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Protein

Cytochrome P450 2F2

Gene

Cyp2f2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl-1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or Clara cells in lung.2 Publications

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi436Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • epoxygenase P450 pathway Source: GO_Central
  • naphthalene metabolic process Source: MGI
  • response to toxic substance Source: MGI
  • trichloroethylene metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211981. Xenobiotics.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2F2 (EC:1.14.14.-)
Alternative name(s):
CYPIIF2
Cytochrome P450-NAH-2
Naphthalene dehydrogenase
Naphthalene hydroxylase
Gene namesi
Name:Cyp2f2
Synonyms:Cyp2f-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:88608. Cyp2f2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517601 – 491Cytochrome P450 2F2Add BLAST491

Proteomic databases

MaxQBiP33267.
PaxDbiP33267.
PeptideAtlasiP33267.
PRIDEiP33267.

PTM databases

iPTMnetiP33267.
PhosphoSitePlusiP33267.
SwissPalmiP33267.

Expressioni

Tissue specificityi

Clara cells in lung and liver.2 Publications

Gene expression databases

BgeeiENSMUSG00000052974.
ExpressionAtlasiP33267. baseline and differential.
GenevisibleiP33267. MM.

Interactioni

Protein-protein interaction databases

IntActiP33267. 2 interactors.
MINTiMINT-1862621.
STRINGi10090.ENSMUSP00000003100.

Structurei

3D structure databases

ProteinModelPortaliP33267.
SMRiP33267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP33267.
KOiK07416.
OMAiHAFLILM.
OrthoDBiEOG091G0BT8.
PhylomeDBiP33267.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR020469. Cyt_P450_CYP2_fam.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01957. EP450ICYP2F.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33267-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGVSTAILL LLLAVISLSL TFSSRGKGQL PPGPKPLPIL GNLLQLRSQD
60 70 80 90 100
LLTSLTKLSK EYGSVFTVYL GSRPVIVLSG YQTVKEALVD KGEEFSGRGA
110 120 130 140 150
YPVFFNFTRG NGIAFSDGER WKILRRFSVQ ILRNFGMGKR SIEERILEEG
160 170 180 190 200
SFLLEVLRKM EGKPFDPVFI LSRSVSNIIC SVVFGSRFDY DDERLLTIIH
210 220 230 240 250
FINDNFKIMS SPWGEMYNIF PSVLDWIPGP HKRLFRNFGG MKDLIARSVR
260 270 280 290 300
EHQDSLDPNS PRDFIDCFLT KMAQEKQDPL SHFNMDTLLM TTHNLLFGGT
310 320 330 340 350
ETVGTTLRHA FLILMKYPKV QARVQEEIDR VVGRSRMPTL EDRTSMPYTD
360 370 380 390 400
AVIHEVQRFA DVIPMNLPHR VTRDTPFRGF LIPKGTDVIT LLNTVHYDSD
410 420 430 440 450
QFKTPQEFNP EHFLDDNHSF KKSPAFMPFS AGRRLCLGEP LARMELFIYF
460 470 480 490
TSILQNFTLQ PLVDPEDIDL TPLSSGLGNL PRPFQLCMHI R
Length:491
Mass (Da):55,949
Last modified:February 1, 1994 - v1
Checksum:iF56AEB956E7EBD25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77497 mRNA. Translation: AAA37517.1. Sequence problems.
BC011089 mRNA. Translation: AAH11089.1.
BC024742 mRNA. Translation: AAH24742.1.
CCDSiCCDS21010.1.
PIRiA39302.
RefSeqiNP_031843.2. NM_007817.2.
UniGeneiMm.4515.

Genome annotation databases

EnsembliENSMUST00000003100; ENSMUSP00000003100; ENSMUSG00000052974.
GeneIDi13107.
KEGGimmu:13107.
UCSCiuc009fuy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77497 mRNA. Translation: AAA37517.1. Sequence problems.
BC011089 mRNA. Translation: AAH11089.1.
BC024742 mRNA. Translation: AAH24742.1.
CCDSiCCDS21010.1.
PIRiA39302.
RefSeqiNP_031843.2. NM_007817.2.
UniGeneiMm.4515.

3D structure databases

ProteinModelPortaliP33267.
SMRiP33267.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP33267. 2 interactors.
MINTiMINT-1862621.
STRINGi10090.ENSMUSP00000003100.

PTM databases

iPTMnetiP33267.
PhosphoSitePlusiP33267.
SwissPalmiP33267.

Proteomic databases

MaxQBiP33267.
PaxDbiP33267.
PeptideAtlasiP33267.
PRIDEiP33267.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003100; ENSMUSP00000003100; ENSMUSG00000052974.
GeneIDi13107.
KEGGimmu:13107.
UCSCiuc009fuy.1. mouse.

Organism-specific databases

CTDi13107.
MGIiMGI:88608. Cyp2f2.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP33267.
KOiK07416.
OMAiHAFLILM.
OrthoDBiEOG091G0BT8.
PhylomeDBiP33267.
TreeFamiTF352043.

Enzyme and pathway databases

ReactomeiR-MMU-211981. Xenobiotics.

Miscellaneous databases

ChiTaRSiCyp2f2. mouse.
PROiP33267.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052974.
ExpressionAtlasiP33267. baseline and differential.
GenevisibleiP33267. MM.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR020469. Cyt_P450_CYP2_fam.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01957. EP450ICYP2F.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP2F2_MOUSE
AccessioniPrimary (citable) accession number: P33267
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.