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P33261

- CP2CJ_HUMAN

UniProt

P33261 - CP2CJ_HUMAN

Protein

Cytochrome P450 2C19

Gene

CYP2C19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 3 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.

    Catalytic activityi

    +-(R)-limonene + NADPH + O2 = (+)-trans-carveol + NADP+ + H2O.
    --(S)-limonene + NADPH + O2 = (-)-trans-carveol + NADP+ + H2O.
    --(S)-limonene + NADPH + O2 = (-)-perillyl alcohol + NADP+ + H2O.

    Cofactori

    Heme group.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)

    GO - Molecular functioni

    1. (R)-limonene 6-monooxygenase activity Source: UniProtKB-EC
    2. (S)-limonene 6-monooxygenase activity Source: UniProtKB-EC
    3. (S)-limonene 7-monooxygenase activity Source: UniProtKB-EC
    4. enzyme binding Source: BHF-UCL
    5. heme binding Source: UniProtKB
    6. iron ion binding Source: InterPro
    7. monooxygenase activity Source: BHF-UCL
    8. oxidoreductase activity Source: BHF-UCL
    9. oxygen binding Source: ProtInc
    10. steroid hydroxylase activity Source: BHF-UCL

    GO - Biological processi

    1. arachidonic acid metabolic process Source: Reactome
    2. drug metabolic process Source: BHF-UCL
    3. epoxygenase P450 pathway Source: Reactome
    4. exogenous drug catabolic process Source: BHF-UCL
    5. heterocycle metabolic process Source: BHF-UCL
    6. monoterpenoid metabolic process Source: BHF-UCL
    7. omega-hydroxylase P450 pathway Source: Reactome
    8. oxidation-reduction process Source: BHF-UCL
    9. small molecule metabolic process Source: Reactome
    10. steroid metabolic process Source: BHF-UCL
    11. xenobiotic metabolic process Source: Reactome

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding, NADP

    Enzyme and pathway databases

    BioCyciMetaCyc:HS09293-MONOMER.
    ReactomeiREACT_13543. Xenobiotics.
    REACT_13797. CYP2E1 reactions.
    REACT_150134. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
    REACT_150417. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    SABIO-RKP33261.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C19 (EC:1.14.13.-)
    Alternative name(s):
    (R)-limonene 6-monooxygenase (EC:1.14.13.80)
    (S)-limonene 6-monooxygenase (EC:1.14.13.48)
    (S)-limonene 7-monooxygenase (EC:1.14.13.49)
    CYPIIC17
    CYPIIC19
    Cytochrome P450-11A
    Cytochrome P450-254C
    Mephenytoin 4-hydroxylase
    Gene namesi
    Name:CYP2C19
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:2621. CYP2C19.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome
    2. intracellular membrane-bounded organelle Source: ProtInc

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    MIMi609535. phenotype.
    Orphaneti240847. Amitriptyline toxicity.
    240865. Clomipramine toxicity.
    240883. Imipramine toxicity.
    240893. Nortriptyline toxicity.
    240931. Resistance to amitriptyline in the treatment of depression.
    240933. Resistance to clomipramine in the treatment of depression.
    240935. Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs.
    240939. Resistance to imipramine in the treatment of depression.
    240941. Resistance to nortripilline in the treatment of depression.
    240949. Resistance to trimipramine in the treatment of depression.
    240951. Resistance to venlafaxine in the treatment of depression.
    240957. Susceptibility to adverse reaction due to amitriptyline treatment.
    240965. Susceptibility to adverse reaction due to clomipramine treatment.
    240971. Susceptibility to adverse reaction due to imipramine treatment.
    240979. Susceptibility to adverse reaction due to nortriptyline treatment.
    240987. Susceptibility to adverse reaction due to trimipramine treatment.
    240989. Susceptibility to adverse reaction due to venlafaxine treatment.
    241003. Susceptibility to hepatitis due to voriconazole treatment.
    240915. Trimipramine toxicity.
    240919. Venlafaxine toxicity.
    240921. Voriconazole toxicity.
    PharmGKBiPA124.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Cytochrome P450 2C19PRO_0000051708Add
    BLAST

    Proteomic databases

    PaxDbiP33261.
    PRIDEiP33261.

