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P33173 (KIF1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin-like protein KIF1A
Alternative name(s):
Axonal transporter of synaptic vesicles
Gene names
Name:Kif1a
Synonyms:Atsv, Kif1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length1695 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Motor for anterograde axonal transport of synaptic vesicle precursors.

Subunit structure

Monomer. Interacts with PPFIA1 and PPFIA4 By similarity.

Subcellular location

Cytoplasm › cytoskeleton By similarity. Note: Expressed in distal regions of neurites By similarity.

Tissue specificity

Expressed almost exclusively in adult brain tissue (mainly in the cerebellum and cerebrum) within a single type of neuronal cell. Within the neuronal cell levels are concentrated around the axon, with smaller amounts in the perinuclear and synaptic regions.

Sequence similarities

Belongs to the kinesin-like protein family. Unc-104 subfamily.

Contains 1 FHA domain.

Contains 1 kinesin-motor domain.

Contains 1 PH domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
Microtubule
   DomainCoiled coil
   LigandATP-binding
Nucleotide-binding
   Molecular functionMotor protein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processmicrotubule-based movement

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule motor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16951695Kinesin-like protein KIF1A
PRO_0000125406

Regions

Domain1 – 361361Kinesin-motor
Domain516 – 57257FHA
Domain1580 – 167899PH
Nucleotide binding97 – 1048ATP
Coiled coil366 – 38318 Potential
Coiled coil429 – 46234 Potential
Coiled coil622 – 68160 Potential
Coiled coil801 – 82222 Potential

Secondary structure

1 ........................................................... 1695
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P33173 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: D6EC3B88CBC9CCC6

FASTA1,695191,725
        10         20         30         40         50         60 
MAGASVKVAV RVRPFNSREM SRDSKCIIQM SGSTTTIVNP KQPKETPKSF SFDYSYWSHT 

        70         80         90        100        110        120 
SPEDINYASQ KQVYRDIGEE MLQHAFEGYN VCIFAYGQTG AGKSYTMMGK QEKDQQGIIP 

       130        140        150        160        170        180 
QLCEDLFSRI NDTTNDNMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 

       190        200        210        220        230        240 
LSKLAVTSYN DIQDLMDSGN KPRTVAATNM NETSSRSHAV FNIIFTQKRH DAETNITTEK 

       250        260        270        280        290        300 
VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEMDS GPNKNKKKKK 

       310        320        330        340        350        360 
TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIRCNAII 

       370        380        390        400        410        420 
NEDPNNKLIR ELKDEVTRLR DLLYAQGLGD ITDMTNALVG MSPSSSLSAL SSRAASVSSL 

       430        440        450        460        470        480 
HERILFAPGS EEAIERLKET EKIIAELNET WEEKLRRTEA IRMEREALLA EMGVAMREDG 

       490        500        510        520        530        540 
GTLGVFSPKK TPHLVNLNED PLMSECLLYY IKDGVTRVGR EDAERRQDIV LSGHFIKEEH 

       550        560        570        580        590        600 
CIFRSDSRGG GEAVVTLEPC EGADTYVNGK KVTEPSILRS GNRIIMGKSH VFRFNHPEQA 

       610        620        630        640        650        660 
RQERERTPCA ETPAEPVDWA FAQRELLEKQ GIDMKQEMEQ RLQELEDQYR REREEATYLL 

       670        680        690        700        710        720 
EQQRLDYESK LEALQKQMDS RYYPEVNEEE EEPEDEVQWT ERECELALWA FRKWKWYQFT 

       730        740        750        760        770        780 
SLRDLLWGNA IFLKEANAIS VELKKKVQFQ FVLLTDTLYS PLPPDLLPPE AAKDRETRPF 

       790        800        810        820        830        840 
PRTIVAVEVQ DQKNGATHYW TLEKLRQRLD LMREMYDRAA EVPSSVVEDC DNVVTGGDPF 

       850        860        870        880        890        900 
YDRFPWFRLV GRAFVYLSNL LYPVPLVHRV AIVSEKGEVK GFLRVAVQAI SADEEAPDYG 

       910        920        930        940        950        960 
SGVRQSGTAK ISFDDQHFEK FQSESCPVVG MSRSGTSQEE LRIVEGQGQG ADAGPSADEV 

       970        980        990       1000       1010       1020 
NNNTCSAVPP EGLMDSPEKA ALDGPLDTAL DHLRLGSTFT FRVTVLQASS ISAEYADIFC 

      1030       1040       1050       1060       1070       1080 
QFNFIHRHDE AFSTEPLKNT GRGPPLGFYH VQNIAVEVTK SFIEYIKSQP IVFEVFGHYQ 

      1090       1100       1110       1120       1130       1140 
QHPFPPLCKD VLSPLRPSRR HFPRVMPLSK PVPATKLSTM TRPSPGPCHC KYDLLVYFEI 

      1150       1160       1170       1180       1190       1200 
CELEANGDYI PAVVDHRGAC MGTFLLHQGI QRRITVTLLH ETGSHIRWKE VRELVVGRIR 

      1210       1220       1230       1240       1250       1260 
NTPETDEALI DPNILSLNIL SSGYVHPAQD DRVFFGNDTR TFYQFEAAWD SSMHNSLLLN 

