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Protein

Cytochrome P450 2C19

Gene

CYP2C19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.

Catalytic activityi

+-(R)-limonene + NADPH + O2 = (+)-trans-carveol + NADP+ + H2O.
--(S)-limonene + NADPH + O2 = (-)-trans-carveol + NADP+ + H2O.
--(S)-limonene + NADPH + O2 = (-)-perillyl alcohol + NADP+ + H2O.

Cofactori

heme1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi435Iron (heme axial ligand)1

GO - Molecular functioni

  • (R)-limonene 6-monooxygenase activity Source: UniProtKB-EC
  • (S)-limonene 6-monooxygenase activity Source: UniProtKB-EC
  • (S)-limonene 7-monooxygenase activity Source: UniProtKB-EC
  • arachidonic acid epoxygenase activity Source: GO_Central
  • enzyme binding Source: BHF-UCL
  • heme binding Source: UniProtKB
  • iron ion binding Source: InterPro
  • monooxygenase activity Source: BHF-UCL
  • oxidoreductase activity Source: BHF-UCL
  • oxygen binding Source: Reactome
  • steroid hydroxylase activity Source: BHF-UCL

GO - Biological processi

  • drug metabolic process Source: BHF-UCL
  • epoxygenase P450 pathway Source: GO_Central
  • exogenous drug catabolic process Source: BHF-UCL
  • heterocycle metabolic process Source: BHF-UCL
  • monoterpenoid metabolic process Source: BHF-UCL
  • omega-hydroxylase P450 pathway Source: Reactome
  • oxidation-reduction process Source: BHF-UCL
  • steroid metabolic process Source: BHF-UCL
  • xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BioCyciMetaCyc:HS09293-MONOMER.
ZFISH:HS09293-MONOMER.
ReactomeiR-HSA-211981. Xenobiotics.
R-HSA-211999. CYP2E1 reactions.
R-HSA-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-HSA-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
SABIO-RKP33261.

Chemistry databases

SwissLipidsiSLP:000001589.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C19 (EC:1.14.13.-)
Alternative name(s):
(R)-limonene 6-monooxygenase (EC:1.14.13.80)
(S)-limonene 6-monooxygenase (EC:1.14.13.48)
(S)-limonene 7-monooxygenase (EC:1.14.13.49)
CYPIIC17
CYPIIC19
Cytochrome P450-11A
Cytochrome P450-254C
Mephenytoin 4-hydroxylase
Gene namesi
Name:CYP2C19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:2621. CYP2C19.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: Reactome
  • intracellular membrane-bounded organelle Source: ProtInc
  • organelle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1557.
MalaCardsiCYP2C19.
MIMi609535. phenotype.
Orphaneti413667. Antidepressant or antipsychotics toxicity or dose selection.
240935. Resistance to clopidogrel.
240921. Voriconazole toxicity.
PharmGKBiPA124.

