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Protein

Cytochrome P450 2C18

Gene

CYP2C18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi435Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-211981 Xenobiotics
SABIO-RKiP33260

Chemistry databases

SwissLipidsiSLP:000001875

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C18 (EC:1.14.14.1)
Alternative name(s):
CYPIIC18
Cytochrome P450-6b/29c
Gene namesi
Name:CYP2C18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000108242.12
HGNCiHGNC:2620 CYP2C18
MIMi601131 gene
neXtProtiNX_P33260

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1562
OpenTargetsiENSG00000108242
PharmGKBiPA127

Chemistry databases

ChEMBLiCHEMBL2408
DrugBankiDB07670 4-METHYL-N-METHYL-N-(2-PHENYL-2H-PYRAZOL-3-YL)BENZENESULFONAMIDE
DB01424 Aminophenazone
DB01435 Antipyrine
DB00921 Buprenorphine
DB00349 Clobazam
DB01559 Clotiazepam
DB00531 Cyclophosphamide
DB00250 Dapsone
DB01151 Desipramine
DB00829 Diazepam
DB00586 Diclofenac
DB01075 Diphenhydramine
DB01181 Ifosfamide
DB00458 Imipramine
DB00448 Lansoprazole
DB00281 Lidocaine
DB00333 Methadone
DB00338 Omeprazole
DB00082 Pegvisomant
DB00850 Perphenazine
DB01174 Phenobarbital
DB00252 Phenytoin
DB00818 Propofol
DB01124 Tolbutamide
DB00755 Tretinoin
DB01361 Troleandomycin
DB00313 Valproic Acid
DB00661 Verapamil
DB06684 Vilazodone
DB00682 Warfarin
GuidetoPHARMACOLOGYi1327

Polymorphism and mutation databases

BioMutaiCYP2C18
DMDMi67476954

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517071 – 490Cytochrome P450 2C18Add BLAST490

Proteomic databases

PaxDbiP33260
PeptideAtlasiP33260
PRIDEiP33260

PTM databases

iPTMnetiP33260
PhosphoSitePlusiP33260

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSG00000108242
CleanExiHS_CYP2C18
GenevisibleiP33260 HS

Interactioni

Protein-protein interaction databases

BioGridi107938, 10 interactors
IntActiP33260, 3 interactors
STRINGi9606.ENSP00000285979

Chemistry databases

BindingDBiP33260

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CIKX-ray1.75C72-80[»]
2H6PX-ray1.90C72-80[»]
ProteinModelPortaliP33260
SMRiP33260
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33260

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00880000137861
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiP33260
KOiK17720
OMAiYTNGLNM
OrthoDBiEOG091G0BT8
PhylomeDBiP33260
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P33260-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPAVALVLC LSCLFLLSLW RQSSGRGRLP SGPTPLPIIG NILQLDVKDM
60 70 80 90 100
SKSLTNFSKV YGPVFTVYFG LKPIVVLHGY EAVKEALIDH GEEFSGRGSF
110 120 130 140 150
PVAEKVNKGL GILFSNGKRW KEIRRFCLMT LRNFGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTN ASPCDPTFIL GCAPCNVICS VIFHDRFDYK DQRFLNLMEK
210 220 230 240 250
FNENLRILSS PWIQVCNNFP ALIDYLPGSH NKIAENFAYI KSYVLERIKE
260 270 280 290 300
HQESLDMNSA RDFIDCFLIK MEQEKHNQQS EFTVESLIAT VTDMFGAGTE
310 320 330 340 350
TTSTTLRYGL LLLLKYPEVT AKVQEEIECV VGRNRSPCMQ DRSHMPYTDA
360 370 380 390 400
VVHEIQRYID LLPTNLPHAV TCDVKFKNYL IPKGTTIITS LTSVLHNDKE
410 420 430 440 450
FPNPEMFDPG HFLDKSGNFK KSDYFMPFSA GKRMCMGEGL ARMELFLFLT
460 470 480 490
TILQNFNLKS QVDPKDIDIT PIANAFGRVP PLYQLCFIPV
Length:490
Mass (Da):55,711
Last modified:June 7, 2005 - v3
Checksum:iC933CF31F078FD1E
GO
Isoform 2 (identifier: P33260-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-272: Missing.

Note: No experimental confirmation available.
Show »
Length:431
Mass (Da):48,805
Checksum:i0FF49ECE8F830455
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_001254385T → M2 PublicationsCorresponds to variant dbSNP:rs1126545Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042520214 – 272Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61853 mRNA No translation available.
M61856 mRNA Translation: AAB59356.1
L16876
, L16871, L16872, L16869, L16870, L16875, L16873, L16874 Genomic DNA Translation: AAA02630.1
AK313403 mRNA Translation: BAG36199.1
AL583836 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50024.1
BC069666 mRNA Translation: AAH69666.1
BC096257 mRNA Translation: AAH96257.1
BC096258 mRNA Translation: AAH96258.1
BC096260 mRNA Translation: AAH96260.1
CCDSiCCDS44460.1 [P33260-2]
CCDS7435.1 [P33260-1]
PIRiA61269
RefSeqiNP_000763.1, NM_000772.2 [P33260-1]
NP_001122397.1, NM_001128925.1 [P33260-2]
UniGeneiHs.511872

Genome annotation databases

EnsembliENST00000285979; ENSP00000285979; ENSG00000108242 [P33260-1]
ENST00000339022; ENSP00000341293; ENSG00000108242 [P33260-2]
GeneIDi1562
KEGGihsa:1562
UCSCiuc001kjv.6 human [P33260-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCP2CI_HUMAN
AccessioniPrimary (citable) accession number: P33260
Secondary accession number(s): B2R8K2
, Q16703, Q16751, Q4VAT5, Q6GRG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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