      1270       1280       1290       1300       1310       1320 
RVTPYREKIY MTLSAYIEME NCTQPAVITK DFCMVFYSRD AKLPASRSIR NLFGSGSLRA 

      1330       1340       1350       1360       1370       1380 
TEGNRVTGVY ELSLCHVADA GSPGMQRRRR RVLDTSVAYV RGEENLAGWR PRSDSLILDH 

      1390       1400       1410       1420       1430       1440 
QWELEKLSLL QEVEKTRHYL LLREKLETTQ RPGPEVLSPA SSEDSESRSS SGASSPLSAE 

      1450       1460       1470       1480       1490       1500 
GQPSPLEAPN ERQRELAVKC LRLLMHTFNR EYTHSHVCIS ASESKLSEMS VTLMRDPSMS 

      1510       1520       1530       1540       1550       1560 
PLGAATLTPS STCPSLIEGR YGATDVRTPQ PCSRPASPEP ELLPELDSKK TPSPVRATET 

      1570       1580       1590       1600       1610       1620 
EKEPQRLLVP DIQEIRVSPI VSKKGYLHFL EPHTAGWAKR FVVVRRPYAY MYNSDKDTVE 

      1630       1640       1650       1660       1670       1680 
RFVLNLSTAQ VEYSEDQQAM LKTPNTFAVC TEHRGILLQA NSDKDMHDWL YAFNPLLAGT 

      1690 
IRSKLSRRRS AQMRV

« Hide

References

[1]"The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors."
Okada Y., Yamazaki H., Sekine-Aizawa Y., Hirokawa N.
Cell 81:769-780(1995) [PubMed: 7539720] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Kinesin family in murine central nervous system."
Aizawa H., Sekine Y., Takemura R., Zhang Z., Nangaku M., Hirokawa N.
J. Cell Biol. 119:1287-1296(1992) [PubMed: 1447303] [Abstract]
Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE OF 100-247.
Tissue: Brain.
[3]"Switch-based mechanism of kinesin motors."
Kikkawa M., Sablin E.P., Okada Y., Yajima H., Fletterick R.J., Hirokawa N.
Nature 411:439-445(2001) [PubMed: 11373668] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1-355 IN COMPLEX WITH ADP.
[4]"KIF1A alternately uses two loops to bind microtubules."
Nitta R., Kikkawa M., Okada Y., Hirokawa N.
Science 305:678-683(2004) [PubMed: 15286375] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 1-355 IN COMPLEX WITH TRANSITION STATE ANALOGS.
[5]"Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin."
Nitta R., Okada Y., Hirokawa N.
Nat. Struct. Mol. Biol. 15:1067-1075(2008) [PubMed: 18806800] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 1-355 IN COMPLEX WITH ADP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D29951 mRNA. Translation: BAA06221.1.
IPIIPI00985705.
PIRA56921.
E44259.
UniGeneMm.276408.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1I5SX-ray2.20A1-355[»]
1I6IX-ray2.00A1-355[»]
1IA0electron microscopy15.00K3-355[»]
1VFVX-ray1.85A1-355[»]
1VFWX-ray2.30A1-355[»]
1VFXX-ray2.55A1-355[»]
1VFZX-ray2.24A1-355[»]
2HXFelectron microscopy10.00C3-355[»]
2HXHelectron microscopy11.00C3-355[»]
2ZFIX-ray1.55A1-355[»]
2ZFJX-ray3.20A1-355[»]
2ZFKX-ray3.61A1-355[»]
2ZFLX-ray2.70A1-355[»]
2ZFMX-ray2.31A1-355[»]
ProteinModelPortalP33173.
SMRP33173. Positions 4-353, 491-607, 1580-1678.
ModBaseSearch...

Protein-protein interaction databases

IntActP33173. 1 interaction.
STRINGP33173.

PTM databases

PhosphoSiteP33173.

Proteomic databases

PRIDEP33173.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:108391. Kif1a.

Phylogenomic databases

eggNOGroNOG15004.
HOVERGENHBG052251.
InParanoidP33173.
OrthoDBEOG447FSB.

Gene expression databases

ArrayExpressP33173.
BgeeP33173.
CleanExMM_KIF1A.
GenevestigatorP33173.
GermOnlineENSMUSG00000014602. Mus musculus.

Family and domain databases

InterProIPR000253. FHA_dom.
IPR022140. KIF1B.
IPR022164. Kinesin-like.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR011993. PH_type.
IPR001849. Pleckstrin_homology.
IPR008984. SMAD_FHA_domain.
[Graphical view]
Gene3DG3DSA:2.60.200.20. FHA. 1 hit.
G3DSA:3.40.850.10. kinesin_motor. 1 hit.
G3DSA:2.30.29.30. PH_type. 1 hit.
PfamPF12473. DUF3694. 1 hit.
PF00498. FHA. 1 hit.
PF12423. KIF1B. 1 hit.
PF00225. Kinesin. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00240. FHA. 1 hit.
SM00129. KISc. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMSSF49879. SMAD_FHA. 1 hit.
PROSITEPS50006. FHA_DOMAIN. 1 hit.
PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameKIF1A_MOUSE
AccessionPrimary (citable) accession number: P33173
Secondary accession number(s): Q61770
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 1, 1997
Last modified: January 25, 2012
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents