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P33265 (CP2CS_MESAU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C28

EC=1.14.14.1
Alternative name(s):
CYPIIC28
Cytochrome P450 HSM4
Gene names
Name:CYP2C28
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the N-demethylation of aminopyrine and benzphetamine, but does not catalyze the hydroxylation of tolbutamide, testosterone, and progesterone.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Liver.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Cytochrome P450 2C28
PRO_0000051716

Sites

Metal binding4351Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P33265 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: DD567183B3A51801

FASTA49055,703
        10         20         30         40         50         60 
MDPVLVLVLT LSCLLLFSVW RQSSGRGRLP PGPTPLPLIG NILQIDIKDI SKSLANFSKV 

        70         80         90        100        110        120 
YGPVFTLYFG TKPTVVVHGY EAVKEALEDL GEEFSGRGNF PIVERMNSGL GIIFSNGTKW 

       130        140        150        160        170        180 
KELRRFSLMT LRNFGMGKRS IEDCIQEEAR CLVEELRKTN GSPCDPTFFL SCAPSNVICS 

       190        200        210        220        230        240 
VVFHNRFDYN DKNFLNLMEK LNENFEILNS PWLQVCNVIP AFLDYLPGSH NKALKNFAEI 

       250        260        270        280        290        300 
KSYILKRVKE HQETLDMNNP RDFIDCFLIK MEKEKDNPHS EFTTESLMAT VADVFVAGSE 

       310        320        330        340        350        360 
TTSTTLRYGL LLLLKHKEVT AKVQKEIDHV IGRDRSPCMQ DRTRMPYTDA MVHEVQRYVN 

       370        380        390        400        410        420 
LIPNNVPHAA TCNVKFRNYV IPKGTDLITS LTSVLHDDKE FPNPKIFDPA HFLDENGNFK 

       430        440        450        460        470        480 
KSDYFMPFSI GKRMCMGEAL ARMELFLLLT TILQNFDLKS LADTKDIDTT PVASTFGCVP 

       490 
PSYQLYFIPR 

« Hide

References

[1]"Isolation and characterization of a new cDNA clone belonging to the cytochrome P450 2C gene subfamily in hamsters."
Sakuma T., Yokoi T., Kamataki T.
Arch. Biochem. Biophys. 319:267-273(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D11437 mRNA. Translation: BAA02003.1.
PIRI48164.
RefSeqNP_001268612.1. NM_001281683.1.

3D structure databases

ProteinModelPortalP33265.
SMRP33265. Positions 30-489.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101832144.

Phylogenomic databases

HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2CS_MESAU
AccessionPrimary (citable) accession number: P33265
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: December 11, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families