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P33268

- CP3A8_MACFA

UniProt

P33268 - CP3A8_MACFA

Protein

Cytochrome P450 3A8

Gene

CYP3A8

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Catalyzes nifedipine and nilvadipine oxidations.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. monooxygenase activity Source: UniProtKB

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A8 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA8
    Cytochrome P-450-MK2
    Cytochrome P450-MKNF2
    Gene namesi
    Name:CYP3A8
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Cytochrome P450 3A8PRO_0000051791Add
    BLAST

    Proteomic databases

    PRIDEiP33268.

    Expressioni

    Inductioni

    By polychlorinated biphenyl (PCB).

    Structurei

    3D structure databases

    ProteinModelPortaliP33268.
    SMRiP33268. Positions 30-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG108567.
    KOiK17689.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33268-1 [UniParc]FASTAAdd to Basket

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    MDLIPDLAVE TWLLLAVTLV LLYLYGTHSH GLFKKLGIPG PTPLPLLGNI    50
    LSYRKGFWTF DMECYKKYGK VWGFYDGRQP VLAITDPNMI KTVLVKECYS 100
    VFTNRRPFGP VGFMKNAISI AEDEEWKRIR SLLSPTFTSG KLKEMVPIIA 150
    KYGDVLVRNL RREAETGKPV TLKDVFGAYS MDVITSTSFG VNIDSLNNPQ 200
    DPFVENTKKL LRFDFLDPFF LSITIFPFII PILEVLNISI FPREVTSFLR 250
    KSVKRIKESR LKDTQKHRVD FLQLMIDSQN SKETESHKAL SDLELVAQSI 300
    IFIFAGYETT SSVLSFIIYE LATHPDVQQK LQEEIDTVLP NKAPPTYDTV 350
    LQMEYLDMVV NETLRIFPIA MRLERVCKKD VEINGIFIPK GVVVMIPSYA 400
    LHHDPKYWPE PEKFLPERFS KKNNDNIDPY IYTPFGSGPR NCIGMRFALM 450
    NMKLAIIRVL QNFSFKPCKE TQIPLKLRLG GLLQTEKPIV LKIESRDGTV 500
    SGA 503
    Length:503
    Mass (Da):57,511
    Last modified:February 1, 1994 - v1
    Checksum:iD701B6FE83AC8BFB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S53047 mRNA. Translation: AAB24952.1.
    PIRiS28168.
    RefSeqiNP_001271463.1. NM_001284534.1.
    UniGeneiMfa.4832.

    Genome annotation databases

    GeneIDi102144258.
    KEGGimcf:102144258.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S53047 mRNA. Translation: AAB24952.1 .
    PIRi S28168.
    RefSeqi NP_001271463.1. NM_001284534.1.
    UniGenei Mfa.4832.

    3D structure databases

    ProteinModelPortali P33268.
    SMRi P33268. Positions 30-496.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P33268.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 102144258.
    KEGGi mcf:102144258.

    Phylogenomic databases

    HOVERGENi HBG108567.
    KOi K17689.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of monkey liver cytochrome P-450 cDNAs: similarity of the primary sequences to human cytochromes P-450."
      Komori M., Kikuchi O., Sakuma T., Funaki J., Kitada M., Kamataki T.
      Biochim. Biophys. Acta 1171:141-146(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Purification of cytochrome P-450 from polychlorinated biphenyl-treated crab-eating monkeys: high homology to a form of human cytochrome P-450."
      Ohta K., Kitada M., Hashizume T., Komori M., Ohi H., Kamataki T.
      Biochim. Biophys. Acta 996:142-145(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-22.
      Tissue: Liver.
    3. "Purification and characterization of two forms of hepatic microsomal cytochrome P450 from untreated cynomolgus monkeys."
      Ohmori S., Horie T., Guengerich F.P., Kiuchi M., Kitada M.
      Arch. Biochem. Biophys. 305:405-413(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiCP3A8_MACFA
    AccessioniPrimary (citable) accession number: P33268
    Secondary accession number(s): P25231
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3