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Reviewed, UniProtKB/Swiss-Prot P33176 (KINH_HUMAN)

Last modified July 22, 2008. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Kinesin-1 heavy chain
Alternative name(s):
    Ubiquitous kinesin heavy chain
      Short name(s)=UKHC
    Conventional kinesin heavy chain
Gene names
Name: KIF5B
Synonyms: KNS, KNS1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length963 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes By similarity.

Subunit structure

Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 By similarity. Interacts with SYBU. Interacts with JAKMIP1.

Subcellular location

Note= Uniformly distributed between soma and neurites in hippocampal neurons By similarity.

Domain

Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.

Sequence similarities

Belongs to the kinesin-like protein family. Kinesin subfamily.

Contains 1 kinesin-motor domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 963963Kinesin-1 heavy chain

Regions

Domain1 – 328328Kinesin-motor
Nucleotide binding85 – 928ATP By similarity
Region915 – 96349Globular
Coiled coil329 – 914586

Secondary structure

................................................................ 963
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P33176-1 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: A1FE5760C3250C8B

FASTA963109,685
        10         20         30         40         50         60 
MADLAECNIK VMCRFRPLNE SEVNRGDKYI AKFQGEDTVV IASKPYAFDR VFQSSTSQEQ 

        70         80         90        100        110        120 
VYNDCAKKIV KDVLEGYNGT IFAYGQTSSG KTHTMEGKLH DPEGMGIIPR IVQDIFNYIY 

       130        140        150        160        170        180 
SMDENLEFHI KVSYFEIYLD KIRDLLDVSK TNLSVHEDKN RVPYVKGCTE RFVCSPDEVM 

       190        200        210        220        230        240 
DTIDEGKSNR HVAVTNMNEH SSRSHSIFLI NVKQENTQTE QKLSGKLYLV DLAGSEKVSK 

       250        260        270        280        290        300 
TGAEGAVLDE AKNINKSLSA LGNVISALAE GSTYVPYRDS KMTRILQDSL GGNCRTTIVI 

       310        320        330        340        350        360 
CCSPSSYNES ETKSTLLFGQ RAKTIKNTVC VNVELTAEQW KKKYEKEKEK NKILRNTIQW 

       370        380        390        400        410        420 
LENELNRWRN GETVPIDEQF DKEKANLEAF TVDKDITLTN DKPATAIGVI GNFTDAERRK 

       430        440        450        460        470        480 
CEEEIAKLYK QLDDKDEEIN QQSQLVEKLK TQMLDQEELL ASTRRDQDNM QAELNRLQAE 

       490        500        510        520        530        540 
NDASKEEVKE VLQALEELAV NYDQKSQEVE DKTKEYELLS DELNQKSATL ASIDAELQKL 

       550        560        570        580        590        600 
KEMTNHQKKR AAEMMASLLK DLAEIGIAVG NNDVKQPEGT GMIDEEFTVA RLYISKMKSE 

       610        620        630        640        650        660 
VKTMVKRCKQ LESTQTESNK KMEENEKELA ACQLRISQHE AKIKSLTEYL QNVEQKKRQL 

       670        680        690        700        710        720 
EESVDALSEE LVQLRAQEKV HEMEKEHLNK VQTANEVKQA VEQQIQSHRE THQKQISSLR 

       730        740        750        760        770        780 
DEVEAKAKLI TDLQDQNQKM MLEQERLRVE HEKLKATDQE KSRKLHELTV MQDRREQARQ 

       790        800        810        820        830        840 
DLKGLEETVA KELQTLHNLR KLFVQDLATR VKKSAEIDSD DTGGSAAQKQ KISFLENNLE 

       850        860        870        880        890        900 
QLTKVHKQLV RDNADLRCEL PKLEKRLRAT AERVKALESA LKEAKENASR DRKRYQQEVD 

       910        920        930        940        950        960 
RIKEAVRSKN MARRGHSAQI AKPIRPGQHP AASPTHPSAI RGGGAFVQNS QPVAVRGGGG 


KQV 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells."
Navone F., Niclas J., Hom-Booher N., Sparks L., Bernstein H.D., McCaffrey G., Vale R.D.
J. Cell Biol. 117:1263-1275(1992) [PubMed: 1607388] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed: 15164054] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons."
Su Q., Cai Q., Gerwin C., Smith C.L., Sheng Z.-H.
Nat. Cell Biol. 6:941-953(2004) [PubMed: 15459722] [Abstract]
Cited for: INTERACTION WITH SYBU.
[5]"Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport."
Vidal R.L., Ramirez O.A., Sandoval L., Koenig-Robert R., Haertel S., Couve A.
Mol. Cell. Neurosci. 35:501-512(2007) [PubMed: 17532644] [Abstract]
Cited for: INTERACTION WITH JAKMIP1.
[6]"Crystal structure of the kinesin motor domain reveals a structural similarity to myosin."
Kull F.J., Sablin E.P., Lau R., Fletterick R.J., Vale R.D.
Nature 380:550-555(1996) [PubMed: 8606779] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1-349.

Cross-references

Sequence databases

X65873 mRNA. Translation: CAA46703.1.
AL161932 Genomic DNA. Translation: CAH71618.1.
BC126279 mRNA. Translation: AAI26280.1.
BC126281 mRNA. Translation: AAI26282.1.
PIRA41919.
RefSeqNP_004512.1.
UniGeneHs.644646

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1BG2X-ray1.80A1-325[»]
1MKJX-ray2.70A1-349[»]
ModBaseSearch...

Protein-protein interaction databases

IntActP33176.

PTM databases

PhosphoSiteP33176.

Genome annotation databases

EnsemblENSG00000170759. Homo sapiens. [Contig view]
GeneID3799.
KEGGhsa:3799.

Organism-specific databases

H-InvDBHIX0035368.
HGNCHGNC:6324. KIF5B.
HPACAB009846.
MIM602809. gene.
PharmGKBPA30108.
GenAtlasSearch...
GeneCardsSearch...
GeneLynxSearch...

Phylogenomic databases

HOGENOMP33176.
HOVERGENP33176.

Gene expression databases

ArrayExpressP33176.
CleanExHS_KIF5B.
GermOnlineENSG00000170759. Homo sapiens.

Family and domain databases

InterProIPR001752. Kinesin_motor.
[Graphical view]
Gene3DG3DSA:3.40.850.10. kinesin_motor. 1 hit.
PfamPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
PROSITEPS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
[Graphical view]
ProDomP33176.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

LinkHubP33176.
SOURCESearch...
ProtoNetSearch...

Entry information

Entry nameKINH_HUMAN
AccessionPrimary (citable) accession number: P33176
Secondary accession number(s): A0AVB2, Q5VZ85
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 22, 2008
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents