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Protein

Interferon-induced GTP-binding protein Mx1

Gene

MX1

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interferon-induced dynamin-like GTPase with antiviral activity.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi72 – 79GTPSequence analysis8
Nucleotide bindingi173 – 177GTPSequence analysis5
Nucleotide bindingi242 – 245GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity, Innate immunity
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx1
Alternative name(s):
Myxoma resistance protein 1
Myxovirus resistance protein 1
Oligodendrocyte GTP-binding protein
Gene namesi
Name:MX1
Synonyms:MX
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065961 – 654Interferon-induced GTP-binding protein Mx1Add BLAST654

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Expressioni

Inductioni

By type I and type III interferons.2 Publications

Interactioni

Subunit structurei

Homooligomer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures (By similarity). Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 (By similarity). Interacts with HSPA5 (By similarity). Interacts with DDX39A and DDX39B (By similarity). Interacts with TUBB/TUBB5.By similarity1 Publication

Structurei

3D structure databases

ProteinModelPortaliP33237
SMRiP33237
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 335Dynamin-type GPROSITE-ProRule annotationAdd BLAST274
Domaini566 – 654GEDPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni72 – 79G1 motifPROSITE-ProRule annotation8
Regioni97 – 99G2 motifPROSITE-ProRule annotation3
Regioni173 – 176G3 motifPROSITE-ProRule annotation4
Regioni242 – 245G4 motifPROSITE-ProRule annotation4
Regioni274 – 277G5 motifPROSITE-ProRule annotation4
Regioni336 – 361Bundle signaling element (BSE)By similarityAdd BLAST26
Regioni361 – 528Middle domainBy similarityAdd BLAST168
Regioni362 – 624StalkBy similarityAdd BLAST263
Regioni549 – 552Critical for lipid-bindingBy similarity4

Domaini

The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.By similarity
The middle domain mediates self-assembly and oligomerization.By similarity

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG008788
KOiK14754

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit

Sequencei

Sequence statusi: Complete.

P33237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSDLDIKE PDSPESGLNG SDDMVREHET ESKGNLYSQY EEKVRPCIDL
60 70 80 90 100
IDSLRALGVE QDLALPAIAV IGDQSSGKSS VLEALSGVAL PRGSGIVTRC
110 120 130 140 150
PLVLRLKKLE KEGEWKGKVS FLDREIEISD ASQVEKEISE AQIAIAGEGM
160 170 180 190 200
GISHELISLE VSSPHVPDLT LIDLPGITRV AVGNQPHDIE YQIKSLIRKY
210 220 230 240 250
ILRQETINLV VVPANVDIAT TEALRMAQDV DPQGDRTIGI LTKPDLVDKG
260 270 280 290 300
TEDKVVDVVR NLVFHLKKGY MIVKCRGQQE IQHRLSLDKA LQRERIFFED
310 320 330 340 350
HTHFRDLLEE GRATIPCLAE RLTNELIMHI CKTLPLLENQ IKETHQRITE
360 370 380 390 400
ELQKYGKDIP EEESEKMFSL IEKIDTFNKE IISTIEGEEH VGQYDSRLFT
410 420 430 440 450
KVRAEFCKWS AVVEKNFEKG HEAIRKEIKQ FENRYRGREL PGFVNYKTFE
460 470 480 490 500
IIIKKQVIVL EEPAVDMLHT VTDIIRNTFT EVSGKHFSEF FNLHRTAKSK
510 520 530 540 550
IEDIRLEQEN EAEKSIRLHF QMEQLVYCQD QVYRRALQQV REKEAEEEKK
560 570 580 590 600
KKSNHYYQSE DSEPSTAEIF QHLMAYHQEV STRISSHIPL IIQFFVLRTY
610 620 630 640 650
GEQLKKSMLQ LLQDKDQYDW LLKERTDTRD KRKFLKERLE RLSRARQRLA

KFPG
Length:654
Mass (Da):75,573
Last modified:February 1, 1994 - v1
Checksum:iCF06250CA7456E04
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45R → L in AAK94466 (PubMed:11754216).Curated1
Sequence conflicti275C → S in AAK94466 (PubMed:11754216).Curated1
Sequence conflicti297F → I in AAK94466 (PubMed:11754216).Curated1
Sequence conflicti352L → F in AAK94466 (PubMed:11754216).Curated1
Sequence conflicti390H → L in AAK94466 (PubMed:11754216).Curated1
Sequence conflicti553S → K in AAK94466 (PubMed:11754216).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66093 mRNA Translation: CAA46888.1
AF399856 mRNA Translation: AAK94466.1
PIRiS21552
RefSeqiNP_001009753.1, NM_001009753.1
UniGeneiOar.62

Genome annotation databases

GeneIDi443146
KEGGioas:443146

Similar proteinsi

Entry informationi

Entry nameiMX1_SHEEP
AccessioniPrimary (citable) accession number: P33237
Secondary accession number(s): Q95MD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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