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Protein

Kinesin-like protein KIF1A

Gene

Kif1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Motor for anterograde axonal transport of synaptic vesicle precursors.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 104ATP8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule binding Source: MGI
  • microtubule motor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF1A
Alternative name(s):
Axonal transporter of synaptic vesicles
Gene namesi
Name:Kif1a
Synonyms:Atsv, Kif1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:108391. Kif1a.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • kinesin complex Source: GO_Central
  • microtubule Source: UniProtKB-KW
  • neuronal cell body Source: MGI
  • neuron projection Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254061 – 1695Kinesin-like protein KIF1AAdd BLAST1695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei416PhosphoserineBy similarity1
Modified residuei418PhosphoserineBy similarity1
Modified residuei419PhosphoserineBy similarity1
Modified residuei607PhosphothreonineCombined sources1
Modified residuei612PhosphothreonineCombined sources1
Modified residuei932PhosphoserineCombined sources1
Modified residuei937PhosphoserineBy similarity1
Modified residuei1315PhosphoserineBy similarity1
Modified residuei1342PhosphoserineCombined sources1
Modified residuei1524PhosphothreonineCombined sources1
Modified residuei1528PhosphothreonineCombined sources1
Modified residuei1533PhosphoserineCombined sources1
Modified residuei1537PhosphoserineCombined sources1
Modified residuei1553PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP33173.
PaxDbiP33173.
PeptideAtlasiP33173.
PRIDEiP33173.

PTM databases

iPTMnetiP33173.
PhosphoSitePlusiP33173.

Expressioni

Tissue specificityi

Expressed almost exclusively in adult brain tissue (mainly in the cerebellum and cerebrum) within a single type of neuronal cell. Within the neuronal cell levels are concentrated around the axon, with smaller amounts in the perinuclear and synaptic regions.

Gene expression databases

CleanExiMM_KIF1A.

Interactioni

Subunit structurei

Monomer. Interacts with PPFIA1 and PPFIA4 (By similarity).By similarity

GO - Molecular functioni

  • microtubule binding Source: MGI

Protein-protein interaction databases

DIPiDIP-46956N.
IntActiP33173. 1 interactor.
STRINGi10090.ENSMUSP00000128432.

Structurei

Secondary structure

11695
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 12Combined sources7
Helixi17 – 21Combined sources5
Beta strandi28 – 31Combined sources4
Beta strandi34 – 37Combined sources4
Beta strandi40 – 42Combined sources3
Beta strandi48 – 51Combined sources4
Beta strandi53 – 57Combined sources5
Beta strandi64 – 66Combined sources3
Helixi70 – 76Combined sources7
Helixi78 – 86Combined sources9
Beta strandi91 – 96Combined sources6
Helixi103 – 107Combined sources5
Helixi112 – 114Combined sources3
Helixi118 – 131Combined sources14
Beta strandi138 – 150Combined sources13
Beta strandi153 – 156Combined sources4
Turni160 – 162Combined sources3
Beta strandi168 – 171Combined sources4
Turni172 – 174Combined sources3
Beta strandi175 – 178Combined sources4
Beta strandi184 – 186Combined sources3
Helixi189 – 203Combined sources15
Helixi206 – 209Combined sources4
Turni210 – 212Combined sources3
Helixi213 – 216Combined sources4
Beta strandi217 – 230Combined sources14
Turni232 – 235Combined sources4
Beta strandi237 – 248Combined sources12
Helixi252 – 254Combined sources3
Helixi265 – 288Combined sources24
Helixi306 – 308Combined sources3
Helixi310 – 314Combined sources5
Helixi316 – 318Combined sources3
Beta strandi320 – 322Combined sources3
Beta strandi324 – 331Combined sources8
Helixi335 – 337Combined sources3
Helixi338 – 350Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I5SX-ray2.20A1-355[»]
1I6IX-ray2.00A1-355[»]
1IA0electron microscopy15.00K1-355[»]
1VFVX-ray1.85A1-355[»]
1VFWX-ray2.30A1-355[»]
1VFXX-ray2.55A1-355[»]
1VFZX-ray2.24A1-355[»]
2HXFelectron microscopy10.00C3-355[»]
2HXHelectron microscopy11.00C3-355[»]
2ZFIX-ray1.55A1-355[»]
2ZFJX-ray3.20A1-355[»]
2ZFKX-ray3.61A1-355[»]
2ZFLX-ray2.70A1-355[»]
2ZFMX-ray2.31A1-355[»]
ProteinModelPortaliP33173.
SMRiP33173.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33173.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 354Kinesin motorPROSITE-ProRule annotationAdd BLAST350
Domaini516 – 572FHAPROSITE-ProRule annotationAdd BLAST57
Domaini1580 – 1678PHPROSITE-ProRule annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili366 – 383Sequence analysisAdd BLAST18
Coiled coili429 – 462Sequence analysisAdd BLAST34
Coiled coili622 – 681Sequence analysisAdd BLAST60
Coiled coili801 – 822Sequence analysisAdd BLAST22

