P33236 (MOKC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulatory protein mokC

Gene names

Name:	mokC
Synonyms:	gefL
Ordered Locus Names:	b0018, JW5879

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	69 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Overlapping regulatory peptide whose translation enables hokC expression Probable. Ref.4
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the hok/gef family.
Caution	Was originally (Ref.1) described as a gef leader peptide.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 69	69	Regulatory protein mokC		PRO_0000044031
Regions
	Transmembrane	24 – 44	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P33236 [UniParc]. Last modified July 11, 2006. Version 2. Checksum: ED07A98BE0F165B4	FASTA	69	7,742
	10 20 30 40 50 60 MLNTCRVPLT DRKVKEKRAM KQHKAMIVAL IVICITAVVA ALVTRKDLCE VHIRTGQTEV AVFTAYESE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The gef gene from Escherichia coli is regulated at the level of translation." Poulsen L.K., Refn A., Molin S., Andersson P. Mol. Microbiol. 5:1639-1648(1991) [PubMed: 1943701] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"Multiple hok genes on the chromosome of Escherichia coli." Pedersen K., Gerdes K. Mol. Microbiol. 32:1090-1102(1999) [PubMed: 10361310] [Abstract] Cited for: PROBABLE FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00096 Genomic DNA. Translation: AAC73129.1. AP009048 Genomic DNA. Translation: BAB96591.1.
RefSeq	NP_414559.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P33236.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000004815; EBESCP00000004815; EBESCG00000003931. EBESCT00000018269; EBESCP00000017560; EBESCG00000017323.
GeneID	944756.
GenomeReviews	Gene locus JW5879 in contig AP009048_GR. Gene locus b0018 in contig U00096_GR.
KEGG	ecj:JW5879. eco:b0018.
PATRIC	32115127. VBIEscCol129921_0015.
Organism-specific databases
EchoBASE	EB1999.
EcoGene	EG12074. mokC.
Phylogenomic databases
GeneTree	EBGT00050000009513.
HOGENOM	HBG473224.
OMA	HKVMIVA.
ProtClustDB	CLSK879539.
Enzyme and pathway databases
BioCyc	EcoCyc:EG10373-MONOMER.
Gene expression databases
Genevestigator	P33236.
Family and domain databases
InterPro	IPR000021. Hok/gef_toxin. IPR018084. Hok/gef_toxin_CS. [Graphical view]
Pfam	PF01848. HOK_GEF. 1 hit. [Graphical view]
PRINTS	PR00281. HOKGEFTOXIC.
ProDom	PD005979. Hok/gef_toxin. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00556. HOK_GEF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MOKC_ECOLI

Accession

Primary (citable) accession number: P33236

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	July 11, 2006
Last modified:	January 25, 2012
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program