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P33265

- CP2CS_MESAU

UniProt

P33265 - CP2CS_MESAU

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Protein

Cytochrome P450 2C28

Gene
CYP2C28
Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the N-demethylation of aminopyrine and benzphetamine, but does not catalyze the hydroxylation of tolbutamide, testosterone, and progesterone.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C28 (EC:1.14.14.1)
Alternative name(s):
CYPIIC28
Cytochrome P450 HSM4
Gene namesi
Name:CYP2C28
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C28PRO_0000051716Add
BLAST

Expressioni

Tissue specificityi

Liver.

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Structurei

3D structure databases

ProteinModelPortaliP33265.
SMRiP33265. Positions 30-489.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33265-1 [UniParc]FASTAAdd to Basket

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MDPVLVLVLT LSCLLLFSVW RQSSGRGRLP PGPTPLPLIG NILQIDIKDI    50
SKSLANFSKV YGPVFTLYFG TKPTVVVHGY EAVKEALEDL GEEFSGRGNF 100
PIVERMNSGL GIIFSNGTKW KELRRFSLMT LRNFGMGKRS IEDCIQEEAR 150
CLVEELRKTN GSPCDPTFFL SCAPSNVICS VVFHNRFDYN DKNFLNLMEK 200
LNENFEILNS PWLQVCNVIP AFLDYLPGSH NKALKNFAEI KSYILKRVKE 250
HQETLDMNNP RDFIDCFLIK MEKEKDNPHS EFTTESLMAT VADVFVAGSE 300
TTSTTLRYGL LLLLKHKEVT AKVQKEIDHV IGRDRSPCMQ DRTRMPYTDA 350
MVHEVQRYVN LIPNNVPHAA TCNVKFRNYV IPKGTDLITS LTSVLHDDKE 400
FPNPKIFDPA HFLDENGNFK KSDYFMPFSI GKRMCMGEAL ARMELFLLLT 450
TILQNFDLKS LADTKDIDTT PVASTFGCVP PSYQLYFIPR 490
Length:490
Mass (Da):55,703
Last modified:February 1, 1994 - v1
Checksum:iDD567183B3A51801
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D11437 mRNA. Translation: BAA02003.1.
PIRiI48164.
RefSeqiNP_001268612.1. NM_001281683.1.

Genome annotation databases

GeneIDi101832144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D11437 mRNA. Translation: BAA02003.1 .
PIRi I48164.
RefSeqi NP_001268612.1. NM_001281683.1.

3D structure databases

ProteinModelPortali P33265.
SMRi P33265. Positions 30-489.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101832144.

Phylogenomic databases

HOVERGENi HBG015789.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of a new cDNA clone belonging to the cytochrome P450 2C gene subfamily in hamsters."
    Sakuma T., Yokoi T., Kamataki T.
    Arch. Biochem. Biophys. 319:267-273(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP2CS_MESAU
AccessioniPrimary (citable) accession number: P33265
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: December 11, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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