Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P33262

- CP2CK_MACFA

UniProt

P33262 - CP2CK_MACFA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytochrome P450 2C20

Gene

CYP2C20

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C20 (EC:1.14.14.1)
Alternative name(s):
CYPIIC20
Cytochrome P450-MK1
Cytochrome P450-MKMP13
Gene namesi
Name:CYP2C20
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C20PRO_0000051709Add
BLAST

Expressioni

Inductioni

By 3-methylcholanthrene (3MC).

Structurei

3D structure databases

ProteinModelPortaliP33262.
SMRiP33262. Positions 28-490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33262-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPFVVLVLC LSFVLLFSLW RQSSGRRKLP PGPTPLPIIG NILQIDVKDI
60 70 80 90 100
CKSFSNFSKV YGPVFTVYFG MNPVVVLHGY ETVKEALIDN AEEFSGRGIL
110 120 130 140 150
PISERITNGL GIISSNGKRW KETRRFSLTT LRNFGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTK ASPCDPTFIL GCAPCNVICS VVFQKRFDYK DENFLTLIKR
210 220 230 240 250
FTVNFRILTS PWIQVCNNFP LLIDCFPGTH NKLLKNVALT KSYIREKVKE
260 270 280 290 300
HQATLDVNNP RDFIDCFLIK MEQEKDNQQS EFTIENLVGT VADLFVAGTE
310 320 330 340 350
TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA
360 370 380 390 400
VIHEIQRYID LVPTGVPHAV TTDIKFRNYL IPKGTIIITL LTSVLHDDKE
410 420 430 440 450
FPNPKIFDPG HFLDENGNFK KSDYFMPFSA GKRICAGEGL ARMELFLFLT
460 470 480 490
TILQNFNLKS VADLKNLNTT SATRGIISLP PSYQICFIPV
Length:490
Mass (Da):55,638
Last modified:February 1, 1994 - v1
Checksum:i7CEC7078C2F25990
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S53046 mRNA. Translation: AAB24950.1.
PIRiS28166.
RefSeqiNP_001270692.1. NM_001283763.1.
UniGeneiMfa.8192.

Genome annotation databases

GeneIDi102117212.
KEGGimcf:102117212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S53046 mRNA. Translation: AAB24950.1 .
PIRi S28166.
RefSeqi NP_001270692.1. NM_001283763.1.
UniGenei Mfa.8192.

3D structure databases

ProteinModelPortali P33262.
SMRi P33262. Positions 28-490.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 102117212.
KEGGi mcf:102117212.

Phylogenomic databases

HOVERGENi HBG015789.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of monkey liver cytochrome P-450 cDNAs: similarity of the primary sequences to human cytochromes P-450."
    Komori M., Kikuchi O., Sakuma T., Funaki J., Kitada M., Kamataki T.
    Biochim. Biophys. Acta 1171:141-146(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP2CK_MACFA
AccessioniPrimary (citable) accession number: P33262
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3