    PTM databases

    PhosphoSiteiP33261.

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Gene expression databases

    BgeeiP33261.
    CleanExiHS_CYP2C19.
    GenevestigatoriP33261.

    Organism-specific databases

    HPAiHPA015066.

    Interactioni

    Protein-protein interaction databases

    BioGridi107935. 1 interaction.
    STRINGi9606.ENSP00000360372.

    Structurei

    Secondary structure

    1
    490
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni37 – 393
    Helixi42 – 443
    Helixi47 – 493
    Helixi50 – 6112
    Beta strandi63 – 697
    Beta strandi72 – 776
    Helixi80 – 878
    Turni88 – 903
    Helixi91 – 944
    Helixi103 – 1064
    Turni107 – 1093
    Helixi117 – 13014
    Beta strandi135 – 1395
    Helixi141 – 15818
    Turni159 – 1613
    Turni166 – 1683
    Helixi169 – 18214
    Beta strandi183 – 1853
    Helixi192 – 20918
    Helixi211 – 2188
    Helixi222 – 2254
    Helixi228 – 25427
    Helixi263 – 27311
    Turni274 – 2763
    Helixi284 – 29714
    Helixi300 – 31516
    Helixi317 – 33014
    Beta strandi333 – 3353
    Helixi339 – 3446
    Helixi346 – 35914
    Beta strandi377 – 3793
    Beta strandi386 – 3894
    Helixi391 – 3955
    Turni398 – 4003
    Beta strandi401 – 4033
    Helixi409 – 4124
    Beta strandi415 – 4173
    Helixi438 – 45518
    Beta strandi456 – 4627
    Turni464 – 4663
    Beta strandi475 – 4773
    Beta strandi485 – 4895

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GQSX-ray2.87A/B/C/D23-489[»]
    ProteinModelPortaliP33261.
    SMRiP33261. Positions 29-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiP33261.
    KOiK17721.
    OMAiRIVSTPW.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiP33261.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33261-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPFVVLVLC LSCLLLLSIW RQSSGRGKLP PGPTPLPVIG NILQIDIKDV    50
    SKSLTNLSKI YGPVFTLYFG LERMVVLHGY EVVKEALIDL GEEFSGRGHF 100
    PLAERANRGF GIVFSNGKRW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR 150
    CLVEELRKTK ASPCDPTFIL GCAPCNVICS IIFQKRFDYK DQQFLNLMEK 200
    LNENIRIVST PWIQICNNFP TIIDYFPGTH NKLLKNLAFM ESDILEKVKE 250
    HQESMDINNP RDFIDCFLIK MEKEKQNQQS EFTIENLVIT AADLLGAGTE 300
    TTSTTLRYAL LLLLKHPEVT AKVQEEIERV VGRNRSPCMQ DRGHMPYTDA 350
    VVHEVQRYID LIPTSLPHAV TCDVKFRNYL IPKGTTILTS LTSVLHDNKE 400
    FPNPEMFDPR HFLDEGGNFK KSNYFMPFSA GKRICVGEGL ARMELFLFLT 450
    FILQNFNLKS LIDPKDLDTT PVVNGFASVP PFYQLCFIPV 490
    Length:490
    Mass (Da):55,931
    Last modified:March 1, 2005 - v3
    Checksum:i17DB04C50A132C53
    GO

