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P33262 (CP2CK_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C20

EC=1.14.14.1
Alternative name(s):
CYPIIC20
Cytochrome P450-MK1
Cytochrome P450-MKMP13
Gene names
Name:CYP2C20
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By 3-methylcholanthrene (3MC).

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Cytochrome P450 2C20
PRO_0000051709

Sites

Metal binding4351Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P33262 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 7CEC7078C2F25990

FASTA49055,638
        10         20         30         40         50         60 
MDPFVVLVLC LSFVLLFSLW RQSSGRRKLP PGPTPLPIIG NILQIDVKDI CKSFSNFSKV 

        70         80         90        100        110        120 
YGPVFTVYFG MNPVVVLHGY ETVKEALIDN AEEFSGRGIL PISERITNGL GIISSNGKRW 

       130        140        150        160        170        180 
KETRRFSLTT LRNFGMGKRS IEDRVQEEAR CLVEELRKTK ASPCDPTFIL GCAPCNVICS 

       190        200        210        220        230        240 
VVFQKRFDYK DENFLTLIKR FTVNFRILTS PWIQVCNNFP LLIDCFPGTH NKLLKNVALT 

       250        260        270        280        290        300 
KSYIREKVKE HQATLDVNNP RDFIDCFLIK MEQEKDNQQS EFTIENLVGT VADLFVAGTE 

       310        320        330        340        350        360 
TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA VIHEIQRYID 

       370        380        390        400        410        420 
LVPTGVPHAV TTDIKFRNYL IPKGTIIITL LTSVLHDDKE FPNPKIFDPG HFLDENGNFK 

       430        440        450        460        470        480 
KSDYFMPFSA GKRICAGEGL ARMELFLFLT TILQNFNLKS VADLKNLNTT SATRGIISLP 

       490 
PSYQICFIPV 

« Hide

References

[1]"Molecular cloning of monkey liver cytochrome P-450 cDNAs: similarity of the primary sequences to human cytochromes P-450."
Komori M., Kikuchi O., Sakuma T., Funaki J., Kitada M., Kamataki T.
Biochim. Biophys. Acta 1171:141-146(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S53046 mRNA. Translation: AAB24950.1.
PIRS28166.
RefSeqNP_001270692.1. NM_001283763.1.
UniGeneMfa.8192.

3D structure databases

ProteinModelPortalP33262.
SMRP33262. Positions 28-490.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID102117212.
KEGGmcf:102117212.

Phylogenomic databases

HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2CK_MACFA
AccessionPrimary (citable) accession number: P33262
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families