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P33241

- LSP1_HUMAN

UniProt

P33241 - LSP1_HUMAN

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Protein
Lymphocyte-specific protein 1
Gene
LSP1, WP34
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in mediating neutrophil activation and chemotaxis By similarity.

GO - Molecular functioni

  1. actin binding Source: ProtInc
  2. signal transducer activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cellular component movement Source: ProtInc
  2. cellular defense response Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiP33241.

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte-specific protein 1
Alternative name(s):
47 kDa actin-binding protein
52 kDa phosphoprotein
Short name:
pp52
Lymphocyte-specific antigen WP34
Gene namesi
Name:LSP1
Synonyms:WP34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:6707. LSP1.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: ProtInc
  2. extracellular vesicular exosome Source: UniProt
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30472.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Lymphocyte-specific protein 1
PRO_0000084503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751Phosphothreonine By similarity
Modified residuei177 – 1771Phosphoserine By similarity
Modified residuei189 – 1891Phosphoserine1 Publication
Modified residuei252 – 2521Phosphoserine; by MAPKAPK22 Publications
Modified residuei327 – 3271N6-acetyllysine1 Publication

Post-translational modificationi

Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis By similarity.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP33241.
PaxDbiP33241.
PeptideAtlasiP33241.
PRIDEiP33241.

2D gel databases

SWISS-2DPAGEP33241.

PTM databases

PhosphoSiteiP33241.

Expressioni

Tissue specificityi

Activated T-lymphocytes.

Gene expression databases

ArrayExpressiP33241.
BgeeiP33241.
CleanExiHS_LSP1.
GenevestigatoriP33241.

Organism-specific databases

HPAiCAB017781.
HPA019693.

Interactioni

Subunit structurei

Binds actin.

Protein-protein interaction databases

BioGridi110224. 6 interactions.
STRINGi9606.ENSP00000308383.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BH8X-ray1.65C249-258[»]
ProteinModelPortaliP33241.

Miscellaneous databases

EvolutionaryTraceiP33241.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG302084.
HOGENOMiHOG000231050.
HOVERGENiHBG001610.
KOiK14957.
OMAiRLTAQWS.
OrthoDBiEOG7FNC7W.
PhylomeDBiP33241.
TreeFamiTF336257.

Family and domain databases

InterProiIPR006018. Caldesmon_LSP.
IPR002211. Lymphspecific.
[Graphical view]
PANTHERiPTHR18949. PTHR18949. 1 hit.
PfamiPF02029. Caldesmon. 1 hit.
[Graphical view]
PRINTSiPR01083. LYMPHSPCIFIC.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P33241-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAEASSDPGA EEREELLGPT AQWSVEDEEE AVHEQCQHER DRQLQAQDEE    50
GGGHVPERPK QEMLLSLKPS EAPELDEDEG FGDWSQRPEQ RQQHEGAQGA 100
LDSGEPPQCR SPEGEQEDRP GLHAYEKEDS DEVHLEELSL SKEGPGPEDT 150
VQDNLGAAGA EEEQEEHQKC QQPRTPSPLV LEGTIEQSSP PLSPTTKLID 200
RTESLNRSIE KSNSVKKSQP DLPISKIDQW LEQYTQAIET AGRTPKLARQ 250
ASIELPSMAV ASTKSRWETG EVQAQSAAKT PSCKDIVAGD MSKKSLWEQK 300
GGSKTSSTIK STPSGKRYKF VATGHGKYEK VLVEGGPAP 339
Length:339
Mass (Da):37,192
Last modified:February 1, 1994 - v1
Checksum:iF2A18533500611D9
GO
Isoform 2 (identifier: P33241-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.

Note: No experimental confirmation available.

Show »
Length:277
Mass (Da):30,213
Checksum:iDA869746FA7B7C6D
GO
Isoform 3 (identifier: P33241-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MAEASSDPGAEEREELLG → MAPIWSPPGR...SGPSTNCSPR

Note: No experimental confirmation available.

