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Protein

Regulatory protein MokC

Gene

mokC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Overlapping regulatory peptide whose translation enables hokC expression.Curated

Enzyme and pathway databases

BioCyciEcoCyc:EG10373-MONOMER.
ECOL316407:JW5879-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein MokC
Gene namesi
Name:mokC
Synonyms:gefL
Ordered Locus Names:b0018, JW5879
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12074. mokC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6969Regulatory protein MokCPRO_0000044031Add
BLAST

Proteomic databases

PaxDbiP33236.

Interactioni

Protein-protein interaction databases

STRINGi511145.b0018.

Structurei

3D structure databases

ProteinModelPortaliP33236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hok/gef family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105WI6. Bacteria.
ENOG41123E9. LUCA.
HOGENOMiHOG000041219.
KOiK18919.
OMAiHKVMIVA.
PhylomeDBiP33236.

Family and domain databases

InterProiIPR000021. Hok/gef_toxin.
IPR018084. Hok/gef_toxin_CS.
[Graphical view]
PfamiPF01848. HOK_GEF. 1 hit.
[Graphical view]
PRINTSiPR00281. HOKGEFTOXIC.
ProDomiPD005979. Hok/gef_toxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00556. HOK_GEF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33236-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNTCRVPLT DRKVKEKRAM KQHKAMIVAL IVICITAVVA ALVTRKDLCE
60
VHIRTGQTEV AVFTAYESE
Length:69
Mass (Da):7,742
Last modified:July 11, 2006 - v2
Checksum:iED07A98BE0F165B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73129.1.
AP009048 Genomic DNA. Translation: BAB96591.1.
RefSeqiNP_414559.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC73129; AAC73129; b0018.
BAB96591; BAB96591; BAB96591.
GeneIDi944756.
KEGGiecj:JW5879.
eco:b0018.
PATRICi32115127. VBIEscCol129921_0015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73129.1.
AP009048 Genomic DNA. Translation: BAB96591.1.
RefSeqiNP_414559.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP33236.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi511145.b0018.

Proteomic databases

PaxDbiP33236.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73129; AAC73129; b0018.
BAB96591; BAB96591; BAB96591.
GeneIDi944756.
KEGGiecj:JW5879.
eco:b0018.
PATRICi32115127. VBIEscCol129921_0015.

Organism-specific databases

EchoBASEiEB1999.
EcoGeneiEG12074. mokC.

Phylogenomic databases

eggNOGiENOG4105WI6. Bacteria.
ENOG41123E9. LUCA.
HOGENOMiHOG000041219.
KOiK18919.
OMAiHKVMIVA.
PhylomeDBiP33236.

Enzyme and pathway databases

BioCyciEcoCyc:EG10373-MONOMER.
ECOL316407:JW5879-MONOMER.

Miscellaneous databases

PROiP33236.

Family and domain databases

InterProiIPR000021. Hok/gef_toxin.
IPR018084. Hok/gef_toxin_CS.
[Graphical view]
PfamiPF01848. HOK_GEF. 1 hit.
[Graphical view]
PRINTSiPR00281. HOKGEFTOXIC.
ProDomiPD005979. Hok/gef_toxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00556. HOK_GEF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOKC_ECOLI
AccessioniPrimary (citable) accession number: P33236
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 11, 2006
Last modified: September 7, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally described as a gef leader peptide.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.