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Protein

L-lactate permease

Gene

lldP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force.

Enzyme regulationi

Inhibited by carbonyl cyanide m-chlorophenylhydrazone (CCCP).

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:LCTP-MONOMER.
ECOL316407:JW3578-MONOMER.
MetaCyc:LCTP-MONOMER.

Protein family/group databases

TCDBi2.A.14.1.1. the lactate permease (lctp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate permease
Gene namesi
Name:lldP
Synonyms:lctP
Ordered Locus Names:b3603, JW3578
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11961. lldP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Transmembranei494 – 514HelicalSequence analysisAdd BLAST21
Transmembranei530 – 550HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002103741 – 551L-lactate permeaseAdd BLAST551

Proteomic databases

PaxDbiP33231.
PRIDEiP33231.

Expressioni

Inductioni

By L-lactate; aerobically.

Interactioni

Protein-protein interaction databases

BioGridi4261271. 6 interactors.
DIPiDIP-10109N.
IntActiP33231. 1 interactor.
MINTiMINT-1233464.
STRINGi511145.b3603.

Structurei

3D structure databases

ProteinModelPortaliP33231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lactate permease family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DAA. Bacteria.
COG1620. LUCA.
HOGENOMiHOG000253321.
InParanoidiP33231.
KOiK00427.
OMAiMSEFHQV.
PhylomeDBiP33231.

Family and domain databases

InterProiIPR003804. Lactate_perm.
[Graphical view]
PANTHERiPTHR30003. PTHR30003. 1 hit.
PfamiPF02652. Lactate_perm. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00795. lctP. 1 hit.

Sequencei

Sequence statusi: Complete.

P33231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLWQQNYDP AGNIWLSSLI ASLPILFFFF ALIKLKLKGY VAASWTVAIA
60 70 80 90 100
LAVALLFYKM PVANALASVV YGFFYGLWPI AWIIIAAVFV YKISVKTGQF
110 120 130 140 150
DIIRSSILSI TPDQRLQMLI VGFCFGAFLE GAAGFGAPVA ITAALLVGLG
160 170 180 190 200
FKPLYAAGLC LIVNTAPVAF GAMGIPILVA GQVTGIDSFE IGQMVGRQLP
210 220 230 240 250
FMTIIVLFWI MAIMDGWRGI KETWPAVVVA GGSFAIAQYL SSNFIGPELP
260 270 280 290 300
DIISSLVSLL CLTLFLKRWQ PVRVFRFGDL GASQVDMTLA HTGYTAGQVL
310 320 330 340 350
RAWTPFLFLT ATVTLWSIPP FKALFASGGA LYEWVINIPV PYLDKLVARM
360 370 380 390 400
PPVVSEATAY AAVFKFDWFS ATGTAILFAA LLSIVWLKMK PSDAISTFGS
410 420 430 440 450
TLKELALPIY SIGMVLAFAF ISNYSGLSST LALALAHTGH AFTFFSPFLG
460 470 480 490 500
WLGVFLTGSD TSSNALFAAL QATAAQQIGV SDLLLVAANT TGGVTGKMIS
510 520 530 540 550
PQSIAIACAA VGLVGKESDL FRFTVKHSLI FTCIVGVITT LQAYVLTWMI

P
Length:551
Mass (Da):59,168
Last modified:February 1, 1994 - v1
Checksum:i086DFDB410E2027B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13970 Unassigned DNA. Translation: AAA03583.1.
U00039 Genomic DNA. Translation: AAB18580.1.
U00096 Genomic DNA. Translation: AAC76627.1.
AP009048 Genomic DNA. Translation: BAE77689.1.
PIRiA49904.
RefSeqiNP_418060.1. NC_000913.3.
WP_001295233.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76627; AAC76627; b3603.
BAE77689; BAE77689; BAE77689.
GeneIDi948114.
KEGGiecj:JW3578.
eco:b3603.
PATRICi32122691. VBIEscCol129921_3722.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13970 Unassigned DNA. Translation: AAA03583.1.
U00039 Genomic DNA. Translation: AAB18580.1.
U00096 Genomic DNA. Translation: AAC76627.1.
AP009048 Genomic DNA. Translation: BAE77689.1.
PIRiA49904.
RefSeqiNP_418060.1. NC_000913.3.
WP_001295233.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP33231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261271. 6 interactors.
DIPiDIP-10109N.
IntActiP33231. 1 interactor.
MINTiMINT-1233464.
STRINGi511145.b3603.

Protein family/group databases

TCDBi2.A.14.1.1. the lactate permease (lctp) family.

Proteomic databases

PaxDbiP33231.
PRIDEiP33231.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76627; AAC76627; b3603.
BAE77689; BAE77689; BAE77689.
GeneIDi948114.
KEGGiecj:JW3578.
eco:b3603.
PATRICi32122691. VBIEscCol129921_3722.

Organism-specific databases

EchoBASEiEB1904.
EcoGeneiEG11961. lldP.

Phylogenomic databases

eggNOGiENOG4105DAA. Bacteria.
COG1620. LUCA.
HOGENOMiHOG000253321.
InParanoidiP33231.
KOiK00427.
OMAiMSEFHQV.
PhylomeDBiP33231.

Enzyme and pathway databases

BioCyciEcoCyc:LCTP-MONOMER.
ECOL316407:JW3578-MONOMER.
MetaCyc:LCTP-MONOMER.

Miscellaneous databases

PROiP33231.

Family and domain databases

InterProiIPR003804. Lactate_perm.
[Graphical view]
PANTHERiPTHR30003. PTHR30003. 1 hit.
PfamiPF02652. Lactate_perm. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00795. lctP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLLDP_ECOLI
AccessioniPrimary (citable) accession number: P33231
Secondary accession number(s): Q2M7R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.