKNLQ 

       250        260        270        280        290        300 
EMLNYIGHIV EKHRATLDPS APRDFIDTYL LRMEKEKSNH HTEFNHQNLV ISVLSLFFAG 

       310        320        330        340        350        360 
TETTSTTLRC TFLIMLKYPH VAEKVQKEID QVIGSHRLPT PDDRTKMPYT DAVIHEIQRF 

       370        380        390        400        410        420 
ADLTPIGLPH RVTKDTVFRG YLLPKNTEVY PILSSALHDP RYFEQPDTFN PEHFLDANGA 

       430        440        450        460        470        480 
LKKSEAFLPF STGKRICLGE GIARNELFIF FTAILQNFTL ASPVAPEDID LTPINIGVGK 

       490 
IPSPYQINFL SR 

« Hide

References

[1]"Sequence of a novel cytochrome CYP2B cDNA coding for a protein which is expressed in a sebaceous gland, but not in the liver."
Friedberg T., Grassow M.A., Bartlomowicz-Oesch B., Siegert P., Arand M., Adesnik M., Oesch F.
Biochem. J. 287:775-783(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X63545 mRNA. Translation: CAA45107.1.
PIRS27160.
RefSeqNP_058852.1. NM_017156.1.
UniGeneRn.144570.

3D structure databases

ProteinModelPortalP33272.
SMRP33272. Positions 29-492.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000048784.

Proteomic databases

PaxDbP33272.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29295.
KEGGrno:29295.

Organism-specific databases

CTD29295.
RGD620088. Cyp2b12.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036992.
HOVERGENHBG015789.
InParanoidP33272.
KOK07412.
PhylomeDBP33272.

Gene expression databases

GenevestigatorP33272.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio608695.

Entry information

Entry nameCP2BC_RAT
AccessionPrimary (citable) accession number: P33272
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families