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Protein

Cadmium-metallothionein

Gene
N/A
Organism
Helix pomatia (Roman snail) (Edible snail)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The metallothioneins are involved in the cellular sequestration of toxic metal ions and regulation of essential trace elements. Binds almost exclusively cadmium.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Cadmium1
Metal bindingi13Cadmium1
Metal bindingi18Cadmium1
Metal bindingi20Cadmium1
Metal bindingi24Cadmium1
Metal bindingi26Cadmium1
Metal bindingi30Cadmium1
Metal bindingi32Cadmium1
Metal bindingi35Cadmium1
Metal bindingi38Cadmium1
Metal bindingi40Cadmium1
Metal bindingi45Cadmium1
Metal bindingi47Cadmium1
Metal bindingi51Cadmium1
Metal bindingi57Cadmium1
Metal bindingi59Cadmium1
Metal bindingi63Cadmium1
Metal bindingi65Cadmium1

GO - Molecular functioni

Keywordsi

LigandCadmium, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Cadmium-metallothionein
Short name:
CD-MT
OrganismiHelix pomatia (Roman snail) (Edible snail)
Taxonomic identifieri6536 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraPanpulmonataEupulmonataStylommatophoraSigmurethraHelicoideaHelicidaeHelix

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973361 – 66Cadmium-metallothioneinAdd BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

Expressioni

Inductioni

By cadmium.

Structurei

3D structure databases

SMRiP33187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

14 cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR001008. Metalthion_mollusc.
PRINTSiPR00875. MTMOLLUSC.

Sequencei

Sequence statusi: Complete.

P33187-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SGKGKGEKCT SACRSEPCQC GSKCQCGEGC TCAACKTCNC TSDGCKCGKE
60
CTGPDSCKCG SSCSCK
Length:66
Mass (Da):6,568
Last modified:October 1, 1993 - v1
Checksum:i6E5EFC5E0A239603
GO

Sequence databases

PIRiS36866.

Similar proteinsi

Entry informationi

Entry nameiMTCD_HELPO
AccessioniPrimary (citable) accession number: P33187
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 27, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families