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P33260

- CP2CI_HUMAN

UniProt

P33260 - CP2CI_HUMAN

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Protein

Cytochrome P450 2C18

Gene

CYP2C18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: ProtInc
  5. oxygen binding Source: ProtInc

GO - Biological processi

  1. small molecule metabolic process Source: Reactome
  2. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_13543. Xenobiotics.
SABIO-RKP33260.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C18 (EC:1.14.14.1)
Alternative name(s):
CYPIIC18
Cytochrome P450-6b/29c
Gene namesi
Name:CYP2C18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:2620. CYP2C18.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA127.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C18PRO_0000051707Add
BLAST

Proteomic databases

PaxDbiP33260.
PRIDEiP33260.

PTM databases

PhosphoSiteiP33260.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiP33260.
CleanExiHS_CYP2C18.
ExpressionAtlasiP33260. baseline and differential.
GenevestigatoriP33260.

Interactioni

Protein-protein interaction databases

BioGridi107938. 10 interactions.
IntActiP33260. 3 interactions.
STRINGi9606.ENSP00000285979.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CIKX-ray1.75C72-80[»]
2H6PX-ray1.90C72-80[»]
ProteinModelPortaliP33260.
SMRiP33260. Positions 30-490.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33260.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP33260.
KOiK17720.
OMAiHNDKEFP.
OrthoDBiEOG7RBZ85.
PhylomeDBiP33260.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P33260) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPAVALVLC LSCLFLLSLW RQSSGRGRLP SGPTPLPIIG NILQLDVKDM
60 70 80 90 100
SKSLTNFSKV YGPVFTVYFG LKPIVVLHGY EAVKEALIDH GEEFSGRGSF
110 120 130 140 150
PVAEKVNKGL GILFSNGKRW KEIRRFCLMT LRNFGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTN ASPCDPTFIL GCAPCNVICS VIFHDRFDYK DQRFLNLMEK
210 220 230 240 250
FNENLRILSS PWIQVCNNFP ALIDYLPGSH NKIAENFAYI KSYVLERIKE
260 270 280 290 300
HQESLDMNSA RDFIDCFLIK MEQEKHNQQS EFTVESLIAT VTDMFGAGTE
310 320 330 340 350
TTSTTLRYGL LLLLKYPEVT AKVQEEIECV VGRNRSPCMQ DRSHMPYTDA
360 370 380 390 400
VVHEIQRYID LLPTNLPHAV TCDVKFKNYL IPKGTTIITS LTSVLHNDKE
410 420 430 440 450
FPNPEMFDPG HFLDKSGNFK KSDYFMPFSA GKRMCMGEGL ARMELFLFLT
460 470 480 490
TILQNFNLKS QVDPKDIDIT PIANAFGRVP PLYQLCFIPV
Length:490
Mass (Da):55,711
Last modified:June 7, 2005 - v3
Checksum:iC933CF31F078FD1E
GO
Isoform 2 (identifier: P33260-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-272: Missing.

Note: No experimental confirmation available.

Show »
Length:431
Mass (Da):48,805
Checksum:i0FF49ECE8F830455
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti385 – 3851T → M.2 Publications
Corresponds to variant rs2281891 [ dbSNP | Ensembl ].
VAR_001254

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei214 – 27259Missing in isoform 2. 1 PublicationVSP_042520Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M61853 mRNA. No translation available.
M61856 mRNA. Translation: AAB59356.1.
L16876
, L16871, L16872, L16869, L16870, L16875, L16873, L16874 Genomic DNA. Translation: AAA02630.1.
AK313403 mRNA. Translation: BAG36199.1.
AL583836 Genomic DNA. Translation: CAH74067.1.
CH471066 Genomic DNA. Translation: EAW50024.1.
BC069666 mRNA. Translation: AAH69666.1.
BC096257 mRNA. Translation: AAH96257.1.
BC096258 mRNA. Translation: AAH96258.1.
BC096260 mRNA. Translation: AAH96260.1.
CCDSiCCDS44460.1. [P33260-2]
CCDS7435.1. [P33260-1]
PIRiA61269.
RefSeqiNP_000763.1. NM_000772.2. [P33260-1]
NP_001122397.1. NM_001128925.1. [P33260-2]
UniGeneiHs.511872.

