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P33268 (CP3A8_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A8

EC=1.14.14.1
Alternative name(s):
CYPIIIA8
Cytochrome P-450-MK2
Cytochrome P450-MKNF2
Gene names
Name:CYP3A8
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes nifedipine and nilvadipine oxidations.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By polychlorinated biphenyl (PCB).

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Cytochrome P450 3A8
PRO_0000051791

Sites

Metal binding4421Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P33268 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: D701B6FE83AC8BFB

FASTA50357,511
        10         20         30         40         50         60 
MDLIPDLAVE TWLLLAVTLV LLYLYGTHSH GLFKKLGIPG PTPLPLLGNI LSYRKGFWTF 

        70         80         90        100        110        120 
DMECYKKYGK VWGFYDGRQP VLAITDPNMI KTVLVKECYS VFTNRRPFGP VGFMKNAISI 

       130        140        150        160        170        180 
AEDEEWKRIR SLLSPTFTSG KLKEMVPIIA KYGDVLVRNL RREAETGKPV TLKDVFGAYS 

       190        200        210        220        230        240 
MDVITSTSFG VNIDSLNNPQ DPFVENTKKL LRFDFLDPFF LSITIFPFII PILEVLNISI 

       250        260        270        280        290        300 
FPREVTSFLR KSVKRIKESR LKDTQKHRVD FLQLMIDSQN SKETESHKAL SDLELVAQSI 

       310        320        330        340        350        360 
IFIFAGYETT SSVLSFIIYE LATHPDVQQK LQEEIDTVLP NKAPPTYDTV LQMEYLDMVV 

       370        380        390        400        410        420 
NETLRIFPIA MRLERVCKKD VEINGIFIPK GVVVMIPSYA LHHDPKYWPE PEKFLPERFS 

       430        440        450        460        470        480 
KKNNDNIDPY IYTPFGSGPR NCIGMRFALM NMKLAIIRVL QNFSFKPCKE TQIPLKLRLG 

       490        500 
GLLQTEKPIV LKIESRDGTV SGA 

« Hide

References

[1]"Molecular cloning of monkey liver cytochrome P-450 cDNAs: similarity of the primary sequences to human cytochromes P-450."
Komori M., Kikuchi O., Sakuma T., Funaki J., Kitada M., Kamataki T.
Biochim. Biophys. Acta 1171:141-146(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Purification of cytochrome P-450 from polychlorinated biphenyl-treated crab-eating monkeys: high homology to a form of human cytochrome P-450."
Ohta K., Kitada M., Hashizume T., Komori M., Ohi H., Kamataki T.
Biochim. Biophys. Acta 996:142-145(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-22.
Tissue: Liver.
[3]"Purification and characterization of two forms of hepatic microsomal cytochrome P450 from untreated cynomolgus monkeys."
Ohmori S., Horie T., Guengerich F.P., Kiuchi M., Kitada M.
Arch. Biochem. Biophys. 305:405-413(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S53047 mRNA. Translation: AAB24952.1.
PIRS28168.
RefSeqNP_001271463.1. NM_001284534.1.
UniGeneMfa.4832.

3D structure databases

ProteinModelPortalP33268.
SMRP33268. Positions 30-496.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP33268.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID102144258.
KEGGmcf:102144258.

Phylogenomic databases

HOVERGENHBG108567.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP3A8_MACFA
AccessionPrimary (citable) accession number: P33268
Secondary accession number(s): P25231
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families