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Protein

Cytochrome P450 2C27

Gene

CYP2C27

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the hydroxylation of tolbutamide and the N-demethylation of aminopyrine and benzphetamine.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C27 (EC:1.14.14.1)
Alternative name(s):
CYPIIC27
Cytochrome P450 HSM3
Gene namesi
Name:CYP2C27
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C27PRO_0000051715Add
BLAST

Expressioni

Tissue specificityi

Specifically expressed by males in kidneys. Expressed predominantly by males in livers.

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Structurei

3D structure databases

ProteinModelPortaliP33264.
SMRiP33264. Positions 30-490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33264-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDAFVVLVFI LSCLFLLSLW RQSSERGKLP PGPTPLPLIG NFFQIDVKDI
60 70 80 90 100
SGSLTNFSKV YGPVFTLYLG RKPAVVLHGY EAVKEALIDH GEEFAGRGSF
110 120 130 140 150
PMAERYNKGL GIVFSNGNRW KDIRRFSLMA LRSLGMGKRS IEDRVQEEAQ
160 170 180 190 200
CLVEELRKTN GSPCDPTFIL SCAPCNVICS IIFQNRFDYT DQDFLTFMEK
210 220 230 240 250
VNENVRILSS PWLQVCNNFP SLIDYCPGSH HTITKNVNYI RSYLSEKIKE
260 270 280 290 300
HQETLDVANP RDFIDYYLIK LKQGNYNQQS EFTLENLATT VRDLFAAGTE
310 320 330 340 350
TTSTTLRYAL LLLLKHPHVT AKVQEEIDQV VGRHRNPCMQ DRSHMPYTDA
360 370 380 390 400
MIHEVQRFID LIPTNLPHAV TCDIKFRDYF IPKGTTIITS LSSVLHDSKE
410 420 430 440 450
FPNPEVFDPG HFLDKNGKFK KSDYFMPFST GKRMCAGEGL ARMELFLFLT
460 470 480 490
TILQNFKLKS LVHPKDIDTT PVVNGLASLP PSYQLCFIPV
Length:490
Mass (Da):55,767
Last modified:February 1, 1994 - v1
Checksum:i450A208070D60D0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11436 mRNA. Translation: BAA02002.1.
PIRiI48163.
RefSeqiNP_001268504.1. NM_001281575.1.

Genome annotation databases

GeneIDi101841752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11436 mRNA. Translation: BAA02002.1.
PIRiI48163.
RefSeqiNP_001268504.1. NM_001281575.1.

3D structure databases

ProteinModelPortaliP33264.
SMRiP33264. Positions 30-490.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101841752.

Phylogenomic databases

HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sex-related differences in the expression of cytochrome P450 in hamsters: cDNA cloning and examination of the expression of three distinct CYP2C cDNAs."
    Sakuma T., Masaki K., Itoh S., Yokoi T., Kamataki T.
    Mol. Pharmacol. 45:228-236(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP2CR_MESAU
AccessioniPrimary (citable) accession number: P33264
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.