Show »
Length:467
Mass (Da):50,389
Checksum:iA3F09D8EECD570D6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti100 – 1001A → T.3 Publications
Corresponds to variant rs621679 [ dbSNP | Ensembl ].
VAR_011867
Natural varianti108 – 1081Q → L.
Corresponds to variant rs11545725 [ dbSNP | Ensembl ].
VAR_061680
Natural varianti229 – 2291Q → K.
Corresponds to variant rs1803928 [ dbSNP | Ensembl ].
VAR_011868

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6262Missing in isoform 2.
VSP_045655Add
BLAST
Alternative sequencei1 – 1818MAEAS…EELLG → MAPIWSPPGRVSGCHLSSGP APGSAVGPWLGTPHPSLPLP LAPHKPPPPGLPGSAGQTSL PAQRECVFPGDAAVHQELCG LGFEECLGSIPQAHQCYLTN GPKRRKCSPRRRGRAPAWLC GGSPPCHQGLGHEHPSSGPS TNCSPR in isoform 3.
VSP_045983Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151Missing in AAB29545. 1 Publication
Sequence conflicti24 – 241S → T in CAA38971. 1 Publication
Sequence conflicti100 – 1012Missing in AAB29545. 1 Publication
Sequence conflicti148 – 1481E → D in BAG52478. 1 Publication
Isoform 3 (identifier: P33241-3)
Sequence conflicti31 – 311G → Q in BAG52478. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33552 mRNA. Translation: AAA59534.1.
X55188 mRNA. Translation: CAA38971.1.
S67783 mRNA. Translation: AAB29545.1.
CR541728 mRNA. Translation: CAG46529.1.
CR541754 mRNA. Translation: CAG46554.1.
AK056576 mRNA. Translation: BAG51753.1.
AK092071 mRNA. Translation: BAG52478.1.
AK222733 mRNA. Translation: BAD96453.1.
AC051649 Genomic DNA. No translation available.
BC001785 mRNA. Translation: AAH01785.1.
CCDSiCCDS31334.1. [P33241-1]
CCDS31335.1. [P33241-2]
CCDS58110.1. [P33241-3]
PIRiA43542.
RefSeqiNP_001013271.1. NM_001013253.1. [P33241-2]
NP_001013272.1. NM_001013254.1. [P33241-2]
NP_001013273.1. NM_001013255.1. [P33241-2]
NP_001229861.1. NM_001242932.1. [P33241-3]
NP_001275934.1. NM_001289005.1. [P33241-2]
NP_002330.1. NM_002339.2. [P33241-1]
XP_005252983.1. XM_005252926.1. [P33241-2]
XP_005252984.1. XM_005252927.1. [P33241-2]
UniGeneiHs.56729.

Genome annotation databases

EnsembliENST00000311604; ENSP00000308383; ENSG00000130592. [P33241-1]
ENST00000381775; ENSP00000371194; ENSG00000130592. [P33241-3]
ENST00000405957; ENSP00000383932; ENSG00000130592. [P33241-2]
ENST00000406638; ENSP00000384022; ENSG00000130592. [P33241-2]
GeneIDi4046.
KEGGihsa:4046.
UCSCiuc001lui.3. human. [P33241-1]

Polymorphism databases

DMDMi462553.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33552 mRNA. Translation: AAA59534.1 .
X55188 mRNA. Translation: CAA38971.1 .
S67783 mRNA. Translation: AAB29545.1 .
CR541728 mRNA. Translation: CAG46529.1 .
CR541754 mRNA. Translation: CAG46554.1 .
AK056576 mRNA. Translation: BAG51753.1 .
AK092071 mRNA. Translation: BAG52478.1 .
AK222733 mRNA. Translation: BAD96453.1 .
AC051649 Genomic DNA. No translation available.
BC001785 mRNA. Translation: AAH01785.1 .
CCDSi CCDS31334.1. [P33241-1 ]
CCDS31335.1. [P33241-2 ]
CCDS58110.1. [P33241-3 ]
PIRi A43542.
RefSeqi NP_001013271.1. NM_001013253.1. [P33241-2 ]
NP_001013272.1. NM_001013254.1. [P33241-2 ]
NP_001013273.1. NM_001013255.1. [P33241-2 ]
NP_001229861.1. NM_001242932.1. [P33241-3 ]
NP_001275934.1. NM_001289005.1. [P33241-2 ]
NP_002330.1. NM_002339.2. [P33241-1 ]
XP_005252983.1. XM_005252926.1. [P33241-2 ]
XP_005252984.1. XM_005252927.1. [P33241-2 ]
UniGenei Hs.56729.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3BH8 X-ray 1.65 C 249-258 [» ]
ProteinModelPortali P33241.
ModBasei Search...