Chemistry databases

ChEMBLiCHEMBL3622.
DrugBankiDB01418. Acenocoumarol.
DB00945. Acetylsalicylic acid.
DB00546. Adinazolam.
DB00918. Almotriptan.
DB06403. Ambrisentan.
DB00357. Aminoglutethimide.
DB01424. Aminophenazone.
DB01118. Amiodarone.
DB00321. Amitriptyline.
DB01060. Amoxicillin.
DB00701. Amprenavir.
DB01435. Antipyrine.
DB06605. Apixaban.
DB00673. Aprepitant.
DB01274. Arformoterol.
DB06413. Armodafinil.
DB06697. Artemether.
DB00289. Atomoxetine.
DB01076. Atorvastatin.
DB06626. Axitinib.
DB00972. Azelastine.
DB00245. Benzatropine.
DB01128. Bicalutamide.
DB04794. Bifonazole.
DB00188. Bortezomib.
DB01558. Bromazepam.
DB00835. Brompheniramine.
DB00297. Bupivacaine.
DB00921. Buprenorphine.
DB00564. Carbamazepine.
DB00748. Carbinoxamine.
DB00395. Carisoprodol.
DB00446. Chloramphenicol.
DB00672. Chlorpropamide.
DB00169. Cholecalciferol.
DB01166. Cilostazol.
DB00501. Cimetidine.
DB00604. Cisapride.
DB00215. Citalopram.
DB01211. Clarithromycin.
DB04920. Clevidipine.
DB00349. Clobazam.
DB01242. Clomipramine.
DB00758. Clopidogrel.
DB01559. Clotiazepam.
DB00257. Clotrimazole.
DB00363. Clozapine.
DB00531. Cyclophosphamide.
DB00091. Cyclosporine.
DB00250. Dapsone.
DB00705. Delavirdine.
DB01151. Desipramine.
DB00967. Desloratadine.
DB01234. Dexamethasone.
DB01191. Dexfenfluramine.
DB00514. Dextromethorphan.
DB00829. Diazepam.
DB00586. Diclofenac.
DB00343. Diltiazem.
DB01093. Dimethyl sulfoxide.
DB01075. Diphenhydramine.
DB00988. Dopamine.
DB00590. Doxazosin.
DB01142. Doxepin.
DB00470. Dronabinol.
DB00625. Efavirenz.
DB00216. Eletriptan.
DB00109. Enfuvirtide.
DB08899. Enzalutamide.
DB01175. Escitalopram.
DB09119. Eslicarbazepine acetate.
DB00736. Esomeprazole.
DB00783. Estradiol.
DB00898. Ethanol.
DB00754. Ethotoin.
DB01628. Etoricoxib.
DB06414. Etravirine.
DB00927. Famotidine.
DB00949. Felbamate.
DB00196. Fluconazole.
DB01544. Flunitrazepam.
DB00472. Fluoxetine.
DB00499. Flutamide.
DB01095. Fluvastatin.
DB00176. Fluvoxamine.
DB00983. Formoterol.
DB01320. Fosphenytoin.
DB00317. Gefitinib.
DB01241. Gemfibrozil.
DB01120. Gliclazide.
DB01296. Glucosamine.
DB01016. Glyburide.
DB01018. Guanfacine.
DB00502. Haloperidol.
DB01355. Hexobarbital.
DB06789. Hydroxyprogesterone caproate.
DB01050. Ibuprofen.
DB09054. Idelalisib.
DB01181. Ifosfamide.
DB00619. Imatinib.
DB00458. Imipramine.
DB00224. Indinavir.
DB00328. Indomethacin.
DB00951. Isoniazid.
DB09570. Ixazomib.
DB06738. Ketobemidone.
DB01026. Ketoconazole.
DB00448. Lansoprazole.
DB01259. Lapatinib.
DB08918. Levomilnacipran.
DB01601. Lopinavir.
DB00455. Loratadine.
DB04871. Lorcaserin.
DB00678. Losartan.
DB00227. Lovastatin.
DB08933. Luliconazole.
DB01283. Lumiracoxib.
DB08932. MACITENTAN.
DB01065. Melatonin.
DB01043. Memantine.
DB00371. Meprobamate.
DB00333. Methadone.
DB00703. Methazolamide.
DB00763. Methimazole.
DB05246. Methsuximide.
DB00849. Methylphenobarbital.
DB00264. Metoprolol.
DB01110. Miconazole.
DB01171. Moclobemide.
DB00745. Modafinil.
DB09049. Naloxegol.
DB00220. Nelfinavir.
DB00622. Nicardipine.
DB00184. Nicotine.
DB00665. Nilutamide.
DB06712. Nilvadipine.
DB00717. Norethisterone.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB00338. Omeprazole.
DB04938. Ospemifene.
DB00776. Oxcarbazepine.
DB00239. Oxiconazole.
DB06412. Oxymetholone.
DB00213. Pantoprazole.
DB00082. Pegvisomant.
DB00738. Pentamidine.
DB00312. Pentobarbital.
DB00850. Perphenazine.
DB00454. Pethidine.
DB00780. Phenelzine.
DB01174. Phenobarbital.
DB00832. Phensuximide.
DB00252. Phenytoin.
DB01100. Pimozide.
DB01132. Pioglitazone.
DB01621. Pipotiazine.
DB01179. Podofilox.
DB06209. Prasugrel.
DB01058. Praziquantel.
DB00635. Prednisone.
DB00794. Primidone.
DB01032. Probenecid.
DB00396. Progesterone.
DB01131. Proguanil.
DB00420. Promazine.
DB00818. Propofol.
DB00571. Propranolol.
DB01589. Quazepam.
DB01224. Quetiapine.
DB00468. Quinine.
DB01129. Rabeprazole.
DB00980. Ramelteon.
DB00863. Ranitidine.
DB08896. Regorafenib.
DB01045. Rifampicin.
DB08864. Rilpivirine.
DB00503. Ritonavir.
DB06176. Romidepsin.
DB00412. Rosiglitazone.
DB01098. Rosuvastatin.
DB01232. Saquinavir.
DB01037. Selegiline.
DB01104. Sertraline.
DB00203. Sildenafil.
DB00641. Simvastatin.
DB06268. Sitaxentan.
DB00398. Sorafenib.
DB00259. Sulfanilamide.
DB00675. Tamoxifen.
DB06204. Tapentadol.
DB00966. Telmisartan.
DB00231. Temazepam.
DB00444. Teniposide.
DB00857. Terbinafine.
DB00624. Testosterone.
DB01041. Thalidomide.
DB00679. Thioridazine.
DB00208. Ticlopidine.
DB00373. Timolol.
DB01007. Tioconazole.
DB00932. Tipranavir.
DB08895. Tofacitinib.
DB01124. Tolbutamide.
DB01036. Tolterodine.
DB00273. Topiramate.
DB00214. Torasemide.
DB05109. Trabectedin.
DB00752. Tranylcypromine.
DB00347. Trimethadione.
DB00726. Trimipramine.
DB01361. Troleandomycin.
DB00313. Valproic Acid.
DB00285. Venlafaxine.
DB00661. Verapamil.
DB08828. Vismodegib.
DB00582. Voriconazole.
DB09068. Vortioxetine.
DB00682. Warfarin.
DB00549. Zafirlukast.
DB00495. Zidovudine.
DB00425. Zolpidem.
DB00909. Zonisamide.
GuidetoPHARMACOLOGYi1328.

