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Reviewed, UniProtKB/Swiss-Prot P33241 (LSP1_HUMAN)

Last modified June 16, 2009. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Lymphocyte-specific protein 1
Alternative name(s):
    52 kDa phosphoprotein
    Protein pp52
    Lymphocyte-specific antigen WP34
    47 kDa actin-binding protein
Gene names
Name: LSP1
Synonyms: WP34
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May play a role in mediating neutrophil activation and chemotaxis By similarity.

Subunit structure

Binds actin.

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue specificity

Activated T-lymphocytes.

Post-translational modification

Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis By similarity.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   PTMPhosphoprotein
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Biological processcell motion Ref.3

Traceable author statement. Source: ProtInc

cellular defense response Ref.2

Traceable author statement. Source: ProtInc

signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular componentactin cytoskeleton Ref.3

Traceable author statement. Source: ProtInc

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionactin binding Ref.3

Traceable author statement. Source: ProtInc

signal transducer activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Lymphocyte-specific protein 1
PRO_0000084503

Amino acid modifications

Modified residue851Phosphoserine By similarity
Modified residue1751Phosphothreonine By similarity
Modified residue1771Phosphoserine By similarity
Modified residue2521Phosphoserine; by MAPKAPK2 Ref.7 Ref.8

Natural variations

Natural variant1001A → T: dbSNP rs621679. Ref.5 Ref.6
VAR_011867
Natural variant2291Q → K: dbSNP rs1803928.
VAR_011868

Experimental info

Sequence conflict151Missing in AAB29545. Ref.3
Sequence conflict241S → T in CAA38971. Ref.2
Sequence conflict100 – 1012Missing in AAB29545. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P33241-1 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: F2A18533500611D9

FASTA33937,192
        10         20         30         40         50         60 
MAEASSDPGA EEREELLGPT AQWSVEDEEE AVHEQCQHER DRQLQAQDEE GGGHVPERPK 

        70         80         90        100        110        120 
QEMLLSLKPS EAPELDEDEG FGDWSQRPEQ RQQHEGAQGA LDSGEPPQCR SPEGEQEDRP 

       130        140        150        160        170        180 
GLHAYEKEDS DEVHLEELSL SKEGPGPEDT VQDNLGAAGA EEEQEEHQKC QQPRTPSPLV 

       190        200        210        220        230        240 
LEGTIEQSSP PLSPTTKLID RTESLNRSIE KSNSVKKSQP DLPISKIDQW LEQYTQAIET 

       250        260        270        280        290        300 
AGRTPKLARQ ASIELPSMAV ASTKSRWETG EVQAQSAAKT PSCKDIVAGD MSKKSLWEQK 

       310        320        330 
GGSKTSSTIK STPSGKRYKF VATGHGKYEK VLVEGGPAP 

« Hide

References

« Hide 'large scale' references
[1]"Human and mouse LSP1 genes code for highly conserved phosphoproteins."
Jongstra-Bilen J., Young A.J., Chong R., Jongstra J.
J. Immunol. 144:1104-1110(1990) [PubMed: 2295815] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen."
Kadiyala R.K., McIntyre B.W., Krensky A.M.
Eur. J. Immunol. 20:2417-2423(1990) [PubMed: 2174784] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lymphocyte.
[3]"The 47-kD protein increased in neutrophil actin dysfunction with 47- and 89-kD protein abnormalities is lymphocyte-specific protein."
Howard T., Li Y., Torres M., Guerrero A., Coates T.
Blood 83:231-241(1994) [PubMed: 8274738] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-100.
Tissue: Dermoid cancer.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-100.
Tissue: Lymph.
[7]"MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization."
Wu Y., Zhan L., Ai Y., Hannigan M., Gaestel M., Huang C.-K., Madri J.A.
Biochem. Biophys. Res. Commun. 358:170-175(2007) [PubMed: 17481585] [Abstract]
Cited for: PHOSPHORYLATION AT SER-252 BY MAPKAPK2.
[8]Carrascal M., Abian J.
Submitted (JUN-2007) to UniProtKB
Cited for: PHOSPHORYLATION AT SER-252, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

M33552 mRNA. Translation: AAA59534.1.
X55188 mRNA. Translation: CAA38971.1.
S67783 mRNA. Translation: AAB29545.1.
CR541728 mRNA. Translation: CAG46529.1.
CR541754 mRNA. Translation: CAG46554.1.
AK222733 mRNA. Translation: BAD96453.1.
BC001785 mRNA. Translation: AAH01785.1.
IPIIPI00013260.
PIRA43542.
RefSeqNP_001013271.1.
NP_001013273.1.
NP_002330.1.
UniGeneHs.56729

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
3BH8X-ray1.65C249-258[»]
ModBaseSearch...

PTM databases

PhosphoSiteP33241.

2-D gel databases

SWISS-2DPAGEP33241.

Proteomic databases

PeptideAtlasP33241.
PRIDEP33241.

Genome annotation databases

EnsemblENSG00000130592. Homo sapiens. [Contig view]
GeneID4046.
KEGGhsa:4046.

Organism-specific databases

GeneCardsGC11P001830.
H-InvDBHIX0009349.
HGNCHGNC:6707. LSP1.
HPACAB017781.
MIM153432. gene.
PharmGKBPA30472.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP33241.
HOVERGENP33241.

Enzyme and pathway databases

Pathway_Interaction_DBp38_mk2pathway. p38 signaling mediated by MAPKAP kinases.

Gene expression databases

ArrayExpressP33241.
BgeeP33241.
CleanExHS_LSP1.
GermOnlineENSG00000130592. Homo sapiens.

Family and domain databases

InterProIPR006018. Caldesmon_LSP.
IPR002211. Lymphspecific.
[Graphical view]
PANTHERPTHR12060. Lymphspecific. 1 hit.
PfamPF02029. Caldesmon. 1 hit.
[Graphical view]
PRINTSPR01083. LYMPHSPCIFIC.
ProtoNetSearch...

Other Resources

NextBio15838.
SOURCESearch...

Entry information

Entry nameLSP1_HUMAN
AccessionPrimary (citable) accession number: P33241
Secondary accession number(s): Q16096 expand/collapse secondary AC list , Q53H48, Q6FHM3, Q9BUY8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 16, 2009
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents