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P33201

- MRT4_YEAST

UniProt

P33201 - MRT4_YEAST

Protein

mRNA turnover protein 4

Gene

MRT4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Involved in mRNA turnover and ribosome assembly.

    GO - Molecular functioni

    1. large ribosomal subunit rRNA binding Source: SGD

    GO - Biological processi

    1. nuclear-transcribed mRNA catabolic process Source: SGD
    2. ribosomal large subunit assembly Source: SGD
    3. ribosomal large subunit biogenesis Source: SGD
    4. rRNA processing Source: SGD

    Keywords - Biological processi

    Ribosome biogenesis

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31818-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    mRNA turnover protein 4
    Gene namesi
    Name:MRT4
    Ordered Locus Names:YKL009W
    ORF Names:YKL160
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKL009w.
    SGDiS000001492. MRT4.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. nucleolus Source: SGD
    2. nucleoplasm Source: SGD
    3. preribosome, large subunit precursor Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 236236mRNA turnover protein 4PRO_0000154815Add
    BLAST

    Proteomic databases

    MaxQBiP33201.
    PaxDbiP33201.
    PeptideAtlasiP33201.

    Expressioni

    Gene expression databases

    GenevestigatoriP33201.

    Interactioni

    Protein-protein interaction databases

    BioGridi34123. 227 interactions.
    DIPiDIP-5283N.
    IntActiP33201. 19 interactions.
    MINTiMINT-8285311.
    STRINGi4932.YKL009W.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J65electron microscopy8.70n1-236[»]
    ProteinModelPortaliP33201.
    SMRiP33201. Positions 5-228.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L10P family.Curated

    Phylogenomic databases

    eggNOGiCOG0244.
    GeneTreeiENSGT00390000006238.
    HOGENOMiHOG000177263.
    KOiK14815.
    OMAiKTKVMAK.
    OrthoDBiEOG7RJQ36.

    Family and domain databases

    InterProiIPR001790. Ribosomal_L10/acidic_P0.
    [Graphical view]
    PfamiPF00466. Ribosomal_L10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33201-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRSKRSKLV TLAQTDKKGR ENKERIFDEV REALDTYRYV WVLHLDDVRT    50
    PVLQEIRTSW AGSKLIMGKR KVLQKALGEK REEEYKENLY QLSKLCSGVT 100
    GLLFTDEDVN TVKEYFKSYV RSDYSRPNTK APLTFTIPEG IVYSRGGQIP 150
    AEEDVPMIHS LEPTMRNKFE IPTKIKAGKI TIDSPYLVCT EGEKLDVRQA 200
    LILKQFGIAA SEFKVKVSAY YDNDSSTVES TNINME 236
    Length:236
    Mass (Da):27,058
    Last modified:February 1, 1994 - v1
    Checksum:i9FCFDEE9F009F427
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S53418 Genomic DNA. Translation: AAB24904.1.
    X61398 Genomic DNA. No translation available.
    Z28009 Genomic DNA. Translation: CAA81844.1.
    S59773 Genomic DNA. Translation: AAC60552.1.
    BK006944 Genomic DNA. Translation: DAA09147.1.
    PIRiS30013.
    RefSeqiNP_012916.1. NM_001179575.1.

    Genome annotation databases

    EnsemblFungiiYKL009W; YKL009W; YKL009W.
    GeneIDi853860.
    KEGGisce:YKL009W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S53418 Genomic DNA. Translation: AAB24904.1 .
    X61398 Genomic DNA. No translation available.
    Z28009 Genomic DNA. Translation: CAA81844.1 .
    S59773 Genomic DNA. Translation: AAC60552.1 .
    BK006944 Genomic DNA. Translation: DAA09147.1 .
    PIRi S30013.
    RefSeqi NP_012916.1. NM_001179575.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J65 electron microscopy 8.70 n 1-236 [» ]
    ProteinModelPortali P33201.
    SMRi P33201. Positions 5-228.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34123. 227 interactions.
    DIPi DIP-5283N.
    IntActi P33201. 19 interactions.
    MINTi MINT-8285311.
    STRINGi 4932.YKL009W.

    Proteomic databases

    MaxQBi P33201.
    PaxDbi P33201.
    PeptideAtlasi P33201.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL009W ; YKL009W ; YKL009W .
    GeneIDi 853860.
    KEGGi sce:YKL009W.

    Organism-specific databases

    CYGDi YKL009w.
    SGDi S000001492. MRT4.

    Phylogenomic databases

    eggNOGi COG0244.
    GeneTreei ENSGT00390000006238.
    HOGENOMi HOG000177263.
    KOi K14815.
    OMAi KTKVMAK.
    OrthoDBi EOG7RJQ36.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31818-MONOMER.

    Miscellaneous databases

    NextBioi 975109.
    PROi P33201.

    Gene expression databases

    Genevestigatori P33201.

    Family and domain databases

    InterProi IPR001790. Ribosomal_L10/acidic_P0.
    [Graphical view ]
    Pfami PF00466. Ribosomal_L10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of a 9.3 kb segment located on the left arm of the yeast chromosome XI reveals five open reading frames including the CCE1 gene and putative products related to MYO2 and to the ribosomal protein L10."
      Pascolo S., Ghazvini M., Boyer J., Colleaux L., Thierry A., Dujon B.
      Yeast 8:987-995(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Sequence of a 7.8 kb segment on the left arm of yeast chromosome XI reveals four open reading frames, including the CAP1 gene, an intron-containing gene and a gene encoding a homolog to the mammalian UOG-1 gene."
      Boyer J., Pascolo S., Richard G.-F., Dujon B.
      Yeast 9:279-287(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 190-236.
    5. "Temperature-sensitive mutations in the Saccharomyces cerevisiae MRT4, GRC5, SLA2 and THS1 genes result in defects in mRNA turnover."
      Zuk D., Belk J.P., Jacobson A.
      Genetics 153:35-47(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE NAME, INVOLVEMENT IN MRNA TURNOVER.
    6. "Composition and functional characterization of yeast 66S ribosome assembly intermediates."
      Harnpicharnchai P., Jakovljevic J., Horsey E., Miles T., Roman J., Rout M., Meagher D., Imai B., Guo Y., Brame C.J., Shabanowitz J., Hunt D.F., Woolford J.L. Jr.
      Mol. Cell 8:505-515(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INVOLVEMENT IN RIBOSOME BIOGENESIS.
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMRT4_YEAST
    AccessioniPrimary (citable) accession number: P33201
    Secondary accession number(s): D6VXS7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 18200 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3