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P33216 (MTLK_RHOSH) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannitol 2-dehydrogenase

Short name=M2DH
Short name=MDH
EC=1.1.1.67
Gene names
Name:mtlK
OrganismRhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Taxonomic identifier1063 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Protein attributes

Sequence length477 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

D-mannitol + NAD+ = D-fructose + NADH.

Subunit structure

Monomer.

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processmannitol metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol 2-dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 477476Mannitol 2-dehydrogenase
PRO_0000170734

Regions

Nucleotide binding19 – 3012NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
P33216 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: F823623B7BA920E8

FASTA47751,538
        10         20         30         40         50         60 
MTRSVTRPSY DRKALTPGIV HIGVGNFHRA HQAVYLDDLF ALGEGHDWAI LGAGVRPTDA 

        70         80         90        100        110        120 
RMREALAAQD NLSTVIELDP AGHRARQVGA MVGFLPVEAD NAALIEAMSD PRIRIVSLTV 

       130        140        150        160        170        180 
TEGGYYVDAS GAFDPTHPDI VADAAHPARP ATAFGAILAA LRARRDAGVT PFTVMSCDNL 

       190        200        210        220        230        240 
PGNGHVTRNA VVGLAELYDA ELAGWVKAQV AFPNGMVDRI TPATGPHERE LAQGFGLADP 

       250        260        270        280        290        300 
VPVTCEPFRQ WVIEDHFPAG RPALEKVGVT FTPHVHAYEA MKIRILNGGH AVIAYPSALM 

       310        320        330        340        350        360 
DIQLVHAAMA HPLIAAFLHK VEVEEILPHV PPVPDTSIPD YLTLIESRFS NPEIADTTRR 

       370        380        390        400        410        420 
LCLDGSNRQP KFIVPSLRDN LAAGTVPKGL VLLSALWCRY CFGTTDSGVV VEPNDPNWTA 

       430        440        450        460        470 
LQDRARRAKE TPAEWLAMTE VYGDLAQNDL LAAEFAAALE AVWRDGAEAV LRRFLAA 

« Hide

References

[1]"Cloning, nucleotide sequence and characterization of the mannitol dehydrogenase gene from Rhodobacter sphaeroides."
Schneider K.-H., Giffhorn F., Kaplan S.
J. Gen. Microbiol. 139:2475-2484(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-44.
Strain: SI-4.
[2]Schneider K.-H., Giffhorn F.
Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: SI-4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF018073 Genomic DNA. Translation: AAC45771.1.

3D structure databases

ProteinModelPortalP33216.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. SSF48179. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLK_RHOSH
AccessionPrimary (citable) accession number: P33216
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: October 16, 2013
This is version 65 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families