    Polymorphismi

    Genetic variation in CYP2C19 is responsible for poor drug metabolism [MIMi:609535]. Individuals can be characterized as either extensive metabolizers (EM) or poor metabolizers (PM). The PM phenotype is inherited in an autosomal recessive manner, with the EM phenotype comprising both homozygous dominant and heteroyzgote genotypes. There are marked interracial differences in the frequency of this polymorphism. Poor metabolizers represent 2-5% of Caucasians, 13-23% of Asian populations, and as many as 38-79% of individuals of some of the islands of Polynesia and Micronesia. Different alleles of CYP2C19 are known: CYP2C19*1A CYP2C19*1B, CYP2C19*1C, CYP2C19*2A (CYP2C19m1 or CYP2C19m1A), CYP2C19*2B (CYP2C19m1B), CYP2C19*2C (CYP2C19*21), CYP2C19*3A (CYP2C19m2), CYP2C19*3B (CYP2C19*20), CYP2C19*4 (CYP2C19m3), CYP2C19*5A (CYP2C19m4), CYP2C19*5B, CYP2C19*6, CYP2C19*7, CYP2C19*8, CYP2C19*9, CYP2C19*10, CYP2C19*11 CYP2C19*12, CYP2C19*13, CYP2C19*14 CYP2C19*15, CYP2C19*16, CYP2C19*18, CYP2C19*19. Defective CYP2C19*2 and CYP2C19*3 alleles are characterized by a splice mutation and a stop codon, respectively, and account for most of the PM alleles. The sequence shown is that of allele CYP2C19*1B.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti17 – 171L → P in allele CYP2C19*14. 1 Publication
    Corresponds to variant rs55752064 [ dbSNP | Ensembl ].
    VAR_021268
    Natural varianti19 – 191I → L in allele CYP2C19*15. 2 Publications
    Corresponds to variant rs17882687 [ dbSNP | Ensembl ].
    VAR_021269
    Natural varianti51 – 511S → G in allele CYP2C19*19. 1 Publication
    VAR_024083
    Natural varianti74 – 741M → T.1 Publication
    Corresponds to variant rs28399505 [ dbSNP | Ensembl ].
    VAR_024718
    Natural varianti92 – 921E → D.2 Publications
    Corresponds to variant rs17878459 [ dbSNP | Ensembl ].
    VAR_021270
    Natural varianti120 – 1201W → R in allele CYP2C19*8; loss of activity. 1 Publication
    Corresponds to variant rs41291556 [ dbSNP | Ensembl ].
    VAR_008357
    Natural varianti122 – 1221E → A.1 Publication
    Corresponds to variant rs17885179 [ dbSNP | Ensembl ].
    VAR_021271
    Natural varianti132 – 1321R → Q in allele CYP2C19*6; loss of activity. 1 Publication
    VAR_008358
    Natural varianti144 – 1441R → H in allele CYP2C19*9. 3 Publications
    Corresponds to variant rs17884712 [ dbSNP | Ensembl ].
    VAR_021272
    Natural varianti150 – 1501R → H in allele CYP2C19*11. 1 Publication
    Corresponds to variant rs58973490 [ dbSNP | Ensembl ].
    VAR_021273
    Natural varianti161 – 1611A → P.1 Publication
    Corresponds to variant rs181297724 [ dbSNP | Ensembl ].
    VAR_024084
    Natural varianti168 – 1681F → L.1 Publication
    Corresponds to variant rs28399510 [ dbSNP | Ensembl ].
    VAR_024719
    Natural varianti227 – 2271P → L in allele CYP2C19*10. 1 Publication
    Corresponds to variant rs6413438 [ dbSNP | Ensembl ].
    VAR_020123
    Natural varianti329 – 3291R → H in allele CYP2C19*18. 1 Publication
    VAR_024085
    Natural varianti331 – 3311V → I in allele CYP2C19*1A, allele CYP2C19*5A, allele CYP2C19*8 and allele CYP2C19*16. 4 Publications
    Corresponds to variant rs3758581 [ dbSNP | Ensembl ].
    VAR_001255
    Natural varianti410 – 4101R → C in allele CYP2C19*13. 2 Publications
    Corresponds to variant rs17879685 [ dbSNP | Ensembl ].
    VAR_021274
    Natural varianti433 – 4331R → W in allele CYP2C19*5A and allele CYP2C19*5B; loss of activity. 2 Publications
    Corresponds to variant rs56337013 [ dbSNP | Ensembl ].
    VAR_008359
    Natural varianti442 – 4421R → C in allele CYP2C19*16; lowered catalytic activity. 1 Publication
    Corresponds to variant rs192154563 [ dbSNP | Ensembl ].
    VAR_021275

