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P33180 (TYRO_RHIML) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosinase

EC=1.14.18.1
Alternative name(s):
Monophenol monooxygenase
Gene names
Name:mepA
Synonyms:melA
Encoded onPlasmid pRmeGR4b
OrganismRhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifier382 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.

L-tyrosine + O2 = dopaquinone + H2O.

Cofactor

Binds 2 copper ions per subunit By similarity.

Sequence similarities

Belongs to the tyrosinase family.

Ontologies

Keywords
   Biological processMelanin biosynthesis
   LigandCopper
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
   Technical termPlasmid
Gene Ontology (GO)
   Biological_processmelanin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

monophenol monooxygenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Tyrosinase
PRO_0000186735

Sites

Metal binding381Copper A By similarity
Metal binding441Copper A By similarity
Metal binding531Copper A By similarity
Metal binding641Copper A By similarity
Metal binding2241Copper B By similarity
Metal binding2281Copper B By similarity
Metal binding2561Copper B By similarity

Sequences

Sequence LengthMass (Da)Tools
P33180 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: B39A1DFCC2C3E962

FASTA49454,109
        10         20         30         40         50         60 
MTSADGQKDL QSYMDAVTAM LKLPPSDRRN WYRNGFIHLM DCPHGDWWFT SWHRGYLGYF 

        70         80         90        100        110        120 
EETCRELSGN PDFALPYWDW TANPEVLPPL FGTILDPVNS SAYIPDHNRF QDIMQEPIKA 

       130        140        150        160        170        180 
YWDSLSPAQL QQQNLRGYPD FDALWSDAMA SFANQPNARF LTAQNPKLNP ATQTAVDIDT 

       190        200        210        220        230        240 
IKASLAPTTF ANDAGAPGLA FNSPVSSSHQ VAPVGFSILE GQPHNRVHMS VGGQSAPYGL 

       250        260        270        280        290        300 
MSQNLSPLDP IFFLHHCNID RLWDVWTRKQ QAMGLPVGPT ADQQTQYDPE PYLFYVNADG 

       310        320        330        340        350        360 
SPVSDKTRAA DYLEIGDFDY DYDPGSGEEV IPVATAGRSA PIPALEAAVS ASAAVAINKP 

       370        380        390        400        410        420 
ATAKLTVSQE LVDVAAKPSE QSRQFAKVSI APPMDVGGLN FLVFISPEGT TPDLNPDGPD 

       430        440        450        460        470        480 
FAGSFEFFGV RHHHTDTVSF TIPIDKALDR LIDDGRLKAG EPIDFAVVVA QEGKRVEGSM 

       490 
PAKAQLTDIQ VGSF 

« Hide

References

[1]"Melanin production by Rhizobium meliloti GR4 is linked to nonsymbiotic plasmid pRmeGR4b: cloning, sequencing, and expression of the tyrosinase gene mepA."
Mercado-Blanco J., Garcia F., Fernandez-Lopez M., Olivares J.
J. Bacteriol. 175:5403-5410(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: GR4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69526 Genomic DNA. Translation: CAA49273.1.
PIRA48657.

3D structure databases

ProteinModelPortalP33180.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.1280.10. 1 hit.
InterProIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSPR00092. TYROSINASE.
SUPFAMSSF48056. SSF48056. 2 hits.
PROSITEPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRO_RHIML
AccessionPrimary (citable) accession number: P33180
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families