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P33264

- CP2CR_MESAU

UniProt

P33264 - CP2CR_MESAU

Protein

Cytochrome P450 2C27

Gene

CYP2C27

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Catalyzes the hydroxylation of tolbutamide and the N-demethylation of aminopyrine and benzphetamine.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C27 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC27
    Cytochrome P450 HSM3
    Gene namesi
    Name:CYP2C27
    OrganismiMesocricetus auratus (Golden hamster)
    Taxonomic identifieri10036 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Cytochrome P450 2C27PRO_0000051715Add
    BLAST

    Expressioni

    Tissue specificityi

    Specifically expressed by males in kidneys. Expressed predominantly by males in livers.

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Structurei

    3D structure databases

    ProteinModelPortaliP33264.
    SMRiP33264. Positions 30-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG015789.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33264-1 [UniParc]FASTAAdd to Basket

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    MDAFVVLVFI LSCLFLLSLW RQSSERGKLP PGPTPLPLIG NFFQIDVKDI    50
    SGSLTNFSKV YGPVFTLYLG RKPAVVLHGY EAVKEALIDH GEEFAGRGSF 100
    PMAERYNKGL GIVFSNGNRW KDIRRFSLMA LRSLGMGKRS IEDRVQEEAQ 150
    CLVEELRKTN GSPCDPTFIL SCAPCNVICS IIFQNRFDYT DQDFLTFMEK 200
    VNENVRILSS PWLQVCNNFP SLIDYCPGSH HTITKNVNYI RSYLSEKIKE 250
    HQETLDVANP RDFIDYYLIK LKQGNYNQQS EFTLENLATT VRDLFAAGTE 300
    TTSTTLRYAL LLLLKHPHVT AKVQEEIDQV VGRHRNPCMQ DRSHMPYTDA 350
    MIHEVQRFID LIPTNLPHAV TCDIKFRDYF IPKGTTIITS LSSVLHDSKE 400
    FPNPEVFDPG HFLDKNGKFK KSDYFMPFST GKRMCAGEGL ARMELFLFLT 450
    TILQNFKLKS LVHPKDIDTT PVVNGLASLP PSYQLCFIPV 490
    Length:490
    Mass (Da):55,767
    Last modified:February 1, 1994 - v1
    Checksum:i450A208070D60D0A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D11436 mRNA. Translation: BAA02002.1.
    PIRiI48163.
    RefSeqiNP_001268504.1. NM_001281575.1.

    Genome annotation databases

    GeneIDi101841752.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D11436 mRNA. Translation: BAA02002.1 .
    PIRi I48163.
    RefSeqi NP_001268504.1. NM_001281575.1.

    3D structure databases

    ProteinModelPortali P33264.
    SMRi P33264. Positions 30-490.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101841752.

    Phylogenomic databases

    HOVERGENi HBG015789.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sex-related differences in the expression of cytochrome P450 in hamsters: cDNA cloning and examination of the expression of three distinct CYP2C cDNAs."
      Sakuma T., Masaki K., Itoh S., Yokoi T., Kamataki T.
      Mol. Pharmacol. 45:228-236(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP2CR_MESAU
    AccessioniPrimary (citable) accession number: P33264
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3