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.PROSITE-ProRule annotation
Contains 1 FHA domain.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0245. Eukaryota.
COG5059. LUCA.
HOVERGENiHBG052251.
InParanoidiP33173.
PhylomeDBiP33173.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
2.60.200.20. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR022164. Kinesin-like.
IPR027640. Kinesin-like_fam.
IPR022140. Kinesin-like_KIF1-typ.
IPR032405. Kinesin_assoc.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF12473. DUF3694. 1 hit.
PF00498. FHA. 1 hit.
PF12423. KIF1B. 1 hit.
PF00225. Kinesin. 1 hit.
PF16183. Kinesin_assoc. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00240. FHA. 1 hit.
SM00129. KISc. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGASVKVAV RVRPFNSREM SRDSKCIIQM SGSTTTIVNP KQPKETPKSF
60 70 80 90 100
SFDYSYWSHT SPEDINYASQ KQVYRDIGEE MLQHAFEGYN VCIFAYGQTG
110 120 130 140 150
AGKSYTMMGK QEKDQQGIIP QLCEDLFSRI NDTTNDNMSY SVEVSYMEIY
160 170 180 190 200
CERVRDLLNP KNKGNLRVRE HPLLGPYVED LSKLAVTSYN DIQDLMDSGN
210 220 230 240 250
KPRTVAATNM NETSSRSHAV FNIIFTQKRH DAETNITTEK VSKISLVDLA
260 270 280 290 300
GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEMDS GPNKNKKKKK
310 320 330 340 350
TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR
360 370 380 390 400
AKQIRCNAII NEDPNNKLIR ELKDEVTRLR DLLYAQGLGD ITDMTNALVG
410 420 430 440 450
MSPSSSLSAL SSRAASVSSL HERILFAPGS EEAIERLKET EKIIAELNET
460 470 480 490 500
WEEKLRRTEA IRMEREALLA EMGVAMREDG GTLGVFSPKK TPHLVNLNED
510 520 530 540 550
PLMSECLLYY IKDGVTRVGR EDAERRQDIV LSGHFIKEEH CIFRSDSRGG
560 570 580 590 600
GEAVVTLEPC EGADTYVNGK KVTEPSILRS GNRIIMGKSH VFRFNHPEQA
610 620 630 640 650
RQERERTPCA ETPAEPVDWA FAQRELLEKQ GIDMKQEMEQ RLQELEDQYR
660 670 680 690 700
REREEATYLL EQQRLDYESK LEALQKQMDS RYYPEVNEEE EEPEDEVQWT
710 720 730 740 750
ERECELALWA FRKWKWYQFT SLRDLLWGNA IFLKEANAIS VELKKKVQFQ
760 770 780 790 800
FVLLTDTLYS PLPPDLLPPE AAKDRETRPF PRTIVAVEVQ DQKNGATHYW
810 820 830 840 850
TLEKLRQRLD LMREMYDRAA EVPSSVVEDC DNVVTGGDPF YDRFPWFRLV
860 870 880 890 900
GRAFVYLSNL LYPVPLVHRV AIVSEKGEVK GFLRVAVQAI SADEEAPDYG
910 920 930 940 950
SGVRQSGTAK ISFDDQHFEK FQSESCPVVG MSRSGTSQEE LRIVEGQGQG
960 970 980 990 1000
ADAGPSADEV NNNTCSAVPP EGLMDSPEKA ALDGPLDTAL DHLRLGSTFT
1010 1020 1030 1040 1050
FRVTVLQASS ISAEYADIFC QFNFIHRHDE AFSTEPLKNT GRGPPLGFYH
1060 1070 1080 1090 1100
VQNIAVEVTK SFIEYIKSQP IVFEVFGHYQ QHPFPPLCKD VLSPLRPSRR
1110 1120 1130 1140 1150
HFPRVMPLSK PVPATKLSTM TRPSPGPCHC KYDLLVYFEI CELEANGDYI
1160 1170 1180 1190 1200
PAVVDHRGAC MGTFLLHQGI QRRITVTLLH ETGSHIRWKE VRELVVGRIR
1210 1220 1230 1240 1250
NTPETDEALI DPNILSLNIL SSGYVHPAQD DRVFFGNDTR TFYQFEAAWD
1260 1270 1280 1290 1300
SSMHNSLLLN RVTPYREKIY MTLSAYIEME NCTQPAVITK DFCMVFYSRD
