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P33207

- FABG_ARATH

UniProt

P33207 - FABG_ARATH

Protein

3-oxoacyl-[acyl-carrier-protein] reductase, chloroplastic

Gene

At1g24360

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (10 Jan 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei213 – 2131SubstrateBy similarity
    Active sitei226 – 2261Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi81 – 10525NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: TAIR
    2. copper ion binding Source: TAIR
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciARA:AT1G24360-MONOMER.
    MetaCyc:AT1G24360-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] reductase, chloroplastic (EC:1.1.1.100)
    Alternative name(s):
    3-ketoacyl-acyl carrier protein reductase
    Gene namesi
    Ordered Locus Names:At1g24360
    ORF Names:F21J9.2, F3I6.30
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G24360.

    Subcellular locationi

    Plastidchloroplast. Plastid
    Note: And non-photosynthetic plastids.

    GO - Cellular componenti

    1. chloroplast Source: TAIR
    2. chloroplast envelope Source: TAIR
    3. chloroplast stroma Source: TAIR
    4. plastid Source: TAIR

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5959ChloroplastBy similarityAdd
    BLAST
    Chaini60 – 3192603-oxoacyl-[acyl-carrier-protein] reductase, chloroplasticPRO_0000031976Add
    BLAST

    Proteomic databases

    PaxDbiP33207.
    PRIDEiP33207.

    Expressioni

    Gene expression databases

    GenevestigatoriP33207.

    Interactioni

    Subunit structurei

    Homotetramer.Curated

    Protein-protein interaction databases

    STRINGi3702.AT1G24360.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliP33207.
    SMRiP33207. Positions 23-319.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1028.
    InParanoidiP33207.
    KOiK00059.
    OMAiEASKLMT.
    PhylomeDBiP33207.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR011284. 3oxo_ACP_reduc.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P33207-1 [UniParc]FASTAAdd to Basket

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    MAAAVAAPRL ISLKAVAKLG FREISQIRQL APLHSAIPHF GMLRCRSRQP    50
    FSTSVVKAQA TATEQSPGEV VQKVESPVVV ITGASRGIGK AIALALGKAG 100
    CKVLVNYARS AKEAEEVAKQ IEEYGGQAIT FGGDVSKATD VDAMMKTALD 150
    KWGTIDVVVN NAGITRDTLL IRMKQSQWDE VIALNLTGVF LCTQAAVKIM 200
    MKKKRGRIIN ISSVVGLIGN IGQANYAAAK GGVISFSKTA AREGASRNIN 250
    VNVVCPGFIA SDMTAELGED MEKKILGTIP LGRYGKAEEV AGLVEFLALS 300
    PAASYITGQA FTIDGGIAI 319
    Length:319
    Mass (Da):33,548
    Last modified:January 10, 2003 - v2
    Checksum:i755ADDD16F3F69DE
    GO

    Sequence cautioni

    The sequence AAC00590.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence AAF97951.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti17 – 171A → G in CAA45794. (PubMed:1575676)Curated
    Sequence conflicti227 – 2293AAA → TAT in CAA45794. (PubMed:1575676)Curated
    Sequence conflicti238 – 2403KTA → ETP in CAA45794. (PubMed:1575676)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64464 mRNA. Translation: CAA45794.1.
    AC000103 Genomic DNA. Translation: AAF97951.1. Sequence problems.
    AC002396 Genomic DNA. Translation: AAC00590.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE30522.1.
    AF324985 mRNA. Translation: AAG40337.1.
    AY059816 mRNA. Translation: AAL24298.1.
    AY081491 mRNA. Translation: AAM10053.1.
    PIRiA86378.
    S22416.
    T00667.
    RefSeqiNP_564216.1. NM_102282.3.
    UniGeneiAt.4.
    At.67665.

    Genome annotation databases

    EnsemblPlantsiAT1G24360.1; AT1G24360.1; AT1G24360.
    GeneIDi839053.
    KEGGiath:AT1G24360.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64464 mRNA. Translation: CAA45794.1 .
    AC000103 Genomic DNA. Translation: AAF97951.1 . Sequence problems.
    AC002396 Genomic DNA. Translation: AAC00590.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE30522.1 .
    AF324985 mRNA. Translation: AAG40337.1 .
    AY059816 mRNA. Translation: AAL24298.1 .
    AY081491 mRNA. Translation: AAM10053.1 .
    PIRi A86378.
    S22416.
    T00667.
    RefSeqi NP_564216.1. NM_102282.3.
    UniGenei At.4.
    At.67665.

    3D structure databases

    ProteinModelPortali P33207.
    SMRi P33207. Positions 23-319.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT1G24360.1-P.

    Proteomic databases

    PaxDbi P33207.
    PRIDEi P33207.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G24360.1 ; AT1G24360.1 ; AT1G24360 .
    GeneIDi 839053.
    KEGGi ath:AT1G24360.

    Organism-specific databases

    TAIRi AT1G24360.

    Phylogenomic databases

    eggNOGi COG1028.
    InParanoidi P33207.
    KOi K00059.
    OMAi EASKLMT.
    PhylomeDBi P33207.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci ARA:AT1G24360-MONOMER.
    MetaCyc:AT1G24360-MONOMER.

    Miscellaneous databases

    PROi P33207.

    Gene expression databases

    Genevestigatori P33207.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR011284. 3oxo_ACP_reduc.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000126. 11-beta-HSD1. 1 hit.
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    TIGRFAMsi TIGR01830. 3oxo_ACP_reduc. 1 hit.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of higher-plant 3-oxoacyl-(acyl carrier protein) reductase. Sequence identities with the nodG-gene product of the nitrogen-fixing soil bacterium Rhizobium meliloti."
      Slabas A.R., Chase D., Nishida I., Murata N., Sidebottom C.M., Safford R., Sheldon P.S., Kekwick R.G.O., Hardie D.G., Mackintosh R.W.
      Biochem. J. 283:321-326(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Leaf.
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiFABG_ARATH
    AccessioniPrimary (citable) accession number: P33207
    Secondary accession number(s): O04463, Q9FPJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: January 10, 2003
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3