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P33262

- CP2CK_MACFA

UniProt

P33262 - CP2CK_MACFA

Protein

Cytochrome P450 2C20

Gene

CYP2C20

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C20 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC20
    Cytochrome P450-MK1
    Cytochrome P450-MKMP13
    Gene namesi
    Name:CYP2C20
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Cytochrome P450 2C20PRO_0000051709Add
    BLAST

    Expressioni

    Inductioni

    By 3-methylcholanthrene (3MC).

    Structurei

    3D structure databases

    ProteinModelPortaliP33262.
    SMRiP33262. Positions 28-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG015789.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33262-1 [UniParc]FASTAAdd to Basket

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    MDPFVVLVLC LSFVLLFSLW RQSSGRRKLP PGPTPLPIIG NILQIDVKDI    50
    CKSFSNFSKV YGPVFTVYFG MNPVVVLHGY ETVKEALIDN AEEFSGRGIL 100
    PISERITNGL GIISSNGKRW KETRRFSLTT LRNFGMGKRS IEDRVQEEAR 150
    CLVEELRKTK ASPCDPTFIL GCAPCNVICS VVFQKRFDYK DENFLTLIKR 200
    FTVNFRILTS PWIQVCNNFP LLIDCFPGTH NKLLKNVALT KSYIREKVKE 250
    HQATLDVNNP RDFIDCFLIK MEQEKDNQQS EFTIENLVGT VADLFVAGTE 300
    TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA 350
    VIHEIQRYID LVPTGVPHAV TTDIKFRNYL IPKGTIIITL LTSVLHDDKE 400
    FPNPKIFDPG HFLDENGNFK KSDYFMPFSA GKRICAGEGL ARMELFLFLT 450
    TILQNFNLKS VADLKNLNTT SATRGIISLP PSYQICFIPV 490
    Length:490
    Mass (Da):55,638
    Last modified:February 1, 1994 - v1
    Checksum:i7CEC7078C2F25990
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S53046 mRNA. Translation: AAB24950.1.
    PIRiS28166.
    RefSeqiNP_001270692.1. NM_001283763.1.
    UniGeneiMfa.8192.

    Genome annotation databases

    GeneIDi102117212.
    KEGGimcf:102117212.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S53046 mRNA. Translation: AAB24950.1 .
    PIRi S28166.
    RefSeqi NP_001270692.1. NM_001283763.1.
    UniGenei Mfa.8192.

    3D structure databases

    ProteinModelPortali P33262.
    SMRi P33262. Positions 28-490.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 102117212.
    KEGGi mcf:102117212.

    Phylogenomic databases

    HOVERGENi HBG015789.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of monkey liver cytochrome P-450 cDNAs: similarity of the primary sequences to human cytochromes P-450."
      Komori M., Kikuchi O., Sakuma T., Funaki J., Kitada M., Kamataki T.
      Biochim. Biophys. Acta 1171:141-146(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP2CK_MACFA
    AccessioniPrimary (citable) accession number: P33262
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3