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P33265

- CP2CS_MESAU

UniProt

P33265 - CP2CS_MESAU

Protein

Cytochrome P450 2C28

Gene

CYP2C28

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Catalyzes the N-demethylation of aminopyrine and benzphetamine, but does not catalyze the hydroxylation of tolbutamide, testosterone, and progesterone.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C28 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC28
    Cytochrome P450 HSM4
    Gene namesi
    Name:CYP2C28
    OrganismiMesocricetus auratus (Golden hamster)
    Taxonomic identifieri10036 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Cytochrome P450 2C28PRO_0000051716Add
    BLAST

    Expressioni

    Tissue specificityi

    Liver.

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Structurei

    3D structure databases

    ProteinModelPortaliP33265.
    SMRiP33265. Positions 30-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG015789.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33265-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPVLVLVLT LSCLLLFSVW RQSSGRGRLP PGPTPLPLIG NILQIDIKDI    50
    SKSLANFSKV YGPVFTLYFG TKPTVVVHGY EAVKEALEDL GEEFSGRGNF 100
    PIVERMNSGL GIIFSNGTKW KELRRFSLMT LRNFGMGKRS IEDCIQEEAR 150
    CLVEELRKTN GSPCDPTFFL SCAPSNVICS VVFHNRFDYN DKNFLNLMEK 200
    LNENFEILNS PWLQVCNVIP AFLDYLPGSH NKALKNFAEI KSYILKRVKE 250
    HQETLDMNNP RDFIDCFLIK MEKEKDNPHS EFTTESLMAT VADVFVAGSE 300
    TTSTTLRYGL LLLLKHKEVT AKVQKEIDHV IGRDRSPCMQ DRTRMPYTDA 350
    MVHEVQRYVN LIPNNVPHAA TCNVKFRNYV IPKGTDLITS LTSVLHDDKE 400
    FPNPKIFDPA HFLDENGNFK KSDYFMPFSI GKRMCMGEAL ARMELFLLLT 450
    TILQNFDLKS LADTKDIDTT PVASTFGCVP PSYQLYFIPR 490
    Length:490
    Mass (Da):55,703
    Last modified:February 1, 1994 - v1
    Checksum:iDD567183B3A51801
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D11437 mRNA. Translation: BAA02003.1.
    PIRiI48164.
    RefSeqiNP_001268612.1. NM_001281683.1.

    Genome annotation databases

    GeneIDi101832144.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D11437 mRNA. Translation: BAA02003.1 .
    PIRi I48164.
    RefSeqi NP_001268612.1. NM_001281683.1.

    3D structure databases

    ProteinModelPortali P33265.
    SMRi P33265. Positions 30-489.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101832144.

    Phylogenomic databases

    HOVERGENi HBG015789.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a new cDNA clone belonging to the cytochrome P450 2C gene subfamily in hamsters."
      Sakuma T., Yokoi T., Kamataki T.
      Arch. Biochem. Biophys. 319:267-273(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP2CS_MESAU
    AccessioniPrimary (citable) accession number: P33265
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3