P33241 (LSP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 107.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Lymphocyte-specific protein 1 Alternative name(s): 47 kDa actin-binding protein 52 kDa phosphoprotein Short name=pp52 Lymphocyte-specific antigen WP34 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 339 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | May play a role in mediating neutrophil activation and chemotaxis By similarity. |
| Subunit structure | Binds actin. |
| Subcellular location | Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
| Tissue specificity | Activated T-lymphocytes. |
| Post-translational modification | Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis By similarity. Ref.7 Ref.8 Ref.9 Ref.10 |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Polymorphism |
| PTM | Acetylation Phosphoprotein |
| Technical term | 3D-structure Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Biological process | cellular component movement Traceable author statement. Source: ProtInc cellular defense responseTraceable author statement. Source: ProtInc |
| Cellular component | Golgi apparatus Inferred from direct assay. Source: HPA actin cytoskeletonTraceable author statement. Source: ProtInc plasma membraneInferred from direct assay. Source: HPA |
| Molecular function | actin binding Traceable author statement. Source: ProtInc signal transducer activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 339 | 339 | Lymphocyte-specific protein 1 | PRO_0000084503 | |||||
Amino acid modifications | |||||||||
| Modified residue | 85 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 175 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 177 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 189 | 1 | Phosphoserine Ref.10 | ||||||
| Modified residue | 252 | 1 | Phosphoserine; by MAPKAPK2 Ref.7 Ref.8 Ref.9 | ||||||
| Modified residue | 327 | 1 | N6-acetyllysine Ref.11 | ||||||
Natural variations | |||||||||
| Natural variant | 100 | 1 | A → T. Ref.5 Ref.6 Corresponds to variant rs621679 [ dbSNP | Ensembl ]. | VAR_011867 | |||||
| Natural variant | 108 | 1 | Q → L. Corresponds to variant rs11545725 [ dbSNP | Ensembl ]. | VAR_061680 | |||||
| Natural variant | 229 | 1 | Q → K. Corresponds to variant rs1803928 [ dbSNP | Ensembl ]. | VAR_011868 | |||||
Experimental info | |||||||||
| Sequence conflict | 15 | 1 | Missing in AAB29545. Ref.3 | ||||||
| Sequence conflict | 24 | 1 | S → T in CAA38971. Ref.2 | ||||||
| Sequence conflict | 100 – 101 | 2 | Missing in AAB29545. Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Human and mouse LSP1 genes code for highly conserved phosphoproteins." Jongstra-Bilen J., Young A.J., Chong R., Jongstra J. J. Immunol. 144:1104-1110(1990) [PubMed: 2295815] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen." Kadiyala R.K., McIntyre B.W., Krensky A.M. Eur. J. Immunol. 20:2417-2423(1990) [PubMed: 2174784] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lymphocyte. |
| [3] | "The 47-kD protein increased in neutrophil actin dysfunction with 47- and 89-kD protein abnormalities is lymphocyte-specific protein." Howard T., Li Y., Torres M., Guerrero A., Coates T. Blood 83:231-241(1994) [PubMed: 8274738] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. |
| [4] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-100. Tissue: Dermoid cancer. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-100. Tissue: Lymph. |
| [7] | "MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization." Wu Y., Zhan L., Ai Y., Hannigan M., Gaestel M., Huang C.-K., Madri J.A. Biochem. Biophys. Res. Commun. 358:170-175(2007) [PubMed: 17481585] [Abstract] Cited for: PHOSPHORYLATION AT SER-252 BY MAPKAPK2. |
| [8] | Carrascal M., Abian J. Submitted (JUN-2007) to UniProtKB Cited for: PHOSPHORYLATION AT SER-252, MASS SPECTROMETRY. |
| [9] | "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed: 19367720] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252, MASS SPECTROMETRY. Tissue: T-cell. |
| [10] | "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189, MASS SPECTROMETRY. Tissue: Leukemic T-cell. |
| [11] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-327, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | M33552 mRNA. Translation: AAA59534.1. X55188 mRNA. Translation: CAA38971.1. S67783 mRNA. Translation: AAB29545.1. CR541728 mRNA. Translation: CAG46529.1. CR541754 mRNA. Translation: CAG46554.1. AK222733 mRNA. Translation: BAD96453.1. BC001785 mRNA. Translation: AAH01785.1. | ||||||||||||
| IPI | IPI00013260. | ||||||||||||
| PIR | A43542. | ||||||||||||
| RefSeq | NP_001013271.1. NM_001013253.1. NP_001013272.1. NM_001013254.1. NP_001013273.1. NM_001013255.1. NP_001229861.1. NM_001242932.1. NP_002330.1. NM_002339.2. | ||||||||||||
| UniGene | Hs.56729. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
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| ProteinModelPortal | P33241. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| STRING | P33241. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | P33241. | ||||||||||||
Polymorphism databases | |||||||||||||
| DMDM | 462553. | ||||||||||||
2D gel databases | |||||||||||||
| SWISS-2DPAGE | P33241. | ||||||||||||
Proteomic databases | |||||||||||||
| PeptideAtlas | P33241. | ||||||||||||
| PRIDE | P33241. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000311604; ENSP00000308383; ENSG00000130592. | ||||||||||||
| GeneID | 4046. | ||||||||||||
| KEGG | hsa:4046. | ||||||||||||
| UCSC | uc001lui.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 4046. | ||||||||||||
| GeneCards | GC11P001874. | ||||||||||||
| H-InvDB | HIX0009349. | ||||||||||||
| HGNC | HGNC:6707. LSP1. | ||||||||||||
| HPA | CAB017781. HPA019693. | ||||||||||||
| MIM | 153432. gene. | ||||||||||||
| neXtProt | NX_P33241. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | prNOG09247. | ||||||||||||
| HOVERGEN | HBG001610. | ||||||||||||
| OrthoDB | EOG4NKBW0. | ||||||||||||
| PhylomeDB | P33241. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| Pathway_Interaction_DB | p38_mk2pathway. p38 signaling mediated by MAPKAP kinases. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P33241. | ||||||||||||
| Bgee | P33241. | ||||||||||||
| CleanEx | HS_LSP1. | ||||||||||||
| Genevestigator | P33241. | ||||||||||||
| GermOnline | ENSG00000130592. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR006018. Caldesmon_LSP. IPR002211. Lymphspecific. [Graphical view] | ||||||||||||
| KO | K14957. | ||||||||||||
| PANTHER | PTHR12060. Lymphspecific. 1 hit. | ||||||||||||
| Pfam | PF02029. Caldesmon. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR01083. LYMPHSPCIFIC. | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| NextBio | 15838. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | LSP1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P33241 Secondary accession number(s): Q16096 Q9BUY8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |

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