Polymorphism and mutation databases

BioMutaiCYP2C19.
DMDMi60416369.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517081 – 490Cytochrome P450 2C19Add BLAST490

Proteomic databases

PaxDbiP33261.
PeptideAtlasiP33261.
PRIDEiP33261.

PTM databases

iPTMnetiP33261.
PhosphoSitePlusiP33261.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSG00000165841.
CleanExiHS_CYP2C19.
ExpressionAtlasiP33261. baseline and differential.
GenevisibleiP33261. HS.

Organism-specific databases

HPAiHPA015066.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107935. 2 interactors.
STRINGi9606.ENSP00000360372.

Chemistry databases

BindingDBiP33261.

Structurei

Secondary structure

1490
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni37 – 39Combined sources3
Helixi42 – 44Combined sources3
Helixi47 – 49Combined sources3
Helixi50 – 61Combined sources12
Beta strandi63 – 69Combined sources7
Beta strandi72 – 77Combined sources6
Helixi80 – 87Combined sources8
Turni88 – 90Combined sources3
Helixi91 – 94Combined sources4
Helixi103 – 106Combined sources4
Turni107 – 109Combined sources3
Helixi117 – 130Combined sources14
Beta strandi135 – 139Combined sources5
Helixi141 – 158Combined sources18
Turni159 – 161Combined sources3
Turni166 – 168Combined sources3
Helixi169 – 182Combined sources14
Beta strandi183 – 185Combined sources3
Helixi192 – 209Combined sources18
Helixi211 – 218Combined sources8
Helixi222 – 225Combined sources4
Helixi228 – 254Combined sources27
Helixi263 – 273Combined sources11
Turni274 – 276Combined sources3
Helixi284 – 297Combined sources14
Helixi300 – 315Combined sources16
Helixi317 – 330Combined sources14
Beta strandi333 – 335Combined sources3
Helixi339 – 344Combined sources6
Helixi346 – 359Combined sources14
Beta strandi377 – 379Combined sources3
Beta strandi386 – 389Combined sources4
Helixi391 – 395Combined sources5
Turni398 – 400Combined sources3
Beta strandi401 – 403Combined sources3
Helixi409 – 412Combined sources4
Beta strandi415 – 417Combined sources3
Helixi438 – 455Combined sources18
Beta strandi456 – 462Combined sources7
Turni464 – 466Combined sources3
Beta strandi475 – 477Combined sources3
Beta strandi485 – 489Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GQSX-ray2.87A/B/C/D23-489[»]
ProteinModelPortaliP33261.
SMRiP33261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP33261.
KOiK17721.
OrthoDBiEOG091G0BT8.
PhylomeDBiP33261.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPFVVLVLC LSCLLLLSIW RQSSGRGKLP PGPTPLPVIG NILQIDIKDV
60 70 80 90 100
SKSLTNLSKI YGPVFTLYFG LERMVVLHGY EVVKEALIDL GEEFSGRGHF
110 120 130 140 150
PLAERANRGF GIVFSNGKRW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTK ASPCDPTFIL GCAPCNVICS IIFQKRFDYK DQQFLNLMEK
210 220 230 240 250
LNENIRIVST PWIQICNNFP TIIDYFPGTH NKLLKNLAFM ESDILEKVKE
260 270 280 290 300
HQESMDINNP RDFIDCFLIK MEKEKQNQQS EFTIENLVIT AADLLGAGTE
310 320 330 340 350
TTSTTLRYAL LLLLKHPEVT AKVQEEIERV VGRNRSPCMQ DRGHMPYTDA
360 370 380 390 400
VVHEVQRYID LIPTSLPHAV TCDVKFRNYL IPKGTTILTS LTSVLHDNKE
410 420 430 440 450
FPNPEMFDPR HFLDEGGNFK KSNYFMPFSA GKRICVGEGL ARMELFLFLT
460 470 480 490
FILQNFNLKS LIDPKDLDTT PVVNGFASVP PFYQLCFIPV
Length:490
Mass (Da):55,931
Last modified:March 1, 2005 - v3
Checksum:i17DB04C50A132C53
GO