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M61854 mRNA. Translation: AAB59426.1.
    M61858 mRNA. Translation: AAA52145.1. Sequence problems.
    L07093 mRNA. Translation: AAA36660.1. Sequence problems.
    AY796203 Genomic DNA. Translation: AAV41877.1.
    AL583836, AL133513 Genomic DNA. Translation: CAH74068.1.
    AL133513, AL583836 Genomic DNA. Translation: CAH73444.1.
    L39098, L39097 Genomic DNA. Translation: AAL31347.1.
    L39102
    , L39099, L39100, L39101 Genomic DNA. Translation: AAL31348.1.
    L31506 Genomic DNA. No translation available.
    L31507 Genomic DNA. No translation available.
    L32982 Genomic DNA. No translation available.
    L32983 Genomic DNA. No translation available.
    CCDSiCCDS7436.1.
    PIRiF38462.
    G38462.
    I52418.
    RefSeqiNP_000760.1. NM_000769.1.
    UniGeneiHs.282409.

    Genome annotation databases

    EnsembliENST00000371321; ENSP00000360372; ENSG00000165841.
    GeneIDi1557.
    KEGGihsa:1557.
    UCSCiuc010qny.2. human.

    Polymorphism databases

    DMDMi60416369.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Cytochrome P450 Allele Nomenclature Committee

    CYP2C19 alleles

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M61854 mRNA. Translation: AAB59426.1 .
    M61858 mRNA. Translation: AAA52145.1 . Sequence problems.
    L07093 mRNA. Translation: AAA36660.1 . Sequence problems.
    AY796203 Genomic DNA. Translation: AAV41877.1 .
    AL583836 , AL133513 Genomic DNA. Translation: CAH74068.1 .
    AL133513 , AL583836 Genomic DNA. Translation: CAH73444.1 .
    L39098 , L39097 Genomic DNA. Translation: AAL31347.1 .
    L39102
    , L39099 , L39100 , L39101 Genomic DNA. Translation: AAL31348.1 .
    L31506 Genomic DNA. No translation available.
    L31507 Genomic DNA. No translation available.
    L32982 Genomic DNA. No translation available.
    L32983 Genomic DNA. No translation available.
    CCDSi CCDS7436.1.
    PIRi F38462.
    G38462.
    I52418.
    RefSeqi NP_000760.1. NM_000769.1.
    UniGenei Hs.282409.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GQS X-ray 2.87 A/B/C/D 23-489 [» ]
    ProteinModelPortali P33261.
    SMRi P33261. Positions 29-490.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107935. 1 interaction.
    STRINGi 9606.ENSP00000360372.

    Chemistry

    BindingDBi P33261.
    ChEMBLi CHEMBL3622.
    DrugBanki DB00546. Adinazolam.
    DB01424. Aminophenazone.
    DB00321. Amitriptyline.
    DB01060. Amoxicillin.
    DB01274. Arformoterol.
    DB00188. Bortezomib.
    DB00395. Carisoprodol.
    DB00356. Chlorzoxazone.
    DB01166. Cilostazol.
    DB00215. Citalopram.
    DB01211. Clarithromycin.
    DB00349. Clobazam.
    DB01151. Desipramine.
    DB00967. Desloratadine.
    DB00586. Diclofenac.
    DB00343. Diltiazem.
    DB00625. Efavirenz.
    DB00736. Esomeprazole.
    DB00927. Famotidine.
    DB00949. Felbamate.
    DB01216. Finasteride.
    DB01544. Flunitrazepam.
    DB00176. Fluvoxamine.
    DB00983. Formoterol.
    DB01320. Fosphenytoin.
    DB01018. Guanfacine.
    DB00458. Imipramine.
    DB00328. Indomethacin.
    DB01026. Ketoconazole.
    DB00448. Lansoprazole.
    DB01259. Lapatinib.
    DB00455. Loratadine.
    DB01065. Melatonin.
    DB00532. Mephenytoin.
    DB00333. Methadone.
    DB00849. Methylphenobarbital.
    DB01171. Moclobemide.
    DB00745. Modafinil.
    DB00220. Nelfinavir.
    DB00622. Nicardipine.
    DB00665. Nilutamide.
    DB00506. Norgestrel.
    DB00338. Omeprazole.
    DB00776. Oxcarbazepine.
    DB00213. Pantoprazole.
    DB00738. Pentamidine.
    DB01174. Phenobarbital.
    DB00252. Phenytoin.
    DB00794. Primidone.
    DB00396. Progesterone.
    DB01131. Proguanil.
    DB00420. Promazine.
    DB00908. Quinidine.
    DB01129. Rabeprazole.
    DB00863. Ranitidine.
    DB00503. Ritonavir.
    DB01037. Selegiline.
    DB01104. Sertraline.
    DB00231. Temazepam.
    DB00444. Teniposide.
    DB00342. Terfenadine.
    DB01041. Thalidomide.
    DB00679. Thioridazine.
    DB00208. Ticlopidine.
    DB01124. Tolbutamide.
    DB00273. Topiramate.
    DB00752. Tranylcypromine.
    DB00197. Troglitazone.
    DB01361. Troleandomycin.
    DB00582. Voriconazole.

