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P33180

- TYRO_RHIML

UniProt

P33180 - TYRO_RHIML

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Protein

Tyrosinase

Gene

mepA

Organism
Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
L-tyrosine + O2 = dopaquinone + H2O.

Cofactori

Cu2+By similarityNote: Binds 2 copper ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381Copper ABy similarity
Metal bindingi44 – 441Copper ABy similarity
Metal bindingi53 – 531Copper ABy similarity
Metal bindingi64 – 641Copper ABy similarity
Metal bindingi224 – 2241Copper BBy similarity
Metal bindingi228 – 2281Copper BBy similarity
Metal bindingi256 – 2561Copper BBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. monophenol monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. melanin biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosinase (EC:1.14.18.1)
Alternative name(s):
Monophenol monooxygenase
Gene namesi
Name:mepA
Synonyms:melA
Encoded oniPlasmid pRmeGR4b0 Publication
OrganismiRhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri382 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494TyrosinasePRO_0000186735Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP33180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.Curated

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 2 hits.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33180-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSADGQKDL QSYMDAVTAM LKLPPSDRRN WYRNGFIHLM DCPHGDWWFT
60 70 80 90 100
SWHRGYLGYF EETCRELSGN PDFALPYWDW TANPEVLPPL FGTILDPVNS
110 120 130 140 150
SAYIPDHNRF QDIMQEPIKA YWDSLSPAQL QQQNLRGYPD FDALWSDAMA
160 170 180 190 200
SFANQPNARF LTAQNPKLNP ATQTAVDIDT IKASLAPTTF ANDAGAPGLA
210 220 230 240 250
FNSPVSSSHQ VAPVGFSILE GQPHNRVHMS VGGQSAPYGL MSQNLSPLDP
260 270 280 290 300
IFFLHHCNID RLWDVWTRKQ QAMGLPVGPT ADQQTQYDPE PYLFYVNADG
310 320 330 340 350
SPVSDKTRAA DYLEIGDFDY DYDPGSGEEV IPVATAGRSA PIPALEAAVS
360 370 380 390 400
ASAAVAINKP ATAKLTVSQE LVDVAAKPSE QSRQFAKVSI APPMDVGGLN
410 420 430 440 450
FLVFISPEGT TPDLNPDGPD FAGSFEFFGV RHHHTDTVSF TIPIDKALDR
460 470 480 490
LIDDGRLKAG EPIDFAVVVA QEGKRVEGSM PAKAQLTDIQ VGSF
Length:494
Mass (Da):54,109
Last modified:October 1, 1993 - v1
Checksum:iB39A1DFCC2C3E962
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69526 Genomic DNA. Translation: CAA49273.1.
PIRiA48657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69526 Genomic DNA. Translation: CAA49273.1 .
PIRi A48657.

3D structure databases

ProteinModelPortali P33180.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1280.10. 1 hit.
InterProi IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view ]
Pfami PF00264. Tyrosinase. 1 hit.
[Graphical view ]
PRINTSi PR00092. TYROSINASE.
SUPFAMi SSF48056. SSF48056. 2 hits.
PROSITEi PS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Melanin production by Rhizobium meliloti GR4 is linked to nonsymbiotic plasmid pRmeGR4b: cloning, sequencing, and expression of the tyrosinase gene mepA."
    Mercado-Blanco J., Garcia F., Fernandez-Lopez M., Olivares J.
    J. Bacteriol. 175:5403-5410(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: GR4.

Entry informationi

Entry nameiTYRO_RHIML
AccessioniPrimary (citable) accession number: P33180
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3