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P33180

- TYRO_RHIML

UniProt

P33180 - TYRO_RHIML

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Protein
Tyrosinase
Gene
mepA, melA
Organism
Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
L-tyrosine + O2 = dopaquinone + H2O.

Cofactori

Binds 2 copper ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381Copper A By similarity
Metal bindingi44 – 441Copper A By similarity
Metal bindingi53 – 531Copper A By similarity
Metal bindingi64 – 641Copper A By similarity
Metal bindingi224 – 2241Copper B By similarity
Metal bindingi228 – 2281Copper B By similarity
Metal bindingi256 – 2561Copper B By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. monophenol monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. melanin biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosinase (EC:1.14.18.1)
Alternative name(s):
Monophenol monooxygenase
Gene namesi
Name:mepA
Synonyms:melA
Encoded oniPlasmid pRmeGR4b0 Publication
OrganismiRhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri382 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Tyrosinase
PRO_0000186735Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP33180.

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 2 hits.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33180-1 [UniParc]FASTAAdd to Basket

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MTSADGQKDL QSYMDAVTAM LKLPPSDRRN WYRNGFIHLM DCPHGDWWFT    50
SWHRGYLGYF EETCRELSGN PDFALPYWDW TANPEVLPPL FGTILDPVNS 100
SAYIPDHNRF QDIMQEPIKA YWDSLSPAQL QQQNLRGYPD FDALWSDAMA 150
SFANQPNARF LTAQNPKLNP ATQTAVDIDT IKASLAPTTF ANDAGAPGLA 200
FNSPVSSSHQ VAPVGFSILE GQPHNRVHMS VGGQSAPYGL MSQNLSPLDP 250
IFFLHHCNID RLWDVWTRKQ QAMGLPVGPT ADQQTQYDPE PYLFYVNADG 300
SPVSDKTRAA DYLEIGDFDY DYDPGSGEEV IPVATAGRSA PIPALEAAVS 350
ASAAVAINKP ATAKLTVSQE LVDVAAKPSE QSRQFAKVSI APPMDVGGLN 400
FLVFISPEGT TPDLNPDGPD FAGSFEFFGV RHHHTDTVSF TIPIDKALDR 450
LIDDGRLKAG EPIDFAVVVA QEGKRVEGSM PAKAQLTDIQ VGSF 494
Length:494
Mass (Da):54,109
Last modified:October 1, 1993 - v1
Checksum:iB39A1DFCC2C3E962
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69526 Genomic DNA. Translation: CAA49273.1.
PIRiA48657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69526 Genomic DNA. Translation: CAA49273.1 .
PIRi A48657.

3D structure databases

ProteinModelPortali P33180.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1280.10. 1 hit.
InterProi IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view ]
Pfami PF00264. Tyrosinase. 1 hit.
[Graphical view ]
PRINTSi PR00092. TYROSINASE.
SUPFAMi SSF48056. SSF48056. 2 hits.
PROSITEi PS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Melanin production by Rhizobium meliloti GR4 is linked to nonsymbiotic plasmid pRmeGR4b: cloning, sequencing, and expression of the tyrosinase gene mepA."
    Mercado-Blanco J., Garcia F., Fernandez-Lopez M., Olivares J.
    J. Bacteriol. 175:5403-5410(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: GR4.

Entry informationi

Entry nameiTYRO_RHIML
AccessioniPrimary (citable) accession number: P33180
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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