Polymorphismi

Genetic variation in CYP2C19 is responsible for poor drug metabolism [MIMi:609535]. Individuals can be characterized as either extensive metabolizers (EM) or poor metabolizers (PM). The PM phenotype is inherited in an autosomal recessive manner, with the EM phenotype comprising both homozygous dominant and heteroyzgote genotypes. There are marked interracial differences in the frequency of this polymorphism. Poor metabolizers represent 2-5% of Caucasians, 13-23% of Asian populations, and as many as 38-79% of individuals of some of the islands of Polynesia and Micronesia. Different alleles of CYP2C19 are known: CYP2C19*1A CYP2C19*1B, CYP2C19*1C, CYP2C19*2A (CYP2C19m1 or CYP2C19m1A), CYP2C19*2B (CYP2C19m1B), CYP2C19*2C (CYP2C19*21), CYP2C19*3A (CYP2C19m2), CYP2C19*3B (CYP2C19*20), CYP2C19*4 (CYP2C19m3), CYP2C19*5A (CYP2C19m4), CYP2C19*5B, CYP2C19*6, CYP2C19*7, CYP2C19*8, CYP2C19*9, CYP2C19*10, CYP2C19*11 CYP2C19*12, CYP2C19*13, CYP2C19*14 CYP2C19*15, CYP2C19*16, CYP2C19*18, CYP2C19*19. Defective CYP2C19*2 and CYP2C19*3 alleles are characterized by a splice mutation and a stop codon, respectively, and account for most of the PM alleles. The sequence shown is that of allele CYP2C19*1B.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02126817L → P in allele CYP2C19*14. 1 PublicationCorresponds to variant rs55752064dbSNPEnsembl.1
Natural variantiVAR_02126919I → L in allele CYP2C19*15. 2 PublicationsCorresponds to variant rs17882687dbSNPEnsembl.1
Natural variantiVAR_02408351S → G in allele CYP2C19*19. 1 Publication1
Natural variantiVAR_02471874M → T.1 PublicationCorresponds to variant rs28399505dbSNPEnsembl.1
Natural variantiVAR_02127092E → D.2 PublicationsCorresponds to variant rs17878459dbSNPEnsembl.1
Natural variantiVAR_008357120W → R in allele CYP2C19*8; loss of activity. 1 PublicationCorresponds to variant rs41291556dbSNPEnsembl.1
Natural variantiVAR_021271122E → A.1 PublicationCorresponds to variant rs17885179dbSNPEnsembl.1
Natural variantiVAR_008358132R → Q in allele CYP2C19*6; loss of activity. 1 Publication1
Natural variantiVAR_021272144R → H in allele CYP2C19*9. 3 PublicationsCorresponds to variant rs17884712dbSNPEnsembl.1
Natural variantiVAR_021273150R → H in allele CYP2C19*11. 1 PublicationCorresponds to variant rs58973490dbSNPEnsembl.1
Natural variantiVAR_024084161A → P.1 PublicationCorresponds to variant rs181297724dbSNPEnsembl.1
Natural variantiVAR_024719168F → L.1 PublicationCorresponds to variant rs28399510dbSNPEnsembl.1
Natural variantiVAR_020123227P → L in allele CYP2C19*10. 1 PublicationCorresponds to variant rs6413438dbSNPEnsembl.1
Natural variantiVAR_024085329R → H in allele CYP2C19*18. 1 Publication1
Natural variantiVAR_001255331V → I in allele CYP2C19*1A, allele CYP2C19*5A, allele CYP2C19*8 and allele CYP2C19*16. 4 PublicationsCorresponds to variant rs3758581dbSNPEnsembl.1
Natural variantiVAR_021274410R → C in allele CYP2C19*13. 2 PublicationsCorresponds to variant rs17879685dbSNPEnsembl.1
Natural variantiVAR_008359433R → W in allele CYP2C19*5A and allele CYP2C19*5B; loss of activity. 2 PublicationsCorresponds to variant rs56337013dbSNPEnsembl.1
Natural variantiVAR_021275442R → C in allele CYP2C19*16; lowered catalytic activity. 1 PublicationCorresponds to variant rs192154563dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61854 mRNA. Translation: AAB59426.1.
M61858 mRNA. Translation: AAA52145.1. Sequence problems.
L07093 mRNA. Translation: AAA36660.1. Sequence problems.
AY796203 Genomic DNA. Translation: AAV41877.1.
AL583836, AL133513 Genomic DNA. Translation: CAH74068.1.
AL133513, AL583836 Genomic DNA. Translation: CAH73444.1.
L39098, L39097 Genomic DNA. Translation: AAL31347.1.
L39102
, L39099, L39100, L39101 Genomic DNA. Translation: AAL31348.1.
L31506 Genomic DNA. No translation available.
L31507 Genomic DNA. No translation available.
L32982 Genomic DNA. No translation available.
L32983 Genomic DNA. No translation available.
CCDSiCCDS7436.1.
PIRiF38462.
G38462.
I52418.
RefSeqiNP_000760.1. NM_000769.2.
UniGeneiHs.282409.

