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P33262

- CP2CK_MACFA

UniProt

P33262 - CP2CK_MACFA

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Protein

Cytochrome P450 2C20

Gene
CYP2C20
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C20 (EC:1.14.14.1)
Alternative name(s):
CYPIIC20
Cytochrome P450-MK1
Cytochrome P450-MKMP13
Gene namesi
Name:CYP2C20
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C20PRO_0000051709Add
BLAST

Expressioni

Inductioni

By 3-methylcholanthrene (3MC).

Structurei

3D structure databases

ProteinModelPortaliP33262.
SMRiP33262. Positions 28-490.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33262-1 [UniParc]FASTAAdd to Basket

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MDPFVVLVLC LSFVLLFSLW RQSSGRRKLP PGPTPLPIIG NILQIDVKDI    50
CKSFSNFSKV YGPVFTVYFG MNPVVVLHGY ETVKEALIDN AEEFSGRGIL 100
PISERITNGL GIISSNGKRW KETRRFSLTT LRNFGMGKRS IEDRVQEEAR 150
CLVEELRKTK ASPCDPTFIL GCAPCNVICS VVFQKRFDYK DENFLTLIKR 200
FTVNFRILTS PWIQVCNNFP LLIDCFPGTH NKLLKNVALT KSYIREKVKE 250
HQATLDVNNP RDFIDCFLIK MEQEKDNQQS EFTIENLVGT VADLFVAGTE 300
TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA 350
VIHEIQRYID LVPTGVPHAV TTDIKFRNYL IPKGTIIITL LTSVLHDDKE 400
FPNPKIFDPG HFLDENGNFK KSDYFMPFSA GKRICAGEGL ARMELFLFLT 450
TILQNFNLKS VADLKNLNTT SATRGIISLP PSYQICFIPV 490
Length:490
Mass (Da):55,638
Last modified:February 1, 1994 - v1
Checksum:i7CEC7078C2F25990
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S53046 mRNA. Translation: AAB24950.1.
PIRiS28166.
RefSeqiNP_001270692.1. NM_001283763.1.
UniGeneiMfa.8192.

Genome annotation databases

GeneIDi102117212.
KEGGimcf:102117212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S53046 mRNA. Translation: AAB24950.1 .
PIRi S28166.
RefSeqi NP_001270692.1. NM_001283763.1.
UniGenei Mfa.8192.

3D structure databases

ProteinModelPortali P33262.
SMRi P33262. Positions 28-490.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 102117212.
KEGGi mcf:102117212.

Phylogenomic databases

HOVERGENi HBG015789.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of monkey liver cytochrome P-450 cDNAs: similarity of the primary sequences to human cytochromes P-450."
    Komori M., Kikuchi O., Sakuma T., Funaki J., Kitada M., Kamataki T.
    Biochim. Biophys. Acta 1171:141-146(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP2CK_MACFA
AccessioniPrimary (citable) accession number: P33262
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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