Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribosome assembly factor MRT4

Gene

MRT4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.4 Publications

Miscellaneous

Present with 18200 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • nuclear-transcribed mRNA catabolic process Source: SGD
  • ribosomal large subunit assembly Source: SGD
  • ribosomal large subunit biogenesis Source: SGD
  • rRNA processing Source: SGD

Keywordsi

Biological processRibosome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-31818-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome assembly factor MRT41 Publication
Alternative name(s):
mRNA turnover protein 41 Publication
Gene namesi
Name:MRT41 Publication
Ordered Locus Names:YKL009WImported
ORF Names:YKL160
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL009W
SGDiS000001492 MRT4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi68G → D: Bypasses the requirement for phosphatase YVH1 for the release of MRT4. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001548151 – 236Ribosome assembly factor MRT4Add BLAST236

Proteomic databases

MaxQBiP33201
PaxDbiP33201
PRIDEiP33201

PTM databases

iPTMnetiP33201

Interactioni

Subunit structurei

Associates with the pre-60S ribosomal particle.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SSB2P401502EBI-26590,EBI-8632

Protein-protein interaction databases

BioGridi34123, 460 interactors
DIPiDIP-5283N
IntActiP33201, 39 interactors
MINTiP33201
STRINGi4932.YKL009W

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JCTelectron microscopy3.08W1-236[»]
4V7Felectron microscopy8.70n1-236[»]
5FL8electron microscopy9.50n1-236[»]
5JCSelectron microscopy9.50n1-236[»]
6ELZelectron microscopy3.30W1-236[»]
6EM1electron microscopy3.60W1-236[»]
6EM5electron microscopy4.30W1-236[»]
ProteinModelPortaliP33201
SMRiP33201
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000006238
HOGENOMiHOG000177263
InParanoidiP33201
KOiK14815
OMAiYWAVEYA
OrthoDBiEOG092C4ONQ

Family and domain databases

CDDicd05796 Ribosomal_P0_like, 1 hit
InterProiView protein in InterPro
IPR033867 Mrt4
IPR001790 Ribosomal_L10P
PfamiView protein in Pfam
PF00466 Ribosomal_L10, 1 hit

Sequencei

Sequence statusi: Complete.

P33201-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSKRSKLV TLAQTDKKGR ENKERIFDEV REALDTYRYV WVLHLDDVRT
60 70 80 90 100
PVLQEIRTSW AGSKLIMGKR KVLQKALGEK REEEYKENLY QLSKLCSGVT
110 120 130 140 150
GLLFTDEDVN TVKEYFKSYV RSDYSRPNTK APLTFTIPEG IVYSRGGQIP
160 170 180 190 200
AEEDVPMIHS LEPTMRNKFE IPTKIKAGKI TIDSPYLVCT EGEKLDVRQA
210 220 230
LILKQFGIAA SEFKVKVSAY YDNDSSTVES TNINME
Length:236
Mass (Da):27,058
Last modified:February 1, 1994 - v1
Checksum:i9FCFDEE9F009F427
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S53418 Genomic DNA Translation: AAB24904.1
X61398 Genomic DNA No translation available.
Z28009 Genomic DNA Translation: CAA81844.1
S59773 Genomic DNA Translation: AAC60552.1
BK006944 Genomic DNA Translation: DAA09147.1
PIRiS30013
RefSeqiNP_012916.1, NM_001179575.1

Genome annotation databases

EnsemblFungiiYKL009W; YKL009W; YKL009W
GeneIDi853860
KEGGisce:YKL009W

Similar proteinsi

Entry informationi

Entry nameiMRT4_YEAST
AccessioniPrimary (citable) accession number: P33201
Secondary accession number(s): D6VXS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 25, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health