Genome annotation databases

EnsembliENST00000371321; ENSP00000360372; ENSG00000165841.
GeneIDi1557.
KEGGihsa:1557.
UCSCiuc010qnz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP2C19 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61854 mRNA. Translation: AAB59426.1.
M61858 mRNA. Translation: AAA52145.1. Sequence problems.
L07093 mRNA. Translation: AAA36660.1. Sequence problems.
AY796203 Genomic DNA. Translation: AAV41877.1.
AL583836, AL133513 Genomic DNA. Translation: CAH74068.1.
AL133513, AL583836 Genomic DNA. Translation: CAH73444.1.
L39098, L39097 Genomic DNA. Translation: AAL31347.1.
L39102
, L39099, L39100, L39101 Genomic DNA. Translation: AAL31348.1.
L31506 Genomic DNA. No translation available.
L31507 Genomic DNA. No translation available.
L32982 Genomic DNA. No translation available.
L32983 Genomic DNA. No translation available.
CCDSiCCDS7436.1.
PIRiF38462.
G38462.
I52418.
RefSeqiNP_000760.1. NM_000769.2.
UniGeneiHs.282409.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GQSX-ray2.87A/B/C/D23-489[»]
ProteinModelPortaliP33261.
SMRiP33261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107935. 2 interactors.
STRINGi9606.ENSP00000360372.