    PTM databases

    PhosphoSitei P33261.

    Polymorphism databases

    DMDMi 60416369.

    Proteomic databases

    PaxDbi P33261.
    PRIDEi P33261.

    Protocols and materials databases

    DNASUi 1557.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371321 ; ENSP00000360372 ; ENSG00000165841 .
    GeneIDi 1557.
    KEGGi hsa:1557.
    UCSCi uc010qny.2. human.

    Organism-specific databases

    CTDi 1557.
    GeneCardsi GC10P096447.
    HGNCi HGNC:2621. CYP2C19.
    HPAi HPA015066.
    MIMi 124020. gene.
    609535. phenotype.
    neXtProti NX_P33261.
    Orphaneti 240847. Amitriptyline toxicity.
    240865. Clomipramine toxicity.
    240883. Imipramine toxicity.
    240893. Nortriptyline toxicity.
    240931. Resistance to amitriptyline in the treatment of depression.
    240933. Resistance to clomipramine in the treatment of depression.
    240935. Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs.
    240939. Resistance to imipramine in the treatment of depression.
    240941. Resistance to nortripilline in the treatment of depression.
    240949. Resistance to trimipramine in the treatment of depression.
    240951. Resistance to venlafaxine in the treatment of depression.
    240957. Susceptibility to adverse reaction due to amitriptyline treatment.
    240965. Susceptibility to adverse reaction due to clomipramine treatment.
    240971. Susceptibility to adverse reaction due to imipramine treatment.
    240979. Susceptibility to adverse reaction due to nortriptyline treatment.
    240987. Susceptibility to adverse reaction due to trimipramine treatment.
    240989. Susceptibility to adverse reaction due to venlafaxine treatment.
    241003. Susceptibility to hepatitis due to voriconazole treatment.
    240915. Trimipramine toxicity.
    240919. Venlafaxine toxicity.
    240921. Voriconazole toxicity.
    PharmGKBi PA124.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    InParanoidi P33261.
    KOi K17721.
    OMAi RIVSTPW.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi P33261.
    TreeFami TF352043.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS09293-MONOMER.
    Reactomei REACT_13543. Xenobiotics.
    REACT_13797. CYP2E1 reactions.
    REACT_150134. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
    REACT_150417. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    SABIO-RK P33261.

    Miscellaneous databases

    GeneWikii CYP2C19.
    GenomeRNAii 1557.
    NextBioi 6430.
    PROi P33261.
    SOURCEi Search...

