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Protein

Cytochrome P450 3A8

Gene

CYP3A8

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes nifedipine and nilvadipine oxidations.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi442Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A8 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA8
Cytochrome P-450-MK2
Cytochrome P450-MKNF2
Gene namesi
Name:CYP3A8
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517911 – 503Cytochrome P450 3A8Add BLAST503

Proteomic databases

PRIDEiP33268

Expressioni

Inductioni

By polychlorinated biphenyl (PCB).

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP33268
SMRiP33268
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

GeneTreeiENSGT00900000140779
HOVERGENiHBG108567
KOiK17689

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR008072 Cyt_P450_E_CYP3A
IPR002402 Cyt_P450_E_grp-II
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00464 EP450II
PR01689 EP450IICYP3A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P33268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLIPDLAVE TWLLLAVTLV LLYLYGTHSH GLFKKLGIPG PTPLPLLGNI
60 70 80 90 100
LSYRKGFWTF DMECYKKYGK VWGFYDGRQP VLAITDPNMI KTVLVKECYS
110 120 130 140 150
VFTNRRPFGP VGFMKNAISI AEDEEWKRIR SLLSPTFTSG KLKEMVPIIA
160 170 180 190 200
KYGDVLVRNL RREAETGKPV TLKDVFGAYS MDVITSTSFG VNIDSLNNPQ
210 220 230 240 250
DPFVENTKKL LRFDFLDPFF LSITIFPFII PILEVLNISI FPREVTSFLR
260 270 280 290 300
KSVKRIKESR LKDTQKHRVD FLQLMIDSQN SKETESHKAL SDLELVAQSI
310 320 330 340 350
IFIFAGYETT SSVLSFIIYE LATHPDVQQK LQEEIDTVLP NKAPPTYDTV
360 370 380 390 400
LQMEYLDMVV NETLRIFPIA MRLERVCKKD VEINGIFIPK GVVVMIPSYA
410 420 430 440 450
LHHDPKYWPE PEKFLPERFS KKNNDNIDPY IYTPFGSGPR NCIGMRFALM
460 470 480 490 500
NMKLAIIRVL QNFSFKPCKE TQIPLKLRLG GLLQTEKPIV LKIESRDGTV

SGA
Length:503
Mass (Da):57,511
Last modified:February 1, 1994 - v1
Checksum:iD701B6FE83AC8BFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S53047 mRNA Translation: AAB24952.1
PIRiS28168
RefSeqiNP_001271463.1, NM_001284534.1
UniGeneiMfa.4832

Genome annotation databases

EnsembliENSMFAT00000014001; ENSMFAP00000039737; ENSMFAG00000046026
GeneIDi102144258
KEGGimcf:102144258

Similar proteinsi

Entry informationi

Entry nameiCP3A8_MACFA
AccessioniPrimary (citable) accession number: P33268
Secondary accession number(s): P25231
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
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Main funding by: National Institutes of Health