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P33264 (CP2CR_MESAU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C27

EC=1.14.14.1
Alternative name(s):
CYPIIC27
Cytochrome P450 HSM3
Gene names
Name:CYP2C27
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the hydroxylation of tolbutamide and the N-demethylation of aminopyrine and benzphetamine.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Specifically expressed by males in kidneys. Expressed predominantly by males in livers.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Cytochrome P450 2C27
PRO_0000051715

Sites

Metal binding4351Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P33264 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 450A208070D60D0A

FASTA49055,767
        10         20         30         40         50         60 
MDAFVVLVFI LSCLFLLSLW RQSSERGKLP PGPTPLPLIG NFFQIDVKDI SGSLTNFSKV 

        70         80         90        100        110        120 
YGPVFTLYLG RKPAVVLHGY EAVKEALIDH GEEFAGRGSF PMAERYNKGL GIVFSNGNRW 

       130        140        150        160        170        180 
KDIRRFSLMA LRSLGMGKRS IEDRVQEEAQ CLVEELRKTN GSPCDPTFIL SCAPCNVICS 

       190        200        210        220        230        240 
IIFQNRFDYT DQDFLTFMEK VNENVRILSS PWLQVCNNFP SLIDYCPGSH HTITKNVNYI 

       250        260        270        280        290        300 
RSYLSEKIKE HQETLDVANP RDFIDYYLIK LKQGNYNQQS EFTLENLATT VRDLFAAGTE 

       310        320        330        340        350        360 
TTSTTLRYAL LLLLKHPHVT AKVQEEIDQV VGRHRNPCMQ DRSHMPYTDA MIHEVQRFID 

       370        380        390        400        410        420 
LIPTNLPHAV TCDIKFRDYF IPKGTTIITS LSSVLHDSKE FPNPEVFDPG HFLDKNGKFK 

       430        440        450        460        470        480 
KSDYFMPFST GKRMCAGEGL ARMELFLFLT TILQNFKLKS LVHPKDIDTT PVVNGLASLP 

       490 
PSYQLCFIPV 

« Hide

References

[1]"Sex-related differences in the expression of cytochrome P450 in hamsters: cDNA cloning and examination of the expression of three distinct CYP2C cDNAs."
Sakuma T., Masaki K., Itoh S., Yokoi T., Kamataki T.
Mol. Pharmacol. 45:228-236(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D11436 mRNA. Translation: BAA02002.1.
PIRI48163.
RefSeqNP_001268504.1. NM_001281575.1.

3D structure databases

ProteinModelPortalP33264.
SMRP33264. Positions 30-490.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101841752.

Phylogenomic databases

HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2CR_MESAU
AccessionPrimary (citable) accession number: P33264
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: December 11, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families