    Gene expression databases

    Bgeei P33261.
    CleanExi HS_CYP2C19.
    Genevestigatori P33261.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily."
      Romkes M., Faletto M.B., Blaisdell J.A., Raucy J.L., Goldstein J.A.
      Biochemistry 30:3247-3255(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CYP2C19*1A).
      Tissue: Liver.
    2. Cited for: SEQUENCE REVISION.
    3. NIEHS SNPs program
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-19; ASP-92; ALA-122; HIS-144; ILE-331 AND CYS-410.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Gene structure, upstream region and allelic variants of cyp2c19, the s-mephenytoin hydroxylase."
      de Morais S.M.F., Blaisdell J.A.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-160 AND 274-490, VARIANT ILE-331.
    6. "Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'-hydroxylation."
      Wrighton S.A., Stevens J.C., Becker G.W., VandenBranden M.
      Arch. Biochem. Biophys. 306:240-245(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-16.
      Tissue: Liver.
    7. "Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes."
      Miyazawa M., Shindo M., Shimada T.
      Drug Metab. Dispos. 30:602-607(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    8. "Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19."
      Reynald R.L., Sansen S., Stout C.D., Johnson E.F.
      J. Biol. Chem. 287:44581-44591(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.87 ANGSTROMS) OF 23-489 IN COMPLEX WITH HEME AND SYNTHETIC INHIBITOR, COFACTOR.
    9. "The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans."
      de Morais S.M.F., Wilkinson G.R., Blaisdell J., Nakamura K., Meyer U.A., Goldstein J.A.
      J. Biol. Chem. 269:15419-15422(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN POOR DRUG METABOLISM, IDENTIFICATION OF ALLELE CYP2C19*2A.
    10. "Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese."
      De Morais S.M.F., Wilkinson G.R., Blaisdell J., Meyer U.A., Nakamura K., Goldstein J.A.
      Mol. Pharmacol. 46:594-598(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN POOR DRUG METABOLISM, IDENTIFICATION OF ALLELE CYP2C19*3A.
    11. "Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele."
      Xiao Z.S., Goldstein J.A., Xie H.G., Blaisdell J., Wang W., Jiang C.H., Yan F.X., He N., Huang S.L., Xu Z.H., Zhou H.H.
      J. Pharmacol. Exp. Ther. 281:604-609(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT TRP-433.
    12. "Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin."
      Ibeanu G.C., Goldstein J.A., Meyer U.A., Benhamou S., Bouchardy C., Dayer P., Ghanayem B.I., Blaisdell J.
      J. Pharmacol. Exp. Ther. 286:1490-1495(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ASP-92 AND GLN-132.
    13. "An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians."
      Ibeanu G.C., Blaisdell J., Ghanayem B.I., Beyeler C., Benhamou S., Bouchardy C., Wilkinson G.R., Dayer P., Daly A.K., Goldstein J.A.
      Pharmacogenetics 8:129-135(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT TRP-433.
    14. "A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin."
      Ibeanu G.C., Blaisdell J., Ferguson R.J., Ghanayem B.I., Brosen K., Benhamou S., Bouchardy C., Wilkinson G.R., Dayer P., Goldstein J.A.
      J. Pharmacol. Exp. Ther. 290:635-640(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ARG-120.
    15. "Identification and functional characterization of new potentially defective alleles of human CYP2C19."
      Blaisdell J., Mohrenweiser H., Jackson J., Ferguson S., Coulter S., Chanas B., Xi T., Ghanayem B., Goldstein J.A.
      Pharmacogenetics 12:703-711(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS PRO-17; LEU-19; HIS-144; HIS-150; LEU-227 AND CYS-410.
    16. "A novel single nucleotide polymorphism (SNP) of the CYP2C19 gene in a Japanese subject with lowered capacity of mephobarbital 4'-hydroxylation."
      Morita J., Kobayashi K., Wanibuchi A., Kimura M., Irie S., Ishizaki T., Chiba K.
      Drug Metab. Pharmacokinet. 19:236-238(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CYS-442.
    17. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
      Solus J.F., Arietta B.J., Harris J.R., Sexton D.P., Steward J.Q., McMunn C., Ihrie P., Mehall J.M., Edwards T.L., Dawson E.P.
      Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS THR-74; HIS-144; LEU-168 AND ILE-331.
    18. Cited for: VARIANTS GLY-51; PRO-161; HIS-329 AND ILE-331.

    Entry informationi

    Entry nameiCP2CJ_HUMAN
    AccessioniPrimary (citable) accession number: P33261
    Secondary accession number(s): P33259
    , Q8WZB1, Q8WZB2, Q9UCD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 140 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    P450-254C was originally listed as a separate gene (CYP2C17). Resequencing demonstrated that it is not a separate gene, but a chimera. The 5'-portion corresponds to a partial 2C18 clone, and the 3'-portion corresponds to a partial 2C19 clone.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3