Chemistry databases

BindingDBiP33261.
ChEMBLiCHEMBL3622.
DrugBankiDB01418. Acenocoumarol.
DB00945. Acetylsalicylic acid.
DB00546. Adinazolam.
DB00918. Almotriptan.
DB06403. Ambrisentan.
DB00357. Aminoglutethimide.
DB01424. Aminophenazone.
DB01118. Amiodarone.
DB00321. Amitriptyline.
DB01060. Amoxicillin.
DB00701. Amprenavir.
DB01435. Antipyrine.
DB06605. Apixaban.
DB00673. Aprepitant.
DB01274. Arformoterol.
DB06413. Armodafinil.
DB06697. Artemether.
DB00289. Atomoxetine.
DB01076. Atorvastatin.
DB06626. Axitinib.
DB00972. Azelastine.
DB00245. Benzatropine.
DB01128. Bicalutamide.
DB04794. Bifonazole.
DB00188. Bortezomib.
DB01558. Bromazepam.
DB00835. Brompheniramine.
DB00297. Bupivacaine.
DB00921. Buprenorphine.
DB00564. Carbamazepine.
DB00748. Carbinoxamine.
DB00395. Carisoprodol.
DB00446. Chloramphenicol.
DB00672. Chlorpropamide.
DB00169. Cholecalciferol.
DB01166. Cilostazol.
DB00501. Cimetidine.
DB00604. Cisapride.
DB00215. Citalopram.
DB01211. Clarithromycin.
DB04920. Clevidipine.
DB00349. Clobazam.
DB01242. Clomipramine.
DB00758. Clopidogrel.
DB01559. Clotiazepam.
DB00257. Clotrimazole.
DB00363. Clozapine.
DB00531. Cyclophosphamide.
DB00091. Cyclosporine.
DB00250. Dapsone.
DB00705. Delavirdine.
DB01151. Desipramine.
DB00967. Desloratadine.
DB01234. Dexamethasone.
DB01191. Dexfenfluramine.
DB00514. Dextromethorphan.
DB00829. Diazepam.
DB00586. Diclofenac.
DB00343. Diltiazem.
DB01093. Dimethyl sulfoxide.
DB01075. Diphenhydramine.
DB00988. Dopamine.
DB00590. Doxazosin.
DB01142. Doxepin.
DB00470. Dronabinol.
DB00625. Efavirenz.
DB00216. Eletriptan.
DB00109. Enfuvirtide.
DB08899. Enzalutamide.
DB01175. Escitalopram.
DB09119. Eslicarbazepine acetate.
DB00736. Esomeprazole.
DB00783. Estradiol.
DB00898. Ethanol.
DB00754. Ethotoin.
DB01628. Etoricoxib.
DB06414. Etravirine.
DB00927. Famotidine.
DB00949. Felbamate.
DB00196. Fluconazole.
DB01544. Flunitrazepam.
DB00472. Fluoxetine.
DB00499. Flutamide.
DB01095. Fluvastatin.
DB00176. Fluvoxamine.
DB00983. Formoterol.
DB01320. Fosphenytoin.
DB00317. Gefitinib.
DB01241. Gemfibrozil.
DB01120. Gliclazide.
DB01296. Glucosamine.
DB01016. Glyburide.
DB01018. Guanfacine.
DB00502. Haloperidol.
DB01355. Hexobarbital.
DB06789. Hydroxyprogesterone caproate.
DB01050. Ibuprofen.
DB09054. Idelalisib.
DB01181. Ifosfamide.
DB00619. Imatinib.
DB00458. Imipramine.
DB00224. Indinavir.
DB00328. Indomethacin.
DB00951. Isoniazid.
DB09570. Ixazomib.
DB06738. Ketobemidone.
DB01026. Ketoconazole.
DB00448. Lansoprazole.
DB01259. Lapatinib.
DB08918. Levomilnacipran.
DB01601. Lopinavir.
DB00455. Loratadine.
DB04871. Lorcaserin.
DB00678. Losartan.
DB00227. Lovastatin.
DB08933. Luliconazole.
DB01283. Lumiracoxib.
DB08932. MACITENTAN.
DB01065. Melatonin.
DB01043. Memantine.
DB00371. Meprobamate.
DB00333. Methadone.
DB00703. Methazolamide.
DB00763. Methimazole.
DB05246. Methsuximide.
DB00849. Methylphenobarbital.
DB00264. Metoprolol.
DB01110. Miconazole.
DB01171. Moclobemide.
DB00745. Modafinil.
DB09049. Naloxegol.
DB00220. Nelfinavir.
DB00622. Nicardipine.
DB00184. Nicotine.
DB00665. Nilutamide.
DB06712. Nilvadipine.
DB00717. Norethisterone.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB00338. Omeprazole.
DB04938. Ospemifene.
DB00776. Oxcarbazepine.
DB00239. Oxiconazole.
DB06412. Oxymetholone.
DB00213. Pantoprazole.
DB00082. Pegvisomant.
DB00738. Pentamidine.
DB00312. Pentobarbital.
DB00850. Perphenazine.
DB00454. Pethidine.
DB00780. Phenelzine.
DB01174. Phenobarbital.
DB00832. Phensuximide.
DB00252. Phenytoin.
DB01100. Pimozide.
DB01132. Pioglitazone.
DB01621. Pipotiazine.
DB01179. Podofilox.
DB06209. Prasugrel.
DB01058. Praziquantel.
DB00635. Prednisone.
DB00794. Primidone.
DB01032. Probenecid.
DB00396. Progesterone.
DB01131. Proguanil.
DB00420. Promazine.
DB00818. Propofol.
DB00571. Propranolol.
DB01589. Quazepam.
DB01224. Quetiapine.
DB00468. Quinine.
DB01129. Rabeprazole.
DB00980. Ramelteon.
DB00863. Ranitidine.
DB08896. Regorafenib.
DB01045. Rifampicin.
DB08864. Rilpivirine.
DB00503. Ritonavir.
DB06176. Romidepsin.
DB00412. Rosiglitazone.
DB01098. Rosuvastatin.
DB01232. Saquinavir.
DB01037. Selegiline.
DB01104. Sertraline.
DB00203. Sildenafil.
DB00641. Simvastatin.
DB06268. Sitaxentan.
DB00398. Sorafenib.
DB00259. Sulfanilamide.
DB00675. Tamoxifen.
DB06204. Tapentadol.
DB00966. Telmisartan.
DB00231. Temazepam.
DB00444. Teniposide.
DB00857. Terbinafine.
DB00624. Testosterone.
DB01041. Thalidomide.
DB00679. Thioridazine.
DB00208. Ticlopidine.
DB00373. Timolol.
DB01007. Tioconazole.
DB00932. Tipranavir.
DB08895. Tofacitinib.
DB01124. Tolbutamide.
DB01036. Tolterodine.
DB00273. Topiramate.
DB00214. Torasemide.
DB05109. Trabectedin.
DB00752. Tranylcypromine.
DB00347. Trimethadione.
DB00726. Trimipramine.
DB01361. Troleandomycin.
DB00313. Valproic Acid.
DB00285. Venlafaxine.
DB00661. Verapamil.
DB08828. Vismodegib.
DB00582. Voriconazole.
DB09068. Vortioxetine.
DB00682. Warfarin.
DB00549. Zafirlukast.
DB00495. Zidovudine.
DB00425. Zolpidem.
DB00909. Zonisamide.
GuidetoPHARMACOLOGYi1328.
SwissLipidsiSLP:000001589.

