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Protein

Cytochrome P450 2C26

Gene

CYP2C26

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the hydroxylation of tolbutamide and the N-demethylation of aminopyrine and benzphetamine.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi435Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C26 (EC:1.14.14.1)
Alternative name(s):
CYPIIC26
Cytochrome P450 HSM2
Gene namesi
Name:CYP2C26
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
Proteomesi
  • UP000189706 Componenti: Genome assembly

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517141 – 490Cytochrome P450 2C26Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei127PhosphoserineBy similarity1
Modified residuei249N6-acetyllysineBy similarity1
Modified residuei375N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Structurei

3D structure databases

ProteinModelPortaliP33263.
SMRiP33263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG015789.
KOiK07413.
OrthoDBiEOG091G0BT8.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

P33263-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAFVVLVFI LSCLFLLSLW RQSSERGKLP PGPTPLPIIG NFLQIDVKDI
60 70 80 90 100
SGSLTNFSKV YGPVFTLYLG MKPTVVLHGY EAVKEALIDH GEEFAGRGSF
110 120 130 140 150
PVAERVNKGL GIVFSNGSRW KETRRFSLMT LRNLGMGKRS IEDRVQEEAQ
160 170 180 190 200
CLVEELRKTN GSPCDPTFIL GCAPCNVICS IIFQNRFDYK DKDFLTFMKK
210 220 230 240 250
LNENARILSS PWFQVCNNFP LLIDYCPGSH HRITKNINYI RSYLSEKMKE
260 270 280 290 300
HQESLDVANP RDFIDYYLIK LKQGNYNQQS EFSPENLATT VSDLFAAGTE
310 320 330 340 350
TTSTTLRYAL LLLLKHPHVT AKVQEEIDQV VGRHRNPCMQ DRSHMPYTDA
360 370 380 390 400
MIHEVQRFID LIPTNLPHAV TCDIKFRDYF IPKGTTIITS LSSVLHDSKE
410 420 430 440 450
FPNPEVFDPG HFLDKNGNFK KSDYFMPFST GKRMCAGEGL ARMELFLFLT
460 470 480 490
TILQNFKLKS LVHPKDIDTT PVLNGFASLP PSYQLCFIPV
Length:490
Mass (Da):55,724
Last modified:February 1, 1994 - v1
Checksum:i01C4F6DB99772D24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11435 mRNA. Translation: BAA02001.1.
PIRiI48162.
RefSeqiNP_001268582.1. NM_001281653.1.

Genome annotation databases

GeneIDi101831088.
KEGGiag:BAA02001.

Similar proteinsi

Entry informationi

Entry nameiCP2CQ_MESAU
AccessioniPrimary (citable) accession number: P33263
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: August 30, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families