1310 1320 1330 1340 1350
AKLPASRSIR NLFGSGSLRA TEGNRVTGVY ELSLCHVADA GSPGMQRRRR
1360 1370 1380 1390 1400
RVLDTSVAYV RGEENLAGWR PRSDSLILDH QWELEKLSLL QEVEKTRHYL
1410 1420 1430 1440 1450
LLREKLETTQ RPGPEVLSPA SSEDSESRSS SGASSPLSAE GQPSPLEAPN
1460 1470 1480 1490 1500
ERQRELAVKC LRLLMHTFNR EYTHSHVCIS ASESKLSEMS VTLMRDPSMS
1510 1520 1530 1540 1550
PLGAATLTPS STCPSLIEGR YGATDVRTPQ PCSRPASPEP ELLPELDSKK
1560 1570 1580 1590 1600
TPSPVRATET EKEPQRLLVP DIQEIRVSPI VSKKGYLHFL EPHTAGWAKR
1610 1620 1630 1640 1650
FVVVRRPYAY MYNSDKDTVE RFVLNLSTAQ VEYSEDQQAM LKTPNTFAVC
1660 1670 1680 1690
TEHRGILLQA NSDKDMHDWL YAFNPLLAGT IRSKLSRRRS AQMRV
Length:1,695
Mass (Da):191,725
Last modified:November 1, 1997 - v2
Checksum:iD6EC3B88CBC9CCC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29951 mRNA. Translation: BAA06221.1.
PIRiA56921.
E44259.
UniGeneiMm.276408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29951 mRNA. Translation: BAA06221.1.
PIRiA56921.
E44259.
UniGeneiMm.276408.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I5SX-ray2.20A1-355[»]
1I6IX-ray2.00A1-355[»]
1IA0electron microscopy15.00K1-355[»]
1VFVX-ray1.85A1-355[»]
1VFWX-ray2.30A1-355[»]
1VFXX-ray2.55A1-355[»]
1VFZX-ray2.24A1-355[»]
2HXFelectron microscopy10.00C3-355[»]
2HXHelectron microscopy11.00C3-355[»]
2ZFIX-ray1.55A1-355[»]
2ZFJX-ray3.20A1-355[»]
2ZFKX-ray3.61A1-355[»]
2ZFLX-ray2.70A1-355[»]
2ZFMX-ray2.31A1-355[»]
ProteinModelPortaliP33173.
SMRiP33173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46956N.
IntActiP33173. 1 interactor.
STRINGi10090.ENSMUSP00000128432.

PTM databases

iPTMnetiP33173.
PhosphoSitePlusiP33173.

Proteomic databases

MaxQBiP33173.
PaxDbiP33173.
PeptideAtlasiP33173.
PRIDEiP33173.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:108391. Kif1a.

Phylogenomic databases

eggNOGiKOG0245. Eukaryota.
COG5059. LUCA.
HOVERGENiHBG052251.
InParanoidiP33173.
PhylomeDBiP33173.

Miscellaneous databases

ChiTaRSiKif1a. mouse.
EvolutionaryTraceiP33173.
PROiP33173.
SOURCEiSearch...

Gene expression databases

CleanExiMM_KIF1A.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
2.60.200.20. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR022164. Kinesin-like.
IPR027640. Kinesin-like_fam.
IPR022140. Kinesin-like_KIF1-typ.
IPR032405. Kinesin_assoc.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF12473. DUF3694. 1 hit.
PF00498. FHA. 1 hit.
PF12423. KIF1B. 1 hit.
PF00225. Kinesin. 1 hit.
PF16183. Kinesin_assoc. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00240. FHA. 1 hit.
SM00129. KISc. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIF1A_MOUSE
AccessioniPrimary (citable) accession number: P33173
Secondary accession number(s): Q61770
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.