Protein-protein interaction databases

BioGridi 110224. 6 interactions.
STRINGi 9606.ENSP00000308383.

PTM databases

PhosphoSitei P33241.

Polymorphism databases

DMDMi 462553.

2D gel databases

SWISS-2DPAGE P33241.

Proteomic databases

MaxQBi P33241.
PaxDbi P33241.
PeptideAtlasi P33241.
PRIDEi P33241.

Protocols and materials databases

DNASUi 4046.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311604 ; ENSP00000308383 ; ENSG00000130592 . [P33241-1 ]
ENST00000381775 ; ENSP00000371194 ; ENSG00000130592 . [P33241-3 ]
ENST00000405957 ; ENSP00000383932 ; ENSG00000130592 . [P33241-2 ]
ENST00000406638 ; ENSP00000384022 ; ENSG00000130592 . [P33241-2 ]
GeneIDi 4046.
KEGGi hsa:4046.
UCSCi uc001lui.3. human. [P33241-1 ]

Organism-specific databases

CTDi 4046.
GeneCardsi GC11P001874.
HGNCi HGNC:6707. LSP1.
HPAi CAB017781.
HPA019693.
MIMi 153432. gene.
neXtProti NX_P33241.
PharmGKBi PA30472.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG302084.
HOGENOMi HOG000231050.
HOVERGENi HBG001610.
KOi K14957.
OMAi RLTAQWS.
OrthoDBi EOG7FNC7W.
PhylomeDBi P33241.
TreeFami TF336257.

Enzyme and pathway databases

SignaLinki P33241.

Miscellaneous databases

ChiTaRSi LSP1. human.
EvolutionaryTracei P33241.
GeneWikii LSP1.
GenomeRNAii 4046.
NextBioi 15838.
PROi P33241.
SOURCEi Search...

Gene expression databases

ArrayExpressi P33241.
Bgeei P33241.
CleanExi HS_LSP1.
Genevestigatori P33241.

Family and domain databases

InterProi IPR006018. Caldesmon_LSP.
IPR002211. Lymphspecific.
[Graphical view ]
PANTHERi PTHR18949. PTHR18949. 1 hit.
Pfami PF02029. Caldesmon. 1 hit.
[Graphical view ]
PRINTSi PR01083. LYMPHSPCIFIC.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human and mouse LSP1 genes code for highly conserved phosphoproteins."
    Jongstra-Bilen J., Young A.J., Chong R., Jongstra J.
    J. Immunol. 144:1104-1110(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen."
    Kadiyala R.K., McIntyre B.W., Krensky A.M.
    Eur. J. Immunol. 20:2417-2423(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lymphocyte.
  3. "The 47-kD protein increased in neutrophil actin dysfunction with 47- and 89-kD protein abnormalities is lymphocyte-specific protein."
    Howard T., Li Y., Torres M., Guerrero A., Coates T.
    Blood 83:231-241(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT THR-100.
    Tissue: Esophagus and Tongue.
  6. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-100.
    Tissue: Dermoid cancer.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-100.
    Tissue: Lymph.
  9. "MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization."
    Wu Y., Zhan L., Ai Y., Hannigan M., Gaestel M., Huang C.-K., Madri J.A.
    Biochem. Biophys. Res. Commun. 358:170-175(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-252 BY MAPKAPK2.
  10. Carrascal M., Abian J.
    Submitted (JUN-2007) to UniProtKB
    Cited for: PHOSPHORYLATION AT SER-252, IDENTIFICATION BY MASS SPECTROMETRY.
  11. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
    Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
    J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: T-cell.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-327, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLSP1_HUMAN
AccessioniPrimary (citable) accession number: P33241
Secondary accession number(s): B3KPP1
, B3KRR6, E9PBV6, E9PFP3, Q16096, Q53H48, Q6FHM3, Q9BUY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 9, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

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