Genome annotation databases

EnsembliENST00000285979; ENSP00000285979; ENSG00000108242. [P33260-1]
ENST00000339022; ENSP00000341293; ENSG00000108242. [P33260-2]
GeneIDi1562.
KEGGihsa:1562.
UCSCiuc001kjv.4. human. [P33260-1]
uc001kjw.4. human. [P33260-2]

Polymorphism databases

DMDMi67476954.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M61853 mRNA. No translation available.
M61856 mRNA. Translation: AAB59356.1 .
L16876
, L16871 , L16872 , L16869 , L16870 , L16875 , L16873 , L16874 Genomic DNA. Translation: AAA02630.1 .
AK313403 mRNA. Translation: BAG36199.1 .
AL583836 Genomic DNA. Translation: CAH74067.1 .
CH471066 Genomic DNA. Translation: EAW50024.1 .
BC069666 mRNA. Translation: AAH69666.1 .
BC096257 mRNA. Translation: AAH96257.1 .
BC096258 mRNA. Translation: AAH96258.1 .
BC096260 mRNA. Translation: AAH96260.1 .
CCDSi CCDS44460.1. [P33260-2 ]
CCDS7435.1. [P33260-1 ]
PIRi A61269.
RefSeqi NP_000763.1. NM_000772.2. [P33260-1 ]
NP_001122397.1. NM_001128925.1. [P33260-2 ]
UniGenei Hs.511872.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CIK X-ray 1.75 C 72-80 [» ]
2H6P X-ray 1.90 C 72-80 [» ]
ProteinModelPortali P33260.
SMRi P33260. Positions 30-490.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107938. 10 interactions.
IntActi P33260. 3 interactions.
STRINGi 9606.ENSP00000285979.

Chemistry

BindingDBi P33260.
ChEMBLi CHEMBL2408.
DrugBanki DB01424. Aminophenazone.
DB01435. Antipyrine.
DB00921. Buprenorphine.
DB00349. Clobazam.
DB01559. Clotiazepam.
DB00531. Cyclophosphamide.
DB00250. Dapsone.
DB01151. Desipramine.
DB00829. Diazepam.
DB00586. Diclofenac.
DB01075. Diphenhydramine.
DB01181. Ifosfamide.
DB00458. Imipramine.
DB00448. Lansoprazole.
DB00281. Lidocaine.
DB00333. Methadone.
DB00338. Omeprazole.
DB00082. Pegvisomant.
DB00850. Perphenazine.
DB01174. Phenobarbital.
DB00252. Phenytoin.
DB00818. Propofol.
DB01124. Tolbutamide.
DB00755. Tretinoin.
DB01361. Troleandomycin.
DB00313. Valproic Acid.
DB00661. Verapamil.
DB06684. Vilazodone.
DB00682. Warfarin.

PTM databases

PhosphoSitei P33260.

Polymorphism databases

DMDMi 67476954.

Proteomic databases

PaxDbi P33260.
PRIDEi P33260.

Protocols and materials databases

DNASUi 1562.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000285979 ; ENSP00000285979 ; ENSG00000108242 . [P33260-1 ]
ENST00000339022 ; ENSP00000341293 ; ENSG00000108242 . [P33260-2 ]
GeneIDi 1562.
KEGGi hsa:1562.
UCSCi uc001kjv.4. human. [P33260-1 ]
uc001kjw.4. human. [P33260-2 ]

Organism-specific databases

CTDi 1562.
GeneCardsi GC10P096433.
HGNCi HGNC:2620. CYP2C18.
MIMi 601131. gene.
neXtProti NX_P33260.
PharmGKBi PA127.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118775.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi P33260.
KOi K17720.
OMAi HNDKEFP.
OrthoDBi EOG7RBZ85.
PhylomeDBi P33260.
TreeFami TF352043.

Enzyme and pathway databases

Reactomei REACT_13543. Xenobiotics.
SABIO-RK P33260.

Miscellaneous databases

EvolutionaryTracei P33260.
GeneWikii CYP2C18.
GenomeRNAii 1562.
NextBioi 6442.
PROi P33260.
SOURCEi Search...

Gene expression databases

Bgeei P33260.
CleanExi HS_CYP2C18.
ExpressionAtlasi P33260. baseline and differential.
Genevestigatori P33260.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily."
    Romkes M., Faletto M.B., Blaisdell J.A., Raucy J.L., Goldstein J.A.
    Biochemistry 30:3247-3255(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-385.
    Tissue: Liver.
  2. Cited for: SEQUENCE REVISION.
  3. "Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18."
    de Morais S.M., Schweikl H., Blaisdell J., Goldstein J.A.
    Biochem. Biophys. Res. Commun. 194:194-201(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-385.
    Tissue: Liver.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Stomach.
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  8. "Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is the result of highly focused, peptide-dependent structural mimicry."
    Archbold J.K., Macdonald W.A., Miles J.J., Brennan R.M., Kjer-Nielsen L., McCluskey J., Burrows S.R., Rossjohn J.
    J. Biol. Chem. 281:34324-34332(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 72-80.

Entry informationi

Entry nameiCP2CI_HUMAN
AccessioniPrimary (citable) accession number: P33260
Secondary accession number(s): B2R8K2
, Q16703, Q16751, Q4VAT5, Q6GRG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 7, 2005
Last modified: October 29, 2014
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3