PTM databases

iPTMnetiP33261.
PhosphoSitePlusiP33261.

Polymorphism and mutation databases

BioMutaiCYP2C19.
DMDMi60416369.

Proteomic databases

PaxDbiP33261.
PeptideAtlasiP33261.
PRIDEiP33261.

Protocols and materials databases

DNASUi1557.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371321; ENSP00000360372; ENSG00000165841.
GeneIDi1557.
KEGGihsa:1557.
UCSCiuc010qnz.3. human.

Organism-specific databases

CTDi1557.
DisGeNETi1557.
GeneCardsiCYP2C19.
HGNCiHGNC:2621. CYP2C19.
HPAiHPA015066.
MalaCardsiCYP2C19.
MIMi124020. gene.
609535. phenotype.
neXtProtiNX_P33261.
Orphaneti413667. Antidepressant or antipsychotics toxicity or dose selection.
240935. Resistance to clopidogrel.
240921. Voriconazole toxicity.
PharmGKBiPA124.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP33261.
KOiK17721.
OrthoDBiEOG091G0BT8.
PhylomeDBiP33261.
TreeFamiTF352043.

Enzyme and pathway databases

BioCyciMetaCyc:HS09293-MONOMER.
ZFISH:HS09293-MONOMER.
ReactomeiR-HSA-211981. Xenobiotics.
R-HSA-211999. CYP2E1 reactions.
R-HSA-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-HSA-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
SABIO-RKP33261.

Miscellaneous databases

GeneWikiiCYP2C19.
GenomeRNAii1557.
PROiP33261.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165841.
CleanExiHS_CYP2C19.
ExpressionAtlasiP33261. baseline and differential.
GenevisibleiP33261. HS.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP2CJ_HUMAN
AccessioniPrimary (citable) accession number: P33261
Secondary accession number(s): P33259
, Q8WZB1, Q8WZB2, Q9UCD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 163 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

P450-254C was originally listed as a separate gene (CYP2C17). Resequencing demonstrated that it is not a separate gene, but a chimera. The 5'-portion corresponds to a partial 2C18 clone, and the 3'-portion corresponds to a partial 2C19 clone.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.