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P33180

- TYRO_RHIML

UniProt

P33180 - TYRO_RHIML

Protein

Tyrosinase

Gene

mepA

Organism
Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
    L-tyrosine + O2 = dopaquinone + H2O.

    Cofactori

    Binds 2 copper ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi38 – 381Copper ABy similarity
    Metal bindingi44 – 441Copper ABy similarity
    Metal bindingi53 – 531Copper ABy similarity
    Metal bindingi64 – 641Copper ABy similarity
    Metal bindingi224 – 2241Copper BBy similarity
    Metal bindingi228 – 2281Copper BBy similarity
    Metal bindingi256 – 2561Copper BBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. monophenol monooxygenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. melanin biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Melanin biosynthesis

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosinase (EC:1.14.18.1)
    Alternative name(s):
    Monophenol monooxygenase
    Gene namesi
    Name:mepA
    Synonyms:melA
    Encoded oniPlasmid pRmeGR4b0 Publication
    OrganismiRhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri382 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 494494TyrosinasePRO_0000186735Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP33180.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tyrosinase family.Curated

    Family and domain databases

    Gene3Di1.10.1280.10. 1 hit.
    InterProiIPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view]
    PfamiPF00264. Tyrosinase. 1 hit.
    [Graphical view]
    PRINTSiPR00092. TYROSINASE.
    SUPFAMiSSF48056. SSF48056. 2 hits.
    PROSITEiPS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33180-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSADGQKDL QSYMDAVTAM LKLPPSDRRN WYRNGFIHLM DCPHGDWWFT    50
    SWHRGYLGYF EETCRELSGN PDFALPYWDW TANPEVLPPL FGTILDPVNS 100
    SAYIPDHNRF QDIMQEPIKA YWDSLSPAQL QQQNLRGYPD FDALWSDAMA 150
    SFANQPNARF LTAQNPKLNP ATQTAVDIDT IKASLAPTTF ANDAGAPGLA 200
    FNSPVSSSHQ VAPVGFSILE GQPHNRVHMS VGGQSAPYGL MSQNLSPLDP 250
    IFFLHHCNID RLWDVWTRKQ QAMGLPVGPT ADQQTQYDPE PYLFYVNADG 300
    SPVSDKTRAA DYLEIGDFDY DYDPGSGEEV IPVATAGRSA PIPALEAAVS 350
    ASAAVAINKP ATAKLTVSQE LVDVAAKPSE QSRQFAKVSI APPMDVGGLN 400
    FLVFISPEGT TPDLNPDGPD FAGSFEFFGV RHHHTDTVSF TIPIDKALDR 450
    LIDDGRLKAG EPIDFAVVVA QEGKRVEGSM PAKAQLTDIQ VGSF 494
    Length:494
    Mass (Da):54,109
    Last modified:October 1, 1993 - v1
    Checksum:iB39A1DFCC2C3E962
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69526 Genomic DNA. Translation: CAA49273.1.
    PIRiA48657.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69526 Genomic DNA. Translation: CAA49273.1 .
    PIRi A48657.

    3D structure databases

    ProteinModelPortali P33180.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.1280.10. 1 hit.
    InterProi IPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view ]
    Pfami PF00264. Tyrosinase. 1 hit.
    [Graphical view ]
    PRINTSi PR00092. TYROSINASE.
    SUPFAMi SSF48056. SSF48056. 2 hits.
    PROSITEi PS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Melanin production by Rhizobium meliloti GR4 is linked to nonsymbiotic plasmid pRmeGR4b: cloning, sequencing, and expression of the tyrosinase gene mepA."
      Mercado-Blanco J., Garcia F., Fernandez-Lopez M., Olivares J.
      J. Bacteriol. 175:5403-5410(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: GR4.

    Entry informationi

    Entry nameiTYRO_RHIML
    AccessioniPrimary (citable) accession number: P33180
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Plasmid

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3