Lymphocyte-specific protein 1 - Homo sapiens (Human)

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P33241 (LSP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 107. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Lymphocyte-specific protein 1

Alternative name(s):
47 kDa actin-binding protein
52 kDa phosphoprotein
Short name=pp52
Lymphocyte-specific antigen WP34

Gene names

Name:	LSP1
Synonyms:	WP34

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in mediating neutrophil activation and chemotaxis By similarity.
Subunit structure	Binds actin.
Subcellular location	Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Tissue specificity	Activated T-lymphocytes.
Post-translational modification	Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis By similarity. Ref.7 Ref.8 Ref.9 Ref.10

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	cellular component movement Traceable author statement. Source: ProtInc cellular defense response Traceable author statement. Source: ProtInc
Cellular component	Golgi apparatus Inferred from direct assay. Source: HPA actin cytoskeleton Traceable author statement. Source: ProtInc plasma membrane Inferred from direct assay. Source: HPA
Molecular function	actin binding Traceable author statement. Source: ProtInc signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 339

339

Lymphocyte-specific protein 1

PRO_0000084503

Amino acid modifications

Modified residue

Phosphoserine By similarity

Modified residue

175

Phosphothreonine By similarity

Modified residue

177

Phosphoserine By similarity

Modified residue

189

Phosphoserine Ref.10

Modified residue

252

Phosphoserine; by MAPKAPK2 Ref.7 Ref.8 Ref.9

Modified residue

327

N6-acetyllysine Ref.11

Natural variations

Natural variant

100

A → T. Ref.5 Ref.6
Corresponds to variant rs621679 [ dbSNP | Ensembl ].

VAR_011867

Natural variant

108

Q → L.
Corresponds to variant rs11545725 [ dbSNP | Ensembl ].

VAR_061680

Natural variant

229

Q → K.
Corresponds to variant rs1803928 [ dbSNP | Ensembl ].

VAR_011868

Experimental info

Sequence conflict

Missing in AAB29545. Ref.3

Sequence conflict

S → T in CAA38971. Ref.2

Sequence conflict

100 – 101

Missing in AAB29545. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

P33241 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: F2A18533500611D9
Show »

FASTA

339

37,192

        10         20         30         40         50         60 
MAEASSDPGA EEREELLGPT AQWSVEDEEE AVHEQCQHER DRQLQAQDEE GGGHVPERPK 

        70         80         90        100        110        120 
QEMLLSLKPS EAPELDEDEG FGDWSQRPEQ RQQHEGAQGA LDSGEPPQCR SPEGEQEDRP 

       130        140        150        160        170        180 
GLHAYEKEDS DEVHLEELSL SKEGPGPEDT VQDNLGAAGA EEEQEEHQKC QQPRTPSPLV 

       190        200        210        220        230        240 
LEGTIEQSSP PLSPTTKLID RTESLNRSIE KSNSVKKSQP DLPISKIDQW LEQYTQAIET 

       250        260        270        280        290        300 
AGRTPKLARQ ASIELPSMAV ASTKSRWETG EVQAQSAAKT PSCKDIVAGD MSKKSLWEQK 

       310        320        330 
GGSKTSSTIK STPSGKRYKF VATGHGKYEK VLVEGGPAP

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human and mouse LSP1 genes code for highly conserved phosphoproteins." Jongstra-Bilen J., Young A.J., Chong R., Jongstra J. J. Immunol. 144:1104-1110(1990) [PubMed: 2295815] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen." Kadiyala R.K., McIntyre B.W., Krensky A.M. Eur. J. Immunol. 20:2417-2423(1990) [PubMed: 2174784] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lymphocyte.
[3]	"The 47-kD protein increased in neutrophil actin dysfunction with 47- and 89-kD protein abnormalities is lymphocyte-specific protein." Howard T., Li Y., Torres M., Guerrero A., Coates T. Blood 83:231-241(1994) [PubMed: 8274738] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-100. Tissue: Dermoid cancer.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-100. Tissue: Lymph.
[7]	"MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization." Wu Y., Zhan L., Ai Y., Hannigan M., Gaestel M., Huang C.-K., Madri J.A. Biochem. Biophys. Res. Commun. 358:170-175(2007) [PubMed: 17481585] [Abstract] Cited for: PHOSPHORYLATION AT SER-252 BY MAPKAPK2.
[8]	Carrascal M., Abian J. Submitted (JUN-2007) to UniProtKB Cited for: PHOSPHORYLATION AT SER-252, MASS SPECTROMETRY.
[9]	"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed: 19367720] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252, MASS SPECTROMETRY. Tissue: T-cell.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-327, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M33552 mRNA. Translation: AAA59534.1.
X55188 mRNA. Translation: CAA38971.1.
S67783 mRNA. Translation: AAB29545.1.
CR541728 mRNA. Translation: CAG46529.1.
CR541754 mRNA. Translation: CAG46554.1.
AK222733 mRNA. Translation: BAD96453.1.
BC001785 mRNA. Translation: AAH01785.1.

IPI

IPI00013260.

PIR

A43542.

RefSeq

NP_001013271.1. NM_001013253.1.
NP_001013272.1. NM_001013254.1.
NP_001013273.1. NM_001013255.1.
NP_001229861.1. NM_001242932.1.
NP_002330.1. NM_002339.2.

UniGene

Hs.56729.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3BH8	X-ray	1.65	C	249-258	[»]

ProteinModelPortal

P33241.

ModBase

Search...

Protein-protein interaction databases

STRING

P33241.

PTM databases

PhosphoSite

P33241.

Polymorphism databases

DMDM

462553.

2D gel databases

SWISS-2DPAGE

P33241.

Proteomic databases

PeptideAtlas

P33241.

PRIDE

P33241.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000311604; ENSP00000308383; ENSG00000130592.

GeneID

4046.

KEGG

hsa:4046.

UCSC

uc001lui.1. human.

Organism-specific databases

CTD

4046.

GeneCards

GC11P001874.

H-InvDB

HIX0009349.

HGNC

HGNC:6707. LSP1.

HPA

CAB017781.
HPA019693.

MIM

153432. gene.

neXtProt

NX_P33241.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG09247.

HOVERGEN

HBG001610.

OrthoDB

EOG4NKBW0.

PhylomeDB

P33241.

Enzyme and pathway databases

Pathway_Interaction_DB

p38_mk2pathway. p38 signaling mediated by MAPKAP kinases.

Gene expression databases

ArrayExpress

P33241.

Bgee

P33241.

CleanEx

HS_LSP1.

Genevestigator

P33241.

GermOnline

ENSG00000130592. Homo sapiens.

Family and domain databases

InterPro

IPR006018. Caldesmon_LSP.
IPR002211. Lymphspecific.
[Graphical view]

K14957.

PANTHER

PTHR12060. Lymphspecific. 1 hit.

Pfam

PF02029. Caldesmon. 1 hit.
[Graphical view]

PRINTS

PR01083. LYMPHSPCIFIC.

ProtoNet

Search...

Other

NextBio

15838.

SOURCE

Search...

Entry information

Entry name

LSP1_HUMAN

Accession

Primary (citable) accession number: P33241
Secondary accession number(s): Q16096

Q9BUY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	January 25, 2012
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents